Research Topics
| A J NokSummaryAffiliation: University of Ibadan Country: Nigeria Publications
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Detail Information
Publications
A novel nonhemorragic protease from the African puff adder (Bitis arietans) venomA J Nok
Department of Biochemsitry, Ahmadu Bello University, Zaria, Nigeria
J Biochem Mol Toxicol 15:215-20. 2001..It had a prolyl endopeptidase and thermolysin-like activity. The enzyme displayed a fast acting alpha-fibrinolytic and delayed gamma-fibrinolytic activity when tested on human fibrinogen. The relevance of these findings is discussed...- Columbin inhibits cholesterol uptake in bloodstream forms of Trypanosoma brucei-A possible trypanocidal mechanismA J Nok
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
J Enzyme Inhib Med Chem 20:365-8. 2005..brucei-infected mice revealed that 25 mg/kg administered for 3 consecutive days, completely cleared the parasites from the peripheral circulation. However, columbin could not clear parasites in the cerebrospinal fluid... - Characterization of a sialidase (neuraminidase) isolated from Clostridium chauvoei (Jakari strain)N M Useh
Department of Veterinary Pathology and Microbiology, Ahmadu Bello University, Zaria, Nigeria
Cell Biochem Funct 24:347-52. 2006..The sialidase inhibitors, 2,3 didehydroneuraminic acid (Neu5Ac2,3en) and paranitrophenyl oxamic acid (pNPO) inhibited the enzyme competitively with Ki values of 40 and 30 microM respectively... - N-acetyl alpha-D-glucosaminidase from the venom of African puff adder (Bitis arietans)A J Nok
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
J Biochem Mol Toxicol 15:221-7. 2001..6 mM. Delineation of the active site by chemical modification revealed the involvement of His and Trp in the catalysis of the enzyme... - Relationship between outbreaks of blackleg in cattle and annual rainfall in Zaria, NigeriaN M Useh
Department of Pathology and Microbiology, Ahmadu Bello University, Zaria, Nigeria
Vet Rec 158:100-1. 2006 - Purification and biochemical characterization of lysosomal acid phosphatases (EC 3.1.3.2) from blood stream forms, Trypanosoma brucei bruceiE Amlabu
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
Parasitol Int 58:238-42. 2009..Thus, differentiating it from ACP I and ACP II. The implication of these findings in relation to the pathology of trypanosomosis is discussed... - Characterization of sialidase from bloodstream forms of Trypanosoma vivaxL B Buratai
Department of Biochemistry, University of Maiduguri, Nigeria
Cell Biochem Funct 24:71-7. 2006..When ghost RBCs were used as substrates, the enzyme desialylated the RBCs from camel, goat, and zebu bull. The RBCs from dog, mouse and ndama bull were resistant to hydrolysis... - Haemagglutination inhibition antibodies, rectal temperature and total protein of chickens infected with a local Nigerian isolate of velogenic Newcastle disease virusS B Oladele
Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Vet Res Commun 29:171-9. 2005..712, p<0.001). It was concluded that NDV Kudu 113 induced increases in values of HI and RT, which occurred concurrently with a decrease in TP concentrations of infected chickens... - The inhibition of Clostridium chauvoei (jakari strain) neuraminidase activity by methanolic extracts of the stem barks of Tamarindus indicus and Combretum fragransN M Useh
Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
J Enzyme Inhib Med Chem 19:339-42. 2004..The KM remained unchanged at 0.42 mM. The computed Index of physiological efficiency was reduced from 1.19min(-1) to 0.57min(-1) and 0.75min(-1) with Tamarindus indicus and Combretum fragrans as inhibitors respectively... - Inhibition of Naja nigricolis venom acidic phospholipase A2 catalysed hydrolysis of ghost red blood cells by columbinA J Nok
J Enzyme Inhib Med Chem 17:55-9. 2002..Columbin also inhibited PLA2 hydrolysis of ghost RBC in a dose-dependent fashion. At least 70% suppression of PLA2-catalysed haemolysis of RBC was observed in the presence of 2 microM columbin... - Purification and activity of two phospholipase enzymes from Naja nigricolis nigricolis Reinhardt venomM S Abubakar
Department of Pharmacognosy and Drug Development, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria
J Biochem Mol Toxicol 17:53-8. 2003..It is apparent that the dimeric enzyme has a more pronounced activity than the monomer has, thus toxic activity may be related to the hydrolysis of phospholipids... - Comparative studies on erythrocyte sialic acid levels in apparently healthy indigenous Nigerian poultry speciesN M Useh
Department of Veterinary Pathology and Microbiology, Ahmadu Bello University, Zaria, Nigeria
Cell Biochem Funct 24:143-6. 2006..It is suggested, based on this study, that erythrocyte sialic acid types in these species should be determined, as the results may be vital in selective breeding... - Pathogenesis and pathology of blackleg in ruminants: the role of toxins and neuraminidase. A short reviewN M Useh
Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Vet Q 25:155-9. 2003..It is suggested that in vivo clinical trials should be carried out to determine the mechanism of action and clinical efficacy of neuraminidase inhibitors... - Mechanism of adsorption of mucin to titanium in vitroJ A Lori
Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
Biomed Mater Eng 14:557-63. 2004..No increase in adsorption was recorded following pretreatment of Ti with potassium. The results indicate the involvement of electrostatic interactions in the absorption of mucin to Ti... - Transferrin coupled azanthraquinone enhances the killing effect on trypanosomes. The role of lysosomal mannosidaseA J Nok
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
Parasite 9:375-9. 2002..congolense and T. b. brucei respectively. The results are discussed as regards the potency of using transferrin as suitable drug carrier in the chemotherapy of Human sleeping sickness... - Aetiology and prevalence of canine anaemia in Zaria: a review of 2139 cases observed at the Veterinary Teaching Hospital of the Ahmadu Bello University, Zaria, Nigeria (1990-2003)N M Useh
Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Vet Q 25:150-4. 2003..A few dogs (n = 55, 2.6%) had anaemia due to poor nutrition, while 68 (3.2%) had anaemia with unknown cause. The public health significance of the parasites reported in this study is discussed... - Phospholipase A2 from Trypanosoma brucei gambiense and Trypanosoma brucei brucei: inhibition by organotinsM N Shuaibu
Protozoology Department, Institute of Tropical Medicine, Nagasaki University, Japan
J Enzyme Inhib 16:433-41. 2001..64 and 32.91 microM for the substrates 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine (PBGPC) and 2-(12-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl-1-hexadecanoyl-sn-glycero-3-phosphocholine (NBDC12-HPC), respectively... - In vitro trypanocidal activity of dibutyltin dichloride and its fatty acid derivativesM N Shuaibu
Protozoology Department, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi 852-8523, Japan
Parasitol Res 91:5-11. 2003..15-0.75 microM for T. b. brucei, T. b. gambiense and T. b. rhodesiense. These observations suggest that organotin has chemotherapeutic potential...