Research Topics
| Cezary WatalaSummaryAffiliation: University of Lodz Country: Poland Publications
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Detail Information
Publications
Merocyanine 540 as a fluorescent probe of altered membrane phospholipid asymmetry in activated whole blood plateletsCezary Watala
Laboratory of Haemostatic Disorders, Medical University of Łódź, Łódź, Poland
Cytometry 49:119-33. 2002..Platelet activation leads to the loss of a natural asymmetry of membrane phospholipids (PL) and the subsequent exposure of negatively charged PL in platelets with procoagulant activity that can be monitored routinely with annexin V (AN-V)...- Increased protein glycation in diabetes mellitus is associated with decreased aspirin-mediated protein acetylation and reduced sensitivity of blood platelets to aspirinCezary Watala
Department of Hemostasis and Hemostatic Disorders, Medical University of Lodz, ul Zeromskiego 113, 90 549 Lodz, Poland
J Mol Med (Berl) 83:148-58. 2005.... - Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)-its relation to metabolic controlCezary Watala
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz ul, Zeromskiego 113 90 549 Lodz, Poland
Thromb Res 113:101-13. 2004..Thus, our findings strongly support the requirements for an excellent near-normal metabolic control and may suggest a need for alternative ASA dosing schedules in DM patients... - Blood platelet reactivity and its pharmacological modulation in (people with) diabetes mellitusCezary Watala
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Poland
Curr Pharm Des 11:2331-65. 2005..Observations from clinical studies rather support the use of multifactorial strategy under such circumstances, like a combined therapy of aspirin plus either purinoreceptor blocker or GPIIb-IIIa antagonist... - Targeting the urine and plasma determinants of thromboxane A2 metabolism in detection of aspirin effectivenessMarcin Dobaczewski
Department of Hemostasis and Hemostatic Disorders, Medical University of Lodz, University Hospital No 2, Lodz, Poland
Blood Coagul Fibrinolysis 19:421-8. 2008.... - Elevated cholesterol reduces acetylsalicylic acid-mediated platelet acetylationMagdalena Boncler
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Medical University Hospital No 2, 113 Zeromskiego Street, 90 549 Lodz, Poland
Biochim Biophys Acta 1770:1651-9. 2007..The molecular basis of such an association remains obscure, notwithstanding it may constitute a link between sub-optimal platelet response to aspirin and lipid metabolic disorders... - Usefulness of whole blood aggregometry and its comparison with thromboxane generation assay in monitoring acetylsalicylic acid effectiveness--a multiparametric study in ratsMarek Nocun
Department of Hemostasis and Hemostatic Disorders, Medical University of Lodz, University Hospital No. 2, Lodz, Poland
Clin Chem Lab Med 44:853-62. 2006..CONCLUSIONS: Analysis of aggregation curves, routinely based only on the amplitude and rate of platelet aggregation, may not be enough discriminative to distinguish between varying ASA doses and treatment schedules... - Acetylsalicylic acid is compounding to antiplatelet effect of C-reactive proteinMagdalena Boncler
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Medical University Hospital No 2, 113 Zeromskiego Street, 90 549 Lodz, Poland
Thromb Res 119:209-16. 2007..Thus, we conclude that the effectiveness of aspirin therapy may strongly depend upon the presence of native CRP in circulation... - High glucose contributes to aspirin insensitivity in streptozotocin-diabetic rats: a multiparametric aggregation studyCezary Watala
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, University Hospital No 2, Lodz, Poland
Blood Coagul Fibrinolysis 17:113-24. 2006..Our data validate the suggestion that the relationship between aspirin ineffectiveness and poor metabolic control, first revealed in humans, concerns also other animals' platelets and holds regardless of the model or type of diabetes... - The effect of a platelet cholesterol modulation on the acetylsalicylic acid-mediated blood platelet inhibition in hypercholesterolemic patientsBoguslawa Luzak
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Poland
Eur J Pharmacol 658:91-7. 2011..This effect may extend beyond the action of atorvastatin as merely a lipid-lowering agent. The mechanisms of resistance of some patients to such a combined ASA-statin treatment remain to be elucidated... - Effectiveness of modified C-reactive protein in the modulation of platelet function under different experimental conditionsMagdalena Boncler
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, University Hospital No 2, 113 Zeromskiego Street, Lodz, Poland
Blood Coagul Fibrinolysis 22:301-9. 2011..Taken together, the modulation of platelet function by mCRP seems to be strongly determined by the presence of the gamma globulin fraction in platelet milieu... - Increased blood plasma hydrolysis of acetylsalicylic acid in type 2 diabetic patients: a role of plasma esterasesPeter Gresner
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Zeromskiego 113, 90 549 Lodz, Poland
Biochim Biophys Acta 1760:207-15. 2006..01). No direct effects of plasma pH or albumin were observed. In conclusion, higher aspirin esterase activity contributes to the lowered response of diabetic platelets to ASA-mediated antiplatelet therapy... - Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin?Leszek Markuszewski
Department of Interventional Cardiology, Cardiodiabetology and Cardiac Rehabilitation, Medical University of Lodz, University Hospital No. 2, Lodz, Poland
Basic Clin Pharmacol Toxicol 98:503-9. 2006..Dyslipidaemia and chronic inflammatory states may promote suboptimal acetylsalicylic acid response in coronary artery disease patients... - Blood platelet abnormalities and pharmacological modulation of platelet reactivity in patients with diabetes mellitusCezary Watala
Department of Haemostasis and Haemostatic Disorders, Medical University of Łódź, Zeromskiego 113, PL 90 549 Łódź, Poland
Pharmacol Rep 57:42-58. 2005..Although we are at the very beginning of complete understanding of so-called 'aspirin-resistance', several potential molecular mechanisms of this phenomenon in diabetes have been evidenced... - French maritime pine bark extract Pycnogenol reduces thromboxane generation in blood from diabetic male ratsMarek Nocun
Department of Hemostasis and Hemostatic Disorders, Medical University of Lodz, University Hospital No 2, 90 549 Lodz, Poland
Biomed Pharmacother 62:168-72. 2008..The results of the present study suggest that Pycnogenol might have a beneficial antithrombotic effect when administered alone or as a supplementation of standard antiplatelet therapy in diabetic patients... - Limited usefulness of the PFA-100 for the monitoring of ADP receptor antagonists--in vitro experienceJacek Golanski
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Lodz, Poland
Clin Chem Lab Med 42:25-9. 2004..The outcomes of this study show that platelet aggregometry in whole blood is characterised by the highest sensitivity in the monitoring of the investigated blood platelet inhibitors... - Effect of the 807 c/t polymorphism in glycoprotein ia on blood platelet reactivityBoguslawa Luzak
Department of Hemostasis and Hemostatic Disorders, , ul. Narutowicza 96, , Poland
J Biomed Sci 10:731-7. 2003..Our results indicate that the 807 T/T genotype is related to increased platelet activation induced by ADP and higher platelet sensitivity to GPIaIIa antagonists... - Is platelet aggregation a more important contributor than platelet adhesion to the overall platelet-related primary haemostasis measured by PFA-100?Cezary Watala
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Poland
Thromb Res 109:299-306. 2003..The inputs of platelet aggregation and platelet adhesion into the real values of CT remain unknown, and this poor discrimination results in the complexity of the PFA-100 measurement... - Resorcylidene aminoguanidine induces antithrombotic action that is not dependent on its antiglycation activityCezary Watala
Department of Haemostasis and Haemostatic Disorders, Chair of Laboratory Diagnostics, Medical University of Lodz, University Hospital No 2, Lodz, Poland
Vascul Pharmacol 51:275-83. 2009..Our results indicate that designing novel RAG derivatives with optimal antithrombotic and antiglycation activities may prove useful to treat diabetic complications... - 1-methylnicotinamide effects on the selected markers of endothelial function, inflammation and haemostasis in diabetic ratsTomasz Przygodzki
Department of Haemostasis and Haemostatic Disorders, Chair of Laboratory Diagnostics, Medical University of Lodz, University Clinical Hospital No 2, Lodz, Poland
Eur J Pharmacol 640:157-62. 2010..Still other potential mechanism(s) await further elucidation... - Inhibition of collagen-induced platelet reactivity by DGEA peptideBoguslawa Luzak
Department of Haemostasis and Haemostatic Disorders, , dz, Poland
Acta Biochim Pol 50:1119-28. 2003.... - Genetic factors underlying differential blood platelet sensitivity to inhibitorsMarcin Rozalski
Department of Hemostasis and Hemostatic Disorders, , Zeromskiego 113, , Poland
Pharmacol Rep 57:1-13. 2005..Additionally, a potential role of 807C/T polymorphism (GPIa), polymorphisms of GPIb and platelet purinoreceptor P2Y12 in affecting platelet sensitivity to blocking agents is discussed... - [Role of C-reactive protein in atherogenesis]Magdalena Boncler
Zakład Zaburzeń Krzepniecia Krwi, Uniwersytet Medyczny w Łodzi, Łódź, Poland
Postepy Hig Med Dosw (Online) 60:538-46. 2006.... - Effect of poly(amido)amine (PAMAM) G4 dendrimer on heart and liver mitochondria in an animal model of diabetesMagdalena Labieniec
Department of General Biophysics, University of Lodz, 12 16 Banacha Street, 90 237 Lodz, Poland
Cell Biol Int 34:89-97. 2010..Thus ameliorating effects of PAMAM G4 on glycation and glycoxidation in experimental diabetes are not sufficient to restore the impaired mitochondrial function in diabetes... - Use of poly(amido)amine dendrimers in prevention of early non-enzymatic modifications of biomacromoleculesMagdalena Labieniec
Department of General Biophysics, University of Lodz, 90 237 Lodz, 12 16 Banacha Street, Poland
Biochimie 92:1296-305. 2010.... - Effects of resorcylidene aminoguanidine (RAG) on selected parameters of isolated rat liver mitochondriaMagdalena Labieniec
Department of General Biophysics, University of Lodz, 12 16 Banacha Str, 90 237 Lodz, Poland
Chem Biol Interact 179:280-7. 2009.... - Antagonists of platelet fibrinogen receptor are less effective in carriers of Pl(A2) polymorphism of beta(3) integrinMarcin Rozalski
Laboratory of Haemostasis and Haemostatic Disorders, Medical University of Łódź, ul Narutowicza 96, 90 141 Łódź, Poland
Eur J Pharmacol 454:1-8. 2002..In conclusion, GPIIb-IIIa blockers representing various classes are less effective inhibitors of platelet aggregation in Pl(A2)(+) carriers; however, the effect of the genotype is both agonist- and antagonist-dependent... - Effect of acetylsalicylic acid on the current-voltage characteristics of planar lipid membranesCezary Watala
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, 113 Zeromski str, 90 549 Lodz, Poland
Biophys Chem 142:27-33. 2009..In conclusion, the effects of ASA on lipid bilayer stability may contribute to drug transport through membrane lipid bilayers... - Extract from Aronia melanocarpa fruits potentiates the inhibition of platelet aggregation in the presence of endothelial cellsBoguslawa Luzak
Department of Haemostasis and Haemostatic Disorders, Medical University Hospital No 2, Medical University of Lodz, Poland
Arch Med Sci 6:141-4. 2010..In this study we evaluated the ability of AM extract to increase the efficacy of human umbilical vein endothelial cells (HUVECs) to inhibit platelet functions in vitro... - A comparative assessment of HER2 status in operable breast cancer by real-time RT-PCR and by immunohistochemistryPiotr Potemski
Department of Chemotherapy, Medical University of Łódź, Copernicus Memorial Hospital, Łódź, Poland
Med Sci Monit 12:MT57-61. 2006..The most commonly used methods for detecting HER2 gene amplification in breast cancer are immunohistochemistry and fluorescence in-situ hybridization. The aim of this retrospective study was to assess HER2 expression by real-time RT-PCR... - Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell lineTomasz Przygodzki
Department of Haemostasis and Haemostatic Disorders, Chair of Laboratory Diagnostics, Medical University of Lodz, University Clinical Hospital No 2, Łódź, Poland
Acta Biochim Pol 58:75-7. 2011..We conclude that inhibition of poly-ADP-ribose polymerase-dependent nucleotide pool reduction may not be sufficient to protect cells from streptozotocin toxicity... - Cerivastatin, a HMG-CoA reductase inhibitor, reduces plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activityMaria Swiatkowska
Department of Molecular and Medical Biophysics, Medical University of Lodz, Poland
Jpn J Pharmacol 90:337-44. 2002.... - Is aspirin resistance a real problem in people with type 2 diabetes?Jozef Drzewoski
Diabetes Care 27:1245-6. 2004 - Phosphatidylserine content is a more important contributor than transmembrane potential to interactions of merocyanine 540 with lipid bilayersIveta Waczulikova
Department of Biophysics and Chemical Physics, Comenius University, Bratislava, Slovak Republic
Biochim Biophys Acta 1567:176-82. 2002..In conclusion, the content of negatively charged PL is more important than TMP in determining the interactions of MC540 with PS/PC membranes... - Blood platelet membrane fluidity and the exposition of membrane protein receptors in Alzheimer disease (AD) patients--preliminary StudyWojciech Kozubski
Department of Neurology, University of Medical Sciences, Poznan, Poland
Alzheimer Dis Assoc Disord 16:52-4. 2002..0001) and activated (p < 0.005) platelets, as well as the expression of P-selectin and beta 3 subunit of GP IIb/IIIa in activated platelets (p < 0.0001; p < 0.04)... - Resistance to oral antiplatelet drugs--a Position Paper of the Working Group on antiplatelet drug resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac SocietyWiktor Kuliczkowski
3rd Department of Cardiology, Silesian Center of Heart Diseases, Zabrze
Kardiol Pol 66:470-6, 480-5; discussion 477-9, 486-7. 2008