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Genomes and Genes | Matthew J DuringSummaryAffiliation: University of Auckland Country: New Zealand Publications
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Publications
HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicityAlisha E Jung
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
Mol Ther 16:1048-55. 2008..Our results suggest that a comparatively modest upregulation of multiple HSPs may be an effective approach for achieving significant neuroprotection in PD...- Glucagon-like peptide-1 receptor is involved in learning and neuroprotectionMatthew J During
Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland 86716, New Zealand
Nat Med 9:1173-9. 2003..Systemic administration of [Ser(2)]exendin(1-9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons. Brain GLP-1R represents a promising new target for both cognitive-enhancing and neuroprotective agents... - VEGF, a mediator of the effect of experience on hippocampal neurogenesisMatthew J During
Department of Neurological Surgery, Weill Medical College of Cornell University, New York, USA
Curr Alzheimer Res 3:29-33. 2006..These data support a model whereby VEGF acting via KDR is a mediator of the effect of the environment on neurogenesis and cognition [1]... - Knockdown and overexpression of NR1 modulates NMDA receptor functionMaggie L Kalev-Zylinska
Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
Mol Cell Neurosci 41:383-96. 2009..In conclusion, the observed consequences of NR1 knockdown and overexpression underscore NMDAR requirement for neuronal plasticity, and are in agreement with its dichotomous functions... - AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult ratsMatthias Klugmann
Department of Molecular Medicine and Pathology, Functional Genomics and Translational Neuroscience Laboratory, University of Auckland, Auckland, New Zealand
Mol Cell Neurosci 28:347-60. 2005..Homer 1g induced anxiety. Moreover, AAV-Homer 1a animals showed attenuation of electrographic seizures in a model of status epilepticus. These results suggest that Homer 1 proteins play an active role in behavioral plasticity... - A novel role of circadian transcription factor DBP in hippocampal plasticityMatthias Klugmann
Functional Genomics and Translational Neuroscience Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Mol Cell Neurosci 31:303-14. 2006..These data suggest that DBP may represent an important transcriptional link between GLP-1R activation and neuroplasticity in the hippocampus... - Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivoXiqun Chen
Department of Neurology, The College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Neurosci 28:672-80. 2008..We conclude that DLK acts primarily through c-jun phosphorylation to mediate cell death in this model... - VEGF links hippocampal activity with neurogenesis, learning and memoryLei Cao
Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA
Nat Genet 36:827-35. 2004..These data support a model in which VEGF, acting through KDR, mediates the effect of the environment on neurogenesis and cognition... - Phosphorylation-dependent degradation of transgenic CREB protein initiated by heterodimerizationAlexandre Mouravlev
Department of Molecular Medicine and Pathology, The University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
Brain Res 1130:31-7. 2007..Hence, heterodimerization of unphosphorylated CREB with either A-CREB or ICER triggers CREB protein degradation, whereas phosphorylation prevents CREB from such degradation both in vitro and in vivo... - Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan diseaseMatthias Klugmann
Laboratory of Functional Genomics and Translational Neuroscience, Department of Molecular Medicine and Pathology, University of Auckland School of Medicine, 85 Park Road, Auckland, New Zealand
Mol Ther 11:745-53. 2005..Moreover, hypomyelination and motor deficits were not resolved by ASPA gene transfer. Our data suggest that NAA-mediated neuronal hyperexcitation but not oligodendrocyte dysfunction can be compensated for by neuronal ASPA expression... - Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure developmentEn-Ju D Lin
Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
Eur J Neurosci 18:2087-92. 2003..The seizure suppression effect of galanin expression in the hippocampus by viral vectors may lead to novel therapeutic strategies for the treatment and management of intractable seizures with focal onset such as temporal lobe epilepsy... - AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington diseaseAdrian P Kells
Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Mol Ther 9:682-8. 2004..These results indicate that AAV-mediated gene transfer of BDNF or GDNF into the striatum provides neuronal protection in a rodent model of HD... - Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging ratsAlexandre Mouravlev
Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland, New Zealand
Proc Natl Acad Sci U S A 103:4705-10. 2006.... - Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trialMichael G Kaplitt
Department of Neurological Surgery, Weill Medical College of Cornell University, New York, NY, USA
Lancet 369:2097-105. 2007..We aimed to measure the safety, tolerability, and potential efficacy of transfer of glutamic acid decarboxylase (GAD) gene with adeno-associated virus (AAV) into the subthalamic nucleus of patients with Parkinson's disease... - Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primatesPatricia A Lawlor
Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
Mol Ther 17:1692-702. 2009.... - Over expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acidJeremy S Francis
Department of Molecular Medicine and Pathology, University of Auckland School of Medicine, Auckland, New Zealand
Brain Res Mol Brain Res 124:199-203. 2004..These results suggest a positive contribution to neuronal survival in the context of stress-induced death, and support an anti-apoptotic role for ATF-3 in the brain... - Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout miceEn Ju Deborah Lin
Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Epilepsia 47:773-80. 2006..We also examined the effect of rAAV-mediated hippocampal NPY overexpression on seizure susceptibility in these receptor knockout mice... - Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's diseaseVincent Ries
Department of Neurology, Columbia University College of Physicians and Surgeons, 650 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 103:18757-62. 2006..Activation of intracellular neurotrophic signaling pathways by vector transfer is a feasible approach to neuroprotection and restorative treatment of neurodegenerative disease... - Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brainMihail Y Mastakov
Functional Genomics and Translational Neuroscience Laboratory, Division of Molecular Medicine, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
J Virol 76:8446-54. 2002..This study provides guidelines for more rational design of gene transfer studies in the rodent brain and, in addition, suggests the use of repeated administration of rAAV as a viable form of therapy for the treatment of chronic diseases... - Gene therapy for Parkinson's diseasePatricia A Lawlor
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
Expert Rev Mol Med 6:1-18. 2004..The merits of these strategies are discussed here, along with remaining hurdles that might impede transfer of gene therapy technology to the clinic as a treatment for PD... - Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusionMihail Y Mastakov
Functional Genomics and Translational Neuroscience Laboratory, Division of Molecular Medicine, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
Mol Ther 5:371-80. 2002.... - Paradoxical facilitatory effect of low-dose alcohol consumption on memory mediated by NMDA receptorsMaggie L Kalev Zylinska
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, 1142 Auckland, New Zealand
J Neurosci 27:10456-67. 2007..In conclusion, adaptive changes in hippocampal NMDA receptor expression may contribute to the positive effects of ethanol on cognition... - Identification and distribution of aspartoacylase in the postnatal rat brainMatthias Klugmann
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand m
Neuroreport 14:1837-40. 2003..Histologically, most abundant expression was observed in white matter tracts and thalamus. On the cellular level, aspartoacylase immunoreactivity is restricted to oligodendrocyte somata in both white and gray matter... - Subthalamic GAD gene therapy in a Parkinson's disease rat modelJia Luo
Functional Genomics and Translational Neuroscience Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Science 298:425-9. 2002..This strategy suggests that there is plasticity between excitatory and inhibitory neurotransmission in the mammalian brain that could be exploited for therapeutic benefit... - Molecular mechanisms of learning and memoryJane Dunning
Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1001, New Zealand
Expert Rev Mol Med 5:1-11. 2003..Here we review the molecular mechanisms thought to underlie memory acquisition and storage, as well as discuss recent evidence regarding the mechanisms of subsequent memory consolidation... - ATF3 enhances c-Jun-mediated neurite sproutingAndree G Pearson
Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Private Bag 92019, Auckland, New Zealand
Brain Res Mol Brain Res 120:38-45. 2003..Our results suggest that a program of axonal regeneration is initiated when both c-Jun and ATF3 are upregulated in neurons in response to axotomy... - Molecular investigation of TBP allele length: a SCA17 cellular model and population studySuzanne J Reid
Department of Molecular Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
Neurobiol Dis 13:37-45. 2003..Importantly, overexpression of expanded TBP results in increased Cre-dependent transcriptional activity. As TBP is required for transcription by all RNA polymerases, this may indicate a mechanism for aberrant polyQ gain of function... - Using the immune system to target epilepsyDeborah Young
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
Adv Exp Med Biol 548:134-44. 2004 - Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesiaJonathan Brouillette
Department of Neurology and Neurosurgery, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
J Neurochem 102:1978-89. 2007..Taken together, these results reveal novel genes and mechanisms involved in scopolamine-induced amnesia, and demonstrate the involvement of both GABA and glutamate neurotransmission in this animal model of cognitive dysfunctions... - NMDA receptors inhibit synapse unsilencing during brain developmentHillel Adesnik
Departments of Cellular and Molecular Pharmacology, Physiology, and Neurology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 105:5597-602. 2008.... - Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolismMarina E Emborg
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA
J Cereb Blood Flow Metab 27:501-9. 2007..The changes in motor cortical glucose utilization observed after gene therapy are consistent with the modulation of metabolic brain networks associated with this disorder... - Synaptic scaffolding protein Homer1a protects against chronic inflammatory painAnke Tappe
Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Nat Med 12:677-81. 2006..Thus, Homer1 function is crucially involved in pain plasticity and constitutes a promising therapeutic target for the treatment of chronic inflammatory pain... - NPY gene transfer in the hippocampus attenuates synaptic plasticity and learningAndreas T Sørensen
Experimental Epilepsy Group, Wallenberg Neuroscience Center, BMC A 11, Lund University Hospital, Lund, Sweden
Hippocampus 18:564-74. 2008.... - Local dopamine production in the dorsal striatum restores goal-directed behavior in dopamine-deficient miceSiobhan Robinson
Neurobiology and Behavior Program, University of Washington, Seattle, WA 98195, USA
Behav Neurosci 120:196-200. 2006..The authors conclude that finely tuned dopaminergic signaling within the dorsal striatum is sufficient for performance of goal-directed behavior... - Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's diseaseAndrew Feigin
Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
Proc Natl Acad Sci U S A 104:19559-64. 2007..Network biomarkers may be used as physiological assays in early-phase trials of experimental therapies for PD and other neurodegenerative disease... - Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampusCristina Richichi
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
J Neurosci 24:3051-9. 2004..Thus, targeted NPY gene transfer provides a potential therapeutic principle for the treatment of drug-resistant partial epilepsies... - Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administrationWilliam A Banks
Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center St Louis, Missouri, USA
J Pharmacol Exp Ther 309:469-75. 2004..These results show that intranasal administration is an effective means of delivering peptide to the brain, especially the olfactory bulb... - Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of spinal cord neurons and astrocytesJames S Harrop
Department of Neurosurgery, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Spine (Phila Pa 1976) 29:2787-92. 2004..Descriptive histologic analysis of spinal cord gene therapy... - A role for dopamine in feeding responses produced by orexigenic agentsThomas S Hnasko
Neurobiology and Behavior Graduate Program, University of Washington, Seattle, WA 98195, USA
Brain Res 1023:309-18. 2004..Since dopamine signaling in the CPu is not sufficient for glucoprivation-induced feeding, we propose that this feeding behavior may be mediated by dopamine in an anatomically distinct brain region... - Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry miceClaire Matson Cannon
Department of Biochemistry and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
Neuron 44:509-20. 2004..We suggest that, at this moderate dose of AMPH, dysregulation of striatal DA is the primary cause of AMPH-induced hypophagia and that regulated striatal dopaminergic signaling may be necessary for normal feeding behaviors... - Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsyFrancesco Noe
Department of Neuroscience, Mario Negri Inst for Pharmacol Res, Via G La Masa 19, 20156 Milano, Italy
Brain 131:1506-15. 2008..Our data show that this gene therapy strategy decreases spontaneous seizures and suppresses their progression in chronic epileptic rats, thus representing a promising new therapeutic strategy... - Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamineCarrie L Heusner
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Brain Res 980:266-74. 2003..These data support previous studies in which accumbal dopamine is required for producing a normal locomotor response to amphetamine and further show that release of dopamine restricted to the NAc is sufficient for this response.. - AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's diseaseNicholas R Franich
1Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
Mol Ther 16:947-56. 2008..These results provide further support for the use of AAV vector-mediated RNAi as a therapeutic strategy for HD... - Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNFJodi L McBride
Department of Neurological Sciences, Rush Presbyterian, St Luke s Medical Center, Chicago, IL 60612, USA
Exp Neurol 181:213-23. 2003..These data indicate that the viral-mediated gene transfer of GDNF into the striatum provides neuroanatomical and behavioral protection in a rodent model of HD... - Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex functionKevin D Lominac
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 25:11586-94. 2005.... - Development and optimization of adeno-associated virus vector transfer into the central nervous systemMatthew J During
CNS Gene Therapy Center, Department of Neurosurgery, Jefferson Medical College, Philadelphia, PA, USA
Methods Mol Med 76:221-36. 2003 - Gene therapy for spinal cord injury and diseaseDavid J Poulsen
University of Montana, Department of Pharmaceutical Sciences, Missoula 59812 1552, USA
J Spinal Cord Med 25:2-9. 2002..This review summarizes the current state of knowledge regarding the limitations and recent advances in gene therapy and potential application of this technology toward spinal cord injury and disease... - Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasisPaul A Baldock
Bone and Mineral Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
J Biol Chem 282:19092-102. 2007..Thus Y1 receptor pathways act powerfully to inhibit bone production and adiposity by nonhypothalamic pathways, with potentially direct effects on bone tissue through a single pathway with Y2 receptors... - Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesityBirgitte Tiesjema
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Obesity (Silver Spring) 15:2424-35. 2007..The aim of this study was to further unravel the contribution of NPY signaling in the PVN to energy balance... - The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damageHossein Aleyasin
Ottawa Health Research Institute, Neuroscience Group, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5
Proc Natl Acad Sci U S A 104:18748-53. 2007..It also highlights the important commonalities among differing neuropathologies... - Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathwaysShu Lin
Neuroscience Research Program, The Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Sydney, Australia
Endocrinology 148:2056-65. 2007..Together these data show that fasting inhibits the somatotropic axis via direct action on Y2 receptors in the Arc and indirectly inhibits the gonadotropic axis via Y4 receptors... - Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brainHelen L Fitzsimons
CNS Gene Therapy Center, Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
Methods 28:227-36. 2002..This review summarizes and compares different promoters and regulatory elements that have been used with rAAV as a reference toward achieving a high level of rAAV-mediated transgene expression in the CNS... - Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate rewardValerie G Olson
Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Science 311:1017-20. 2006..Morphine-induced locomotion was partially restored by DBH expression in either brain region. These data suggest that NE signaling by the nucleus tractus solitarius is necessary for morphine reward... - Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivoJuliet Rashidian
Ottawa Health Research Institute, Neuroscience Group, Ottawa, ON, Canada K1H 8M5
Proc Natl Acad Sci U S A 102:14080-5. 2005..Hence, our data both characterize the functional significance of the cell cycle Cdk4 and neuronal Cdk5 signals as well as define the pathways and circumstances by which they act to control ischemic/hypoxic damage... - Regression of upper gastric cancer in mice by FHIT gene deliveryHideshi Ishii
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
FASEB J 17:1768-70. 2003..This dramatic reduction in tumor burden emphasizes the efficacy of targeting the FHIT apoptotic pathway for tumor eradication... - Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemiaWalid M Abi-Saab
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Cereb Blood Flow Metab 22:271-9. 2002.... - Homer proteins regulate sensitivity to cocaineKaren K Szumlinski
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
Neuron 43:401-13. 2004..These data show that Homer deletion mimics the behavioral and neurochemical phenotype produced by repeated cocaine administration and implicate Homer in regulating addiction to cocaine... - Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivoFrancesco Trapasso
Kimmel Cancer Institute, Thomas Jefferson University, 233S 10th Street, Philadelphia, PA 19107, USA
Carcinogenesis 25:2107-14. 2004..The data suggest that restoration of DEP-1/HPTPeta expression could be a useful tool for the gene therapy of human pancreatic cancers...