Research Topics
| R Sá-LeãoSummaryAffiliation: Universidade Nova de Lisboa Country: Portugal Publications
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Detail Information
Publications
Large screening of CA-MRSA among Staphylococcus aureus colonizing healthy young children living in two areas (urban and rural) of PortugalDébora A Tavares
Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica ITQB, Universidade Nova de Lisboa UNL, Oeiras, Portugal
BMC Infect Dis 10:110. 2010..5%...- Analysis of invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines reveals heterogeneous behavior of clones expressing the same serotypeRaquel Sá-Leão
Instituto de Tecnologia Quimica e Biologica, Rua da Quinta Grande, 6 Oeiras, 2780 156 Oeiras, Portugal
J Clin Microbiol 49:1369-75. 2011..Continuous surveillance should be maintained, and current research should focus on uncovering the genetic determinants that contribute to the heterogeneity of invasive disease potential of clones sharing the same serotype... - Identification, prevalence and population structure of non-typable Streptococcus pneumoniae in carriage samples isolated from preschoolers attending day-care centresRaquel Sá-Leão
Molecular Genetics Laboratory, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Rua da Quinta Grande, 6, 2780 106 Oeiras, Portugal
Microbiology 152:367-76. 2006..These observations seem to indicate that NTPn have diverse genetic backgrounds and may have evolved as a distinct group of pneumococcal isolates... - High rates of transmission of and colonization by Streptococcus pneumoniae and Haemophilus influenzae within a day care center revealed in a longitudinal studyRaquel Sá-Leão
Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, 2780 156 Oeiras, Portugal
J Clin Microbiol 46:225-34. 2008..DCCs are units where permanent introduction of new clones occurs, and attendees, as a whole, provide a pool of hosts where the fittest clones find privileged opportunities to persist and expand... - Changes in pneumococcal serotypes and antibiotypes carried by vaccinated and unvaccinated day-care centre attendees in Portugal, a country with widespread use of the seven-valent pneumococcal conjugate vaccineR Sá-Leão
Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
Clin Microbiol Infect 15:1002-7. 2009..Rates of antibiotic resistance remained unchanged due to a balance between reduction in VT and an increase in antimicrobial-resistant NVT... - Properties of novel international drug-resistant pneumococcal clones identified in day-care centers of Lisbon, PortugalNatacha G Sousa
, , Universidade Nova de Lisboa, Oeiras, Portugal
J Clin Microbiol 43:4696-703. 2005..We propose the inclusion of these novel international clones in the PMEN... - Emergence of a serotype 1 Streptococcus pneumoniae lineage colonising healthy children in Portugal in the seven-valent conjugate vaccination eraS Nunes
Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
Clin Microbiol Infect 14:82-4. 2008..4% in 2003, and 3.1% in 2006. These observations paralleled the introduction and increased use of the seven-valent pneumococcal conjugate vaccine in the study group, suggesting a direct relationship between these events... - Optochin resistance among Streptococcus pneumoniae strains colonizing healthy children in PortugalSónia Nunes
Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, 2780 156 Oeiras, Portugal
J Clin Microbiol 46:321-4. 2008..Novel optochin-resistant lineages were detected over time, suggesting that there was a continuous, although sporadic, emergence of optochin resistance... - Diversity of penicillin-nonsusceptible Streptococcus pneumoniae circulating in Iceland after the introduction of penicillin-resistant clone Spain(6B)-2Raquel Sá-Leão
Laboratory of Microbiology, Rockefeller University, New York, New York 10021, USA
J Infect Dis 186:966-75. 2002..The major mechanism of dissemination of penicillin resistance in Iceland appears to be the repeated introduction of multiple lineages, followed by clonal spread... - Pilot study of the genetic diversity of the pneumococcal nasopharyngeal flora among children attending day care centersRaquel Sá-Leão
Laboratory of Microbiology, The Rockefeller University, 1230 York Avenue, New York, NY, USA
J Clin Microbiol 40:3577-85. 2002..Quantitative resolution of majority and minority components of the pneumococcal NP flora will be of importance for evaluation of the impact of intervention strategies such as vaccination or introduction of new antimicrobial agents... - Clonal evolution leading to maintenance of antibiotic resistance rates among colonizing Pneumococci in the PCV7 era in PortugalAlexandra S Simões
Laboratory of Molecular Microbiology, Instituto de Tecnologia Quimica e Biologica, Rua da Quinta Grande, 6, Oeiras, 2780 156 Oeiras, Portugal
J Clin Microbiol 49:2810-7. 2011..In the era of PCVs, antimicrobial resistance remains a problem among the carried pneumococci. Continuous surveillance is warranted to evaluate serotype and clonal shifts leading to maintenance of antimicrobial resistance... - Highly penicillin-resistant multidrug-resistant pneumococcus-like strains colonizing children in Oeiras, Portugal: genomic characteristics and implications for surveillanceAlexandra S Simões
Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras 2780 156, Portugal
J Clin Microbiol 48:238-46. 2010..In our study, after correct identification of the penicillin-resistant true pneumococci, we found that penicillin resistance levels among pneumococci remained stable from 2003 to 2006...