The limit fold change model: a practical approach for selecting differentially expressed genes from microarray dataDavid M Mutch
Metabolic and Genomic Regulation, Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
BMC Bioinformatics 3:17. 2002
..Systematic and global mathematical approaches that can be readily applied to a large number of experimental designs become fundamental to correctly handle the otherwise overwhelming data sets...
- Nutrigenomics and nutrigenetics: the emerging faces of nutrition
David M Mutch
Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
FASEB J 19:1602-16. 2005
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- Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice
David M Mutch
The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA 92037, USA
Genome Biol 8:R38. 2007
..Using an untargeted comprehensive metabolite profiling approach coupled with targeted gene expression analyses, the perturbed biochemistry and functional redundancy of PLSCR proteins was assessed...
- Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
David M Mutch
INSERM, Nutriomique U872 Team 7, Paris, France
Am J Clin Nutr 89:51-7. 2009
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- The disruption of hepatic cytochrome p450 reductase alters mouse lipid metabolism
David M Mutch
Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
J Proteome Res 6:3976-84. 2007
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- An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet
David M Mutch
, Vers-chez-les-Blanc, Lausanne, Switzerland
FASEB J 19:599-601. 2005
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- A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects
David M Mutch
INSERM, U, Nutriomique, Paris, France
Am J Clin Nutr 94:1399-409. 2011
..Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge...
- Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery
David M Mutch
Nutriomique U872 Team 7, Institut National de la Sante et de la Recherche Medicale, Paris, France
PLoS ONE 4:e7905. 2009
..To generate further insight into the numerous metabolic adaptations associated with RYGB surgery, we profiled serum metabolites before and after gastric bypass surgery and integrated metabolite changes with clinical data...
- Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression
Alvin Berger
Metabolic and Genomic Regulation, Nestle Research Center, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
Genome Biol 3:PREPRINT0004. 2002
..Novel hippocampal PUFA-molecular targets suggest that PUFA transcriptionally regulated genes with roles in appetite and learning...
- Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders
David M Mutch
INSERM, Nutriomique U872, Paris, France
PLoS ONE 2:e1344. 2007
..Therefore, we asked whether it is possible to identify subjects who will lose weight during dietary intervention using only a single gene expression snapshot...
- Unraveling the genetics of human obesity
David M Mutch
French National Institute of Health and Medical Research (INSERM) U755 Nutriomique, Paris, France
PLoS Genet 2:e188. 2006
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- Regional variations in ABC transporter expression along the mouse intestinal tract
David M Mutch
, CH-1000 Lausanne 26, Switzerland
Physiol Genomics 17:11-20. 2004
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- Genetics of human obesity
David M Mutch
INSERM, U755 Nutriomique, 75004 Paris, France
Best Pract Res Clin Endocrinol Metab 20:647-64. 2006
..It is now necessary to integrate data of various origins (environment, genotype, expression) to clarify this field...
- Impact of commensal microbiota on murine gastrointestinal tract gene ontologies
David M Mutch
, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
Physiol Genomics 19:22-31. 2004
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- The Global Error Assessment (GEA) model for the selection of differentially expressed genes in microarray data
Robert Mansourian
, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
Bioinformatics 20:2726-37. 2004
..AVAILABILITY: The GEA code for R software is freely available upon request to authors...
- Putting the 'Ome' in lipid metabolism
David M Mutch
, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
Biotechnol Annu Rev 12:67-84. 2006
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- Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver
David M Mutch
Nutrient Bioavailability, Nestlé Research Center Vers Chez Les Blanc, Lausanne 26, Switzerland
Am J Physiol Gastrointest Liver Physiol 291:G63-72. 2006
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- Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes
Pascale Anderle
ISREC, Swiss Institute for Experimental Cancer Research, 1066 Epalinges s Lausanne, Switzerland
BMC Genomics 6:69. 2005
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