P Popik

Summary

Country: Poland

Publications

  1. ncbi Effects of memantine, an NMDA receptor antagonist, on place preference conditioned with drug and nondrug reinforcers in mice
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Behav Pharmacol 14:237-44. 2003
  2. ncbi The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice
    Tomasz Kos
    Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 214:911-21. 2011
  3. ncbi Neurohypophyseal peptides and social recognition in rats
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Prog Brain Res 119:415-36. 1998
  4. ncbi Cognitive effects of Colostral-Val nonapeptide in aged rats
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Behav Brain Res 118:201-8. 2001
  5. ncbi Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Neuropharmacology 43:1210-7. 2002
  6. ncbi Human opiorphin: the lack of physiological dependence, tolerance to antinociceptive effects and abuse liability in laboratory mice
    Piotr Popik
    Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Behav Brain Res 213:88-93. 2010
  7. ncbi Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA
    Piotr Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Neuropsychopharmacology 28:457-67. 2003
  8. ncbi Nicotine and nicotinic receptor antagonists potentiate the antidepressant-like effects of imipramine and citalopram
    Piotr Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Br J Pharmacol 139:1196-202. 2003
  9. ncbi Lack of persistent effects of ketamine in rodent models of depression
    Piotr Popik
    Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Psychopharmacology (Berl) 198:421-30. 2008
  10. ncbi Reinstatement of morphine-conditioned reward is blocked by memantine
    Piotr Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 31:160-70. 2006

Detail Information

Publications48

  1. ncbi Effects of memantine, an NMDA receptor antagonist, on place preference conditioned with drug and nondrug reinforcers in mice
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Behav Pharmacol 14:237-44. 2003
    ..These findings suggest that the effects of NMDA receptor blockade may not be limited to drug-reinforced behaviors...
  2. ncbi The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice
    Tomasz Kos
    Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Psychopharmacology (Berl) 214:911-21. 2011
    ..Although phencyclidine disturbs cognitive flexibility, little is known about the effects of ketamine and other NMDA antagonists that differ in receptor subunit selectivity, particularly in the mouse species...
  3. ncbi Neurohypophyseal peptides and social recognition in rats
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Prog Brain Res 119:415-36. 1998
    ..Social memory paradigms can reveal information about memory processes in animals that is relevant for memory deficits in humans...
  4. ncbi Cognitive effects of Colostral-Val nonapeptide in aged rats
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Behav Brain Res 118:201-8. 2001
    ..The present findings indicate that colostrinin-derived nonapeptide may delay the extinction of long-term memories...
  5. ncbi Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Neuropharmacology 43:1210-7. 2002
    ..In contrast to 0.1 mg/kg of MK-801, which inhibited the acquisition of this task, 30 mg/kg of MPEP affected neither learning nor memory retrieval. These data suggest that mGluR5 may be involved in conditioned morphine reward...
  6. ncbi Human opiorphin: the lack of physiological dependence, tolerance to antinociceptive effects and abuse liability in laboratory mice
    Piotr Popik
    Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Behav Brain Res 213:88-93. 2010
    ..The present set of results confirms the beneficial effects of opiorphin in pain management, and suggests a lack of opioid-like side effects as well as the presence of antidepressant-like actions of this peptide...
  7. ncbi Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA
    Piotr Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Neuropsychopharmacology 28:457-67. 2003
    ..Results suggest involvement of GCP II (NAALADase) in phenomena related to opioid addiction...
  8. ncbi Nicotine and nicotinic receptor antagonists potentiate the antidepressant-like effects of imipramine and citalopram
    Piotr Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Br J Pharmacol 139:1196-202. 2003
    ..7. The present results demonstrate an unexpected interaction between nAChR ligands and imipramine and citalopram in the tail-suspension test...
  9. ncbi Lack of persistent effects of ketamine in rodent models of depression
    Piotr Popik
    Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Psychopharmacology (Berl) 198:421-30. 2008
    ..We investigated the immediate and enduring effects of ketamine in behavioral and neurochemical assays predictive of antidepressant activity...
  10. ncbi Reinstatement of morphine-conditioned reward is blocked by memantine
    Piotr Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 31:160-70. 2006
    ....
  11. ncbi Nicotine produces antidepressant-like actions: Behavioral and neurochemical evidence
    Piotr Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 515:128-33. 2005
    ..It appears that the potentiation of the dopamine-mimetic-induced hyperactivity cannot be explained by beta-adrenoceptor down-regulation...
  12. ncbi Chronic treatment with antidepressants affects glycine/NMDA receptor function: behavioral evidence
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Neuropharmacology 39:2278-87. 2000
    ....
  13. ncbi Memantine reduces consumption of highly palatable food in a rat model of binge eating
    Piotr Popik
    Behavioral Neuroscience, Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Amino Acids 40:477-85. 2011
    ....
  14. ncbi Clinically available NMDA receptor antagonists memantine and dextromethorphan reverse existing tolerance to the antinociceptive effects of morphine in mice
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Naunyn Schmiedebergs Arch Pharmacol 361:425-32. 2000
    ..These data indicate that low-affinity, clinically available and/or therapeutically promising NMDA receptor antagonists may be used to inhibit ongoing morphine tolerance...
  15. ncbi Inhibition of reinforcing effects of morphine and naloxone-precipitated opioid withdrawal by novel glycine site and uncompetitive NMDA receptor antagonists
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Neuropharmacology 37:1033-42. 1998
    ..These data suggest that novel glycine site and uncompetitive NMDA receptor antagonists may have therapeutic potential in the treatment of opioid abuse...
  16. ncbi A partial agonist at strychnine-insensitive glycine sites facilitates spatial learning in aged rats
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 50:139-51. 1999
    ..It is suggested that ACPC may alleviate learning deficits observed in the elderly...
  17. ncbi Mesolimbic NMDA receptors are implicated in the expression of conditioned morphine reward
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Naunyn Schmiedebergs Arch Pharmacol 359:288-94. 1999
    ..These findings suggest that activation of NMDA receptors in the nucleus accumbens and ventral tegmental area is necessary for the elicitation of approach by environments previously associated with morphine's rewarding action...
  18. ncbi Facilitation and attenuation of social recognition in rats by different oxytocin-related peptides
    P Popik
    Polish Academy of Sciences, Department of Biochemistry, Krakow, Poland
    Eur J Pharmacol 308:113-6. 1996
    ..It is concluded that the active moieties for attenuation and facilitation of social memory reside in different parts of the oxytocin molecule, e.g. the 5-7 and 8-9 region, respectively...
  19. ncbi The NMDA antagonist memantine blocks the expression and maintenance of morphine dependence
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Pharmacol Biochem Behav 53:791-7. 1996
    ....
  20. ncbi Clinically available NMDA antagonist, memantine, attenuates tolerance to analgesic effects of morphine in a mouse tail flick test
    P Popik
    Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Pol J Pharmacol 51:223-31. 1999
    ..95 mg/kg, respectively, corresponding to 3.35, 1.02 and 0.94 fold changes. These data indicate that low affinity, clinically available NMDA receptor antagonist, memantine, may be used to inhibit the development of morphine tolerance...
  21. ncbi Facilitation of memory retrieval by the "anti-addictive" alkaloid, ibogaine
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Life Sci 59:PL379-85. 1996
    ....
  22. ncbi Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice
    T Kos
    Laboratory of Behavioral Neuroscience, Department of Biochemistry, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland
    Eur Neuropsychopharmacol 16:297-310. 2006
    ..5-25 and 1 mg/kg). The present data suggest that 5-HT(3) receptor blockade does not reverse the behavioral deficits of ketamine and may even enhance its certain effects, such as the antidepressant-like action...
  23. ncbi Colostrinin, a polypeptide isolated from early milk, facilitates learning and memory in rats
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pharmacol Biochem Behav 64:183-9. 1999
    ..Given the fact that colostrum is the first nutritive agent of neonates, it might be speculated that its peptides may facilitate the early postnatal development of the cerebral neurons and their plasticity...
  24. ncbi Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats
    E Kozela
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343, Krakow, Poland
    Eur J Pharmacol 423:17-26. 2001
    ..These findings suggest that low-affinity NMDA receptor antagonists modulate differently morphine antinociceptive activity recorded from the tail and hind paws...
  25. ncbi Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by N-methyl-D-aspartate receptor antagonist, memantine
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Smetna
    J Pharmacol Exp Ther 280:854-65. 1997
    ..5 mg/kg blocks the reinforcing effects of morphine and aversive effects of morphine withdrawal in rats, which suggests a new potential clinical indication for this agent in the treatment of opioid abuse...
  26. ncbi Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice
    P Popik
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Br J Pharmacol 130:1425-31. 2000
    ..4. The present results are the first to suggest that the development of antinociceptive morphine tolerance may be inhibited by metabotropic group II glutamate agonist...
  27. ncbi Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice
    Ewa Kozela
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Psychopharmacology (Berl) 165:245-51. 2003
    ..The role of metabotropic receptors for glutamate (mGluR) in opiate tolerance is less known...
  28. ncbi 2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice
    Ewa Kozela
    Department of Biochemistry, Laboratory of Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Psychopharmacology (Berl) 183:275-84. 2005
    ..In the present study, we investigated in more detail the effects of GCP II inhibition on opioid dependence and tolerance to its antinociceptive effect in C57/Bl mice using a novel GCP II inhibitor...
  29. ncbi The effects of NMDA receptor antagonists on acute morphine antinociception in mice
    E Kozela
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Amino Acids 23:163-8. 2002
    ..It appears that the effects of NMDA receptor antagonists on morphine tolerance are not causally related to their acute effects on morphine antinociception...
  30. ncbi Antidepressants alleviate the impact of reinforcer downshift
    Agnieszka Nikiforuk
    Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur Neuropsychopharmacol 19:41-8. 2009
    ..The present results suggest that the antidepressants selectively inhibiting serotonin reuptake and a benzodiazepine anxiolytic but not psychostimulant cocaine may specifically protect animals from the effects of a reinforcer downshift...
  31. ncbi A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice
    T Kos
    Institute of Pharmacology, Polish Academy of Sciences, , Poland
    Behav Pharmacol 16:155-61. 2005
    ..The present data indicate that different doses of memantine are required for the purportedly therapeutic and side-effects, and that tolerance may develop to the ataxic, but not anti-immobility actions...
  32. ncbi Nicotine potentiates imipramine-induced effects on catecholamine metabolism: possible relation to antidepressant activity
    Lucyna Antkiewicz-Michaluk
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 58:836-45. 2006
    ..We suggest that nicotine may potentiate the antidepressant-like effects of imipramine by promoting some plastic changes in the brain within dopamine and noradrenaline system considerably more strongly than imipramine alone...
  33. ncbi Attenuation of estrous cycle-dependent marble burying in female rats by acute treatment with progesterone and antidepressants
    Tomasz Schneider
    Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Psychoneuroendocrinology 32:651-9. 2007
    ..This manifestation may be used to elucidate the neuroendocrine mechanisms triggering premenstrual irritability, and the detailed mode of action of antidepressants when used for PMDD...
  34. ncbi A complete analysis of NMDA receptor subunits in periaqueductal grey and ventromedial medulla of morphine tolerant mice
    Ewa Kozela
    Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Drug Alcohol Depend 86:290-3. 2007
    ..Although behavioral test indicated that morphine antinociceptive tolerance developed, changes in the expression of NMDA-R subunits were not observed, either in the PAG or in the RVM...
  35. ncbi An animal model of premenstrual dysphoric disorder sensitive to antidepressants
    Tomasz Schneider
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Curr Protoc Neurosci . 2009
    ..This model may be used to study the neuroendocrine mechanisms triggering premenstrual irritability, and the mode of action of antidepressants used for the treatment of PMDD...
  36. ncbi Mazindol attenuates ketamine-induced cognitive deficit in the attentional set shifting task in rats
    Agnieszka Nikiforuk
    Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur Neuropsychopharmacol 20:37-48. 2010
    ..The beneficial effects of mazindol on ASST performance may have therapeutic implications for the treatment of schizophrenia...
  37. ncbi Stability and variability of locomotor responses of laboratory rodents. III. Effect of environmental factors and lack of catecholamine receptor correlates
    J Vetulani
    Institute of Pharmacology, Polish Academy of Sciences, , Poland
    Pol J Pharmacol Pharm 40:273-80. 1988
    ..No correlation between the native locomotor activity and cortical and striatal binding sites for [3H]prazosin and [3H]spiroperidol was found...
  38. ncbi Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677
    Piotr Popik
    Behavioral Neuroscience Laboratory, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland
    Cell Mol Neurobiol 26:857-73. 2006
    ..5. In summary, DOV 102,677 is an orally active, "balanced" inhibitor of DAT, NET and SERT with therapeutic versatility in treating neuropsychiatric disorders beyond depression...
  39. ncbi Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study
    Marcin Siwek
    Department of Psychiatry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    J Affect Disord 118:187-95. 2009
    ..Zinc, a non competitive NMDA receptor antagonist exhibits preclinical antidepressant efficacy. Moreover, a preliminary clinical report suggests augmentation of antidepressant therapy by zinc in depression...
  40. ncbi Increased depressive-like traits in an animal model of premenstrual irritability
    Tomasz Schneider
    Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Horm Behav 51:142-8. 2007
    ..This phenomenon could potentially aid the elucidation of premenstrual emotional dysfunctions and might be used as an ethological model to study a biochemical and genetic proneness to depression...
  41. ncbi Enhancement of antidepressant-like effects but not brain-derived neurotrophic factor mRNA expression by the novel N-methyl-D-aspartate receptor antagonist neramexane in mice
    Tomasz Kos
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St, , Poland
    J Pharmacol Exp Ther 318:1128-36. 2006
    ....
  42. ncbi The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors
    Piotr Popik
    Behavioral Neuroscience, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Pharmacol Exp Ther 319:1244-52. 2006
    ....
  43. ncbi Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor
    Phil Skolnick
    DOV Pharmaceutical, Inc, Continental Plaza, 433 Hackensack Avenue, Hackensack, NJ 07601, USA
    Eur J Pharmacol 461:99-104. 2003
    ....
  44. ncbi "Broad spectrum" antidepressants: is more better for the treatment of depression?
    Phil Skolnick
    DOV Pharmaceutical, Inc, 433 Hackensack Avenue, Hackensack, NJ 07601, USA
    Life Sci 73:3175-9. 2003
    ....
  45. ncbi Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice
    Adam Bisaga
    Division on Substance Abuse, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Drug Alcohol Depend 95:147-51. 2008
    ..We suggest that it is DXM, rather than DXT, that is responsible for the attenuating effect on the intensity of opioid withdrawal syndrome, and that the beneficial action of QND on the effect of DXM should be more pronounced in humans...
  46. ncbi Peripherally acting NMDA receptor/glycineB site receptor antagonists inhibit morphine tolerance
    Wojciech Danysz
    Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt/Main, Germany
    Neuropharmacology 48:360-71. 2005
    ..The present data suggest that blockade of NMDA receptor/glycine(B) sites in the periphery may attenuate tolerance to the antinociceptive effects of morphine...
  47. ncbi Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain
    Anthony S Basile
    DOV Pharmaceutical, Inc, 150 Pierce St, Somerset, NJ 08873 4185, USA
    J Pharmacol Exp Ther 321:1208-25. 2007
    ....
  48. ncbi Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor
    Phil Skolnick
    DOV Pharmaceutical, Inc, Hackensack, NJ 08873, USA
    CNS Drug Rev 12:123-34. 2006
    ..These findings provide preliminary evidence of a clinically meaningful antidepressant action with a molecule capable of inhibiting the three transmitters most closely linked to major depressive disorder...