Jozef Dulak

Summary

Affiliation: Jagiellonian University
Country: Poland

Publications

  1. ncbi Opposite effects of HIF-1? and HIF-2? on the regulation of IL-8 expression in endothelial cells
    Urszula Florczyk
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, 30 387 Krakow, Poland
    Free Radic Biol Med 51:1882-92. 2011
  2. ncbi Stem cells in pharmaceutical biotechnology
    Ewa K Zuba-Surma
    Department of Medical Biotechnology, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Curr Pharm Biotechnol 12:1760-73. 2011
  3. ncbi Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice
    Agnieszka Jazwa
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Genet Vaccines Ther 8:6. 2010
  4. ncbi Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 10:1767-812. 2008
  5. ncbi 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress
    Alicja Jozkowicz
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 10:2035-46. 2008
  6. ncbi Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Atherosclerosis 187:26-30. 2006
  7. ncbi HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells
    Agnieszka Loboda
    Department of Medical Biotechnology, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 11:1501-17. 2009
  8. ncbi HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Vascul Pharmacol 51:133-9. 2009
  9. ncbi Angiogenic transcriptome of human microvascular endothelial cells: Effect of hypoxia, modulation by atorvastatin
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
    Vascul Pharmacol 44:206-14. 2006
  10. ncbi Heme oxygenase-1 accelerates cutaneous wound healing in mice
    Anna Grochot-Przeczek
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    PLoS ONE 4:e5803. 2009

Collaborators

Detail Information

Publications38

  1. ncbi Opposite effects of HIF-1? and HIF-2? on the regulation of IL-8 expression in endothelial cells
    Urszula Florczyk
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, 30 387 Krakow, Poland
    Free Radic Biol Med 51:1882-92. 2011
    ..However, despite stabilization of both isoforms in hypoxia the effect of HIF-1 is predominant, and downregulation of IL-8 expression in hypoxia is caused by attenuation of Nrf2 and c-Myc...
  2. ncbi Stem cells in pharmaceutical biotechnology
    Ewa K Zuba-Surma
    Department of Medical Biotechnology, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Curr Pharm Biotechnol 12:1760-73. 2011
    ..All together, the applications of various cell types derived from patient specific pluripotent stem cells may lead to targeted drug and cellular therapies for certain individuals...
  3. ncbi Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice
    Agnieszka Jazwa
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Genet Vaccines Ther 8:6. 2010
    ....
  4. ncbi Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 10:1767-812. 2008
    ....
  5. ncbi 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress
    Alicja Jozkowicz
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 10:2035-46. 2008
    ..In summary, we showed that 15d-PGJ(2), acting through oxidative stress, may exert proinflammatory effects. The upregulation of IL-8 is mostly associated with p38-mediated stabilization of mRNA...
  6. ncbi Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Atherosclerosis 187:26-30. 2006
    ..Therefore, we suggest that the protective effect of statins at their pharmacological concentrations is not mediated by enhancement of HO-1 activity, but may involve eNOS...
  7. ncbi HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells
    Agnieszka Loboda
    Department of Medical Biotechnology, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 11:1501-17. 2009
    ..However, expression of IL-8 is independent of HO-1. Cross-talk between HIF-1 and Nrf2 may influence the outcome of anti-angiogenic therapies aimed at targeting HIF-1. Antioxid...
  8. ncbi HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Vascul Pharmacol 51:133-9. 2009
    ..The regulation of Ref-1 by statins may be considered as a novel mechanism of their beneficial effects on endothelium...
  9. ncbi Angiogenic transcriptome of human microvascular endothelial cells: Effect of hypoxia, modulation by atorvastatin
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
    Vascul Pharmacol 44:206-14. 2006
    ..The influence of atorvastatin on angiogenic gene expression is complex, and final pro- or anti-angiogenic outcome of statin therapy remains to be established for numerous angiogenesis-related diseases...
  10. ncbi Heme oxygenase-1 accelerates cutaneous wound healing in mice
    Anna Grochot-Przeczek
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    PLoS ONE 4:e5803. 2009
    ..In summary, induction of HO-1 is necessary for efficient wound closure and neovascularization. Impaired wound healing in diabetic mice may be associated with delayed HO-1 upregulation and can be improved by HO-1 gene transfer...
  11. ncbi Biliverdin reductase: new features of an old enzyme and its potential therapeutic significance
    Urszula M Florczyk
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, Krakow, Poland
    Pharmacol Rep 60:38-48. 2008
    ..These features make BVR unusually interesting and unique among all enzymes characterized to date...
  12. ncbi Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: effect of HO-1 knockout
    Jarosław Cisowski
    Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Biochem Biophys Res Commun 326:670-6. 2005
    ..Additionally, knock out of HO-1 gene impaired induction of VEGF by hemin, lysophosphatidylcholine, and prostaglandin-J(2). Our results provide confirmation for the involvement of HO-1 in regulation of angiogenesis...
  13. ncbi Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes
    Agnieszka Jazwa
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Free Radic Biol Med 40:1250-63. 2006
    ..Recently the involvement of HO-1 in angiogenesis has been shown; however, the role of heme and HO-1 in wound healing angiogenesis has not been yet investigated...
  14. ncbi Atorvastatin affects several angiogenic mediators in human endothelial cells
    Jozef Dulak
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Endothelium 12:233-41. 2005
    ..In conclusion, the present findings points to other angiogenesis-related effects of atorvastatin, which may be of relevance to the beneficial influence of statins in cardiovascular system...
  15. ncbi Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells--the involvement of SP-1 and HIFs transcription factors
    Anna Stachurska
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Toxicol Lett 204:118-26. 2011
    ..These observations provide new insight into complex impact of AAI and OTA on angiogenic gene regulation. Additionally, it adds to our understanding of hypoxia influence on nephropathies pathology...
  16. ncbi Heme oxygenase-1 in tumor biology and therapy
    Halina Was
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Curr Drug Targets 11:1551-70. 2010
    ..Finally, it suggests that pharmacological agents that regulate HO activity or HO-1 gene silencing may become powerful tools for preventing the onset or progression of various cancers and sensitize them to anticancer therapies...
  17. ncbi Heme oxygenase-1 in neovascularisation: A diabetic perspective
    Anna Grochot-Przeczek
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Thromb Haemost 104:424-31. 2010
    ..This review focuses on the role of HO-1 in angiogenesis and vasculogenesis, having a closer look at the significance of this system in diabetes...
  18. ncbi Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice
    Halina Was
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Free Radic Biol Med 51:1717-26. 2011
    ..Thus, HO-1 may protect healthy tissues against carcinogen-induced injury, but in already growing tumors it seems to favor their progression toward more malignant forms...
  19. ncbi Overexpression of biliverdin reductase enhances resistance to chemotherapeutics
    Urszula Florczyk
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Cancer Lett 300:40-7. 2011
    ..Therefore activity of BVR may be of significance in tumors and may influence the effectiveness of therapies...
  20. ncbi Haem oxygenase-1: non-canonical roles in physiology and pathology
    Anna Grochot-Przeczek
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Clin Sci (Lond) 122:93-103. 2012
    ....
  21. ncbi New vectors and strategies for cardiovascular gene therapy
    Agnieszka Jazwa
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Curr Gene Ther 7:7-23. 2007
    ....
  22. ncbi New strategies for cardiovascular gene therapy: regulatable pre-emptive expression of pro-angiogenic and antioxidant genes
    Jozef Dulak
    Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Cell Biochem Biophys 44:31-42. 2006
    ..Here, we demonstrated some indications of these drawbacks. Therefore, the final acceptance of these promising strategies for clinical trials requires careful validation in animal experiments...
  23. ncbi Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis
    Jozef Dulak
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
    Circulation 117:231-41. 2008
    ..This review will provide an overview of the role of heme oxygenase-1 and carbon monoxide in angiogenesis...
  24. ncbi Heme oxygenase-1 inhibits myoblast differentiation by targeting myomirs
    Magdalena Kozakowska
    Department of Medical Biotechnology, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 16:113-27. 2012
    ..Its overexpression has been suggested as a strategy improving survival of transplanted muscle precursors...
  25. ncbi CD45-CD14 +CD34 + murine bone marrow low-adherent mesenchymal primitive cells preserve multilineage differentiation potential in long-term in vitro culture
    Krzysztof Szade
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Mol Cells 31:497-507. 2011
    ..In sum, we isolated the novel multipotent subpopulation of CD45(-)CD14(+) CD34(+) bone marrow-derived cells that could be maintained in long-term culture without losing this potential...
  26. ncbi Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor
    Jolanta Grzenkowicz-Wydra
    Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Mol Cell Biochem 264:169-81. 2004
    ..This data suggest the feasibility of stimulation of angiogenesis by overexpression of SOD1...
  27. ncbi Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice
    Halina Was
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Am J Pathol 169:2181-98. 2006
    ....
  28. ncbi HIF-1 and HIF-2 transcription factors--similar but not identical
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Mol Cells 29:435-42. 2010
    ..Finally, recent data showing link between HIFs and specific microRNA have been presented...
  29. ncbi Heme oxygenase-1 in tumors: is it a false friend?
    Alicja Jozkowicz
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 9:2099-117. 2007
    ..Accordingly, inhibition of HO-1 can be suggested as a potential therapeutic approach sensitizing tumors to radiation, chemotherapy, or photodynamic therapy...
  30. ncbi MicroRNAs as biomarkers of disease onset
    Maciej Ciesla
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Anal Bioanal Chem 401:2051-61. 2011
    ..Together with relative stability, specificity, and reproducibility, they are seen as good candidates for early recognition of the onset of disease. Thus, miRNAs might be considered as biomarkers for many pathological states...
  31. ncbi Effect of heme oxygenase-1 on vascular function and disease
    Jozef Dulak
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Curr Opin Lipidol 19:505-12. 2008
    ..The present review summarizes the most recent studies about heme oxygenase-1 involvement in atherosclerosis, neovascularization and endothelial progenitor cells biology...
  32. ncbi Oxidative stress in tumor angiogenesis- therapeutic targets
    Magdalena Tertil
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Curr Pharm Des 16:3877-94. 2010
    ....
  33. ncbi Helper-dependent adenoviral vectors in experimental gene therapy
    Alicja Jozkowicz
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 52:589-99. 2005
    ..In this review we characterize the basic features of HdAd vectors and describe some of their experimental and potential clinical applications...
  34. ncbi Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells
    Jozef Dulak
    Division of Cardiology, Innsbruck University, Innsbruck, Austria
    Antioxid Redox Signal 4:229-40. 2002
    ..As CO and iron, respectively the inducer and the inhibitor of VEGF synthesis, are concomitantly produced during the degradation of heme, these data indicate that HO by-products may differentially modulate VEGF production...
  35. ncbi Nitric oxide-dependent synthesis of vascular endothelial growth factor is impaired by high glucose
    Jozef Dulak
    Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Life Sci 75:2573-86. 2004
    ..This may play a role in the development and progression of vascular dysfunctions in cardiovascular diseases...
  36. ncbi Anti-angiogenic and anti-inflammatory effects of statins: relevance to anti-cancer therapy
    Jozef Dulak
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Curr Cancer Drug Targets 5:579-94. 2005
    ..Herein, the reasons for those outcomes are discussed and the rationale for further studies is presented...
  37. ncbi HIF-1: the knowns and unknowns of hypoxia sensing
    Anna Zagorska
    Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 51:563-85. 2004
    ..Further understanding of the processes that control HIF-1 activity will be crucial for the development of new diagnostic and therapeutic strategies...
  38. ncbi Complex role of heme oxygenase-1 in angiogenesis
    Jozef Dulak
    Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Antioxid Redox Signal 6:858-66. 2004
    ....