George Parris

Summary

Publications

  1. ncbi 2-deoxy-D-glucose as a potential drug against fusogenic viruses including HIV
    George E Parris
    Med Hypotheses 70:776-82. 2008
  2. ncbi Hypothesis links emergence of chloroquine-resistant malaria and other intracellular pathogens and suggests a new strategy for treatment of diseases caused by intracellular parasites
    George E Parris
    9601 Warfield Road, Gaithersburg, MD 20882, USA
    Med Hypotheses 62:354-7. 2004
  3. ncbi How did the ancestral HIV-1 group M retrovirus get to Leopoldville from southeastern Cameroon?
    G E Parris
    9601 Warfield Road, Gaithersburg, MD 20882, USA
    Med Hypotheses 69:1098-101. 2007
  4. ncbi Mechanism and history of evolution of symbiotic HIV strains into lethal pandemic strains: the key event may have been a 1927 trial of pamaquine in Leopoldville (Kinshasa), Congo
    George E Parris
    Med Hypotheses 69:838-48. 2007
  5. ncbi Why G3139 works poorly in cancer trials but might work well against HIV
    George E Parris
    Med Hypotheses 69:537-40. 2007
  6. ncbi Developmental diseases and the hypothetical Master Development Program
    George E Parris
    Tufts University School of Medicine Adjunct, 9601 Warfield Road Gaithersburg, MD 20882, USA
    Med Hypotheses 74:564-73. 2010
  7. ncbi AIDS: caused by development of resistance to drugs in a non-target intracellular parasite
    George E Parris
    9601 Warfield Road, Gaithersburg, MD 20882, United States
    Med Hypotheses 68:151-7. 2007
  8. ncbi The cell clone ecology hypothesis and the cell fusion model of cancer progression and metastasis (II): three pathways for spontaneous cell-cell fusion and escape from the intercellular matrix
    George Parris
    Med Hypotheses 67:172-6. 2006
  9. ncbi The cell clone ecology hypothesis and the cell fusion model of cancer progression and metastasis: history and experimental support
    George E Parris
    9601 Warfield Road, Gaithersburg, MD 20882, USA
    Med Hypotheses 66:76-83. 2006
  10. ncbi Clinically significant cancer evolves from transient mutated and/or aneuploid neoplasia by cell fusion to form unstable syncytia that give rise to ecologically viable parasite species
    George E Parris
    Med Hypotheses 65:846-50. 2005

Detail Information

Publications16

  1. ncbi 2-deoxy-D-glucose as a potential drug against fusogenic viruses including HIV
    George E Parris
    Med Hypotheses 70:776-82. 2008
    ..These drugs may have broader utility and lower cost than drugs designed specifically to target the gp41 protein of HIV, which have become popular as viral-entry inhibitors for treatment of HIV/AIDS...
  2. ncbi Hypothesis links emergence of chloroquine-resistant malaria and other intracellular pathogens and suggests a new strategy for treatment of diseases caused by intracellular parasites
    George E Parris
    9601 Warfield Road, Gaithersburg, MD 20882, USA
    Med Hypotheses 62:354-7. 2004
    ..This approach to prevent or eliminate active infections might be particularly attractive against a range of parasites (virus, bacteria, protozoa, fungus) when safe and effective vaccines are not available...
  3. ncbi How did the ancestral HIV-1 group M retrovirus get to Leopoldville from southeastern Cameroon?
    G E Parris
    9601 Warfield Road, Gaithersburg, MD 20882, USA
    Med Hypotheses 69:1098-101. 2007
    ..The diagnosis and monitoring of these protozoan diseases (trypanosomiasis and malaria) involved repetitive sampling of blood, which provides many opportunities for spreading the ancestral HIV-1 infection...
  4. ncbi Mechanism and history of evolution of symbiotic HIV strains into lethal pandemic strains: the key event may have been a 1927 trial of pamaquine in Leopoldville (Kinshasa), Congo
    George E Parris
    Med Hypotheses 69:838-48. 2007
    ..This drug is much more toxic that chloroquine and appears to have strongly selected for resistance to apoptosis in infected cells, which allows these subgroups to attrite bystander cells leading to AIDS...
  5. ncbi Why G3139 works poorly in cancer trials but might work well against HIV
    George E Parris
    Med Hypotheses 69:537-40. 2007
    ..Indeed, G3139 has been shown to cause apoptosis in EBV-infected cells leading to clearance of the virus...
  6. ncbi Developmental diseases and the hypothetical Master Development Program
    George E Parris
    Tufts University School of Medicine Adjunct, 9601 Warfield Road Gaithersburg, MD 20882, USA
    Med Hypotheses 74:564-73. 2010
    ..The retro-transcripts are though to be produced during episodic retrovirus epidemics and account for punctuated equilibrium in species evolution...
  7. ncbi AIDS: caused by development of resistance to drugs in a non-target intracellular parasite
    George E Parris
    9601 Warfield Road, Gaithersburg, MD 20882, United States
    Med Hypotheses 68:151-7. 2007
    ..SARS and Ebola also fit this pattern...
  8. ncbi The cell clone ecology hypothesis and the cell fusion model of cancer progression and metastasis (II): three pathways for spontaneous cell-cell fusion and escape from the intercellular matrix
    George Parris
    Med Hypotheses 67:172-6. 2006
    ..The latency between tumor recognition and exposure to mutagens and the increased incidence of cancer with age can probably be related to slow breakdown of the intercellular matrix that provides a barrier to cell-cell fusion...
  9. ncbi The cell clone ecology hypothesis and the cell fusion model of cancer progression and metastasis: history and experimental support
    George E Parris
    9601 Warfield Road, Gaithersburg, MD 20882, USA
    Med Hypotheses 66:76-83. 2006
    ..The paper also summarizes work on the cell surface glycoprotein CD44 that implicates it as a key element in cell-cell fusion and hence cancer...
  10. ncbi Clinically significant cancer evolves from transient mutated and/or aneuploid neoplasia by cell fusion to form unstable syncytia that give rise to ecologically viable parasite species
    George E Parris
    Med Hypotheses 65:846-50. 2005
    ..Similarly, active suppression of viruses or other conditions that catalyze cell fusion should also slow down evolution of cancer clones...
  11. ncbi The possible use of arsine (AsH3) as therapy for malaria
    George E Parris
    Med Hypotheses 64:1100-1. 2005
    ..It is not known, but should be easily determined experimentally, what the relative toxicity of arsine (AsH3) is to normal erythrocytes and malaria-infected erythrocytes...
  12. ncbi The role of viruses in cell fusion and its importance to evolution, invasion and metastasis of cancer clones
    George E Parris
    Med Hypotheses 64:1011-4. 2005
    ....
  13. ncbi Update on hypothesis linking chloroquine-resistant malaria to disease-causing HIV
    George E Parris
    Med Hypotheses 67:670-1. 2006
  14. ncbi Anti-fusion drug candidates that may have beneficial effects against cancer, virus infections and autoimmune disorders
    George E Parris
    Med Hypotheses 70:463. 2008
  15. ncbi Cell-cell fusion is the rate-limiting step in causation and progression of clinically significant cancers
    George E Parris
    Cancer Genet Cytogenet 185:113. 2008
  16. ncbi HIV-infection of CD4+ T-cells enhances their effectiveness against hepatocytes infected with malaria parasites
    George E Parris
    Med Hypotheses 68:1187-8. 2007