Reduced temporal mismatch negativity in late-life depression: an event-related potential index of cognitive deficit and functional disability?Sharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Australia
J Affect Disord 138:71-8. 2012
..This study examined MMN elicited by duration deviant stimuli in older people with lifetime depression, and explored its relationship with neuropsychological functioning and disability...
- Sleep-wake changes and cognition in neurodegenerative disease
Sharon L Naismith
Healthy Brain Ageing Clinic, Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
Prog Brain Res 190:21-52. 2011
..Such research will hopefully lead to targeted early intervention approaches for cognitive decline in older people...
- Sleep disturbance relates to neuropsychological functioning in late-life depression
Sharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, Australia
J Affect Disord 132:139-45. 2011
..Sleep-wake disturbance in older people is a risk factor for depression onset and recurrence. The aim of this study was to determine if objective sleep-wake disturbance in late-life depression relates to neuropsychological functioning...
- Does sleep disturbance mediate neuropsychological functioning in older people with depression?
Sharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 94 Mallet Street, Camperdown NSW 2050, Australia
J Affect Disord 116:139-43. 2009
..However, the association between sleep disturbance and neuropsychological functioning in depression has not been well evaluated. The current study therefore aimed to investigate these relationships...
- Psychomotor slowing in older patients with major depression: Relationships with blood flow in the caudate nucleus and white matter lesions
Ian B Hickie
Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Psychiatry Res 155:211-20. 2007
..Reduced %rCBF is associated with demonstrable psychomotor slowing and presence of WMLs. While psychomotor slowing is determined in part by subcortical changes, other cortical and illness-dependent factors are likely to be relevant...
- Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associations
Daniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, The University of Sydney, Sydney, Australia
Prog Neuropsychopharmacol Biol Psychiatry 34:822-9. 2010
..Such deficits in FEP appear to have important links with higher-order cognitive and psychosocial functioning...
- Cognitive training in affective disorders improves memory: a preliminary study using the NEAR approach
Sharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, NSW, Australia
J Affect Disord 121:258-62. 2010
..Some of these changes persist despite antidepressant treatment. While research in other areas of psychiatry has shown cognitive training techniques to be effective, only one study has evaluated this approach in depression...
- Sleep disturbances in Parkinson disease and their potential role in heterogeneity
David G Gunn
Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
J Geriatr Psychiatry Neurol 23:131-7. 2010
..It also emphasizes the need for further studies that explore the heterogeneity of all disease features in PD...
- Fronto-striatal correlates of impaired implicit sequence learning in major depression: an fMRI study
Sharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
J Affect Disord 125:256-61. 2010
..This study sought to probe the integrity of fronto-striatal circuits using functional magnetic resonance imaging (fMRI) in conjunction with a theoretically-driven motor sequencing implicit learning (IL) task...
- Sleep well, think well: sleep-wake disturbance in mild cognitive impairment
Sharon L Naismith
Ageing Brain Centre, Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
J Geriatr Psychiatry Neurol 23:123-30. 2010
..This preliminary data suggests that sleep-wake disturbance in nonamnestic forms of MCI is related to cognitive functioning and may be indicative of shared neurobiological underpinnings...
- Neuropsychological clustering highlights cognitive differences in young people presenting with depressive symptoms
Daniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
J Int Neuropsychol Soc 17:267-76. 2011
..Distinct neuropsychological profiling may help to predict later psychiatric outcomes and enhance individually-tailored early intervention strategies...
- Can older "at risk" adults benefit from psychoeducation targeting healthy brain aging?
Louisa M Norrie
Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, NSW, Australia
Int Psychogeriatr 23:413-24. 2011
..The current study sought to investigate whether older adults "at risk" of cognitive decline benefit from psychoeducation targeting healthy brain aging...
- Impaired verbal memory in young adults with unipolar and bipolar depression
Daniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
Early Interv Psychiatry 4:227-33. 2010
..Specifically, deficits in verbal memory have been linked to depression in young people. This study examined whether young adults with unipolar compared with bipolar depression showed similar neurocognitive deficits...
- Neuropsychological functioning in Parkinson's disease: differential relationships with self-reported sleep-wake disturbances
Sharon L Naismith
Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
Mov Disord 26:1537-41. 2011
..However, prior studies exploring the association between specific sleep-wake disturbances and neuropsychological functions have been limited...
- The specific contributions of set-shifting to freezing of gait in Parkinson's disease
Sharon L Naismith
Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
Mov Disord 25:1000-4. 2010
..This was apparent even after controlling for slowed processing speed, disease stage and depressive symptoms. The results support the recently proposed hypothesis for the pathophysiology underlying FOG in PD...
- Early intervention for cognitive decline: is there a role for multiple medical or behavioural interventions?
Sharon L Naismith
Brain and Mind Research Institute, The George Institute for International Health, University of Sydney, Sydney, New South Wales, Australia
Early Interv Psychiatry 3:19-27. 2009
..Evidence for the beneficial effects of providing relevant interventions is assessed...
- Enhancing memory in late-life depression: the effects of a combined psychoeducation and cognitive training program
Sharon L Naismith
Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, NSW, Australia
Am J Geriatr Psychiatry 19:240-8. 2011
..To evaluate the efficacy of a multifactorial cognitive training (CT) program for older people with a lifetime history of depressive disorder...
- How does social functioning in the early stages of psychosis relate to depression and social anxiety?
Catherine Chudleigh
Clinical Research Unit, Brain and Mind Research Institute, New South Wales, Australia
Early Interv Psychiatry 5:224-32. 2011
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- Utilising functional MRI (fMRI) to explore the freezing phenomenon in Parkinson's disease
James M Shine
Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales 2050, Australia
J Clin Neurosci 18:807-10. 2011
..The results of this single study highlight the potential utility of this approach in elucidating the underlying neural correlate of freezing behaviour in PD...
- Visual misperceptions and hallucinations in Parkinson's disease: dysfunction of attentional control networks?
James M Shine
Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
Mov Disord 26:2154-9. 2011
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- Internet-based treatment for older adults with depression and co-morbid cardiovascular disease: protocol for a randomised, double-blind, placebo controlled trial
Nicole L Cockayne
Brain and Mind Research Institute, The University of Sydney, Camperdown NSW, Australia
BMC Psychiatry 11:10. 2011
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- How well do caregivers detect mild cognitive change in Parkinson's disease?
Sharon L Naismith
Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
Mov Disord 26:161-4. 2011
..The capacity for caregivers to rate mild cognitive change in PD may be useful to assist in early screening and intervention approaches...
- Disability is already pronounced in young people with early stages of affective disorders: data from an early intervention service
Blake A Hamilton
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, 2050 Australia
J Affect Disord 131:84-91. 2011
..This study examined patient self-reported disability in young people attending a designated early intervention service...
- Impaired implicit sequence learning in depression: a probe for frontostriatal dysfunction?
Sharon L Naismith
Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Psychol Med 36:313-23. 2006
..Consequently, it is ideally suited for testing elements of the frontostriatal model of major depression and performance can be related to key clinical, neuropsychological, vascular and biochemical data...
- "DASH" symptoms in patients with Parkinson's disease: red flags for early cognitive decline
Sharon L Naismith
Parkinson s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia
J Clin Neurosci 18:352-5. 2011
..The DASH score may represent a simple screening method for highlighting early cognitive decline, which in turn is associated with the development of dementia in PD...
- Early intervention for cognitive decline: can cognitive training be used as a selective prevention technique?
Loren Mowszowski
Department of Psychology, Macquarie University, Sydney, NSW, Australia
Int Psychogeriatr 22:537-48. 2010
..It also considers the underlying mechanism of CT, namely that which suggests that CT acts via promoting neuroplasticity...
- A systematic review of the impact of adherence on the effectiveness of e-therapies
Liesje Donkin
Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
J Med Internet Res 13:e52. 2011
..Understanding the role of adherence may be crucial to understanding how program usage influences the effectiveness of e-therapy interventions...
- Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression
Ian B Hickie
Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
J Affect Disord 98:137-42. 2007
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- Disability in major depression related to self-rated and objectively-measured cognitive deficits: a preliminary study
Sharon L Naismith
Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
BMC Psychiatry 7:32. 2007
..This study examined the relationships between self-rated disability in persons with MD and both self-rated and objectively-measured cognitive functioning...
- The relationship between actigraphically defined sleep disturbance and REM sleep behaviour disorder in Parkinson's Disease
Sharon L Naismith
Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, 94 Mallett St, Camperdown, NSW 2050, Australia
Clin Neurol Neurosurg 112:420-3. 2010
..In this study, we sought to evaluate the utility of actigraphy for examining symptoms of rapid eye movement sleep behaviour disorder (RSBD)...
- The role of mild depression in sleep disturbance and quality of life in Parkinson's disease
Sharon L Naismith
Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
J Neuropsychiatry Clin Neurosci 22:384-9. 2010
..Overall, these data highlight the need to screen patients for even mild levels of depression because its relationship with sleep and quality of life are evident early in the disease course...
- Neuropsychological performance in patients with depression is associated with clinical, etiological and genetic risk factors
Sharon L Naismith
School of Psychiatry, University of New South Wales, Sydney, Australia
J Clin Exp Neuropsychol 25:866-77. 2003
..These findings underscore the need to consider subtypes when investigating neuropsychological deficits in patients with depression...
- The impact of gender on early ill-health retirement in people with heart disease and depression
Matt B Paradise
Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
Aust N Z J Psychiatry 46:249-56. 2012
..Given the deleterious effects of ill-health retirement, identifying at-risk groups is important for guiding targeted interventions...
- Frontal lobe changes occur early in the course of affective disorders in young people
Jim Lagopoulos
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
BMC Psychiatry 12:4. 2012
..Contrasts were carried out between controls subjects and patients cohorts with attenuated syndromes and discrete disorders, separately...
- Amphetamine psychosis: a model for studying the onset and course of psychosis
Daniel F Hermens
Brain and Mind Research Institute, University of Sydney, Sydney, NSW
Med J Aust 190:S22-5. 2009
..It is possible that the same approach may be used in young people known to be at risk of schizophrenia and related disorders, by informing models that involve other environmental or genetic risks...
- Targeted primary care-based mental health services for young Australians
Elizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, Sydney, NSW
Med J Aust 196:136-40. 2012
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- Effect of oral appliance therapy on neurobehavioral functioning in obstructive sleep apnea: a randomized controlled trial
Sharon L Naismith
Department of Respiratory and Sleep Medicine, St George Hospital, The University of New South Wales, Sydney, Australia
J Clin Sleep Med 1:374-80. 2005
..This study aimed to assess the efficacy of a custom-made mandibular advancement splint for the treatment of obstructive sleep apnea with respect to neuropsychological functioning and mood state...
- A novel paradigm for modelling freezing of gait in Parkinson's disease
Sharon L Naismith
Brain and Mind Research Institute, The University of Sydney, Level 4, Building F, 94 Mallett Street, Camperdown, New South Wales 2050, Australia
J Clin Neurosci 17:984-7. 2010
..We believe this paradigm is capable of accurately modelling FOG and will have validity in future functional neuroimaging and therapeutic intervention studies...
- Investigating visual misperceptions in Parkinson's disease: a novel behavioral paradigm
James M Shine
Parkinson s Disease Clinic, Brain and Mind Research Institute, The University of Sydney, New South Wales, Australia
Mov Disord 27:500-5. 2012
..We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD...
- Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional study
Matt B Paradise
Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW 2050, Australia
BMC Psychiatry 11:108. 2011
..We therefore aimed to test the hypothesis that vascular risk factors were associated with SMC, independent of psychological distress, in a middle-aged community-dwelling population...
- Electroconvulsive therapy-induced persistent retrograde amnesia: could it be minimised by ketamine or other pharmacological approaches?
Emily M Gregory-Roberts
Brain and Mind Research Institute, University of Sydney, Australia
J Affect Disord 126:39-45. 2010
..This review examines mechanisms for electroconvulsive therapy-induced retrograde amnesia, and evaluates the suitability of the anaesthetic ketamine for preventing this amnestic outcome...
