Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venomNada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia
Toxicon 41:861-70. 2003
..Apoptosis, necrosis, and lysis of tumor cells are other possible mechanisms by which bee venom inhibits tumor growth...
- Bee venom in cancer therapy
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10000, Zagreb, Croatia
Cancer Metastasis Rev 31:173-94. 2012
..The recent applications of melittin in various cancers and a molecular explanation for the antiproliferative properties of bee venom are discussed...
- DNA-protective effects of quercetin or naringenin in alloxan-induced diabetic mice
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10000 Zagreb, Croatia
Eur J Pharmacol 656:110-8. 2011
..Various co-operative and synergistic action mechanisms of the tested flavonoids may lead to the protection of the whole organism against diabetes...
- Prevention of peritoneal carcinomatosis in mice by combining hyperthermal intraperitoneal chemotherapy with the water extract from Burr parsley (Caucalis platycarpos L.)
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Planta Med 76:773-9. 2010
..The stimulative effect of CPL on immunomodulation may be a possible mechanism which protects mice from developing peritoneal carcinomatosis and reduces the side effects of chemotherapy, increasing the life span of mice...
- Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, Zagreb, 10000, Croatia
Med Oncol 27:1346-58. 2010
....
- Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Biol Pharm Bull 30:946-51. 2007
..Treatment with test components after lethal irradiation was ineffective. These results suggest that propolis and its polyphenolic compounds given to mice before irradiation protect mice from the lethal effects of whole-body irradiation...
- Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells
Nada Orsolic
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer Sci 97:952-60. 2006
..In conclusion, adaphostin showed significant and selective activity against CML and AML cells and its development for clinical testing is warranted...
- Direct and indirect mechanism(s) of antitumour activity of propolis and its polyphenolic compounds
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Planta Med 72:20-7. 2006
....
- Effects of local administration of propolis and its polyphenolic compounds on tumor formation and growth
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb 10000 Zagreb, Rooseveltov trg 6, Croatia
Biol Pharm Bull 28:1928-33. 2005
..Based on these results, we postulate that the antitumor activity of polyphenolic compounds includes direct cytotoxic effects on tumor cells...
- Antitumor, hematostimulative and radioprotective action of water-soluble derivative of propolis (WSDP)
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, Croatia
Biomed Pharmacother 59:561-70. 2005
....
- Peroral application of water-soluble derivative of propolis (WSDP) and its related polyphenolic compounds and their influence on immunological and antitumour activity
N Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia
Vet Res Commun 29:575-93. 2005
....
- Immunomodulation by water-soluble derivative of propolis: a factor of antitumor reactivity
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia
J Ethnopharmacol 84:265-73. 2003
..Based on results we postulate that the antimetastatic activity of propolis includes a pronounced immunomodulatory activity mainly toward augmentation of nonspecific antitumor resistance in mice via macrophage activation...
- Inhibitory effect of water-soluble derivative of propolis and its polyphenolic compounds on tumor growth and metastasizing ability: a possible mode of antitumor action
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Nutr Cancer 47:156-63. 2003
....
- Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000, Croatia
J Ethnopharmacol 94:307-15. 2004
..The experimental data support that WSDP, CA, CAPE and QU could be potentially useful in the control of tumor growth in experimental models...
- Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages
Nada Orsolic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10 000 Zagreb, Croatia
J Ethnopharmacol 102:37-45. 2005
..It is likely that part of the antitumor efficacy of the assayed components against EAT cells was the results of increased macrophage activity...
- DNA damage and repair after exposure to sevoflurane in vivo, evaluated in Swiss albino mice by the alkaline comet assay and micronucleus test
G Brozovic
Department of Anaesthesiology and ICU, University Hospital for Tumours, HR 10 000 Zagreb, Ilica 197, Croatia
J Appl Genet 51:79-86. 2010
..Number of micronuclei in reticulocytes showed a statistically significant increase, as compared with the control group at all observed times after the treatment...
- Enhanced antitumor activity of irinotecan combined with propolis and its polyphenolic compounds on Ehrlich ascites tumor in mice
V Benkovic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia
Biomed Pharmacother 61:292-7. 2007
..These results suggest that clinical trials using a propolis preparation EEP combined with irinotecan may be beneficial in maximizing antitumor activity and minimizing post-chemotherapeutic reactions to the cytostatic drug...
- Evaluation of DNA damage in vivo induced by combined application of cisplatin and sevoflurane
G Brozovic
University Hospital for Tumours, Department of Anaesthesiology and ICU, Zagreb, Croatia
Eur J Anaesthesiol 25:642-7. 2008
..The influence of the combined application of cisplatin and sevoflurane on a variety of cell types of healthy mice or mice bearing Ehrlich ascites tumour has been investigated in an in vivo study...
- Radioprotective effects of propolis and quercetin in gamma-irradiated mice evaluated by the alkaline comet assay
V Benkovic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10000 Zagreb, Rooseveltov trg 6, Croatia
Phytomedicine 15:851-8. 2008
..The exact mechanisms of radioprotection by these compounds and their effects on DNA repair processes are still to be elucidated...
- Troxacitabine and imatinib mesylate combination therapy of chronic myeloid leukaemia: preclinical evaluation
Nada Orsolic
Department of Leukemia, M.D. Anderson Cancer Center, The University of Texas, Houston 77030-4009, USA
Br J Haematol 124:727-38. 2004
..These data indicate that the combination of troxacitabine and IM has significant preclinical activity in advanced CML and that clinical evaluation of this combination is warranted...
- Proportions and phenotypic expression of peripheral blood leucocytes in pigs vaccinated with an attenuated C strain and a subunit E2 vaccine against classical swine fever
S Terzic
Croatian Veterinary Institute, Savska cesta 143, 10000 Zagreb, Croatia
J Vet Med B Infect Dis Vet Public Health 50:166-71. 2003
..Thus, both vaccines were able to influence the porcine immune system, by activating different subsets of the immune effector/accessory cells...
- MER1, a novel organic arsenic derivative, has potent PML-RARalpha-independent cytotoxic activity against leukemia cells
Mirna Golemovic
Department of Leukemia, The University of Texas M D Anderson Cancer Center, Unit 428, 1515 Holcombe Blvd, Houston, TX 77030, USA
Invest New Drugs 28:402-12. 2010
..This agent, therefore, combines low in vivo toxicity with formidable in vitro pro-apoptotic ROS-mediated activity, and may represent a novel OAD suitable for clinical development against a variety of hematological malignancies...
