Katarzyna Kulig

Summary

Country: Poland

Publications

  1. ncbi The role of structure activity relationship studies in the search for new GABA uptake inhibitors
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland
    Mini Rev Med Chem 8:1214-23. 2008
  2. ncbi Application of RP-TLC technique for the determination of dissociation constants of 1-substituted pyrrolidin-2-one derivatives
    Katarzyna Kulig
    Departament of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland
    Biomed Chromatogr 22:1225-9. 2008
  3. ncbi Synthesis and pharmacological evaluation of pyrrolidin-2-one derivatives as antiarrhythmic, antihypertensive and alpha-adrenolytic agents
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 62:68-85. 2010
  4. ncbi Synthesis and pharmacological evaluation of new 1-[3-(4-phenylpiperazin-1-yl)-propyl]- and 1-[3-(4-phenylpiperidine)-propyl]- 3-aryl-3-alkyl-pyrrolidin-2-one derivatives with antiarrhythmic and antihypertensive activity
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Pharmaceutical Faculty, Jagiellonian University Medical College, 9 Medyczna St, 30 688 Krakow, Poland
    Acta Pol Pharm 66:649-62. 2009
  5. ncbi Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Faculty of Pharmacy, 30 688 Krakow, Poland
    Eur J Med Chem 44:3994-4003. 2009
  6. ncbi Synthesis and development of new 2-substituted 1-[3-(4-arylpiperazin-1-yl)propyl]-pyrrolidin-2-one derivatives with antiarrhythmic, hypotensive, and alpha-adrenolytic activity
    Barbara Malawska
    Department of Physicochemical Drug Analysis, Jagiellonian University, Medical College, Krakow, Poland
    Farmaco 60:793-803. 2005
  7. ncbi Design, synthesis and pharmacological evaluation of alpha-substituted N-benzylamides of gamma-hydroxybutyric acid with potential GABA-ergic activity. Part 6. Search for new anticonvulsant compounds
    Barbara Malawska
    Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30 688 Krakow, Poland
    Acta Pol Pharm 64:127-37. 2007
  8. ncbi Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity
    Barbara Malawska
    Department of Pharmaceutical Chemistry, Collegium Medicum of Jagiellonian University, 9 Medyczna St, 30 688, Krakow, Poland
    Eur J Med Chem 37:183-95. 2002
  9. ncbi Synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxypropyl]-pyrrolidin-2-one derivatives with anti-arrhythmic, hypotensive, and alpha-adrenolytic activity
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland
    Arch Pharm (Weinheim) 340:466-75. 2007
  10. ncbi Antiarrhythmic and antioxidant activity of novel pyrrolidin-2-one derivatives with adrenolytic properties
    Jacek Sapa
    Department of Pharmacodynamic, Laboratory of Pharmacological Screening, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30 688 Krakow, Poland
    Naunyn Schmiedebergs Arch Pharmacol 383:13-25. 2011

Detail Information

Publications20

  1. ncbi The role of structure activity relationship studies in the search for new GABA uptake inhibitors
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland
    Mini Rev Med Chem 8:1214-23. 2008
    ..This review is focus on structure activity relationship studies aiming the search for new GABA uptake inhibitors...
  2. ncbi Application of RP-TLC technique for the determination of dissociation constants of 1-substituted pyrrolidin-2-one derivatives
    Katarzyna Kulig
    Departament of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland
    Biomed Chromatogr 22:1225-9. 2008
    ..The Marvin program is a better tool for preliminary estimation of dissociation constant than the Pallas one...
  3. ncbi Synthesis and pharmacological evaluation of pyrrolidin-2-one derivatives as antiarrhythmic, antihypertensive and alpha-adrenolytic agents
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 62:68-85. 2010
    ..5 mg/ kg iv, and their hypotensive effects lasted for longer than an hour...
  4. ncbi Synthesis and pharmacological evaluation of new 1-[3-(4-phenylpiperazin-1-yl)-propyl]- and 1-[3-(4-phenylpiperidine)-propyl]- 3-aryl-3-alkyl-pyrrolidin-2-one derivatives with antiarrhythmic and antihypertensive activity
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Pharmaceutical Faculty, Jagiellonian University Medical College, 9 Medyczna St, 30 688 Krakow, Poland
    Acta Pol Pharm 66:649-62. 2009
    ..v.). Some of the compounds tested significantly decreased the systolic and diastolic pressure in normotensive anesthetized rats at a dose of 5.0 mg/kg i.v. and their hypotensive effects lasted for longer than an hour...
  5. ncbi Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Faculty of Pharmacy, 30 688 Krakow, Poland
    Eur J Med Chem 44:3994-4003. 2009
    ..To determine detailed information concerning the structure-activity relationship, a preliminary molecular modeling study was undertaken...
  6. ncbi Synthesis and development of new 2-substituted 1-[3-(4-arylpiperazin-1-yl)propyl]-pyrrolidin-2-one derivatives with antiarrhythmic, hypotensive, and alpha-adrenolytic activity
    Barbara Malawska
    Department of Physicochemical Drug Analysis, Jagiellonian University, Medical College, Krakow, Poland
    Farmaco 60:793-803. 2005
    ....
  7. ncbi Design, synthesis and pharmacological evaluation of alpha-substituted N-benzylamides of gamma-hydroxybutyric acid with potential GABA-ergic activity. Part 6. Search for new anticonvulsant compounds
    Barbara Malawska
    Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30 688 Krakow, Poland
    Acta Pol Pharm 64:127-37. 2007
    ..Molecular modeling studies have revealed that anticonvulsant activity of the alpha-substituted amides of GHB might partially be explained by the orientation of the terminal benzylamide fragment...
  8. ncbi Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity
    Barbara Malawska
    Department of Pharmaceutical Chemistry, Collegium Medicum of Jagiellonian University, 9 Medyczna St, 30 688, Krakow, Poland
    Eur J Med Chem 37:183-95. 2002
    ....
  9. ncbi Synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxypropyl]-pyrrolidin-2-one derivatives with anti-arrhythmic, hypotensive, and alpha-adrenolytic activity
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland
    Arch Pharm (Weinheim) 340:466-75. 2007
    ..v.). It was found that the presence of the piperazine ring and a hydroxy group in the second position of the propyl chain are critical structural features in determining the affinity of the compounds tested...
  10. ncbi Antiarrhythmic and antioxidant activity of novel pyrrolidin-2-one derivatives with adrenolytic properties
    Jacek Sapa
    Department of Pharmacodynamic, Laboratory of Pharmacological Screening, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30 688 Krakow, Poland
    Naunyn Schmiedebergs Arch Pharmacol 383:13-25. 2011
    ..A biological activity prediction using the PASS software shows that compound EP-35 and EP-40 can be characterized by antiischemic activity; whereas, compound EP-68, EP-70, EP-71 could be good tachycardia agents...
  11. ncbi Antidepressant-like activity of the phenylpiperazine pyrrolidin-2-one derivatives in mice
    Jacek Sapa
    Department of Pharmacodynamic, Laboratory of Pharmacological Screening, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, PL 30 688 Krakow, Poland
    Pharmacol Rep 63:71-8. 2011
    ..Currently, it is not possible to determine which mechanisms are involved in the witnessed antidepressant-like activity of novel phenylpiperazine pyrrolidin-2-one derivatives...
  12. ncbi Estimation of the lipophilicity of antiarrhythmic and antihypertensive active 1-substituted pyrrolidin-2-one and pyrrolidine derivatives
    Katarzyna Kulig
    Department of Pharmaceutical Chemistry, Medical College, , Medyczna 9, Poland
    Biomed Chromatogr 17:318-24. 2003
    ..0 TLC) and clog D(7.0 HPLC) values. Preliminary quantitative structure-activity relationship studies indicated that for active compounds there is a dependence between affinity for alpha(2)-adrenoceptors and their clog D(7.0 HPLC) values...
  13. ncbi Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Jagiellonian University Medical College, Medyczna 9, 30 688 Krakow, Poland
    Eur J Med Chem 46:183-90. 2011
    ..96). The results pointed out that benzhydryl and benzylamide moieties are crucial for the activity of this class of compounds as murine GAT inhibitors...
  14. ncbi The study of the lipophilicity of alpha-(4-phenylpiperazin-1-yl)-gamma-phthalimidobutyramides using chromatographic and computational methods
    Barbara Malawska
    Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, 30 688 Krakow, Medyczna 9 St, Poland
    Biomed Chromatogr 22:688-94. 2008
    ..All the obtained data, both from experimental methods and computational calculations, were compared and a suitable conclusion was reached...
  15. ncbi Brivaracetam: a new drug in development for epilepsy and neuropathic pain
    Barbara Malawska
    Jagiellonian University Medical College, Department of Physicochemical Drug Analysis, 30 688 Krakow, Medyczna 9, Poland
    Expert Opin Investig Drugs 17:361-9. 2008
    ..5-1.0% of the population. Many potent antiepileptic drugs (AED) have been used for treatment but still about 30% of patients are resistant to current AEDs. Some AEDs are also used for the treatment of neuropathic pain...
  16. ncbi Carisbamate, a new carbamate for the treatment of epilepsy
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30 688 Krakow, Poland
    IDrugs 10:720-7. 2007
    ..Data from preclinical brain injury studies with carisbamate and the analog RWJ-333369-A have also been reported. This drug profile will focus on the development of carisbamate in epilepsy...
  17. ncbi Estimation of phospholipophilicity of 1-[3-(arylpiperazin-1-yl)-propyl]-pyrrolidin-2-one derivatives on immobilized artificial membrane stationary phase and its correlation with biological data
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Medical College Jagiellonian University, 9 Medyczna St, , Poland
    Biomed Chromatogr 20:1129-35. 2006
    ..It could also be used as a tool for further research into this group of compounds...
  18. ncbi Brivaracetam UCB
    Barbara Malawska
    Jagiellonian University Medical College, Department of Physicochemical Drug Analysis, Medyczna 9, 30 688 Krakow, Poland
    Curr Opin Investig Drugs 6:740-6. 2005
    ..By December 2003, UCB reported that phase II epilepsy trials had begun [517569]...
  19. ncbi Trends in the development of new drugs for treatment of benign prostatic hyperplasia
    Katarzyna Kulig
    Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9 Str, , Poland
    Curr Med Chem 13:3395-416. 2006
    ..These new agents can be used for the design of future targets and development of new drugs in the treatment of BPH. The discovery of a number of active leads may also ultimately help in developing new safe and effective drugs...
  20. ncbi Investigation into new anticonvulsant derivatives of alpha-substituted N-benzylamides of gamma-hydroxy- and gamma-acetoxybutyric acid. Part 5: search for new anticonvulsant compounds
    Barbara Malawska
    Department of Pharmaceutical Chemistry, Medical College of Jagiellonian University, Medyczna 9, 30 688 Krakow, Poland
    Bioorg Med Chem 12:625-32. 2004
    ..It has been shown that the anticonvulsant activities of the newly synthesized compounds might partially be explained on the basis of their lipophilicity (calculated log P values) and the presence of a hydroxyl group in the molecule...