Mark H Vickers

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi Dysregulation of the adipoinsular axis -- a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming
    M H Vickers
    Liggins Institute for Medical Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Endocrinol 170:323-32. 2001
  2. ncbi Developmental programming and adult obesity: the role of leptin
    Mark H Vickers
    Liggins Institute and the National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Curr Opin Endocrinol Diabetes Obes 14:17-22. 2007
  3. ncbi The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy
    Mark H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Endocrinology 149:1906-13. 2008
  4. ncbi Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range
    Bright Starling Emerald
    Growth, Development and Metabolism Programme, Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore
    BMC Genomics 12:509. 2011
  5. ncbi Supplementation with a mixture of complex lipids derived from milk to growing rats results in improvements in parameters related to growth and cognition
    Mark H Vickers
    Liggins Institute and the National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Nutr Res 29:426-35. 2009
  6. ncbi 20-kDa placental hGH-V has diminished diabetogenic and lactogenic activities compared with 22-kDa hGH-N while retaining antilipogenic activity
    M H Vickers
    Liggins Institute and the National Research Centre for Growth and Development, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 297:E629-37. 2009
  7. ncbi Is later obesity programmed in utero?
    Mark H Vickers
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Curr Drug Targets 8:923-34. 2007
  8. ncbi Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age rat
    M H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 291:E1212-9. 2006
  9. ncbi Neonatal leptin treatment reverses developmental programming
    M H Vickers
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
    Endocrinology 146:4211-6. 2005
  10. ncbi Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment
    M H Vickers
    The Liggins Institute for Medical Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Endocrinol 175:615-23. 2002

Collaborators

Detail Information

Publications32

  1. ncbi Dysregulation of the adipoinsular axis -- a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming
    M H Vickers
    Liggins Institute for Medical Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Endocrinol 170:323-32. 2001
    ....
  2. ncbi Developmental programming and adult obesity: the role of leptin
    Mark H Vickers
    Liggins Institute and the National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Curr Opin Endocrinol Diabetes Obes 14:17-22. 2007
    ..Recent work has highlighted the importance of the hormone leptin during critical windows of development in the pathogenesis of programming related disorders...
  3. ncbi The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy
    Mark H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Endocrinology 149:1906-13. 2008
    ..These data further reinforce the importance of leptin in determining long-term energy homeostasis, and suggest that leptin's effects are modulated by gender and both prenatal and postnatal nutritional status...
  4. ncbi Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range
    Bright Starling Emerald
    Growth, Development and Metabolism Programme, Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore
    BMC Genomics 12:509. 2011
    ..abstract:..
  5. ncbi Supplementation with a mixture of complex lipids derived from milk to growing rats results in improvements in parameters related to growth and cognition
    Mark H Vickers
    Liggins Institute and the National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Nutr Res 29:426-35. 2009
    ..Supplementation with a CML containing gangliosides had positive growth and learning behavioral effects in young normal growing rats...
  6. ncbi 20-kDa placental hGH-V has diminished diabetogenic and lactogenic activities compared with 22-kDa hGH-N while retaining antilipogenic activity
    M H Vickers
    Liggins Institute and the National Research Centre for Growth and Development, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 297:E629-37. 2009
    ..In summary, placental 20-kDa hGH-V retains some of the growth-promoting and all antilipogenic activities of pituitary 22-kDa hGH-N but has diminished diabetogenic and lactogenic properties compared with the native 22-kDa hGH-N...
  7. ncbi Is later obesity programmed in utero?
    Mark H Vickers
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Curr Drug Targets 8:923-34. 2007
    ..This review summarises recent work in animal models and observations in the clinical and epidemiological settings on the in-utero origins of obesity and related metabolic disorders...
  8. ncbi Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age rat
    M H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 291:E1212-9. 2006
    ....
  9. ncbi Neonatal leptin treatment reverses developmental programming
    M H Vickers
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
    Endocrinology 146:4211-6. 2005
    ..The complete normalization of the programmed phenotype by neonatal leptin treatment implies that leptin has effects that reverse the prenatal adaptations resulting from relative fetal undernutrition...
  10. ncbi Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment
    M H Vickers
    The Liggins Institute for Medical Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Endocrinol 175:615-23. 2002
    ..Our data demonstrated that GH treatment reduces hypertension and improves cardiovascular function in animals exposed to adverse environmental conditions during fetal or postnatal life...
  11. ncbi Maternal supplementation with a complex milk lipid mixture during pregnancy and lactation alters neonatal brain lipid composition but lacks effect on cognitive function in rats
    Malin Gustavsson
    Liggins Institute and the National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Nutr Res 30:279-89. 2010
    ....
  12. ncbi Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes
    Nichola M Thompson
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Endocrinology 148:2345-54. 2007
    ..The origin of insulin hypersecretion in IUGR offspring may be independent of the mechanistic events that trigger the insulin resistance commonly observed in DIO...
  13. ncbi Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour
    Greg C Smith
    Department of Molecular Medicine and Pathology and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
    Schizophr Res 115:30-40. 2009
    ..This study compares clozapine and quetiapine and investigates the effects of these on the development of obesity and the direct effects of these drugs on glucose metabolism compared with those caused by the obesity per se...
  14. ncbi Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression
    Bettina A Ikenasio-Thorpe
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    J Endocrinol 193:31-7. 2007
    ..Increased susceptibility to diet-induced obesity develops if a mismatch between the anticipated and the actual conditions are encountered...
  15. ncbi Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet
    Christopher Torrens
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland, New Zealand
    Br J Nutr 101:27-33. 2009
    ....
  16. ncbi Global undernutrition during gestation influences learning during adult life
    Jason Landon
    University ofAuckland, Auckland, New Zealand
    Learn Behav 35:79-86. 2007
    ..These results provide direct experimental evidence for a link between prenatal environmental conditions and reduced behavioral adaptability--learning--in later life...
  17. ncbi IGF-I treatment reduces hyperphagia, obesity, and hypertension in metabolic disorders induced by fetal programming
    M H Vickers
    Liggins Institute for Medical Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand 92019
    Endocrinology 142:3964-73. 2001
    ..Our data suggest that IGF-I treatment alleviates hyperphagia, obesity, hyperinsulinemia, hyperleptinemia, and hypertension in rats programmed to develop the metabolic syndrome X...
  18. ncbi NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat
    Jian Guan
    Liggins Institute, The University of Auckland, Auckland, New Zealand
    Behav Brain Res 210:221-8. 2010
    ..The data suggest that NNZ-2591 prevents scopolamine-induced acute impairment in memory and modulation of acetylcholine neurotransmission may be the mode of action underlying the memory improvement...
  19. ncbi The atypical anti-psychotic clozapine decreases bone mass in rats in vivo
    Jessica L Costa
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Schizophr Res 126:291-7. 2011
    ..The mechanisms by which skeletal fragility is increased in patients with psychosis include increased risk of falling, but direct skeletal toxicity of anti-psychotic drugs is a possibility that has not been investigated...
  20. ncbi Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
    Peter D Gluckman
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Proc Natl Acad Sci U S A 104:12796-800. 2007
    ....
  21. ncbi Pre- and postnatal methyl deficiency in the rat differentially alters glucose homeostasis
    Greg C Smith
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Nutrigenet Nutrigenomics 4:175-91. 2011
    ..We ascertained whether dietary methyl-donor deficiency in the mother during pregnancy or during postweaning growth in the rat would impair glucose homeostasis, insulin secretion and pancreatic endocrine development in young adults...
  22. ncbi Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation
    Kevin J Dudley
    Liggins Institute and the National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    PLoS ONE 6:e21662. 2011
    ..It is likely that these offspring are predisposed to long-term hepatic dysfunction...
  23. ncbi Pre- and postnatal nutritional histories influence reproductive maturation and ovarian function in the rat
    Deborah M Sloboda
    The Liggins Institute and the National Research Centre for Growth and Development, The University of Auckland, Auckland, New Zealand
    PLoS ONE 4:e6744. 2009
    ..In the present study we employed an established model of nutritional programming to evaluate the relative influences of prenatal and postnatal nutrition on growth and ovarian function in female offspring...
  24. ncbi Maternal fructose intake during pregnancy and lactation alters placental growth and leads to sex-specific changes in fetal and neonatal endocrine function
    M H Vickers
    Liggins Institute, University of Auckland, Auckland 1142, New Zealand
    Endocrinology 152:1378-87. 2011
    ..Independent follow-up studies are essential to investigate the long-term consequences of maternal FR consumption on offspring health...
  25. ncbi The effects of bovine recombinant growth hormone administration on insulin-like growth factor-I and the haemopoietic system in thoroughbred geldings
    Z J Champion
    Research Centre in Reproductive Medicine, Faculty of Medicine and Health Science, The University of Auckland, Auckland, New Zealand
    Vet J 160:147-52. 2000
    ..Red blood cell count was not affected by any of the rbGH doses. These results indicated that rbGH is biologically active in the horse and that rbGH at a dose rate of 10 microg/kg or more could be used therapeutically...
  26. ncbi Effects of maternal captopril treatment on growth, blood glucose and plasma insulin in the fetal spontaneously hypertensive rat
    R M Lewis
    Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand
    Reprod Fertil Dev 11:403-8. 1999
    ..The differences in the effect of captopril on the two strains suggest that there are underlying endocrine differences in the SHR...
  27. ncbi Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring
    Angelica B Bernal
    The Liggins Institute, The University of Auckland and the National Research Centre for Growth and Development, Auckland, New Zealand
    PLoS ONE 5:e15558. 2010
    ....
  28. ncbi Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet
    G J Howie
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Grafton, Auckland, New Zealand
    J Physiol 587:905-15. 2009
    ....
  29. ncbi Impaired sperm characteristics in postpubertal growth-hormone-deficient dwarf (dw/dw) rats
    C G Gravance
    Department of Obstetrics and Gynaecology, University of Auckland, New Zealand
    Anim Reprod Sci 49:71-6. 1997
    ..The GH-deficient rat appears to be a suitable model for the study of the effects of GH on sperm characteristics...
  30. ncbi Fetal programming of appetite and obesity
    B H Breier
    Liggins Institute for Medical Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mol Cell Endocrinol 185:73-9. 2001
    ....
  31. ncbi Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition
    M H Vickers
    FRS, Liggins Institute, Faculty of Medical and Health Sciences, Univ. of Auckland, Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 285:R271-3. 2003
    ....
  32. ncbi Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro
    Zahra J Champion
    Research Centre in Reproductive Medicine, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    Theriogenology 57:1793-800. 2002
    ..This study has shown that GH and IGF-I are effective in promoting the in vitro longevity of spermatozoa...