Complementary aspects of diffusion imaging and fMRI; I: structure and functionRobert V Mulkern
Department of Radiology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Imaging 24:463-74. 2006
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- Magnetization transfer studies of the fast and slow tissue water diffusion components in the human brain
Robert V Mulkern
Department of Radiology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
NMR Biomed 18:186-94. 2005
..The conclusions do not lend support to a direct interpretation of the 'components' of the biexponential diffusion decay in terms of the 'compartments' associated with intra- and extracellular water...
- On the strong field dependence and nonlinear response to gadolinium contrast agent of proton transverse relaxation rates in dairy cream
Robert V Mulkern
Department of Radiology, Children s Hospital, Boston, MA 02468, USA
Magn Reson Imaging 23:757-64. 2005
..7 T provided experimental parameters from which model parameters are extracted and compared with expectations available from the literature...
- Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men: a 1H spectroscopic imaging study
Robert V Mulkern
Department of Radiology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Med 52:552-8. 2004
..Proton spectroscopic studies of vertebral marrow revealed differences between non-HIV- and HIV-infected men that may prove useful for studying the effects of this disease and/or antiretroviral agents on body composition...
- Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model
Yanping Sun
Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
NMR Biomed 17:399-404. 2004
..64 +/- 0.06 s. The mean T(2) in tumor was 0.062 +/- 0.002 s and in normal brain tissue was 0.048 +/- 0.001 s. The mean ADC, T1 and T2 of the tumor compared to normal tissue were significantly different (p < 0.005)...
- Fast spectroscopic imaging strategies for potential applications in fMRI
Robert V Mulkern
Department of Radiology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Imaging 22:1395-405. 2004
..Fast spectroscopic methods directed towards the 31P signals from phosphocreatine (PCr) and adenosine tri-phosphates (ATP) are also technically feasible and may prove useful for studying cerebral energetics within fMRI contexts...
- Biexponential characterization of prostate tissue water diffusion decay curves over an extended b-factor range
Robert V Mulkern
Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
Magn Reson Imaging 24:563-8. 2006
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- Multi-contrast high spatial resolution black blood inner volume three-dimensional fast spin echo MR imaging in peripheral vein bypass grafts
Frank J Rybicki
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women s Hospital, Boston, MA, USA
Int J Cardiovasc Imaging 26:683-91. 2010
..Vessel wall area differences suggest that LE-PVBG vessel wall tissues produce distinct signal characteristics under T1 and T2 MR contrast weightings...
- In vivo differentiation of two vessel wall layers in lower extremity peripheral vein bypass grafts: application of high-resolution inner-volume black blood 3D FSE
Dimitris Mitsouras
Department of Radiology, Applied Imaging Science Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Magn Reson Med 62:607-15. 2009
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- Carr-Purcell-Meiboom-Gill imaging of prostate cancer: quantitative T2 values for cancer discrimination
Joseph R Roebuck
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Imaging 27:497-502. 2009
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- Regional brain development in serial magnetic resonance imaging of low-risk preterm infants
Andrea U J Mewes
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Massachusetts 02115, USA
Pediatrics 118:23-33. 2006
..In this study, we investigated serial MRI of low-risk preterm infants with the aim to identify regions of altered brain development...
- Complimentary aspects of diffusion imaging and fMRI: II. Elucidating contributions to the fMRI signal with diffusion sensitization
Robert V Mulkern
Department of Radiology, Children s Hospital, Boston, MA 02115, USA
Magn Reson Imaging 25:939-52. 2007
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- An empirical investigation of motion effects in eMRI of interictal epileptiform spikes
Padmavathi Sundaram
Department of Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Imaging 29:1401-9. 2011
..These findings make bulk head motion an unlikely generator of the large spike-related MR signal changes that we had observed. Further work is required to precisely identify the underlying mechanisms...
- Erratum: Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model
Yanping Sun
Department of Radiology, Brigham and Women s Hospital, Boston, MA, USA
NMR Biomed 23:218. 2010
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- Immobilization of iron oxide magnetic nanoparticles for enhancement of vessel wall magnetic resonance imaging--an ex vivo feasibility study
Binh Thai Nguyen
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard MIT Division of Heath Sciences and Technology, 65 Landsdowne Street, Cambridge, MA 02139, USA
Bioconjug Chem 21:1408-12. 2010
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- Fast, exact k-space sample density compensation for trajectories composed of rotationally symmetric segments, and the SNR-optimized image reconstruction from non-Cartesian samples
Dimitris Mitsouras
Cardiovascular Imaging Section, Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Magn Reson Med 60:339-49. 2008
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- PSF-choice: a novel MRI method for shaping point-spread functions in phase-encoding dimensions
Lawrence P Panych
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Magn Reson Med 54:159-68. 2005
..In the sense that the same number of encodes are required as with standard phase encoding, temporal resolution is also maintained. Phantom experiments demonstrate the initial feasibility of the method to eliminate ringing artifact...
- Temperature mapping considerations in the breast with line scan echo planar spectroscopic imaging
Nathan Mcdannold
Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Magn Reson Med 58:1117-23. 2007
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- High-resolution peripheral vein bypass graft wall studies using high sampling efficiency inner volume 3D FSE
Dimitris Mitsouras
Cardiovascular Imaging Section, Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Magn Reson Med 59:650-4. 2008
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- On high b diffusion imaging in the human brain: ruminations and experimental insights
Robert V Mulkern
Department of Radiology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Imaging 27:1151-62. 2009
..g.,"ruminations," which have been proposed to account for the nonmonoexponentiality to date...
- Strategies for inner volume 3D fast spin echo magnetic resonance imaging using nonselective refocusing radio frequency pulses
Dimitris Mitsouras
Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Med Phys 33:173-86. 2006
..We conclude that the SNR efficiency of volume imaging in conjunction with the short echo spacing afforded by hard pulse trains enables high-resolution 3D HPFSE MRI of a small field-of-view (FOV) with minimal aliasing artifact...
- Biexponential parameterization of diffusion and T2 relaxation decay curves in a rat muscle edema model: decay curve components and water compartments
Zaid Ababneh
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Med 54:524-31. 2005
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- Immobilized contrast-enhanced MRI: Gadolinium-based long-term MR contrast enhancement of the vein graft vessel wall
Dimitris Mitsouras
Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Magn Reson Med 65:176-83. 2011
..Signal enhancement due to the covalently immobilized contrast agent is demonstrated for excised human vein specimens imaged at 3 T, and its long-term stability is demonstrated during a 4-month incubation period...
- Magnetic resonance-guided prostate interventions
Steven J Haker
Department of Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Top Magn Reson Imaging 16:355-68. 2005
..We describe current developments with a robot assist system being developed to aid radioactive seed placement...
- Age-related vascular changes in the epiphysis, physis, and metaphysis: normal findings on gadolinium-enhanced MRI of piglets
Diego Jaramillo
Department of Radiology, Harvard Medical School and Massachusetts General Hospital, 32 Fruit St, Boston, MA 02114, USA
AJR Am J Roentgenol 182:353-60. 2004
..With maturity and progressive epiphyseal ossification, epiphyseal cartilage enhancement decreased, and physeal cartilage enhancement increased...
- Volumetric MRI study of brain in children with intrauterine exposure to cocaine, alcohol, tobacco, and marijuana
Michael J Rivkin
Developmental Neuroimaging Laboratory, Department of Neurology, Childrens Hospital Boston and Harvard Medical School, Pavilion 154, 300 Longwood Ave, Boston, MA 02115, USA
Pediatrics 121:741-50. 2008
..The objective of this study was to use volumetric MRI to study brain volumes in 10- to 14-year-old children with and without intrauterine exposure to cocaine, alcohol, cigarettes, or marijuana...
- Biexponential diffusion tensor analysis of human brain diffusion data
Stephan E Maier
Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Magn Reson Med 51:321-30. 2004
..The second and third diffusion eigenvector directions also appeared to be aligned, but they exhibited significant deviations in localized areas...
- Basis function cross-correlations for robust k-space sample density compensation, with application to the design of radiofrequency excitations
Dimitris Mitsouras
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Magn Reson Med 57:338-52. 2007
..For typical RF excitation durations (<20 ms) it is shown that density compensation can even be achieved without numerical iteration...
- Biexponential analysis of diffusion-related signal decay in normal human cortical and deep gray matter
Stephan E Maier
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Magn Reson Imaging 26:897-904. 2008
..The relative component size showed nonsignificant differences among all tissues investigated. Cellular architecture in GM and WM are fundamentally different and may explain the two- to threefold higher slow diffusion coefficient in GM...
- A paradoxical signal intensity increase in fatty livers using opposed-phase gradient echo imaging with fat-suppression pulses
Robert V Mulkern
Department of Radiology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Pediatr Radiol 38:1099-104. 2008
..The result is a paradoxical increase in signal from fatty liver that will depend on both fat content and the relative longitudinal relaxation times of fat methylene protons and water...
- Detection of prostate cancer by integration of line-scan diffusion, T2-mapping and T2-weighted magnetic resonance imaging; a multichannel statistical classifier
Ian Chan
Surgical Planning Laboratory, Department of Radiology, Division of MRI, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Med Phys 30:2390-8. 2003
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- Normal and ischemic epiphysis of the femur: diffusion MR imaging study in piglets
Diego Jaramillo
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit St, Boston, MA 02114, USA
Radiology 227:825-32. 2003
..To evaluate normal diffusion characteristics in the femur in piglets and changes in diffusion with increasing duration of femoral head ischemia...
- Diffusion imaging of brain tumors
Stephan E Maier
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
NMR Biomed 23:849-64. 2010
..More advanced methods require improvement in acquisition speed and spatial resolution to gain clinical acceptance...
- Reduced intravertebral bone marrow fat in HIV-infected men
Jeannie S Huang
Massachusetts General Hospital, Neuroendocrine Unit, Boston, MA 02114, USA
AIDS 16:1265-9. 2002
..Further studies are necessary to determine the relationship between marrow fat and osteopenia and the effect of antiretroviral therapy on marrow fat in this population...
- Spatially selective T2 and T2 * measurement with line-scan echo-planar spectroscopic imaging
Nan kuei Chen
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Magn Reson 171:90-6. 2004
..The proposed spatially selective T2 and T2* mapping technique is especially well suited for studies, where T2/T2* quantification needs to be performed dynamically in a pre-selected 2D or 3D region...
- Magnetic resonance imaging of iron deposition in neurological disorders
Steven D Brass
Center for Neurological Imaging, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Top Magn Reson Imaging 17:31-40. 2006
..The potential role of iron deposition and its assessment by MRI provides exciting potential applications to the diagnosis, longitudinal monitoring, and therapeutic development for disorders of the brain...
- Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model
Jonathan A Meisel
Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Boston, MA 02115, USA
J Pediatr Surg 46:666-73. 2011
..There is mounting evidence that fish oil-based emulsions may prevent this liver injury. This study compares 5 emulsions with different fat compositions and their effect on hepatic steatosis, one of the first hits in PNALD...
- A functional magnetic resonance imaging study of paced finger tapping in children
Michael J Rivkin
Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
Pediatr Neurol 28:89-95. 2003
..Posterior superior temporal gyrus may be important for encoding auditory information, and presupplementary motor area and midline cerebellum play an important role in self-paced finger tapping...
- Bone marrow changes in adolescent girls with anorexia nervosa
Kirsten Ecklund
Department of Radiology, Children s Hospital Boston, Boston, MA, USA
J Bone Miner Res 25:298-304. 2010
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- Magnetic resonance spectroscopy-guided transperineal prostate biopsy and brachytherapy for recurrent prostate cancer
Agnieszka Szot Barnes
Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Urology 66:1319. 2005
..We propose that MRI/MRS can help detect recurrent prostate cancer, guide prostate biopsy, and help manage salvage treatment decisions...
- Characterization of normal brain and brain tumor pathology by chisquares parameter maps of diffusion-weighted image data
Stephan E Maier
Department of Radiology MRI, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Eur J Radiol 45:199-207. 2003
..To characterize normal and pathologic brain tissue by quantifying the deviation of diffusion-related signal from a simple monoexponential decay, when measured over a wider than usual range of b-factors...
- Fast human brain magnetic resonance responses associated with epileptiform spikes
Padmavathi Sundaram
Department of Radiology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Magn Reson Med 64:1728-38. 2010
..Potential extension of this technique into a general purpose functional neuroimaging tool requires further study of the MR signal changes accompanying lower amplitude neuronal activity than those discussed here...
- Magnetic resonance relaxivity of dendrimer-linked nitroxides
Carl S Winalski
Department of Radiology and Cartilage Repair Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Magn Reson Med 48:965-72. 2002
..From these results, it is evident that target-specific dendrimer-linked nitroxides can be designed...
- The route of lipid administration affects parenteral nutrition-induced hepatic steatosis in a mouse model
Patrick J Javid
Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 40:1446-53. 2005
..CONCLUSIONS: These data provide preliminary evidence that lipid administered through the enteral route protects against PN-associated hepatic injury in an animal model...
- Early experience alters brain function and structure
Heidelise Als
Department of Psychiatry, Harvard Medical School and Children s Hospital Boston, Pediatric Research Laboratories, Boston, Massachusetts 02115, USA
Pediatrics 113:846-57. 2004
..To investigate the effects of early experience on brain function and structure...
- Establishment and results of a magnetic resonance quality assurance program for the pediatric brain tumor consortium
Robert V Mulkern
Department of Radiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Acad Radiol 15:1099-110. 2008
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- Lower extremity peripheral vein bypass graft wall thickness changes demonstrated at 1 and 6 months after surgery with ultra-high spatial resolution black blood inner volume three-dimensional fast spin echo magnetic resonance imaging
Frank John Rybicki
Department of Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Int J Cardiovasc Imaging 24:529-33. 2008
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- Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning
Marc G Weisskopf
Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Landmark Center, 401 Park Drive, PO Box 15697, Boston, MA 02215, USA
Environ Health Perspect 112:620-5. 2004
..Nevertheless, the results point to the potential utility of MRS in determining mechanisms of neurotoxicity not only for lead but also for other neurotoxicants as well...
- Activation of peripheral excitatory amino acid receptors decreases the duration of local anesthesia
Brian E Cairns
Department of Anesthesia, Harvard Medical School Children s Hospital, Boston, Massachusetts 02115, USA
Anesthesiology 98:521-9. 2003
..One possible mechanism for this effect is that increased glutamate concentrations, caused by tissue damage, sensitize nociceptive primary afferent fibers through activation of peripheral excitatory amino acid receptors...
- Iatrogenic hyperthermia during cardiac magnetic resonance imaging
Barry D Kussman
Department of Anesthesiology, Perioperative and Pain Medicine, Children s Hospital, Boston, MA 02115, USA
Anesth Analg 99:1053-5, table of contents. 2004
..In addition to stressing the clinical importance of temperature monitoring, this report suggests that the recommended specific absorption rates to prevent excessive patient heating may need to be revised for infants and young children...
- Perfusion MRI of U87 brain tumors in a mouse model
Yanping Sun
Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Magn Reson Med 51:893-9. 2004
..The large difference in ICBF between the tumor core and normal tissue suggests that this index might be useful for the assessment of the efficacy of antiangiogenic therapy...
- Double inversion black-blood fast spin-echo imaging of the human heart: a comparison between 1.5T and 3.0T
Robert L Greenman
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
J Magn Reson Imaging 17:648-55. 2003
..To evaluate the effectiveness of blood suppression and the quality of black-blood cardiac images acquired at 3.0 Tesla using a double-inversion recovery fast spin-echo sequence by comparing data acquired at 3.0T to data acquired at 1.5T...
- Comments on T2 measurements of prostate tissue
Robert V Mulkern
Radiology 232:624-5; author reply 625-6. 2004
- Feasibility of internally referenced brain temperature imaging with a metabolite signal
Kagayaki Kuroda
Department of Image Based Medicine, Institute of Biomedical Research and Innovation, Kobe, Japan
Magn Reson Med Sci 2:17-22. 2003
..5 cm3 and 4.5 min. A higher signal-to-noise ratio and optimization of the water and outer-volume suppression capabilities will be required to further enhance the temperature-mapping capabilities...
- Comments on ultrahigh field 31P ATP T2 values
Robert V Mulkern
Magn Reson Med 50:654-5; author reply 656-8. 2003
- In re: characterization of benign and metastatic vertebral compression fractures with quantitative diffusion MR imaging
Robert V Mulkern
AJNR Am J Neuroradiol 24:1489-90; author reply 1490-1. 2003
- Detection of fetal lactate with two-dimensional-localized proton magnetic resonance spectroscopy
Julian N Robinson
Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York, USA
Obstet Gynecol 104:1208-10. 2004
..Antenatal surveillance is inefficient for accurately detecting fetal compromise. A noninvasive technique for assessing fetal metabolic status would be useful for clinical management...
