Research Topics
Genomes and Genes | Kristian LøvåsSummaryAffiliation: Haukeland University Hospital Country: Norway Publications
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Publications
Replacement therapy for Addison's disease: recent developmentsKristian Løvås
University of Bergen, Institute of Medicine, Section of Endocrinology, 5021 Bergen, Norway
Expert Opin Investig Drugs 17:497-509. 2008..Despite such treatment these patients self-report impaired health-related quality of life (HRQoL) and recent research has indicated increased mortality...- Immunology of Addison's disease and premature ovarian failureEystein S Husebye
Section of Endocrinology, Institute of Medicine, University of Bergen, Bergen, Norway
Endocrinol Metab Clin North Am 38:389-405, ix. 2009..Little is known about its immunogenetics, but in contrast to Addison's disease, several experimental models of autoimmune premature ovarian insufficiency are available for study... - [Salivary cortisol in adrenal diseases]Kristian Løvås
Institutt for indremedisin, Universitetet i Bergen
Tidsskr Nor Laegeforen 127:730-2. 2007..Salivary cortisol reflects the free and biologically active fraction of cortisol in serum. We evaluated the usefulness of salivary cortisol measurements in the assessment of Cushing's syndrome and adrenal insufficiency... - Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationK Løvås
Institute of Medicine, University of Bergen, Bergen, Norway
Diabetes Obes Metab 11:304-14. 2009..We conducted an exploratory study of safety and effects of this novel drug in patients with type 2 diabetes mellitus and investigated the mechanism of action in human cell lines... - Development of a disease-specific quality of life questionnaire in Addison's diseaseKristian Løvås
Institute of Medicine, Haukeland University Hospital, 5021 Bergen, Norway
J Clin Endocrinol Metab 95:545-51. 2010..Conclusions: We envisage AddiQoL having utility in trials of hormone replacement and management of patients with Addison's disease, analogous to similar questionnaires in GH deficiency (AGHDA) and acromegaly (AcroQoL)... - [Fooled by the diurnal rhythm]Kristian Løvås
Medisinsk avdeling, Haukeland Universitetssykehus, Bergen
Tidsskr Nor Laegeforen 123:1858-9. 2003..It is important to understand the variation in cortisol secretion when analysing results of cortisol tests... - [Primary adrenal failure--causes, diagnostics and therapy]Kristian Løvås
Institutt for indremedisin, Universitetet i Bergen, Medisinsk avdeling Haukeland Universitetssykehus
Tidsskr Nor Laegeforen 125:155-8. 2005..2 mg in one dose per day. Treatment with 20 - 50 mg dehydroepiandrosterone has been studied in adrenal failure, but the evidence for positive effects is weak, and it can not be recommended as standard treatment in primary adrenal failure... - Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registryMartina M Erichsen
Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
J Clin Endocrinol Metab 94:4882-90. 2009..We aimed to determine the clinical, immunological, and genetic features of a national registry-based cohort... - Normal overall mortality rate in Addison's disease, but young patients are at risk of premature deathMartina M Erichsen
Section for Endocrinology, Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
Eur J Endocrinol 160:233-7. 2009..Primary adrenal insufficiency (Addison's disease) is a rare autoimmune disease. Until recently, life expectancy in Addison's disease patients was considered normal... - Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: effects on boneKristian Løvås
Institute of Medicine, University of Bergen, 5020 Bergen, Norway Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway
Eur J Endocrinol 160:993-1002. 2009..Context Patients with primary adrenal insufficiency (Addison's disease) receive more glucococorticoids than the normal endogenous production, raising concern about adverse effects on bone... - Continuous subcutaneous hydrocortisone infusion in Addison's diseaseKristian Løvås
Division of Endocrinology, Institute of Medicine, University of Bergen, Norway
Eur J Endocrinol 157:109-12. 2007..We explored the feasibility and safety of continuous s.c. hydrocortisone infusion (CSHI) as a novel mode of glucocorticoid replacement therapy... - Sexuality and fertility in women with Addison's diseaseMartina M Erichsen
Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
J Clin Endocrinol Metab 95:4354-60. 2010..Females with primary adrenal insufficiency (Addison's disease) have reduced levels of circulating androgens, which are allegedly important for sexual functioning... - Sleep disturbances in patients with Addison's diseaseKristian Løvås
Institute of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
Eur J Endocrinol 148:449-56. 2003..The aim of the study was to describe the prevalence and characteristics of sleep disturbances in patients with Addison's disease... - Replacement of dehydroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trialKristian Løvås
Haukeland University Hospital, N 5021 Bergen, Norway
J Clin Endocrinol Metab 88:1112-8. 2003..Premenopausal androgen levels can be restored with 25 mg DHEA daily in most female patients, but side-effects are frequent... - Pathogenesis of primary adrenal insufficiencyEystein Husebye
Department of Medicine, Haukeland University Hospital, Section of Endocrinology, Institute of Medicine, University of Bergen, Bergen, Norway
Best Pract Res Clin Endocrinol Metab 23:147-57. 2009.... - Grapefruit juice and licorice increase cortisol availability in patients with Addison's diseasePaal Methlie
Institute of Medicine, University of Bergen, 5021 Bergen, Norway
Eur J Endocrinol 165:761-9. 2011..Some patients report benefit from the use of various nutritional compounds. The objective of this study was to investigate the impact of licorice and grapefruit juice (GFJ) on the absorption and metabolism of cortisone acetate (CA)... - Subjective health status in Norwegian patients with Addison's diseaseKristian Løvås
Division of Endocrinology, Institute of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
Clin Endocrinol (Oxf) 56:581-8. 2002..The subjective health status in Addison's disease was compared with normative data from the general population... - High prevalence and increasing incidence of Addison's disease in western NorwayKristian Løvås
Division of Endocrinology, Institute of Medicine, Haukeland University Hospital, Bergen, Norway
Clin Endocrinol (Oxf) 56:787-91. 2002..We have carried out an epidemiological study to obtain a confident point prevalence estimate in the Norwegian population for the end of 1999, and to find out whether the incidence is changing... - Quality of life in European patients with Addison's disease: validity of the disease-specific questionnaire AddiQoLMarianne Øksnes
Institute of Medicine, Haukeland University Hospital, Jonas Liesvei 65, N 5021 Bergen, Norway
J Clin Endocrinol Metab 97:568-76. 2012..Patients with Addison's disease (AD) self-report impairment in specific dimensions on well-being questionnaires. An AD-specific quality-of-life questionnaire (AddiQoL) was developed to aid evaluation of patients... - Genome-wide copy number variation (CNV) in patients with autoimmune Addison's diseaseIngeborg Brønstad
Institute of Medicine, University of Bergen, 5021 Bergen, Norway
BMC Med Genet 12:111. 2011..The aim of the present study was to investigate if gene dosage in the form of copy number variation (CNV) could add to the repertoire of genetic susceptibility to autoimmune AD... - Retarded bone growth in thyroid hormone resistance. A clinical study of a large family with a novel thyroid hormone receptor mutationPer H Kvistad
University of Bergen, Institute for Clinical Medicine and Molecular Medicine, Central Hospital, Children s Department, N 6807 Forde, Norway
Eur J Endocrinol 150:425-30. 2004..Symptoms, clinical findings and laboratory tests of 29 affected individuals were compared with those of 16 first-degree relatives...