Alexandra M M Antunes

Summary

Country: Portugal

Publications

  1. ncbi Oxidation of 2-hydroxynevirapine, a phenolic metabolite of the anti-HIV drug nevirapine: evidence for an unusual pyridine ring contraction
    Alexandra M M Antunes
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisboa 1049 001, Portugal
    Molecules 17:2616-27. 2012
  2. ncbi Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine--a possible factor in nevirapine toxicity
    Alexandra M M Antunes
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisboa, Portugal
    Chem Res Toxicol 23:888-99. 2010
  3. ncbi Protein adducts as prospective biomarkers of nevirapine toxicity
    Alexandra M M Antunes
    Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Lisboa, Portugal
    Chem Res Toxicol 23:1714-25. 2010
  4. ncbi Synthesis and oxidation of 2-hydroxynevirapine, a metabolite of the HIV reverse transcriptase inhibitor nevirapine
    Alexandra M M Antunes
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, 1049 001, Lisboa, Portugal
    Org Biomol Chem 9:7822-35. 2011
  5. ncbi Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity
    Catarina Charneira
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, 1049 001 Lisboa, Portugal
    Chem Res Toxicol 24:2129-41. 2011

Collaborators

  • Catarina Charneira
  • Emilia C Monteiro
  • M Conceição Oliveira
  • M Matilde Marques
  • Sofia A Pereira
  • Ana L A Godinho

Detail Information

Publications5

  1. ncbi Oxidation of 2-hydroxynevirapine, a phenolic metabolite of the anti-HIV drug nevirapine: evidence for an unusual pyridine ring contraction
    Alexandra M M Antunes
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisboa 1049 001, Portugal
    Molecules 17:2616-27. 2012
    ..We report herein the isolation and full structural characterization of a 1H-pyrrole-2,5-dione derivative as a major product, stemming from an unusual pyridine ring contraction...
  2. ncbi Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine--a possible factor in nevirapine toxicity
    Alexandra M M Antunes
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisboa, Portugal
    Chem Res Toxicol 23:888-99. 2010
    ..Additionally, we obtained reliable, fully characterized standards for the assessment of protein modification by NVP in vivo, which should help clarify the potential role of metabolism in NVP-induced toxicity...
  3. ncbi Protein adducts as prospective biomarkers of nevirapine toxicity
    Alexandra M M Antunes
    Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Lisboa, Portugal
    Chem Res Toxicol 23:1714-25. 2010
    ....
  4. ncbi Synthesis and oxidation of 2-hydroxynevirapine, a metabolite of the HIV reverse transcriptase inhibitor nevirapine
    Alexandra M M Antunes
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, 1049 001, Lisboa, Portugal
    Org Biomol Chem 9:7822-35. 2011
    ..These observations suggest that metabolic activation of NVP, via Phase I oxidation to 2-hydroxy-NVP and subsequent generation of a quinone-imine, could occur in vivo and play a role in NVP-induced toxicity...
  5. ncbi Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity
    Catarina Charneira
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, 1049 001 Lisboa, Portugal
    Chem Res Toxicol 24:2129-41. 2011
    ....