M Niimi

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi Differential profiles of soluble proteins during the initiation of morphogenesis in Candida albicans
    M Niimi
    Experimental Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, School of Dentistry, University of Otago, P O Box 647, Dunedin, New Zealand
    Arch Microbiol 166:260-8. 1996
  2. ncbi Temperature-related expression of the vacuolar aspartic proteinase (APR1) gene and beta-N-acetylglucosaminidase (HEX1) gene during Candida albicans morphogenesis
    M Niimi
    Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand
    FEMS Microbiol Lett 148:247-54. 1997
  3. ncbi Candida albicans pathogenicity: a proteomic perspective
    M Niimi
    Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, Dunedin, New Zealand
    Electrophoresis 20:2299-308. 1999
  4. ncbi Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters
    K Nakamura
    Department of Oral Sciences and Orthodontics, University of Otago, Dunedin, New Zealand
    Antimicrob Agents Chemother 45:3366-74. 2001
  5. ncbi Regulation of N-acetylglucosaminidase production in Candida albicans
    K Niimi
    Department of Oral Biology and Oral Pathology, School of Dentistry, University of Otago, Dunedin, New Zealand
    Arch Microbiol 168:464-72. 1997
  6. ncbi Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility
    K Niimi
    Department of Oral Sciences, University of Otago, P.O. Box 647, 310 Great King Street, Dunedin, New Zealand
    Antimicrob Agents Chemother 50:1148-55. 2006
  7. ncbi Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity
    K Niimi
    Department of Oral Sciences, University of Otago, 310 Great King St, Dunedin 9054, New Zealand
    J Antimicrob Chemother 65:842-52. 2010
  8. ncbi Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative
    K Niimi
    Department of Oral Sciences, University of Otago, Dunedin, New Zealand
    Antimicrob Agents Chemother 48:1256-71. 2004
  9. ncbi Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance
    G D Albertson
    Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand
    Antimicrob Agents Chemother 40:2835-41. 1996

Collaborators

Detail Information

Publications9

  1. ncbi Differential profiles of soluble proteins during the initiation of morphogenesis in Candida albicans
    M Niimi
    Experimental Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, School of Dentistry, University of Otago, P O Box 647, Dunedin, New Zealand
    Arch Microbiol 166:260-8. 1996
    ..albicans morphogenesis may be differentially synthesised...
  2. ncbi Temperature-related expression of the vacuolar aspartic proteinase (APR1) gene and beta-N-acetylglucosaminidase (HEX1) gene during Candida albicans morphogenesis
    M Niimi
    Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand
    FEMS Microbiol Lett 148:247-54. 1997
    ..The expression of HEX1 mRNA is in part under the control of culture pH and translation of HEX1 mRNA seems to be regulated by glucose...
  3. ncbi Candida albicans pathogenicity: a proteomic perspective
    M Niimi
    Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, Dunedin, New Zealand
    Electrophoresis 20:2299-308. 1999
    ..albicans cells. This article describes the potential of applying proteome analysis to C. albicans in order to better understand pathogenicity and identify new antifungal targets...
  4. ncbi Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters
    K Nakamura
    Department of Oral Sciences and Orthodontics, University of Otago, Dunedin, New Zealand
    Antimicrob Agents Chemother 45:3366-74. 2001
    ..albicans Cdr1p in an S. cerevisiae background deficient in other pumps allows the functional analysis of pumping specificity and mechanisms of a major ABC transporter involved in drug efflux from an important human pathogen...
  5. ncbi Regulation of N-acetylglucosaminidase production in Candida albicans
    K Niimi
    Department of Oral Biology and Oral Pathology, School of Dentistry, University of Otago, Dunedin, New Zealand
    Arch Microbiol 168:464-72. 1997
    ..The cellular location of the enzyme and the regulation of production by the carbon source indicate a scavenging role for C. albicans N-acetylglucosaminidase...
  6. ncbi Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility
    K Niimi
    Department of Oral Sciences, University of Otago, P.O. Box 647, 310 Great King Street, Dunedin, New Zealand
    Antimicrob Agents Chemother 50:1148-55. 2006
    ..The assessment of micafungin and caspofungin potency is therefore assay dependent; the differences seen with agar plate drug resistance assays occur over narrow ranges of echinocandin concentrations and are not of clinical significance...
  7. ncbi Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity
    K Niimi
    Department of Oral Sciences, University of Otago, 310 Great King St, Dunedin 9054, New Zealand
    J Antimicrob Chemother 65:842-52. 2010
    ..To determine the mechanism of intermediate- and high-level echinocandin resistance, resulting from heterozygous and homozygous mutations in GSC1 (FKS1), in both laboratory-generated and clinical isolates of Candida albicans...
  8. ncbi Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative
    K Niimi
    Department of Oral Sciences, University of Otago, Dunedin, New Zealand
    Antimicrob Agents Chemother 48:1256-71. 2004
    ..KN20 therefore appears to indirectly chemosensitize cells to FLC by a nonlethal permeabilization of the fungal plasma membrane...
  9. ncbi Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance
    G D Albertson
    Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand
    Antimicrob Agents Chemother 40:2835-41. 1996
    ..These results suggest that fluconazole enters C. albicans cells by facilitated diffusion and that fluconazole resistance may involve energy-dependent drug efflux associated with increased expression of Benr and/or Cdr1...