Research Topics
| D A HooksSummaryAffiliation: University of Auckland Country: New Zealand Publications
|
Detail Information
Publications
Intramural multisite recording of transmembrane potential in the heartD A Hooks
Department of Physiology, School of Medicine, University of Auckland, Auckland, New Zealand
Biophys J 81:2671-80. 2001..The optics and electronics are easily expandable to accommodate multiple optical probes. The system is used to record the first simultaneous measurements of transmembrane potential at a number of sites through the intact heart wall...- Construction and validation of a plunge electrode array for three-dimensional determination of conductivity in the heartDarren A Hooks
Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 10101, New Zealand
IEEE Trans Biomed Eng 55:626-35. 2008..A bidomain model of current injection in the heart is then used to test an approximate relationship between the monodomain conductivities measured by the array, and the full set of bidomain conductivities that describe cardiac tissue... - Laminar arrangement of ventricular myocytes influences electrical behavior of the heartDarren A Hooks
Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
Circ Res 101:e103-12. 2007..More generally, the mechanisms governing the destabilization of coordinated electrical propagation into ventricular arrhythmia need to be evaluated in the light of this discovery... - Myocardial segment-specific model generation for simulating the electrical action of the heartDarren A Hooks
Bioengineering Institute, University of Auckland, New Zealand
Biomed Eng Online 6:21. 2007..This paper presents to-date the largest database of porcine left ventricular segment microstructural architecture, for use in both electrical and mechanical simulation... - Do intramural virtual electrodes facilitate successful defibrillation? Model-based analysis of experimental evidenceDarren A Hooks
Bioengineering Institute, University of Auckland, New Zealand
J Cardiovasc Electrophysiol 17:305-11. 2006..It is not known how this constraint limits the interpretation of these experiments in terms of the shock response of the intact ventricle... - Cardiac microstructure: implications for electrical propagation and defibrillation in the heartDarren A Hooks
Bioengineering Research Group, Department of Physiology, School of Medicine, University of Auckland, Auckland, New Zealand
Circ Res 91:331-8. 2002.... - Three distinct directions of intramural activation reveal nonuniform side-to-side electrical coupling of ventricular myocytesBryan J Caldwell
Auckland Bioengineering Institute, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Circ Arrhythm Electrophysiol 2:433-40. 2009..We present new experimental evidence that contradicts this view... - Intramural measurement of transmembrane potential in the isolated pig heart: validation of a novel techniqueBryan J Caldwell
Bioengineering Institute and Physiology Department, University of Auckland, Auckland, New Zealand
J Cardiovasc Electrophysiol 16:1001-10. 2005..CONCLUSIONS: We have demonstrated that our optrode provides reliable intramural transmembrane potential recordings in the isolated pig heart preparation... - Cardiac electrophysiology and tissue structure: bridging the scale gap with a joint measurement and modelling paradigmMark L Trew
Bioengineering Institute, The University of Auckland, New Zealand
Exp Physiol 91:355-70. 2006..Our models have enabled us to consider key hypotheses regarding discontinuous activation. We also consider the future developments of our intact tissue experimental programme... - Automated imaging of extended tissue volumes using confocal microscopyGregory B Sands
Bioengineering Institute, The University of Auckland, Auckland, New Zealand
Microsc Res Tech 67:227-39. 2005.... - Cardiac structure and electrical activation: models and measurementBruce H Smaill
Bioengineering Institute and Department of Physiology, University of Auckland, Auckland, New Zealand
Clin Exp Pharmacol Physiol 31:913-9. 2004..4. We conclude that structural discontinuities in ventricular myocardium may play a role in the initiation of re-entrant arrhythmia and discuss future studies that address this hypothesis... - Correction of motion artifact in transmembrane voltage-sensitive fluorescent dye emission in heartsDean C-S Tai
Bioengineering Institute, The University of Auckland, Auckland, New Zealand
Am J Physiol Heart Circ Physiol 287:H985-93. 2004..This novel subtraction approach may therefore provide a means of reducing the concentration of uncoupling agents used in cardiac optical mapping studies... - Modeling cardiac electrical activity at the cell and tissue levelsTravis M Austin
Bioengineering Institute, The University of Auckland, Auckland, New Zealand
Ann N Y Acad Sci 1080:334-47. 2006..Our models, which can incorporate ion channel models at the cell level into the reaction-diffusion equations at the tissue level, have enabled us to consider key hypotheses regarding discontinuous activation... - Illumination and fluorescence collection volumes for fiber optic probes in tissueDean C S Tai
The University of Auckland, Bioengineering Institute and Department of Physics, Auckland, New Zealand 1001
J Biomed Opt 12:034033. 2007..We provide information that will facilitate the design of optical probes for tissue imaging or therapeutic applications...