Eirik Bratland

Summary

Affiliation: Institute of Medicine
Country: Norway

Publications

  1. ncbi The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: the major autoantigen in autoimmune Addison's disease
    Eirik Bratland
    Department of Medicine, Section for Endocrinology, Institute of Medicine, Haukeland University Hospital, Bergen, Norway
    J Autoimmun 33:58-67. 2009
  2. ncbi T cell responses to steroid cytochrome P450 21-hydroxylase in patients with autoimmune primary adrenal insufficiency
    Eirik Bratland
    Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
    J Clin Endocrinol Metab 94:5117-24. 2009
  3. ncbi Cellular immunity and immunopathology in autoimmune Addison's disease
    Eirik Bratland
    Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
    Mol Cell Endocrinol 336:180-90. 2011
  4. ncbi Radioimmunoassay for autoantibodies against interferon omega; its use in the diagnosis of autoimmune polyendocrine syndrome type I
    Bergithe E Oftedal
    Section of Endocrinology, Institute of Medicine, University of Bergen, Bergen, Norway
    Clin Immunol 129:163-9. 2008
  5. ncbi The substrate-binding domain of 21-hydroxylase, the main autoantigen in autoimmune Addison's disease, is an immunodominant T cell epitope
    Eystein S Husebye
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Endocrinology 147:2411-6. 2006
  6. ncbi Epitope mapping of human aromatic L-amino acid decarboxylase
    Eirik Bratland
    Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
    Biochem Biophys Res Commun 353:692-8. 2007

Detail Information

Publications6

  1. ncbi The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: the major autoantigen in autoimmune Addison's disease
    Eirik Bratland
    Department of Medicine, Section for Endocrinology, Institute of Medicine, Haukeland University Hospital, Bergen, Norway
    J Autoimmun 33:58-67. 2009
    ..We conclude that the recombinant preparation of 21OH presented here is of sufficient purity and quality to be used for studies of cellular and humoral immunity in autoimmune Addison's disease...
  2. ncbi T cell responses to steroid cytochrome P450 21-hydroxylase in patients with autoimmune primary adrenal insufficiency
    Eirik Bratland
    Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
    J Clin Endocrinol Metab 94:5117-24. 2009
    ..Autoantibodies against the steroidogenic cytochrome P450 enzyme 21-hydroxylase (21OH) are found in most patients, and 21OH is therefore a likely target for antigen-specific T cells...
  3. ncbi Cellular immunity and immunopathology in autoimmune Addison's disease
    Eirik Bratland
    Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
    Mol Cell Endocrinol 336:180-90. 2011
    ..The aim of the present review is to summarize the current knowledge on the role of T cells and cellular immunity in the pathogenesis of autoimmune Addison's disease...
  4. ncbi Radioimmunoassay for autoantibodies against interferon omega; its use in the diagnosis of autoimmune polyendocrine syndrome type I
    Bergithe E Oftedal
    Section of Endocrinology, Institute of Medicine, University of Bergen, Bergen, Norway
    Clin Immunol 129:163-9. 2008
    ..It provides an alternative, sensitive and specific diagnostic test for APS I, and an ideal screening tool to precede mutational analyses of the AIRE gene in suspected APS I cases...
  5. ncbi The substrate-binding domain of 21-hydroxylase, the main autoantigen in autoimmune Addison's disease, is an immunodominant T cell epitope
    Eystein S Husebye
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Endocrinology 147:2411-6. 2006
    ..21OH (342-361) corresponds to the substrate binding site of the enzyme. The p342-361 region may be involved in the pathogenesis of autoimmune adrenal failure in humans...
  6. ncbi Epitope mapping of human aromatic L-amino acid decarboxylase
    Eirik Bratland
    Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
    Biochem Biophys Res Commun 353:692-8. 2007
    ..Replacement of amino acids 227-230 (ERDK) with alanine residues reduced the reactivity towards AADC by >80% in all patient sera tested, suggesting that amino acids 227-230 are an important part of an immunodominant epitope...