M H Tawhai

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape
    Merryn H Tawhai
    Auckland Bioengineering Institute, The University of Auckland, Auckland 1142, New Zealand
    J Appl Physiol 107:912-20. 2009
  2. ncbi Generation of an anatomically based three-dimensional model of the conducting airways
    M Howatson Tawhai
    Department of Engineering Science, School of Engineering, The University of Auckland, New Zealand
    Ann Biomed Eng 28:793-802. 2000
  3. ncbi Image-based modeling of lung structure and function
    Merryn H Tawhai
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
    J Magn Reson Imaging 32:1421-31. 2010
  4. ncbi The lung physiome: merging imaging-based measures with predictive computational models
    Merryn H Tawhai
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Wiley Interdiscip Rev Syst Biol Med 1:61-72. 2009
  5. ncbi Modelling pulmonary blood flow
    Merryn H Tawhai
    Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand
    Respir Physiol Neurobiol 163:150-7. 2008
  6. ncbi Multi-scale models of the lung airways and vascular system
    Merryn H Tawhai
    University of Auckland, Bioengineering Institute
    Adv Exp Med Biol 605:190-4. 2008
  7. ncbi Computational models of structure-function relationships in the pulmonary circulation and their validation
    Merryn H Tawhai
    Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Exp Physiol 91:285-93. 2006
  8. ncbi An imaging-based computational approach to model ventilation distribution and soft-tissue deformation in the ovine lung
    Merryn H Tawhai
    Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Acad Radiol 13:113-20. 2006
  9. ncbi Developing integrative computational models of pulmonary structure
    Merryn H Tawhai
    Bioengineering Institute, The University of Auckland, New Zealand
    Anat Rec B New Anat 275:207-18. 2003
  10. ncbi Modeling water vapor and heat transfer in the normal and the intubated airways
    Merryn H Tawhai
    Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Ann Biomed Eng 32:609-22. 2004

Research Grants

  1. Airway Hyper-responsiveness: from molecule to organ
    Merryn Tawhai; Fiscal Year: 2007

Detail Information

Publications32

  1. ncbi Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape
    Merryn H Tawhai
    Auckland Bioengineering Institute, The University of Auckland, Auckland 1142, New Zealand
    J Appl Physiol 107:912-20. 2009
    ..A smaller prone gradient was predicted without shape change of the "container" or support of the heart by the lung. The influence of the heart was to constrain the shape in which the lung deformed...
  2. ncbi Generation of an anatomically based three-dimensional model of the conducting airways
    M Howatson Tawhai
    Department of Engineering Science, School of Engineering, The University of Auckland, New Zealand
    Ann Biomed Eng 28:793-802. 2000
    ..The resulting model is a computational mesh that can be used for simulating transport phenomena...
  3. ncbi Image-based modeling of lung structure and function
    Merryn H Tawhai
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
    J Magn Reson Imaging 32:1421-31. 2010
    ....
  4. ncbi The lung physiome: merging imaging-based measures with predictive computational models
    Merryn H Tawhai
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Wiley Interdiscip Rev Syst Biol Med 1:61-72. 2009
    ..Methods for deriving multiscale models of the airway geometry for individual subjects in the Atlas are outlined, and methods for modeling turbulent flows in the airway are reviewed...
  5. ncbi Modelling pulmonary blood flow
    Merryn H Tawhai
    Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand
    Respir Physiol Neurobiol 163:150-7. 2008
    ..The studies that are reviewed illustrate the different complementary approaches that can be used to address the same physiological question of flow heterogeneity...
  6. ncbi Multi-scale models of the lung airways and vascular system
    Merryn H Tawhai
    University of Auckland, Bioengineering Institute
    Adv Exp Med Biol 605:190-4. 2008
    ..An extension of the multi-scale models is incorporation of respiratory gas exchange, which can also be considered at several scales of interest...
  7. ncbi Computational models of structure-function relationships in the pulmonary circulation and their validation
    Merryn H Tawhai
    Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Exp Physiol 91:285-93. 2006
    ..Validation of such predictions against measures from functional imaging holds significant potential for explaining and differentiating normal and disease-related heterogeneity in regional blood flow calculated using perfusion imaging...
  8. ncbi An imaging-based computational approach to model ventilation distribution and soft-tissue deformation in the ovine lung
    Merryn H Tawhai
    Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Acad Radiol 13:113-20. 2006
    ..The aim of this approach is to enable predictions of the effect of perturbations in geometry or functional parameters on imaged function of the lung...
  9. ncbi Developing integrative computational models of pulmonary structure
    Merryn H Tawhai
    Bioengineering Institute, The University of Auckland, New Zealand
    Anat Rec B New Anat 275:207-18. 2003
    ..The models are designed to be integrative: they relate multiple structural systems within the same individual, and their use as computational meshes allows application of spatially distributed properties...
  10. ncbi Modeling water vapor and heat transfer in the normal and the intubated airways
    Merryn H Tawhai
    Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Ann Biomed Eng 32:609-22. 2004
    ....
  11. ncbi CT-based geometry analysis and finite element models of the human and ovine bronchial tree
    Merryn H Tawhai
    Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Appl Physiol 97:2310-21. 2004
    ..The resulting models are subject-specific computational meshes with anatomically consistent geometry, suitable for application in simulation studies...
  12. ncbi Multibreath washout analysis: modelling the influence of conducting airway asymmetry
    M H Tawhai
    Department of Engineering Science, Bioengineering Research Group, University of Auckland, Floor 6, 70 Symonds Street, Auckland, New Zealand
    Respir Physiol 127:249-58. 2001
    ..Non-uniform flow also alters S(n), indicating that an accurate description of the pleural pressure gradient will be necessary for more accurate simulations...
  13. ncbi Characterising respiratory airway gas mixing using a lumped parameter model of the pulmonary acinus
    M H Tawhai
    Department of Engineering Science, Bioengineering Research Group, University of Auckland, Floor 6, 70 Symonds Street, Auckland, New Zealand
    Respir Physiol 127:241-8. 2001
    ..The current lumped parameter model is most accurate for tidal volumes between 500 and 1500 ml, and equal inspiration and expiration durations of 2 sec. The model's accuracy decreases for changes in breath duration...
  14. ncbi Contribution of serial and parallel microperfusion to spatial variability in pulmonary inter- and intra-acinar blood flow
    A R Clark
    Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    J Appl Physiol 108:1116-26. 2010
    ..This proximal-to-distal pattern of perfusion may act in concert with diffusional screening to optimize the potential for gas exchange...
  15. ncbi The interdependent contributions of gravitational and structural features to perfusion distribution in a multiscale model of the pulmonary circulation
    A R Clark
    Auckland Bioengineering Institute, Univ of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    J Appl Physiol 110:943-55. 2011
    ....
  16. ncbi The impact of micro-embolism size on haemodynamic changes in the pulmonary micro-circulation
    A R Clark
    Auckland Bioengineering Institute, The University of Auckland, New Zealand
    Respir Physiol Neurobiol 175:365-74. 2011
    ..This study focuses on the effect of mechanical obstruction alone; however, we present simple models of vasoconstriction illustrating an increased impact on PVR...
  17. ncbi The effect of intracellular calcium oscillations on fluid secretion in airway epithelium
    N J Warren
    Auckland Bioengineering Institute, Level 6, 70 Symond St, Auckland, New Zealand
    J Theor Biol 265:270-7. 2010
    ..These differences are shown to be due to saturation of the Ca(2+) activated ion channels...
  18. ncbi Anatomically based geometric modelling of the musculo-skeletal system and other organs
    J W Fernandez
    Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Biomech Model Mechanobiol 2:139-55. 2004
    ..Geometries of the lower limb, knee joint, forearm and neck are also presented. Finally, the issues and limitations of the methods are discussed...
  19. ncbi Mathematical modelling of calcium wave propagation in mammalian airway epithelium: evidence for regenerative ATP release
    N J Warren
    Auckland Bioengineering Institute, Level 6, 70 Symonds Street, CBD, Auckland, New Zealand
    Exp Physiol 95:232-49. 2010
    ..This suggests that an additional mechanism is important in Ca2+ wave propagation, such as regenerative release of ATP from cells downstream of the stimulated cell...
  20. ncbi A mathematical model of calcium-induced fluid secretion in airway epithelium
    N J Warren
    Auckland Bioengineering Institute, CBD, Auckland, New Zealand
    J Theor Biol 259:837-49. 2009
    ....
  21. ncbi Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels
    Kelly S Burrowes
    Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Appl Physiol 99:731-8. 2005
    ....
  22. ncbi Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network
    Kelly S Burrowes
    Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Ann Biomed Eng 32:585-95. 2004
    ..This model enables flow properties and cell transit time behavior in the pulmonary microcirculation under varying conditions, for example in different "zones" of the lung, to be explored...
  23. ncbi A simplified model of airway narrowing due to bronchial mucosal folding
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    Respir Physiol Neurobiol 171:144-50. 2010
    ..We show that this model generates predictions in good agreement with existing models while being vastly simpler to solve...
  24. ncbi Investigation of the relative effects of vascular branching structure and gravity on pulmonary arterial blood flow heterogeneity via an image-based computational model
    Kelly S Burrowes
    Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Acad Radiol 12:1464-74. 2005
    ..A computational model of blood flow through the human pulmonary arterial tree has been developed to investigate the relative influence of branching structure and gravity on blood flow distribution in the human lung...
  25. ncbi A continuous-binding cross-linker model for passive airway smooth muscle
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
    Biophys J 99:3164-71. 2010
    ..Furthermore, experiments in noncontractile tissue show qualitatively similar behavior, suggesting support for the protein-filament theory as a biomechanical basis for the behavior...
  26. ncbi Computational predictions of pulmonary blood flow gradients: gravity versus structure
    Kelly S Burrowes
    Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Respir Physiol Neurobiol 154:515-23. 2006
    ..Results in the isolated arterial tree demonstrate that the vascular path lengths and therefore the positioning of the pulmonary trunk relative to the rest of the network play a significant role in the determination of flow...
  27. ncbi Evidence for minimal oxygen heterogeneity in the healthy human pulmonary acinus
    Annalisa J Swan
    Auckland Bioengineering Institute, The Univ of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    J Appl Physiol 110:528-37. 2011
    ..Heterogeneity increases slightly when the acinus is stressed by exercise. However, even during exercise the acinus retains a reasonably homogeneous gas phase...
  28. ncbi The role of airway epithelium in replenishment of evaporated airway surface liquid from the human conducting airways
    N J Warren
    Auckland Bioengineering Institute, University of Auckland, New Zealand
    Ann Biomed Eng 38:3535-49. 2010
    ..SMGs could also provide a significant supply of fluid for airway hydration, a hypothesis which is corroborated by comparing the distribution of SMGs as a function of airway generation with the distribution of airway evaporative flux...
  29. ncbi A multiscale, spatially distributed model of asthmatic airway hyper-responsiveness
    Antonio Z Politi
    Department of Mathematics, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    J Theor Biol 266:614-24. 2010
    ..By incorporating and coupling the models at these scales, we obtain a detailed, computational multiscale model incorporating important physiological phenomena associated with asthma...
  30. ncbi Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways
    Ching Long Lin
    Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, IA 52242, USA
    Respir Physiol Neurobiol 157:295-309. 2007
    ..Thus, airflow modeling, particularly subject specific evaluations, should consider upper as well as intra-thoracic airway geometry...
  31. ncbi Point:Counterpoint: Gravity is/is not the major factor determining the distribution of blood flow in the human lung
    Kelly S Burrowes
    J Appl Physiol 104:1538. 2008
  32. ncbi The comprehensive imaging-based analysis of the lung: a forum for team science
    Eric A Hoffman
    Department of Radiology, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Acad Radiol 11:1370-80. 2004

Research Grants2

  1. Airway Hyper-responsiveness: from molecule to organ
    Merryn Tawhai; Fiscal Year: 2007
    ..With this approach, the key events in AHR can be identified and targeted for therapeutic intervention. ..