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Genomes and GenesSpecies | Mei ZhangSummaryCountry: New Zealand Publications
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Publications
Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milkMei Zhang
Department of Clinical Pharmacology, Christchurch Hospital, New Zealand
J Chromatogr B Analyt Technol Biomed Life Sci 766:175-9. 2002..Standard curves were linear over the concentration range 20.0-4000 microg/l. Intra- and inter-day coefficients of variation were <9.0% and the limit of quantification was around 20 microg/l...- Determination of dexamethasone and dexamethasone sodium phosphate in human plasma and cochlear perilymph by liquid chromatography/tandem mass spectrometryMei Zhang
Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand
J Chromatogr B Analyt Technol Biomed Life Sci 879:17-24. 2011..5 ?g/L for both Dex and Dex SP. The assay has been used successfully in a clinical pharmacokinetics study of Dex and Dex SP in cochlear perilymph and plasma... - Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometryMei Zhang
Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand
J Chromatogr B Analyt Technol Biomed Life Sci 877:3025-30. 2009..1%, and the limit of quantification was 10microg/L for both perhexiline and hydroxyperhexiline. The assay is being used successfully in clinical practice to enhance the safe and effective use of perhexiline... - Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assayMei Zhang
Clinical Pharmacology, Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
J Chromatogr B Analyt Technol Biomed Life Sci 830:245-8. 2006..99). Bias was </=+/-15% from 20 to 2000 microg/L in both matrices, intra- and inter-day coefficients of variation (imprecision) were <10%, and the limit of quantification was 10 microg/L... - Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assayMei Zhang
Department of Clinical Pharmacology, Christchurch School of Medicine and Health Sciences, University of Otago, P O Box 4345, Christchurch, New Zealand
J Chromatogr B Analyt Technol Biomed Life Sci 807:217-21. 2004..Standard curves were linear over the concentration range 10-2000 microg/L (r2 >0.99). Intra- and inter-day coefficients of variation for both matrices were <10% and the limit of quantification was around 10 microg/L... - Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexateLisa K Stamp
Department of Medicine, University of Otago, Christchurch, New Zealand
Pharmacogenet Genomics 20:367-76. 2010..To determine whether genetic polymorphisms within the folate pathway are associated with red blood cell (RBC) methotrexate (MTX) polyglutamate concentrations, RBC folate concentrations and MTX efficacy/toxicity... - Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapyLisa K Stamp
University of Otago, Christchurch, New Zealand
Arthritis Rheum 62:359-68. 2010.... - Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritisJudith M Dalrymple
University of Otago, Christchurch, New Zealand
Arthritis Rheum 58:3299-308. 2008.... - Effects of changing from oral to subcutaneous methotrexate on red blood cell methotrexate polyglutamate concentrations and disease activity in patients with rheumatoid arthritisLisa K Stamp
Department of Medicine, University of Otago, Christchurch, New Zealand
J Rheumatol 38:2540-7. 2011..To determine the effects of changing from oral to subcutaneous (SC) methotrexate (MTX) in patients with rheumatoid arthritis (RA) on red blood cell MTX polyglutamate (RBC MTXGlu(n)) concentrations, disease activity, and adverse effects... - Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-foldSharon J Gardiner
Department of Medicine, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
Clin Gastroenterol Hepatol 6:654-60; quiz 604. 2008..The purpose of this study was to determine thiopurine dose requirements in intermediate versus normal TPMT metabolism status... - Quantification of infant exposure to celecoxib through breast milkSharon J Gardiner
Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
Br J Clin Pharmacol 61:101-4. 2006..To determine the milk-to-plasma (M/P) concentration ratio of celecoxib, and estimate likely infant exposure... - Transfer of rofecoxib into human milkSharon J Gardiner
Department of Clinical Pharmacology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
Eur J Clin Pharmacol 61:405-8. 2005..To determine the milk-to-plasma (M/P) concentration ratio of rofecoxib in lactating mothers and estimate likely infant exposure... - Transfer of metformin into human milkSharon J Gardiner
Department of Clinical Pharmacology and Diabetes Centre, Christchurch Hospital, Christchurch, New Zealand
Clin Pharmacol Ther 73:71-7. 2003..Our objectives were to determine the milk-to-plasma ratio of metformin in lactating mothers and to estimate infant exposure... - Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including those with renal impairmentLisa K Stamp
University of Otago, Christchurch, New Zealand
Arthritis Rheum 63:412-21. 2011..To determine the efficacy and safety of increasing the allopurinol dose above the proposed creatinine clearance-based dose in patients with gout... - Protein binding of cefazolin is saturable in vivo both between and within patientsJane W A Vella Brincat
Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
Br J Clin Pharmacol 63:753-7. 2007.... - Metformin increases plasma ghrelin in Type 2 diabetesMatthew P Doogue
Department of Clinical Pharmacology, Canterbury District Health Board, Christchurch, New Zealand
Br J Clin Pharmacol 68:875-82. 2009..Reports are conflicting about how metformin affects ghrelin concentrations, and this study was aimed at resolving this issue in patients with Type 2 diabetes... - Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymphPhilip A Bird
Department of Otolaryngology Head and Neck Surgery, Christchurch Hospital, Christchurch, New Zealand
Otol Neurotol 32:933-6. 2011..To measure dexamethasone concentrations in the plasma and perilymph of the human ear after intravenous (IV) and intratympanic (IT) administration and to compare these with previous studies with methylprednisolone... - Stability of benzylpenicillin during continuous home intravenous therapyJane W A Vella-Brincat
Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
J Antimicrob Chemother 53:675-7. 2004..9% at constant and variable temperatures... - Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymphPhilip A Bird
Department of Otolaryngology, Head and Neck Surgery, Christchurch Hospital, New Zealand
Otol Neurotol 28:1124-30. 2007..To compare methylprednisolone concentrations in the perilymph of the human ear and in plasma after intratympanic (IT) or intravenous (IV) administration... - Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairsSharon J Gardiner
Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
Br J Clin Pharmacol 62:453-6. 2006..To determine infant exposure to 6-thioguanine and 6-methylmercaptopurine nucleotides (6-TGN and 6-MMPN, respectively) during maternal use of azathioprine in breastfeeding... - Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatmentLisa K Stamp
Department of Mediicne, University of Otago, Christchurch, New Zealand
Arthritis Rheum 60:2248-56. 2009..This study was undertaken to determine nongenetic factors that influence red blood cell (RBC) MTXGlun concentrations in patients receiving long-term stable low-dose oral MTX... - Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer statusMurray L Barclay
Department of Clinical Pharmacology, Christchurch Hospital and Department of Pathology, Christchurch, New Zealand
Pharmacogenetics 13:627-32. 2003..Determination of CYP2D6 genotype before therapy with perhexiline may help predict perhexiline dose requirements and reduce the risk of perhexiline concentration-related toxicity... - Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel diseaseAlenka J Brooks
Department of Clinical Pharmacology, Christchurch Hospital, University of Otago, Christchurch, New Zealand
Ther Drug Monit 29:619-25. 2007..RBC MTXGlu4&5 concentrations were higher in patients experiencing adverse effects. These findings suggest that RBC MTXGlu1-5 concentration monitoring may be of value in IBD and could assist with planning of larger studies... - Free and total cefazolin plasma and interstitial fluid concentrations at steady state during continuous infusionGrant W Howard
Department of Clinical Pharmacology, Christchurch Hospital, PO Box 4710, Christchurch, New Zealand
J Antimicrob Chemother 50:429-32. 2002..82, P = 0.005 versus r(2) = 0.54, P = 0.056). In all patients, the free concentrations in the interstitial fluid were at least two-fold the MIC(90) for Staphylococcus aureus... - Stereoselective urinary excretion of formoterol and its glucuronide conjugate in humanMei Zhang
Department of Clinical Pharmacology, Christchurch School of Medicine, School of Pharmacy, University of Otago, PO Box 913, Dunedin, New Zealand
Br J Clin Pharmacol 54:246-50. 2002..The different pattern of metabolism in the female subject provides impetus for further studies of the effect of gender on the stereoselective metabolism and pharmacokinetics of formoterol... - 6-thioguanine nucleotides and thiopurine methyltransferase activity: important factors determining response to treatment and incidence of adverse effects from azathioprine and 6-MPRichard Gearry
N Z Med J 116:U531. 2003 - Comment: Breast-feeding during maternal use of azathioprineSharon J Gardiner
Ann Pharmacother 41:719-20; author reply 720. 2007 - Cardiolipin is not required to maintain mitochondrial DNA stability or cell viability for Saccharomyces cerevisiae grown at elevated temperaturesMei Zhang
Department of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 278:35204-10. 2003..These results suggest that all phenotypes reported for cells carrying the his3 Delta 200 allele and lacking CL should be re-evaluated... - Two new coumarins from Herpetospermum caudigerumMei Zhang
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, PR China
Chem Pharm Bull (Tokyo) 56:192-3. 2008..The structures of the new coumarins were elucidated on the basis of chemical and physicochemical evidences. Herpetone exhibited protective effects on CCl(4)-induced hepatocyte injury... - Effect of resveratrol on microcirculation disorder and lung injury following severe acute pancreatitis in ratsYong Meng
Department of Hepatobiliary Surgery, First Hospital, Xi an Jiaotong University, Xi an 710061, Shaanxi Province, China
World J Gastroenterol 11:433-5. 2005..To investigate the mechanism of resveratrol underlying the microcirculation disorder and lung injury following severe acute pancreatitis (SAP)... - Changes in integrin expression during adipocyte differentiationJun Liu
Department of Internal Medicine, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Cell Metab 2:165-77. 2005..These findings demonstrate a role for integrin alpha6 in connecting morphogenesis with signaling processes leading to terminal differentiation... - [Effects of lactone I from Atractylodes macrocephala Koidz on cytokines and proteolysis-inducing factors in cachectic cancer patients]Yi Liu
Department of Traditional Chinese Medicine, First affiliated Hospital of Xian Jiaotong University, Xi an 710061, China
Di Yi Jun Yi Da Xue Xue Bao 25:1308-11. 2005..To observe the effect of lactone I from Atractylodes macrocephala Koidz (LAMK I) on the cytokines and proteolysis-inducing factors (PIF) in cachectic cancer patients... - [A new sesqui-norlignan from Herpetospermum pedunculosum]Mei Zhang
Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
Yao Xue Xue Bao 41:659-61. 2006..To study the chemical components from the bioactive extract of Herpetospermum pedunculosum, a Tibetan medicinal herb for liver diseases... - KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heartDong-Mei Wu
Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Heart Rhythm 3:1469-80. 2006..CONCLUSION: Our data suggest that KCNE2 is in close proximity to KCNQ1 and KCNE1 in cardiomyocytes and may participate in dynamic regulation of I(Ks) current amplitude in the heart... - Probing the interaction between KCNE2 and KCNQ1 in their transmembrane regionsXian Sheng Liu
Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
J Membr Biol 216:117-27. 2007..We propose that the KCNE2 TMD adopts an alpha-helical secondary structure with one face making intimate contact with the KCNQ1 pore domain, while the contacts with the KCNQ1 voltage-sensing domain appear more dynamic... - Synthesis and microstructure of La-doped ceria nanoparticlesLili Liu
Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, PR China
J Nanosci Nanotechnol 7:2883-8. 2007..The formation mechanism of the solid solution has been discussed and the maximum percentage of La2O3 in Ce(l-x)La(x)O(2-delta) (0 < or = x < or = 0.2) solid solution was near to 20 percent... - Oral respiratory syncytial virus (RSV) DNA vaccine expressing RSV F protein delivered by attenuated Salmonella typhimuriumCan Xie
Department of Immunology, Anhui Medical University, Hefei, Anhui 230032, People s Republic of China
Hum Gene Ther 18:746-52. 2007..01) between the two groups. In summary, our results demonstrate the potential of orally administered SL7207-based DNA vaccines against RSV infection... - [Study of diagnostic criteria of intima-media thickening and effects of drugs on peripheral arteries]Mei Zhang
Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China
Zhonghua Yi Xue Za Zhi 84:1252-6. 2004..High frequency ultrasound technique is reliable in monitoring the progression or regression of atherosclerosis in peripheral arteries...