Research Topics
Genomes and Genes | P BrandtzaegSummaryAffiliation: The Norwegian Radium Hospital Country: Norway Publications
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Publications
Mucosal immunity in the female genital tractP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
J Reprod Immunol 36:23-50. 1997..In addition, paracellular diffusion of serum-derived and locally produced IgG through epithelia is an important part of humoral immunity in the female genital tract...- Maternal allergy influences the proliferation of neonatal T cells expressing CCR4, CXCR5 or CD103U Haddeland
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Department and Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
Clin Exp Allergy 37:856-64. 2007..Elevated proliferative response to allergen in cord blood mononuclear cells (CBMCs) is related to subsequent allergy development of the neonate and has been suggested as a screening marker for high allergy risk... - Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac diseaseE M Nilsen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
Gastroenterology 115:551-63. 1998..Duodenal biopsy specimens from patients with celiac disease and histologically normal controls were investigated to see if cytokine expression is related to disease activity... - A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptorH Schjerven
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
J Immunol 167:6412-20. 2001..Several intronic DNA elements found to be functionally important in the human gene are highly conserved between the human and mouse pIgR/SC genes, suggesting the presence of a conserved cytokine-responsive enhancer region... - Regional specialization in the mucosal immune system: primed cells do not always home along the same trackP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, N 0027 Oslo, Norway
Immunol Today 20:267-77. 1999..However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut... - Role of J chain in secretory immunoglobulin formationF E Johansen
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
Scand J Immunol 52:240-8. 2000..Therefore, both the J chain and the pIgR/SC are key proteins in secretory immunity... - Identification of residues within the extracellular domain 1 of bovine Fc gamma 2R essential for binding bovine IgG2H C Morton
Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
J Biol Chem 276:47794-800. 2001..Furthermore, single amino acid mutational analysis of this region identified Phe-82 and Trp-87 as being critical for bIgG2 binding... - Different regulatory pathways employed in cytokine-enhanced expression of secretory component and epithelial HLA class I genesE M Nilsen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Norway
Eur J Immunol 29:168-79. 1999..Our observations in vitro likely parallel events in vivo by which activated mucosal T cells and macrophages enhance pIg receptor-mediated external transport of secretory IgA and IgM and up-regulate epithelial HLA expression... - Domain deletions in the human polymeric Ig receptor disclose differences between its dimeric IgA and pentameric IgM interactionI N Norderhaug
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
Eur J Immunol 29:3401-9. 1999..Moreover, our studies imply that dimeric human IgA binds differently to pIgR from various species. This observation cautions against interpretation of functional studies performed with non-homologous receptor-ligand pairs... - The B-cell system of human mucosae and exocrine glandsP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
Immunol Rev 171:45-87. 1999..Rational design of local vaccines will depend on better knowledge of both inductive and migratory properties of human mucosal B cells... - Culture characterization of differentiated high endothelial venule cells from human tonsilsE S Baekkevold
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Norway
Lab Invest 79:327-36. 1999..Our rapid and reproducible method to establish HEVEC cultures provides a useful mechanistic tool for identification of the factors that induce and maintain the HEV phenotype, as well as a source for isolation of HEV-specific genes... - Regional specialization in the mucosal immune system: what happens in the microcompartments?P Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
Immunol Today 20:141-51. 1999..Here, Per Brandtzaeg and colleagues discuss compartmentalized regulation of mucosal B cells and mechanisms that might explain the strikingly regionalized effector disparity of the human mucosal immune system... - Recombinant expression of polymeric IgA: incorporation of J chain and secretory component of human originF E Johansen
Laboratory of Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
Eur J Immunol 29:1701-8. 1999..Development of production systems for human antigen-specific recombinant SIgA may be important for applications in passive mucosal vaccination... - Interferon-gamma-secreting T cells localize to the epithelium in coeliac diseaseR W Olaussen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
Scand J Immunol 56:652-64. 2002..We conclude that isolated T cells spontaneously secreting IFN-gamma localize preferentially in the epithelium of patients with classical and refractory CD... - Ontogeny of the mucosal immune system and IgA deficiencyP Brandtzaeg
University of Oslo, Norway
Gastroenterol Clin North Am 20:397-439. 1991..The immaturity of the IgA system revealed in this disorder bears a striking resemblance to that seen in newborn infants. It may therefore be worthwhile to consider IgA deficiency in relation to the ontogeny of mucosal immunity... - Mucosal immunity: induction, dissemination, and effector functionsP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation, University of Oslo, Division and Institute of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Scand J Immunol 70:505-15. 2009..The airways also receive such cells from nasopharynx-associated lymphoid tissue - but by different homing receptors. Such compartmentalization is a challenge for development of mucosal vaccines... - Hypersensitivity and oral tolerance in the absence of a secretory immune systemM R Karlsson
Centre for Immune Regulation, Oslo University Hospital, University of Oslo, Rikshospitalet, Norway
Allergy 65:561-70. 2010..Lack of secretory antibodies may cause immune dysfunction and affect mucosally induced (oral) tolerance against food antigens... - Age-related changes in CCR9+ circulating lymphocytes: are CCR9+ naive T cells recent thymic emigrants?R W Olaussen
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N-0027 Oslo, Norway
Scand J Immunol 54:435-9. 2001.... - Expression and modulation of the human immunoglobulin A Fc receptor (CD89) and the FcR gamma chain on myeloid cells in blood and tissueR Hamre
The Laboratory of Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, Rikshospitalet, Oslo, Norway
Scand J Immunol 57:506-16. 2003..The implications of our current findings on the biological functioning of CD89 are discussed... - The J chain is essential for polymeric Ig receptor-mediated epithelial transport of IgAF E Johansen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
J Immunol 167:5185-92. 2001..Nevertheless, these polymers bound free SC with nearly the same affinity as pIgA containing wild-type J chain, but were transcytosed by pIgR-expressing polarized epithelial cells at a reduced efficiency... - The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitmentE S Baekkevold
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
J Exp Med 193:1105-12. 2001..We conclude that perivascular ELC is transcytosed to the luminal surfaces of HEVs and participates in CCR7-mediated triggering of lymphocyte arrest... - Immunology of tonsils and adenoids: everything the ENT surgeon needs to knowP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo N 0027, Norway
Int J Pediatr Otorhinolaryngol 67:S69-76. 2003.... - Depletion of CD4+ CD25+ regulatory T cells inhibits local tumour growth in a mouse model of B cell lymphomaI Heier
LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Clin Exp Immunol 152:381-7. 2008.... - Heterogeneity of intraepithelial lymphocytes in refractory sprue: potential implications of CD30 expressionI N Farstad
Department of Pathology, and Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
Gut 51:372-8. 2002..Refractory sprue is defined as primary or secondary failure to respond to a gluten free diet in patients with coeliac disease-like enteropathy and may signify cryptic or overt enteropathy associated T cell lymphoma... - Inflammatory bowel disease: clinics and pathology. Do inflammatory bowel disease and periodontal disease have similar immunopathogeneses?P Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
Acta Odontol Scand 59:235-43. 2001..Several targets for new therapy have tentatively been identified to block immunopathological mechanisms in IBD, and inhibition of TNF has a striking beneficial effect in CD, supporting a central role of this cytokine... - Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesionsL Farkas
Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
Am J Pathol 159:237-43. 2001..Together, our findings suggested that P-DCs are an important source of IFN-alpha/beta in cutaneous LE lesions and may therefore be of pathogenic importance... - Impaired interleukin (IL)-4-associated generation of CCR4-expressing T cells in neonates with hereditary allergy riskU Haddeland
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Clin Exp Immunol 139:314-22. 2005..Conversely, Th1 responses to antigen in the presence of LPS did not appear to be reduced compared with controls... - Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficienciesD E Nilssen
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
Clin Exp Immunol 83:17-24. 1991..The possible clinical consequences of such variable mucosal expression of IgG subclass deficiencies remain to be studied... - Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient miceF E Johansen
Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
J Exp Med 190:915-22. 1999..Production of SIgA might therefore be a variable in the initiation of human immunopathology such as inflammatory bowel disease or gluten-sensitive enteropathy... - Increased mucosal production of monomeric IgA1 but no IgA1 protease activity in Helicobacter pylori gastritisA E Berstad
Laboratory for Immunohistochemistry, Institute of Pathology, University of Oslo, Oslo, Norway
Am J Pathol 155:1097-104. 1999..7% versus 87.9% (P = 0.0002), and for IgA2 cells to 48.9% versus 87.8% (P = 0.0002). This down-regulation of the J chain suggested that a large fraction of IgA monomers is produced in gastritis... - Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional responseH Schjerven
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
J Immunol 165:3898-906. 2000..This mechanism may represent a general strategy for how pleiotropic cytokines elicit cell type-specific transcriptional responses... - Secretory component mRNA and protein expression in colorectal adenomas and carcinomasP Krajci
Laboratory for Immunohistochemisty and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet, University of Oslo, Norway
Br J Cancer 73:1503-10. 1996.... - Intestinal B cell hyperactivity in AIDS is controlled by highly active antiretroviral therapyD E Nilssen
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
Gut 53:487-93. 2004..HAART could significantly reverse this perturbation, suggesting restored ability of the mucosal immune system to control intestinal infections... - B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissueH S Carlsen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, and Department of Surgery, University of Oslo, Rikshospitalet, Oslo, Norway
Gut 51:364-71. 2002..Hence to elucidate the potential role of this chemokine and its receptor in human gut associated lymphoid tissue (GALT), we analysed their expression in normal intestine and ulcerative colitis (UC)... - A composite DNA element in the promoter of the polymeric immunoglobulin receptor regulates its constitutive expressionF E Johansen
Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Norway
Eur J Immunol 28:1161-71. 1998..Finally, a mutation in the pIgR promoter that inhibited protein binding to the E-box and the formation of the larger complex, abolished activated transcription from the reporter gene... - CD89: the human myeloid IgA Fc receptorH C Morton
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Norway
Arch Immunol Ther Exp (Warsz) 49:217-29. 2001..Here we review current knowledge concerning the genetics, structure and biological function of CD89... - Bronchial response pattern of antigen presenting cells and regulatory T cells in children less than 2 years of ageI Heier
LIIPAT, The Pathology Clinic, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
Thorax 63:703-9. 2008.... - Early detection of liver metastasis in patients with colorectal carcinoma by increased levels of circulating IgA- and IgM-associated secretory componentD Kvale
Institute of Pathology, University of Oslo, National Hospital, Norway
Br J Cancer 56:629-32. 1987..5 months median lead time from the first positive serum sample to clinically manifest liver disease. These data are interesting in view of the promising results reported for liver resection in patients with colorectal carcinoma... - Mucosal immunityP Brandtzaeg
Institute of Pathology, University of Oslo, Rikshospitalet, Norway
Dev Biol (Basel) 115:111-7. 2003 - Oligoclonality of rat intestinal intraepithelial T lymphocytes: overlapping TCR beta-chain repertoires in the CD4 single-positive and CD4/CD8 double-positive subsetsL Helgeland
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Department of Anatomy, University of Oslo, Oslo, Norway
J Immunol 162:2683-92. 1999..The limited Vbeta usage and overlapping TCR repertoire expressed by CD4 SP and CD4/CD8 DP cells suggest that these two IEL populations recognize restricted intestinal ligands and are developmentally and functionally related... - Complement activation directly induced by Helicobacter pyloriA E Berstad
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Rikshospitalet, Institute of Pathology, N 0027 Oslo, Norway
Gastroenterology 120:1108-16. 2001..Helicobacter pylori is a frequent gram-negative colonizer of the human stomach. Its interaction with complement may be involved in the pathogenesis of chronic gastritis, and was mechanistically studied in vitro... - Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergyF L Jahnsen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
J Immunol 165:4062-8. 2000..Together, our findings suggested that P-DCs are involved in the triggering of airway allergy and that they are directed to allergic lesions by adhesion molecules that normally mediate leukocyte extravasation in organized lymphoid tissue... - Homeostatic impact of indigenous microbiota and secretory immunityP Brandtzaeg
Department and Institute of Pathology, Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation CIR, Oslo University Hospital, Rikshospitalet, Norway
Benef Microbes 1:211-27. 2010..They therefore have a hyper-reactive immune system and show predisposition for systemic anaphylaxis after sensitisation; but this development is counteracted by enhanced oral tolerance induction as a homeostatic back-up mechanism... - Cloning and sequencing of a cDNA encoding the bovine FcR gamma chainH C Morton
Laboratory of Immunohistochemistry and Immunopathology LIIPAT, Institute for Pathology, University of Oslo, Rikshospitalet, N 0027, Oslo, Norway
Vet Immunol Immunopathol 82:101-6. 2001..Cloning of a cDNA encoding, the bovine FcR gamma chain will allow for a better understanding of signal transduction processes triggered by bovine FcRs... - Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interactionM Røe
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
J Immunol 162:6046-52. 1999.... - Neisseria meningitidis lipopolysaccharides in human pathologyP Brandtzaeg
Departments of Pediatrics, Ulleval University Hospital, University of Oslo, Oslo, Norway
J Endotoxin Res 7:401-20. 2001..Early antibiotic treatment is mandatory. Three intervention trials to block lipid A have not significantly reduced the mortality of meningococcal septicemia... - Immunoglobulin-binding sites of human FcalphaRI (CD89) and bovine Fcgamma2R are located in their membrane-distal extracellular domainsH C Morton
Laboratory of Immunohistochemistry and Immunopathology LIIPAT, The National Hospital, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
J Exp Med 189:1715-22. 1999..In terms of FcR-Ig interactions characterized thus far, this location is unique and surprising because it has been shown previously that leukocyte FcgammaRs and FcepsilonRI bind Ig via sites principally located in their EC2 domains... - Nature and function of gastrointestinal antigen-presenting cellsP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
Allergy 56:16-20. 2001..Thus, APCs are involved in active immunity as well as in induction of oral tolerance. However, their precise role in food allergy remains to be defined... - Glandular distribution of immunoglobulins, J chain, secretory component, and HLA-DR in the human endometrium throughout the menstrual cycleS Bjercke
Department of Obstetrics and Gynaecology, University of Oslo, National Hospital, Rikshospitalet, Norway
Hum Reprod 8:1420-5. 1993.... - Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophiliaF L Jahnsen
Laboratory for Immunohistochemistry, Institute of Pathology, Department of Ear, Nose, and Throat, University of Oslo, The National Hospital, Rikshospitalet, Norway
J Immunol 163:1545-51. 1999.... - M cell pockets of human Peyer's patches are specialized extensions of germinal centersT Yamanaka
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
Eur J Immunol 31:107-17. 2001..We propose that this M cell-associated event contributes to memory B cell survival and diversification of intestinal immunity, representing a specialized limb of GC function...