Sashi Nadanaciva

Summary

Publications

  1. ncbi Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays
    Sashi Nadanaciva
    MitoSciences Inc, 1850 Millrace Drive, Eugene, OR 97403, USA
    Toxicol In Vitro 21:902-11. 2007
  2. ncbi Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration
    Sashi Nadanaciva
    MitoSciences, Inc, 1850 Millrace Drive, Eugene, OR 97403, USA
    Toxicol Appl Pharmacol 223:277-87. 2007
  3. ncbi Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis
    Sashi Nadanaciva
    MitoSciences Inc, Eugene, OR 97403, USA
    J Immunol Methods 343:1-12. 2009
  4. ncbi The molecular mechanism of ATP synthesis by F1F0-ATP synthase
    Alan E Senior
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Box 712, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1553:188-211. 2002
  5. ncbi In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone
    James A Dykens
    Drug Safety Research and Development, Pfizer, Inc, Sandwich CT139NJ, UK
    Toxicol Sci 103:335-45. 2008

Detail Information

Publications5

  1. ncbi Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays
    Sashi Nadanaciva
    MitoSciences Inc, 1850 Millrace Drive, Eugene, OR 97403, USA
    Toxicol In Vitro 21:902-11. 2007
    ..A major advantage of the immunocapture approach is that it can be used throughout drug screening from early compound evaluation to clinical trials...
  2. ncbi Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration
    Sashi Nadanaciva
    MitoSciences, Inc, 1850 Millrace Drive, Eugene, OR 97403, USA
    Toxicol Appl Pharmacol 223:277-87. 2007
    ..In several cases, the combination additively uncoupled or inhibited respiration, suggesting that some combinations are more likely to yield clinically relevant drug-induced mitochondrial side effects than others...
  3. ncbi Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis
    Sashi Nadanaciva
    MitoSciences Inc, Eugene, OR 97403, USA
    J Immunol Methods 343:1-12. 2009
    ..The assay has high reproducibility, requires small amounts of sample, is quantitative, and is able to identify drugs which ultimately lead to a decrease in mtDNA-encoded proteins...
  4. ncbi The molecular mechanism of ATP synthesis by F1F0-ATP synthase
    Alan E Senior
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Box 712, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1553:188-211. 2002
    ..In this review we summarize current state of knowledge and present a hypothesis for the molecular mechanism of ATP synthesis...
  5. ncbi In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone
    James A Dykens
    Drug Safety Research and Development, Pfizer, Inc, Sandwich CT139NJ, UK
    Toxicol Sci 103:335-45. 2008
    ..Our results suggest that the mitochondrial impairment imposed by nefazodone is profound and likely contributes to its hepatotoxicity, especially in patients cotreated with other drugs with mitochondrial liabilities...