Janusz Marcinkiewicz

Summary

Country: Poland

Publications

  1. ncbi Antimicrobial and cytotoxic activity of hypochlorous acid: interactions with taurine and nitrite
    J Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Cracow, Poland
    Inflamm Res 49:280-9. 2000
  2. ncbi Is Taurolidine a candidate for treatment of rheumatoid arthritis?
    J Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Cracow, Poland
    Clin Exp Rheumatol 25:211-8. 2007
  3. ncbi Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide
    J Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, 18 Czysta St, 31 121, Cracow, Poland
    Inflamm Res 54:42-9. 2005
  4. ncbi Differential inflammatory mediator response in vitro from murine macrophages to lactobacilli and pathogenic intestinal bacteria
    J Marcinkiewicz
    Chair of Immunology Jagiellonian University Medical College, Cracow, Poland
    Int J Exp Pathol 88:155-64. 2007
  5. ncbi Oxidative modification of type II collagen differentially affects its arthritogenic and tolerogenic capacity in experimental arthritis
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Krakow, Poland
    Arch Immunol Ther Exp (Warsz) 52:284-91. 2004
  6. ncbi Prostanoids and MPO-halide system products as a link between innate and adaptive immunity
    Janusz Marcinkiewicz
    Department of Immunology, Collegium Medicum, Jagiellonian University, 18 Czysta Street, 31 121, Krakow, Poland
    Immunol Lett 89:187-91. 2003
  7. ncbi Topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study
    Janusz Marcinkiewicz
    Department of Immunology Jagiellonian University Medical College, Krakow, Poland
    Eur J Dermatol 18:433-9. 2008
  8. ncbi Susceptibility of Propionibacterium acnes and Staphylococcus epidermidis to killing by MPO-halide system products. Implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Czysta 18, 31 121, Krakow, Poland
    Arch Immunol Ther Exp (Warsz) 54:61-8. 2006
  9. ncbi Anti-inflammatory effects of taurine derivatives (taurine chloramine, taurine bromamine, and taurolidine) are mediated by different mechanisms
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Krakow, Poland
    Adv Exp Med Biol 583:481-92. 2006
  10. ncbi Taurine bromamine (TauBr)--its role in immunity and new perspectives for clinical use
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Krakow, Poland
    J Biomed Sci 17:S3. 2010

Collaborators

Detail Information

Publications43

  1. ncbi Antimicrobial and cytotoxic activity of hypochlorous acid: interactions with taurine and nitrite
    J Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Cracow, Poland
    Inflamm Res 49:280-9. 2000
    ..The present study was conducted to elucidate the effect of nitrite on bactericidal and some immunoregulatory properties of HOCl and TauCl...
  2. ncbi Is Taurolidine a candidate for treatment of rheumatoid arthritis?
    J Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Cracow, Poland
    Clin Exp Rheumatol 25:211-8. 2007
    ..To study the therapeutic potential of taurolidine (TRD), a derivative of taurine with known anti-inflammatory and anti-proliferative properties, in various experimental models of synovitis...
  3. ncbi Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide
    J Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, 18 Czysta St, 31 121, Cracow, Poland
    Inflamm Res 54:42-9. 2005
    ..Moreover, the effect of nitrites and H(2)O(2) on TauBr activity was investigated...
  4. ncbi Differential inflammatory mediator response in vitro from murine macrophages to lactobacilli and pathogenic intestinal bacteria
    J Marcinkiewicz
    Chair of Immunology Jagiellonian University Medical College, Cracow, Poland
    Int J Exp Pathol 88:155-64. 2007
    ..The beneficial immunoregulatory properties of candidate probiotic bacteria for the treatment of IBD are discussed...
  5. ncbi Oxidative modification of type II collagen differentially affects its arthritogenic and tolerogenic capacity in experimental arthritis
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Krakow, Poland
    Arch Immunol Ther Exp (Warsz) 52:284-91. 2004
    ..The aim of this study was to examine whether HOCl may affect immunogenic, tolerogenic, and arthritogenic properties of collagen...
  6. ncbi Prostanoids and MPO-halide system products as a link between innate and adaptive immunity
    Janusz Marcinkiewicz
    Department of Immunology, Collegium Medicum, Jagiellonian University, 18 Czysta Street, 31 121, Krakow, Poland
    Immunol Lett 89:187-91. 2003
    ..Finally, we conclude that eicosanoids and ROIs provide an important link between the afferent branches and the innate and adaptive immune response...
  7. ncbi Topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study
    Janusz Marcinkiewicz
    Department of Immunology Jagiellonian University Medical College, Krakow, Poland
    Eur J Dermatol 18:433-9. 2008
    ..In conclusion, these data support our concept that TauBr can be used as a topical agent in the treatment of acne vulgaris, especially in patients who have already developed antibiotic resistance...
  8. ncbi Susceptibility of Propionibacterium acnes and Staphylococcus epidermidis to killing by MPO-halide system products. Implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Czysta 18, 31 121, Krakow, Poland
    Arch Immunol Ther Exp (Warsz) 54:61-8. 2006
    ..Moreover, the influence of these haloamines on the generation of reactive oxygen species (ROS) by activated neutrophils was also tested...
  9. ncbi Anti-inflammatory effects of taurine derivatives (taurine chloramine, taurine bromamine, and taurolidine) are mediated by different mechanisms
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Krakow, Poland
    Adv Exp Med Biol 583:481-92. 2006
    ..TRD, in contrast to TauCl and TauBr, does not induce expression of HO-1, a stress inducible enzyme with strong anti-inflammatory properties...
  10. ncbi Taurine bromamine (TauBr)--its role in immunity and new perspectives for clinical use
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, Krakow, Poland
    J Biomed Sci 17:S3. 2010
    ..Further studies are necessary to substantiate the more extended use of TauBr as an anti-inflammatory and anti-oxidant agent in human medicine...
  11. ncbi Taurine haloamines and heme oxygenase-1 cooperate in the regulation of inflammation and attenuation of oxidative stress
    Janusz Marcinkiewicz
    Chair of Immunology, Institute of Rheumatology, Poland
    Adv Exp Med Biol 643:439-50. 2009
    ..Therefore, HO-1 and TauCl may independently regulate the production of proinflammatory cytokines. We suggest that TauCl and TauBr provide a link between the two antioxidant systems: the cysteine pathway and the heme oxygenase system...
  12. ncbi Taurine bromamine: a new therapeutic option in inflammatory skin diseases
    Janusz Marcinkiewicz
    Department of Immunology, Jagiellonian University School of Medicine, Krakow, Poland
    Pol Arch Med Wewn 119:673-6. 2009
    ..Therefore, the results from clinical studies are consistent with previous in vitro data and strongly suggest that TauBr could be considered a new therapeutic option in inflammatory acne...
  13. ncbi 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages
    Rafał Biedroń
    Department of Immunology, Jagiellonian University College of Medicine, Czysta 18, 31 121 Kraków, Poland
    Arch Immunol Ther Exp (Warsz) 56:127-34. 2008
    ..In this study the influence of exogenous MNA and NA in vivo on the generation of inflammatory mediators by macrophages (Mvarphi) was investigated...
  14. ncbi Selective inhibition of cyclooxygenase 2-generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramine
    Ewa Kontny
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Arthritis Rheum 48:1551-5. 2003
    ..CONCLUSION: Tau-Cl inhibits IL-1beta-triggered elevation of COX-2 and generation of PGE(2) by RA FLS. These results expand the spectrum of known antiinflammatory activities of this compound...
  15. ncbi Leukotrienes modulate cytokine release from dendritic cells
    Szczepan Jozefowski
    Department of Immunology, Jagiellonian University School of Medicine, Krakow, Poland
    Immunology 116:418-28. 2005
    ..Our results indicate that both autocrine and paracrine leukotrienes may modulate cytokine release from DCs, in a manner that is consistent with previously reported T helper 2-polarizing effects of leukotrienes...
  16. ncbi Aggregates of denatured proteins stimulate nitric oxide and superoxide production in macrophages
    Szczepan Jozefowski
    Department of Immunology, Jagiellonian University School of Medicine, Cracow, Poland
    Inflamm Res 59:277-89. 2010
    ....
  17. ncbi Cytotoxicity of taurine metabolites depends on the cell type
    Ewa Kontny
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Adv Exp Med Biol 583:157-71. 2006
    ..This observation is clinically relevant because Tau-Cl is used in many animal inflammatory models and its sodium salt (used in this study) has been introduced to human therapy (Gottardi and Nagl, 2002; Teuchner et al., 2005)...
  18. ncbi Lactobacillus rhamnosus Exopolysaccharide Ameliorates Arthritis Induced by the Systemic Injection of Collagen and Lipopolysaccharide in DBA/1 Mice
    Bernadeta Nowak
    Department of Immunology, Jagiellonian University Medical College, 18 Czysta, 31 121, Krakow, Poland
    Arch Immunol Ther Exp (Warsz) 60:211-20. 2012
    ..Therefore, we suggest that EPS or EPS-producing probiotics may be promising agents for the supporting therapy of patients with rheumatoid arthritis...
  19. ncbi Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin
    Krzysztof Bryniarski
    Department of Immunology Jagiellonian University Medical College, Krakow, Poland
    Eur J Pharmacol 578:332-8. 2008
    ..Accordingly, our results demonstrate for the first time that anti-inflammatory properties of MNA are linked to endothelial, PGI(2)-mediated mechanisms...
  20. ncbi Anti-inflammatory activities of taurine chloramine: implication for immunoregulation and pathogenesis of rheumatoid arthritis
    Ewa Kontny
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Adv Exp Med Biol 526:329-40. 2003
  21. ncbi Therapeutic vaccines based on genetically modified Salmonella: a novel strategy in cancer immunotherapy
    Paulina Chorobik
    Department of Immunology, Jagiellonian University Medical College, Krakow, Poland
    Pol Arch Med Wewn 121:461-6. 2011
    ..Additionally, to potentiate antitumor activity, the genetic material of VNP20009 has been engineered to overproduce an endogenous proapoptotic protein, which targets cancer and immune cells promoting tumor growth...
  22. ncbi Influence of macrophage activation on their capacity to bind bacterial antigens studied with atomic force microscopy
    Marta Targosz
    Institute of Physics, Jagiellonian University, Cracow, Poland
    Nanomedicine 2:82-8. 2006
    ..This may suggest that in vivo commensal enteric bacteria, such as lactobacilli, will enhance the defense potential of local macrophages against pathogens expressing LPS...
  23. ncbi Immunoregulatory potential of exopolysaccharide from Lactobacillus rhamnosus KL37. Effects on the production of inflammatory mediators by mouse macrophages
    Marta Ciszek-Lenda
    Chair of Immunology, Jagiellonian University Medical College, Cracow, Poland Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland
    Int J Exp Pathol 92:382-91. 2011
    ..However, to predict whether EPS could be clinically useful as an immunomodulatory agent, further in vivo studies with highly purified EPS are necessary...
  24. ncbi Improving tumor targeting and therapeutic potential of Salmonella VNP20009 by displaying cell surface CEA-specific antibodies
    Michal Bereta
    Department of Immunology, Jagiellonian University Medical School, Krakow, Poland
    Vaccine 25:4183-92. 2007
    ..The display of antibody fragments on the surface of VNP represents a novel strategy for both targeting CEA-expressing tumors and increasing the immunogenicity of Salmonella-based vaccines for cancer...
  25. ncbi What is a role of haeme oxygenase-1 in psoriasis? Current concepts of pathogenesis
    Anna Wojas Pelc
    Department of Dermatology, Jagiellonian University Medical College, Cracow, Poland
    Int J Exp Pathol 88:95-102. 2007
    ..We will try to answer a question whether enhanced HO-1 expression in keratinocytes results in beneficial or detrimental effect on the development and severity of psoriatic lesions...
  26. ncbi Taurine chloramine and taurine bromamine induce heme oxygenase-1 in resting and LPS-stimulated J774.2 macrophages
    R Olszanecki
    Chair of Pharmacology, Jagiellonian University Medical College Kraków, Krakow, Poland
    Amino Acids 27:29-35. 2004
    ..These results suggest that at a site of inflammation, TauCl and TauBr may provide a link between taurine-dependent and HO-1-dependent cytoprotective mechanisms...
  27. ncbi Taurine chloramine inhibits proliferation of rheumatoid arthritis synoviocytes by triggering a p53-dependent pathway
    E Kontny
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Spartafska 1, 02 637, Warsaw, Poland
    Inflamm Res 55:446-55. 2006
    ..The present study was conducted to investigate the mechanism of the Tau-Cl effect on the proliferation of these cells in culture...
  28. ncbi Myeloperoxidase-mediated protein oxidation: its possible biological functions
    Jerzy W Naskalski
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Clin Chem Lab Med 40:463-8. 2002
    ..Thus, a growing body of data suggest that the specific role of protein oxidation by activated PMN is oxidative protein tagging facilitating further development of the immune reaction...
  29. ncbi Comparison of taurine chloramine and taurine bromamine effects on rheumatoid arthritis synoviocytes
    E Kontny
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Amino Acids 32:447-52. 2007
    ..Thus, Tau-Cl is more effective than Tau-Br in normalization of pro-inflammatory RA FLS functions...
  30. ncbi The effect of taurine chloramine on pro-inflammatory cytokine production by peripheral blood mononuclear cells isolated from rheumatoid arthritis and osteoarthritis patients
    M Chorazy-Massalska
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Clin Exp Rheumatol 22:692-8. 2004
    ..CONCLUSION: TauCl at high concentrations down-regulates pro-inflammatory cytokine production. However, the impact of TauCl on TNF-alpha production by PBMCs from RA is more limited than in cells isolated from OA patients...
  31. ncbi Heme oxygenase-1 participates in the anti-inflammatory activity of taurine chloramine
    B Muz
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Amino Acids 35:397-402. 2008
    ..Thus, the present results: (i) support HO-1 activity to be relevant to negatively control production of pro-inflammatory cytokines, and (ii) underline implication of HO-1 in mediating Tau-Cl inhibitory action...
  32. ncbi Atomic force microscopy-based molecular studies on the recognition of immunogenic chlorinated ovalbumin by macrophage receptors
    Szczepan Zapotoczny
    Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30 060 Krakow, Poland
    J Mol Recognit 25:82-8. 2012
    ....
  33. ncbi Scavenger receptors and ?-glucan receptors participate in the recognition of yeasts by murine macrophages
    Szczepan Jozefowski
    Department of Immunology, Jagiellonian University Medical College, 18 Czysta Street, 31 121, Krakow, Poland
    Inflamm Res 61:113-26. 2012
    ..Numerous receptors have been implicated in recognition of pathogenic fungi by macrophages, including the ?-glucan receptor dectin-1. The role of scavenger receptors (SRs) in anti-fungal immunity is not well characterized...
  34. ncbi Myeloid-derived suppressor cells: a double-edged sword?
    Agnieszka Pastuła
    Department of Immunology, Jagiellonian University Medical College, Krakow, Poland
    Int J Exp Pathol 92:73-8. 2011
    ..This finding can shed a new light on antitumour immunity which is believed to be impaired in immunosuppressive environments...
  35. ncbi Differential effects of pentoxifylline, a non-specific phosphodiesterase inhibitor, on the production of IL-10, IL-12 p40 and p35 subunits by murine peritoneal macrophages
    J Marcinkiewicz
    Department of Immunology, Jagiellonian University Medical College, 18 Czysta Street, 31 121, Cracow, Poland
    Immunopharmacology 49:335-43. 2000
    ..These results further confirm the relevance of the use of PTX in clinical trials of immunological disorders characterised by inappropriate Th1 type immune responses...
  36. ncbi Taurine chloramine modulates cytokine production by human peripheral blood mononuclear cells
    M Chorazy
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Amino Acids 23:407-13. 2002
    ..These results indicate that Tau-Cl modulates synthesis of pro-inflammatory cytokines, and therefore it may play a role in the initiation and propagation of immune response...
  37. ncbi The role of heme oxygenase-1 in down regulation of PGE2 production by taurine chloramine and taurine bromamine in J774.2 macrophages
    R Olszanecki
    Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland
    Amino Acids 35:359-64. 2008
    ..Our data suggest that HO-1 might participate in anti-inflammatory effects of TauCl/TauBr possibly by inhibition of COX-2 activity and decrease of PGE(2) production...
  38. ncbi Pulsating electromagnetic field stimulation prevents cell death of puromycin treated U937 cell line
    J Kaszuba-Zwoinska
    Department of Pathophysiology, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 61:201-5. 2010
    ..PEMF effects on the human lymphoid cell line depends upon cell density. Increased density induced cells death and on the other hand prevented cells death induced by puromycin...