Research Topics
| Paul Leslie HofmanSummaryAffiliation: University of Auckland Country: New Zealand Publications
| Collaborators
|
Detail Information
Publications
Design and testing of an MRI-compatible cycle ergometer for non-invasive cardiac assessments during exerciseSilmara Gusso
Liggins Institute, University of Auckland, Auckland, New Zealand
Biomed Eng Online 11:13. 2012..abstract:..- Needle with a novel attachment versus conventional screw-thread needles: a preference and ease-of-use test among children and adolescents with diabetesPaul Hofman
Liggins Institute, University of Auckland, Auckland, New Zealand
J Diabetes Sci Technol 5:1480-7. 2011..This usability test investigated the overall preference and usability of the novel NovoTwist® insulin pen needle versus conventional screw-thread needles, when used with Next Generation FlexPen®, in children and adolescents with diabetes... - Defining the ideal injection techniques when using 5-mm needles in children and adultsPaul Leslie Hofman
Liggins Institute, University of Auckland, Auckland, New Zealand
Diabetes Care 33:1940-4. 2010..We aimed to establish the ideal injection techniques using 5-mm needles to reliably inject insulin into the subcutaneous fat in both children and adults and to quantify the associated pain and leakage of the test medium... - Prematurity--another example of perinatal metabolic programming?P L Hofman
Liggins Institute, University of Auckland, Auckland, New Zealand
Horm Res 66:33-9. 2006..We present data demonstrating that premature infants also have metabolic abnormalities similar to those observed in term, SGA children and that these occur irrespective of whether they are SGA or appropriate for gestational age (AGA)... - Insulin sensitivity in people born pre-term, with low or very low birth weight and small for gestational ageP L Hofman
Liggins Institute, University of Auckland, Auckland, New Zealand
J Endocrinol Invest 29:2-8. 2006.... - Premature birth and later insulin resistancePaul L Hofman
Liggins Institute, Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand
N Engl J Med 351:2179-86. 2004.... - The metabolic consequences of prematurityP L Hofman
Liggins Institute, University of Auckland, 2 6 Park Avenue, Auckland, New Zealand
Growth Horm IGF Res 14:S136-9. 2004.... - Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age ratM H Vickers
Liggins Institute, University of Auckland, Auckland, New Zealand
Am J Physiol Endocrinol Metab 291:E1212-9. 2006.... - Neonatal leptin treatment reverses developmental programmingM H Vickers
Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
Endocrinology 146:4211-6. 2005..The complete normalization of the programmed phenotype by neonatal leptin treatment implies that leptin has effects that reverse the prenatal adaptations resulting from relative fetal undernutrition... - Evaluation of the buserelin stimulation test in diagnosing gonadotropin deficiency in males with delayed pubertyDyanne A Wilson
Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
J Pediatr 148:89-94. 2006..CONCLUSIONS: The buserelin stimulation test is a highly specific and sensitive GnRH agonist test for the investigation of males with delayed puberty... - Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetesS Lalande
Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand
Acta Physiol (Oxf) 199:23-30. 2010..The purpose of this study was to examine the influence of LV function and LV loading conditions on stroke volume in men with type 2 diabetes... - An angled insertion technique using 6-mm needles markedly reduces the risk of intramuscular injections in children and adolescentsP L Hofman
Liggins Institute, University of Auckland, Auckland, New Zealand
Diabet Med 24:1400-5. 2007.... - Could epigenetics play a role in the developmental origins of health and disease?Wayne S Cutfield
Liggins Institute, National Research Centre for Growth and Development, University of Auckland, Department of Pediatrics, New Zealand
Pediatr Res 61:68R-75R. 2007..The relevance of these animal studies to IVF, SGA, and very premature children are discussed as are potential candidate genes that may have undergone epigenetic modification to alter growth and metabolism... - The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancyMark H Vickers
Liggins Institute, University of Auckland, Auckland, New Zealand
Endocrinology 149:1906-13. 2008..These data further reinforce the importance of leptin in determining long-term energy homeostasis, and suggest that leptin's effects are modulated by gender and both prenatal and postnatal nutritional status... - The endocrine consequences for very low birth weight premature infantsWayne S Cutfield
Department of Paediatrics, Faculty of Medicine and Health Sciences, Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
Growth Horm IGF Res 14:S130-5. 2004..Conversely, term SGA children have elevated plasma IGF-I and IGFBP-3 levels. When combined, premature birth plays a more dominant role than SGA on the IGF-IGF binding protein axis... - Massive hepatic hemangioendothelioma and consumptive hypothyroidismFrances Mouat
The Liggins Institute, The University ofAuckland, New Zealand
J Pediatr Endocrinol Metab 21:701-3. 2008..Large doses of thyroxine were initially required to normalise TSH. Thyroxine was tapered as the tumor regressed and was discontinued at 16 months old. Thyroid function remains normal without treatment... - Reduced insulin sensitivity during growth hormone therapy for short children born small for gestational ageWayne S Cutfield
Department of Paediatrics, the Liggins Institue for Medical Research, University of Auckland, Auckland, New Zealand
J Pediatr 142:113-6. 2003..CONCLUSIONS: Children SGA are known to have reduced insulin sensitivity. There was a further reduction in insulin sensitivity with rhGH therapy that did not recover 3 months after rhGH therapy was stopped... - The impact of early nutrition in premature infants on later childhood insulin sensitivity and growthFiona M Regan
Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Pediatrics 118:1943-9. 2006..We speculate that a high carbohydrate neonatal diet may lead to greater weight gain and a greater reduction in insulin sensitivity in this group... - IGFs and binding proteins in short children with intrauterine growth retardationWayne S Cutfield
Department of Pediatrics, University of Auckland, Auckland 92019, New Zealand
J Clin Endocrinol Metab 87:235-9. 2002..We speculate that hyperinsulinism secondary to insulin resistance may have led to these changes to the IGF-IGFBP axis in the IUGR group... - Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal childrenWayne S Cutfield
Department of Paediatrics and the Health Research Council Biostatistics Unit, University of Auckland, Private Bag 92019, Auckland, New Zealand
Pediatr Diabetes 4:119-25. 2003..The aim of this study was to compare HOMA and QUICKI to the minimal model as measures of SI in prepubertal children... - Insulin resistance in healthy prepubertal twinsCraig A Jefferies
Liggins Institute, Health Research Council Biostatistics Unit, Department of Community Health, University of Auckland, Auckland, New Zealand
J Pediatr 144:608-13. 2004..14). CONCLUSIONS: Twin children, independent of prematurity or birth weight, had a marked reduction in S(I). To use twins as a model to study the fetal origins of adult diseases for glucose homeostasis is not valid... - Insulin resistance is not due to persistently elevated serum tumor necrosis-alpha levels in small for gestational age, premature, or twin childrenCraig A Jefferies
Department of Paediatrics and Liggins Institute, University of Auckland, Auckland, New Zealand
Pediatr Diabetes 5:20-5. 2004..We hypothesized that an adverse fetal or early neonatal environment for SGA, twin, and premature children leads to persistently elevated TNF-alpha levels that induce insulin resistance in each of these groups... - Simple fasting methods to assess insulin sensitivity in childhoodWayne S Cutfield
Liggins Institute, University of Auckland, Auckland, New Zealand
Horm Res 64:25-31. 2005..However, if the study groups are small or longitudinal changes in insulin sensitivity are sought, more precise techniques such as the clamp or minimal model should be used... - Fetal origins of adult disease: a paediatric perspectiveHarriet L Miles
Liggins Institute, University of Auckland, Private Bag 92019, New Zealand
Rev Endocr Metab Disord 6:261-8. 2005..Future research in this field is likely to focus on the mechanisms through which environmental changes lead to these programmed effects... - Insulin sensitivity in the offspring of women with type 1 and type 2 diabetesWendy A Hunter
Liggins Institute, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand
Diabetes Care 27:1148-52. 2004..To determine if insulin sensitivity is altered in prepubertal offspring exposed to a diabetic intrauterine environment... - Increased nocturnal blood pressure in healthy prepubertal twinsCraig A Jefferies
Department of Paediatrics and Liggins Institute, University of Auckland, New Zealand
J Hypertens 21:1319-24. 2003..As these BP abnormalities are not associated with twin birth weight, the twin model may not be appropriate in investigating the fetal origins of disease in later adult life... - Reduced leg blood flow during submaximal exercise in type 2 diabetesSophie Lalande
Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand
Med Sci Sports Exerc 40:612-7. 2008..It is unclear whether impaired cardiac and/or vascular function contribute to exercise intolerance in patients with type 2 diabetes... - In vitro fertilization improves childhood growth and metabolismHarriet L Miles
The National Research Centre for Growth and Development and Liggins Institute, University of Auckland, Auckland 1010, New Zealand
J Clin Endocrinol Metab 92:3441-5. 2007..There is limited information regarding the long-term outcome of children born after in vitro fertilization (IVF), although an increase in rare imprinted gene disorders such as Beckwith-Wiedemann syndrome has been reported... - Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statementCraig Munns
The Children s Hospital at Westmead, Sydney, NSW, Australia
Med J Aust 185:268-72. 2006..High-dose bolus therapy (300,000-500,000 IU) should be considered for children over 12 months of age if compliance or absorption issues are suspected...