E A Jankowska

..The higher incidence of side-effects with RGZ than PGZ, may be explained by a detailed study of the mechanism by which glitazones down-regulate androgen biosynthesis and action, resulting in a state of androgen deficiency...

..Hence, iron deficiency (ID) is anticipated to limit exercise capacity. We investigated whether ID predicted exercise intolerance in patients with systolic chronic heart failure (CHF)...

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..Diminished cholinergic signalling (mainly nicotinergic) activates inflammation and stimulates immune response. These two phenomena predict prognosis and represent therapeutic targets in the syndrome of CHF...

..In vitro experiments were used to elucidate the role of lipopolysaccharide (LPS) as a stimulus for the NF-kappaB system in PBL...

..In contrast, there were no social differences in other analysed hormonal parameters...

..Bone status has not been comprehensively studied in chronic heart failure (CHF). In CHF men, we evaluated bone status, bone loss over time, and their clinical and hormonal determinants...

..Estrogens are formed by the aromatization of androgens; therefore, abnormal estrogen metabolism would be anticipated in HF...

..Anabolic hormones (testosterone, dehydroepiandrosterone sulfate, insulin-like growth factor 1 [IGF1]) contribute to exercise capacity in healthy men. This issue remains unclear in CHF...

..We sought to examine the relationship between ID and survival in patients with systolic CHF...

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..We investigated, whether in CHF selective resistance training without accompanying aerobic regime favourably affects muscle strength, muscle mass and improves exercise capacity...

..An evaluation of relationships between bone density and blood pressure in healthy men...

..Elderly men with androgen deficiencies are prone to develop late-onset depression. We investigated links between circulating androgens and depression, and their combined impact on outcome in men with chronic heart failure (CHF)...

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..The aim of the present study was to compare menarche in 14-year-old Polish girls of low and normal birthweight, along with an evaluation of the impact of socio-economic status and body mass index (BMI)...

..5%). CONCLUSIONS: In CHF, overactivation of the ergoreflex is associated with the progression of the syndrome and may be responsible for reduced exercise tolerance. Reproducibility of ergoreflex measurements is satisfactory...

..The results also confirm that bone density (with its age-related changes in the course of normal male ageing) is one of the biological features characteristic of this particular regional population...

..73, P = 0.006). In the healthy Polish male population, BMI was of minor significance as a predictor of BMC at the ultra-distal radius, whereas visceral adiposity (assessed by WHR) was significantly linked to reduced bone mass in men...

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..The findings on parathormone activity in alcohol male abusers are not consistent. Additionally, chronic alcoholism is frequently accompanied by an increase of cortisol levels, andropenia, dietary, vitamin and electrolyte deficiencies...

..Most of the data come from experimental models. Further studies, in particular performed in clinical settings, are warranted...

..Cardiovascular autonomic neuropathy (CAN) is a complication of diabetes mellitus (DM) and has been regarded as a parameter associated with a poor outcome...

..Whether ventilatory response to early phase of exercise is useful for risk stratification in CHF is unknown...

..This study investigates whether hyperuricaemia (defined as serum UA level > or = 6.5 mg/dL) extends its prognostic value on population with less advanced CHF...

..The aim of this report is to assess the effect of low birthweight on stature, relative weight and fat distribution in 14-year-old boys and girls from Wroclaw, Poland...

..Age-related decline in circulating androgens in men is associated with poor cardiovascular (CV) outcome. Men with type II diabetes mellitus (DM) are prone to develop androgen deficiency...

..Classifications are based on the time course of the clinical presentation of heart failure, severity of symptoms and signs of heart failure, structural changes within the heart, predominant etiology and comorbidities...

..We examined the activity of nuclear factor kappa-B (NF-kappaB), the major mediator of immune response, in peripheral blood mononuclear cells (PBMC) isolated from cachectic and non-cachectic patients with CHF...

..Therefore--in the context of essential relationships between overweight and both mortality and morbidity--the health status of urban population in Poland is highly disturbing...

..Regardless of educational level, the highest prevalence of obesity (BMI exceeding 30 kg/m2) was found among females with at least three children (15.6%, and 26.4% of women from higher or lower social groups, respectively)...

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..We performed the study in order to describe the age-related changes and social gradients in the intensity of aging males' symptoms in healthy men in Poland...

..The precise mechanisms responsible for the observed sex difference in this phenomenon need to be established in further studies...

..With regard to the changes in rates of premature mortality among adults, the benefits have prevailed, although individuals with the lowest educational level benefited less than those with the highest education...