Lars J Vatten

..In the present study based on the Norwegian Breast Cancer Screening Program, tumor growth was estimated from a large population using a new estimating procedure/model...

..It has been suggested that physical activity may reduce the impact of factors associated with metabolic syndrome, but it is not known whether physical activity may reduce mortality in people with metabolic syndrome...

..Birth size, and particularly birth length, is positively associated with breast cancer risk in adulthood. The objective of this study was to examine whether birth size is associated with survival among breast cancer patients...

..High circulating levels of insulin-like growth factor (IGF-I) may elevate the risk of breast cancer in premenopausal women, possibly by increasing cell proliferation and reducing apoptosis...

..High blood pressure increases cardiovascular mortality, but whether the effect is counteracted by physical activity is not clear...

..7, 2.0 and 2.0, respectively (P for linear trend, 0.11). In men, there was no association with blood pressure...

..To investigate whether cardiovascular mortality related to obesity could be modified by physical activity...

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..The stronger risk reduction related to having a son suggests a role for sex-dependent hormones in pregnancy...

..To assess whether circulating IGF-I and IGF-binding protein-1 (IGFBP-1) in the first and second trimester are associated with subsequent risk of preterm and term preeclampsia...

..Adjustment for smoking, blood lipids and brachial blood pressure did not substantially change these results. In conclusion, the prevalence of IC was more than three times higher in patients with DM compared to non-diabetic participants...

..These findings suggest that low as well as high birth weight of the offspring may indicate increased cardiovascular risk for the mother...

..We investigated whether factors that tend to differ between ART and spontaneously conceived pregnancies may explain the higher risk of breech deliveries associated with ART...

..The aim of this study was to determine whether blood pressure, body mass index (BMI), serum lipids, glucose, and renal function are associated with left ventricular (LV) and right ventricular function in a low-risk population...

..We found no association between physical activity and overall risk of prostate cancer. We conclude that recreational physical exercise is associated with reduced risk of advanced prostate cancer and prostate cancer death...

..This study was undertaken to assess changes in placenta growth factor and soluble fms-like tyrosine kinase-1 as predictors of preeclampsia...

..Recent studies have suggested that the association of low thyroid function with high body mass is restricted to nonsmokers...

..Using more informative expressions of conventional risk factors for ischemic heart disease may improve both the validity and precision of estimates of risk, and may be useful both clinically and for preventive purposes...

..We have studied the association of head circumference at birth with later deaths from coronary heart disease (CHD), and assessed whether maternal height and adult body mass could modify the association...

..To study the association of hypertensive pregnancy disorders with modifiable risk factors for cardiovascular and metabolic diseases and to estimate the feasibility for early detection and prevention...

..We therefore compared pregnancy outcomes in women who had singleton pregnancies conceived both spontaneously and after assisted fertilisation...

..Reference values for annular velocities should be specified by sex and age. The average of inferoseptal and anterolateral wall velocities may be the preferred index of left ventricular performance...

..This finding suggests that placental function is important in the association of intrauterine factors with cardiovascular disease later in life...

..5-fold increased risk of SGA. Low maternal soluble Flt-1 in early pregnancy followed by a strong subsequent increase in soluble Flt-1 and soluble endoglin was associated with a particularly high risk of severe fetal growth restriction...

..To study whether perceived pubertal timing is related to the prevalence of alcohol drinking and cigarette smoking among adolescent boys and girls...

..The positive association related to birth length suggests that factors that stimulate intrauterine longitudinal growth are particularly important...

..Conversely, relatively low serum TSH could predict future hyperthyroidism...

..We have prospectively examined the influence of early sexual maturation on subsequent overweight in late adolescence and assessed if this association was modified by central adiposity in early adolescence...

..We assessed sex-specific associations of iron status with ischaemic heart disease (IHD) mortality and explored whether the strength of the associations changed during follow-up...

..Shorter adult stature has been attributed to early sexual maturation, as well as early adiposity, but it is not clear if these factors are interrelated...

..We have assessed whether the effect can be attributed to factors that operate in pregnancy or to prepregnancy risk factors that are shared by both disorders...

..We have studied the association between normal thyroid function, defined as TSH within the reference range of a general population, and concentrations of serum lipids...

..To determine the independent contributions to infant birth size of insulin-like growth factor I (IGF-I) and leptin measured in umbilical cord plasma...

..The net effect of birth size on long-term mortality has only been assessed in individual studies, with conflicting results...

..To investigate whether female offspring of preeclamptic pregnancies have higher blood pressure, lower height, higher body mass index (BMI), and later age at menarche compared with offspring of normotensive pregnancies...

..Recent studies suggest that relatively low thyroid function within the clinical reference range is positively associated with risk factors for coronary heart disease (CHD), but the association with CHD mortality is not resolved...

..The observation that exercise training reduces cardiovascular mortality is robust and consistent, but the amount and intensity of exercise that is required for risk reduction is not yet resolved...

..Low thyroid function may be associated with reduced glomerular filtration rate (GFR). We therefore studied the association of thyroid function with estimated GFR (eGFR) in a population-based study...

..The association between tobacco smoking and thyroid function is incompletely understood...

..It has been hypothesized that thyroid function may influence cancer risk, but few studies with adequate statistical power have investigated this question, and the results have not been consistent...

..Blood pressure is positively associated with ischaemic heart disease (IHD) mortality, but the strength of the association declines with age, and may differ between lean and obese people...

..These results support the hypothesis that factors that determine intrauterine growth could be important for aggressive forms of prostate cancer in adulthood...

..The association between thyroid function and blood pressure is insufficiently studied...

..The unbalanced pregnancy survival by offspring sex may also be reflected in higher proportion of preterm male births, and in unbalanced sex distribution in certain pregnancy conditions, such as preeclampsia...

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..To assess the influence of glycaemic control on long-term mortality from ischaemic heart disease (IHD) in patients with newly diagnosed diabetes...

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..Current and previous smoking habits were positively associated with the prevalence of IC, and smoking cessation was negatively associated in men and women. Passive smoking was not associated with IC in this study...

..Data from this study also indicate that high levels of physical activity may reduce prostate cancer risk...

..In conclusion, persistently low IGFBP-1 in pregnancy is associated with relatively higher birth weight. Maternal insulin resistance may provide a link between IGFBP-1 and offspring birth weight...

..In boys, late sexual maturation was associated with reduced risk of advanced drinking...

..To examine trends in fatal coronary heart disease in adults with and without diabetes...

..Women who change partner may have individual characteristics that increase risk of adverse outcomes, but change of partner could also be associated with unfavourable changes in behaviour...

..Whether the increased risk is due to factors related to the reproductive technology, or associated with maternal factors, is not known...

..A common feature of such factors would be their ability to stimulate foetal growth and, simultaneously, to influence intrauterine development of the mammary gland...

..Among consecutive colorectal cancer (CRC) patients, we aimed at identifying all patients with a hereditary predisposition, and to study a possible discrepancy with assessments made by the responsible clinicians...

..The objective of this study was to assess the association of RHR with IHD mortality, and to evaluate the potentially modifying effect of PA on this association...

..To study the association between umbilical plasma levels of interleukin-6 (IL-6) in relation to fetal growth in subgroups of preeclampsia, and in control pregnancies...

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..These results suggest that an anti-oestrogenic effect associated with pre-eclampsia may be mediated through high levels of alpha-foetoprotein rather than low levels of oestradiol...

..A better understanding of the underlying processes could provide an insight into the pathogenesis of breast cancer...

..If the first pregnancy lasted less than 32 weeks, the risk was 22% (95% confidence interval, -3% to 53%) less than after a pregnancy of 40 weeks or more, with a significant declining trend in risk (P for trend=0.02)...

..To determine if the influence of preeclampsia on birth size varies with clinical manifestations of the disease, and to evaluate whether maternal factors, such as smoking, modify the effect of preeclampsia on fetal growth...

..To explore to what extent different lifestyle factors are associated with the risk of pancreatic cancer, data from a large health screening survey in a county in Norway were analyzed...

..10 (95% CI, 0.41-2.90). These results showed no association, positive or negative, between androgens measured in serum and the subsequent risk of developing prostate cancer...

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..To compare the effects on pregnancy outcomes of changing partner between the first two births with having the same partner for both births...

..To study the distribution of longitudinal systolic strain and strain rate (SR) as indicators of myocardial deformation according to age and sex in a healthy population...

..2, 3 d.f., P = 0.02). In summary, the results of this study suggest that coffee consumption reduces the risk of breast cancer in lean women, whereas coffee might have the opposite effect in relatively obese women...

..17 (95% CI 1.07-1.27), which was confined to cancer of the breast, lung and cervix. With few clear exceptions women with children had a better survival than nulliparous women (overall hazard ratio = 0.80, 95% CI 0.74-0.87)...

..abstract:..

..We have assessed the prevalence of children's health symptoms according to whether peer victimization was reported by the children, by their teachers, or by their parents...

..Alternative multivariable models and different sensitivity analyses suggest that the results were robust, especially concerning difficulties initiating sleep. Conclusions- Insomnia is associated with a moderately increased risk for AMI...

..We also found that overweight and obesity, as measured many years prior to diagnosis, were associated with poorer survival...

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..Among women born before or after the war we found no clear association with height. The association with height in the WWII cohort may imply a role for early nutrition in breast cancer aetiology...

..These results suggest that physical and sexual development in puberty and adolescence is influenced by prenatal factors, and in combination, these factors may influence health and disease later in life...

..CONCLUSION: The prevalence of CLI was 0.24%, similar for both genders, and increased with age. Risk factors usually seen in atherosclerotic patients were associated with suspected CLI...

..The negative association with BMI may be related to a lower rate of cell division of breast tissue among obese premenopausal women...

..We estimated the associations of parity and offspring birthweight with the risk of shoulder dystocia, and studied whether the association of offspring birthweight differed by parity...

..In this cross-sectional study of school children we assessed how factors assumed to promote wellbeing and factors assumed to adversely influence wellbeing were associated with self-reported wellbeing in school...

..CONCLUSION: TC/HDL cholesterol and triglycerides were positively, and HDL cholesterol negatively associated with IC in both genders. In women, but not in men, BMI, waist and hip circumference were positively associated with IC...

..CONCLUSION: the prevalence of intermittent claudication increased gradually by age. However, in contrast to previous reports, there was no difference by sex...

..To assess the impact on risk of pre-eclampsia of genes that work through the mother, and genes of paternal origin that work through the fetus...

..Factors that increase growth velocity may be related to increased risk, whereas factors with anti-oestrogenic properties may have a protective effect...

..Our findings indicate that progesterone may have a role in the late manifestation of pre-eclampsia pathology but are also compatible with the hypothesis that increases in progesterone represent an early compensatory mechanism...

..We assessed serum levels of immunoglobulin E (IgE) in the first and second trimester, and changes in concentration between trimesters, in relation to risk of preeclampsia...

..This could be reflected in differences in placenta weight. Therefore, we compared placenta weight in pregnancies with preterm or term pre-eclampsia to placenta weight in pregnancies without pre-eclampsia...

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..High concentrations of the anti-angiogenic factor sFlt-1 in maternal circulation during pregnancy may be associated with an increased risk of excess post-partum bleeding...