Research Topics
| Helge WiigSummaryAffiliation: University of Bergen Country: Norway Publications
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Detail Information
Publications
Pathophysiology of tissue fluid accumulation in inflammationHelge Wiig
Department of Biomedicine, Jonas Lies vei 91, N 5009 Bergen, Norway
J Physiol 589:2945-53. 2011..Although often overlooked, extravascular or interstitial factors may therefore contribute significantly to the inflammatory process and thus the ensuing oedema associated with inflammation...- The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential therapeutic consequencesHelge Wiig
Department of Biomedicine, University of Bergen, Bergen, Norway
Microcirculation 15:283-96. 2008..Here, we provide an overview of the structural components of the interstitium and discuss the importance the sterical and electrostatical components have on the dynamics of transcapillary fluid exchange... - Interstitial fluid: the overlooked component of the tumor microenvironment?Helge Wiig
Department of Biomedicine, University of Bergen, Bergen, Norway
Fibrogenesis Tissue Repair 3:12. 2010..Here we focus on the interstitial fluid phase of tumors, i.e., the fluid bathing the tumor and stromal cells. Novel knowledge on this compartment may provide important insight into how tumors develop and how they respond to therapy... - Effect of hydration on interstitial distribution of charged albumin in rat dermis in vitroHelge Wiig
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
J Physiol 569:631-41. 2005..Furthermore, screening of negative charges suggested that hyaluronan associated with collagen may influence intrafibrillar volume of collagen and thereby available and excluded volume fraction... - The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix componentsHelge Wiig
Department Biomedicine, Section of Physiology, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
J Physiol 567:557-67. 2005..Our experiments suggest that the tumour interstitium acts as a negatively charged matrix and is an important factor in determining the macromolecular distribution volume... - Isolation of rat trachea interstitial fluid and demonstration of local cytokine production in lipopolysaccharide-induced systemic inflammationElvira Semaeva
Dept of Biomedicine, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
J Appl Physiol 104:809-20. 2008..Trachea interstitial fluid may also reflect lower airways and thus be of importance for understanding, e.g., inflammatory-induced airway obstruction... - Importance of lymph vessels in the transcapillary fluid balance in the gingiva studied in a transgenic mouse modelLilian Ephrem Mkonyi
Dept of Biomedicine, Jonas Lies vei 91, Bergen 5009, Norway
Am J Physiol Heart Circ Physiol 299:H275-83. 2010..Our study demonstrates an important role of gingival lymphatics in transcapillary fluid balance in the steady-state condition and during acute perturbations... - Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemiaBengt Age Sørby Borge
Dept of Biomedicine, Univ of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
Am J Physiol Heart Circ Physiol 296:H735-44. 2009..Muscle cells apparently constitute an important source of several different cytokines during endotoxemia, governing the level in the muscle microenvironment, and are likely to contribute significantly to cytokine levels in plasma... - Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammationElvira Semaeva
Department of Biomedicine, University of Bergen, Bergen, Norway
J Immunol 184:4547-56. 2010..We conclude that analysis of spleen lymph may unravel immune cell migration patterns and local signaling, and immune cells exit via lymph having acquired specific activation signatures after exposure to the spleen microenvironment... - Cytokine signalling in rat pulp interstitial fluid and transcapillary fluid exchange during lipopolysaccharide-induced acute inflammationAthanasia Bletsa
Department of Biomedicine, Section for Physiology, Jonas Lies vei 91, N-5009 Bergen, Norway
J Physiol 573:225-36. 2006..Our findings show that pulp IF can be isolated by centrifugation and that this method is useful when studying fluid balance and extracellular signalling mechanisms in the dental pulp in normal and pathological conditions... - Isolation of interstitial fluid from skeletal muscle and subcutis in mice using a wick methodCarl Erik Markhus
Dept. of Biomedicine, Section of Physiology, Jonas Lies vei 91, N-5009 Bergen, Norway
Am J Physiol Heart Circ Physiol 287:H2085-90. 2004..We conclude that the wick technique can be easily adapted for use in mice and may represent a reliable method to isolate interstitial fluid and study transcapillary fluid flux in this species... - Demonstration of altered signaling responses in bone marrow extracellular fluid during increased hematopoiesis in rats using a centrifugation methodHelge Wiig
Department of Physiology, University of Bergen, 5009 Bergen, Norway
Am J Physiol Heart Circ Physiol 286:H2028-34. 2004.... - Effect of charge on interstitial distribution of albumin in rat dermis in vitroHelge Wiig
Department of Physiology and Locus on Circulatory Research, University of Bergen, Norway
J Physiol 550:505-14. 2003.... - A new method for isolation of interstitial fluid from human solid tumors applied to proteomic analysis of ovarian carcinoma tissueHanne Haslene-Hox
Department of Biomedicine, University of Bergen, Bergen, Norway
PLoS ONE 6:e19217. 2011.... - Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in ratsTorbjørn Nedrebø
Department of Physiology, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
J Physiol 556:193-202. 2004..For IL-1beta local production dominates in both conditions. Thus, there is a differential pattern of cytokine production and the current method allows the study of the role of cytokines in IF during different inflammatory reactions... - Peritumoral TNFalpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumoursLinda E B Stuhr
Department of Biomedicine, University of Bergen, Bergen, Norway
Scand J Clin Lab Invest 68:602-11. 2008.... - In vivo determination of steric and electrostatic exclusion of albumin in rat skin and skeletal muscleChristina C Gyenge
Department of Physiology, University of Bergen, Norway
J Physiol 552:907-16. 2003.... - Lowering of interstitial fluid pressure in rat submandibular gland: a novel mechanism in saliva secretionEllen Berggreen
Section for Physiology, Dept of Biomedicine, University of Bergen, Norway
Am J Physiol Heart Circ Physiol 290:H1460-8. 2006..The relatively low interstitial compliance of the organ will enhance the effect of the myoepithelial cells on P(if) during reduced V(i)... - Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedemaTine V Karlsen
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
J Physiol 574:583-96. 2006.... - Effect of topical anaesthetics on interstitial colloid osmotic pressure in human subcutaneous tissue sampled by wick techniqueHans Jørgen Timm Guthe
Department of Paediatrics, Haukeland University Hospital, Bergen, Norway
PLoS ONE 7:e31332. 2012..wet wick and implantation time on COP(i)... - Simultaneous measurement of interstitial fluid pressure and load in rat skin after strain application in vitroDavid M Wright
Department of Physiology, University of Bergen, Jonas Lies Vei 91 5009 Bergen, Norway
Ann Biomed Eng 31:1246-54. 2003..P(if) and stress can be measured simultaneously with the apparatus, though more precise determination of the depth at which pressure is measured is required for quantitative comparison of the magnitude of these two parameters... - Minimally invasive quantification of lymph flow in mice and rats by imaging depot clearance of near-infrared albuminTine V Karlsen
Department of Biomedicine, Hematology Section, University of Bergen, Jonas Lies vei 91, Bergen, Norway
Am J Physiol Heart Circ Physiol 302:H391-401. 2012..The method offers a minimally invasive, reproducible, and simple alternative to assess lymphatic function in mice and rats... - Isolation of interstitial fluid from rat mammary tumors by a centrifugation methodHelge Wiig
Department of Physiology, University of Bergen, Norway
Am J Physiol Heart Circ Physiol 284:H416-24. 2003..We conclude that low-speed centrifugation may be a simple and reliable method to isolate interstitial fluid from tumors... - Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinomaAlexei V Salnikov
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Int J Cancer 119:2795-802. 2006..Furthermore, our data indicate that the reduction of inflammation resulting in reduced vascular permeability and decrease in the tumor extracellular fluid volume by bevacizumab contributes to reduced tumor P(IF)... - Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetrationJaehwa Choi
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA
Clin Cancer Res 12:1906-12. 2006.... - Interstitial exclusion of albumin in rabbit lung measured with the continuous infusion method in combination with the wick techniqueDaniela Negrini
Department of Biomedical, Experimental Clinical Sciences, University of Insubria, Varese, 21100, Italy
Microcirculation 10:153-65. 2003..To determine albumin exclusion from the pulmonary perivascular interstitium by using the continuous infusion methods coupled with direct samples of pulmonary interstitial fluid via the wick technique... - PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesisMarko Uutela
Molecular Cancer Biology Laboratory, Ludwig Institute for Cancer Research, Helsinki University, Finland
Blood 104:3198-204. 2004..These results show that full-length PDGF-D is activated in tissues and is capable of increasing interstitial fluid pressure and macrophage recruitment and the maturation of blood vessels in angiogenic processes... - Interstitial exclusion of albumin in rabbit lung during development of pulmonary oedemaDaniela Negrini
Department of Biomedical, Experimental and Clinical Sciences, University of Insubria, Varese, 21100, Italy
J Physiol 548:907-17. 2003..23 +/- 0.01, 33.2 % of the control value. Data indicate that, at variance with what is observed in tissues like skin and muscle, pulmonary Fe,a is highly sensitive to tissue fluid content... - Acute peritoneal dialysis in rats results in a marked reduction of interstitial colloid osmotic pressureBert Inge Rosengren
Department of Nephrology, University Hospital of Lund, S 221 85 Lund, Sweden
J Am Soc Nephrol 15:3111-6. 2004..It is speculated that the increase in peritoneal hydrostatic pressure after PD causes an increase in interstitial tissue volume, with primarily a dilution of interstitial colloids... - Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesisPer Ole Iversen
Department of Nutrition, Institute of Basic Medical Research, University of Oslo, Norway
Clin Cancer Res 11:6793-9. 2005..Using a novel method to isolate bone marrow interstitial fluid, we examined if this fluid from 10 adult AML patients could affect normal bone marrow hematopoiesis... - Differential degradation of matrix proteoglycans and edema development in rabbit lungDaniela Negrini
Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Universita degli Studi dell Insubria, via J H Dunant 5, 21100, Varese, Italy
Am J Physiol Lung Cell Mol Physiol 290:L470-7. 2006.... - Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor modelMatthias Hofmann
Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe University, Frankfurt Main D 60590, Germany
Neoplasia 8:89-95. 2006..These data suggest that the mechanical stretch induced by TIFP is a positive modulator of tumor proliferation...