Research Topics
Species | Andrew D LaurieSummaryCountry: New Zealand Publications
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Detail Information
Publications
Evaluation of high-resolution melting analysis for screening the LDL receptor geneAndrew D Laurie
Molecular Pathology, Canterbury Health Laboratories, Christchurch, New Zealand
Clin Biochem 42:528-35. 2009..High-resolution melting analysis has been validated for screening several genes of clinical significance. We evaluated whether it would be useful for detecting mutations in the LDL receptor gene (LDLR)...
Detection of factor VIII gene mutations by high-resolution melting analysisAndrew D Laurie
Department of Molecular Pathology, Canterbury Health Laboratories, Christchurch, New Zealand
Clin Chem 53:2211-4. 2007..Because F8 is a large gene, mutation screening using denaturing HPLC or DNA sequencing is time-consuming and expensive...
Preimplantation genetic diagnosis for hemophilia A using indirect linkage analysis and direct genotyping approachesA D Laurie
Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand
J Thromb Haemost 8:783-9. 2010..Although many clinics offer PGD for HA by gender selection, an approach that detects the presence of the underlying F8 mutation has several advantages...
Identification and characterization of two non-secreted PCSK9 mutants associated with familial hypercholesterolemia in cohorts from New Zealand and South AfricaVivienne M Homer
Canterbury Health Laboratories, 8001 Christchurch, New Zealand
Atherosclerosis 196:659-66. 2008..Our study therefore indicates that PCSK9 mediated inhibition of the LDLR does not require PCSK9 autocatalytic cleavage or secretion, suggesting that PCSK9 may also function intracellularly...
Preventing cardiovascular disease: a review of the effectiveness of identifying the people with familial hypercholesterolaemia in New ZealandLauretta A Muir
Centre for Postgraduate Nursing Studies, University of Otago, Christchurch, Christchurch, New Zealand
N Z Med J 123:97-102. 2010..To identify the diagnostic and treatment rates for familial hypercholesterolaemia (FH) in New Zealand...
