Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effectsArunachalam Muthuraman
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India
BMC Complement Altern Med 11:24. 2011
..Present study investigated the attenuating role of Acorus calamus plant extract in chronic constriction injury (CCI) of sciatic nerve induced peripheral neuropathy in rats...
- Mitochondrial dependent apoptosis: ameliorative effect of flunarizine on ischemia-reperfusion of celiac artery-induced gastric lesions in the rat
Arunachalam Muthuraman
Rayat Institute of Pharmacy, Nawanshahr District, Near Railmajra, Ropar, 144533, Punjab, India
Dig Dis Sci 56:2244-51. 2011
..Mitochondrial permeability transition pore opening is the cause of apoptosis. In our present study, we tried to evaluate the role of flunarizine in ischemia and reperfusion of celiac artery-induced gastric lesion in the rat...
- Development of animal model for vasculatic neuropathy: Induction by ischemic-reperfusion in the rat femoral artery
Arunachalam Muthuraman
Rayat Institute of Pharmacy, Ropar Campus, Nawanshahr District, Railmajra, Near Ropar 144533, Punjab, India
J Neurosci Methods 186:215-21. 2010
..This model can be used to explore pathophysiological mechanisms implied in the genesis of neuropathic pain and also to evaluate the new analgesic agents, peripheral neuro-vasoactive substances and neuroprotective drugs...
- Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats
Arunachalam Muthuraman
Rayat Institute of Pharmacy, Ropar Campus, Nawanshahr District, Railmajra, Near Ropar 144533, Punjab, India
J Brachial Plex Peripher Nerve Inj 5:13. 2010
..Ischemia reperfusion (I/R) is common in various pathological conditions like diabetic complication, rheumatic arthritis, necrotizing vascular occlusive disease and trauma...
- The antiinflammatory potential of phenolic compounds from Emblica officinalis L. in rat
Arunachalam Muthuraman
Rayat Institute of Pharmacy, Nawanshahr District, Near Railmajra, Ropar, 144533, Punjab, India
Inflammopharmacology 19:327-34. 2011
..In conclusion, phenolic compounds of E. officinalis may serve as potential herbal candidate for amelioration of acute and chronic inflammation due to their modulatory action of free radicals...
- Reno-protective role of flunarizine (mitochondrial permeability transition pore inactivator) against gentamicin induced nephrotoxicity in rats
Arunachalam Muthuraman
Rayat Institute of Pharmacy, Ropar Campus, Nawanshahr District, Near Railmajra, Punjab, India
Yakugaku Zasshi 131:437-43. 2011
..The results of this study clearly revealed that flunarizine protected the kidney against the nephrotoxic effect of GEM via mitochondrial permeability transition pore (MPTP) inactivation potential...
- Ameliorative effect of flunarizine in cisplatin-induced acute renal failure via mitochondrial permeability transition pore inactivation in rats
Arunachalam Muthuraman
Rayat Institute of Pharmacy, Ropar Campus, Nawanshahr District, Near Railmajra, Ropar, 144533 Punjab, India
Naunyn Schmiedebergs Arch Pharmacol 383:57-64. 2011
..The results of this study clearly revealed that flunarizine protected the kidney against the nephrotoxic effect of cisplatin via mitochondrial permeability transition pore inactivation potential...
- Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and anti-oxidative activity
Arunachalam Muthuraman
Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India
Food Chem Toxicol 49:2557-63. 2011
..HAE-AC attenuated vincristine induced painful neuropathy, which may be attributed to its multiple effects including anti-oxidative, anti-inflammatory, and calcium inhibitory actions...
- Antisecretory, antioxidative and antiapoptotic effects of montelukast on pyloric ligation and water immersion stress induced peptic ulcer in rat
Arunachalam Muthuraman
Rayat Institute of Pharmacy, Nawanshahr District, Railmajra, Near Ropar, Punjab 144533, India
Prostaglandins Leukot Essent Fatty Acids 83:55-60. 2010
..Hence, the gastroprotective effect of montelukast may be attributed to its antisecretory, antioxidative along with its antiapoptotic effect...
- Role of 7,8-dimethoxycoumarin in anti-secretary and anti-inflammatory action on pyloric ligation-induced gastritis in rats
Shailja Sood
Rayat Institute of Pharmacy, Ropar, Punjab, India
J Asian Nat Prod Res 12:593-9. 2010
..Compound 7,8-DMC (100 mg/kg) showed ameliorative effect on gastric inflammation and may be used as a therapeutic agent in the treatment of gastritis...
- Activity of tacrolimus: an immunosuppressant, in pyloric ligation-induced peptic ulcer in the rat
Shailja Sood
Rayat Institute of Pharmacy, Nawanshahr District, Railmajra, Punjab, India
Yakugaku Zasshi 129:1523-8. 2009
..It can be concluded that tacrolimus can play an important role in the treatment of peptic ulcer disorder to improve the quality of life...
- Attenuating effect of hydroalcoholic extract of Acorus calamus in vincristine-induced painful neuropathy in rats
Arunachalam Muthuraman
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India
J Nat Med 65:480-7. 2011
..Acorus calamus prevented vincristine-induced neuropathic pain, which may be attributed to its anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory actions, among others...
- Ameliorative potential of montelukast on ischemia-reperfusion injury induced vasculitic neuropathic pain in rat
Arunachalam Muthuraman
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India Rayat institute of pharmacy, Ropar Campus, Nawanshahr District, Railmajra, Near Ropar 144533, Punjab, India
Life Sci 90:755-62. 2012
..The present study evaluated the effect of montelukast, a cysteinyl leukotriene receptor (Cys-LTC(4) and Cys-LTD(4)) antagonist on ischemia -reperfusion (I/R) induced vasculitic neuropathic pain in rats...
- Investigating the role of endogenous opioids and K(ATP) channels in glycerol-induced acute renal failure
Dharmraj Singh Sauriyal
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India
Fundam Clin Pharmacol 26:347-55. 2012
..It is concluded that hypertonic glycerol-induced rhabdomyolysis may involve release of endogenous opioids that in turn modulate K(ATP) channels to contribute in the pathogenesis of ARF...
- Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract
Shailja Sood
Rayat Institute of Pharmacy, Nawanshahr District, Punjab, India
Inflammopharmacology 17:267-74. 2009
..The Citrus decumana peel extract may be useful as a natural antioxidant in the treatment of inflammation and pain...
- Exploring the potential of flunarizine for Cisplatin-induced painful uremic neuropathy in rats
Arunachalam Muthuraman
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India
Int Neurourol J 15:127-34. 2011
..The present study was designed to explore the potential of flunarizine for cisplatin induced painful uremic neuropathy in rats...
