Research Topics
Genomes and GenesSpecies | A V PandeySummaryPublications
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Publications
Biochemical analysis of mutations in P450 oxidoreductaseA V Pandey
Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3010 Bern, Switzerland
Biochem Soc Trans 34:1186-91. 2006..Understanding the genetic and biochemical basis of POR-mediated drug metabolism will provide valuable information about possible differences in P450-mediated reactions among the individuals carrying a variant or polymorphic form of POR...
Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductaseAmit V Pandey
Pediatric Endocrinology and Diabetology, University of Bern, Freiburgstrasse 15, G3 812, CH 3010 Bern, Switzerland
Mol Endocrinol 21:2579-95. 2007..Because POR supports many P450s involved in steroidogenesis, bone formation, and drug metabolism, variations in the effects of POR mutations on specific enzyme activities may explain the broad clinical spectrum of POR deficiency...
Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductaseAmit V Pandey
Pediatric Endocrinology, Diabetology and Metabolism, Department of Clinical Research, University of Bern, Tiefenaustrasse 120c, CH 3004 Bern, Switzerland
Biochem Biophys Res Commun 400:374-8. 2010..Further examination of patients affected with POR deficiency will be required to assess the metabolic effects of reduced HO-1 activity in affected individuals...
