Trine Husøy

Summary

Affiliation: Norwegian Institute of Public Health
Country: Norway

Publications

  1. ncbi Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Carcinogenesis 24:643-50. 2003
  2. ncbi Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Eur J Cancer 40:1599-603. 2004
  3. ncbi Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes
    T Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, NO 0403 Oslo, Norway
    Mutat Res 580:111-8. 2005
  4. ncbi Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Int J Cancer 116:351-8. 2005
  5. ncbi Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure
    T Husøy
    Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, 0403 Oslo, NO, Norway
    Food Chem Toxicol 46:3697-702. 2008
  6. ncbi Intestinal adenomas of Min-mice lack enterochromaffin cells, and have increased lysozyme production in non-Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 26:1797-802. 2006
  7. ncbi Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners - a risk benefit assessment
    T Husøy
    Department of Food Safety and Nutrition, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Food Chem Toxicol 46:3099-105. 2008
  8. ncbi 5-Hydroxymethylfurfural and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of Min/+ mice
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 29:1921-6. 2009
  9. ncbi Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
    Helle K Knutsen
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Anticancer Res 25:3781-9. 2005
  10. ncbi The min mouse on FVB background: susceptibility to spontaneous and carcinogen-induced intestinal tumourigenesis
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 31:785-8. 2011

Detail Information

Publications11

  1. ncbi Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Carcinogenesis 24:643-50. 2003
    ..Reduction in GJIC and Cx43 level in IMCE cells may be caused by reduced Cx43 transport as a result of alterations in microtubule function...
  2. ncbi Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Eur J Cancer 40:1599-603. 2004
    ..Absence of matrilysin in Min mice reduces adenoma development. Reduced Cx32 and increased matrilysin secretion from Paneth cells could be important to neoplastic development in the intestine...
  3. ncbi Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes
    T Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, NO 0403 Oslo, Norway
    Mutat Res 580:111-8. 2005
    ..We conclude that Min-mice are less sensitive than wt-mice to MN induction by PhIP that forms bulky DNA adducts, while Min-mice and wt-mice are equally sensitive to MN induction by acrylamide and glycidamide that form DNA base adducts...
  4. ncbi Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Int J Cancer 116:351-8. 2005
    ..We hypothesise that gap junctions may be of importance in the transfer of signals between epithelium and stroma...
  5. ncbi Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure
    T Husøy
    Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, 0403 Oslo, NO, Norway
    Food Chem Toxicol 46:3697-702. 2008
    ..In spite of this there was a significant correlation (r=0.57, P<0.001) between the estimated HMF intake and urinary HMFA. Further studies are needed to reveal alternative sources for HMF exposure...
  6. ncbi Intestinal adenomas of Min-mice lack enterochromaffin cells, and have increased lysozyme production in non-Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 26:1797-802. 2006
    ..Paneth and enterochromaffin cells were studied in the intestine and intestinal adenomas from Min-mice with heterozygote and homozygote mutations in Apc, respectively...
  7. ncbi Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners - a risk benefit assessment
    T Husøy
    Department of Food Safety and Nutrition, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Food Chem Toxicol 46:3099-105. 2008
    ..The highest intake of benzoic acid was observed for 1- to 2-year-old children, and benzoic acid intake in Norwegian children is therefore considered to be of special concern...
  8. ncbi 5-Hydroxymethylfurfural and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of Min/+ mice
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 29:1921-6. 2009
    ....
  9. ncbi Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
    Helle K Knutsen
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Anticancer Res 25:3781-9. 2005
    ..ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not...
  10. ncbi The min mouse on FVB background: susceptibility to spontaneous and carcinogen-induced intestinal tumourigenesis
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 31:785-8. 2011
    ..Treatment with PhIP significantly increased both the number and incidence of tumours in the small intestine, and gave a non-significant increase of tumours and flat ACF in the colon...
  11. ncbi The detection of hamster connexins: a comparison of expression profiles with wild-type mouse and the cancer-prone Min mouse
    Véronique Cruciani
    Department of Environmental and Occupational Cancer, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Cell Commun Adhes 11:155-71. 2004
    ..In contrast, there were minimal differences in expression profiles between wild type and Min mice. Species-specific expression profiles should be considered in attempts to make animal models of human connexin-associated diseases...