Spinal radiosurgery--efficacy and safety after prior conventional radiotherapyKatharina Nikolajek
Department of Radiation Oncology, Ludwig Maximilians University, Campus Grosshadern, Marchioninistr, 15, 81377 Munchen, Germany
Radiat Oncol 6:173. 2011
..Nevertheless, spinal radiosurgery results in relevant dose deposition within the myelon with potential toxicity. Aim of the study was to retrospectively analyse the efficacy and feasibility for salvage radiosurgery of spinal metastases...
- Development of a streamlined, non-invasive robotic radiosurgery method for treatment of uveal melanoma
Alexander Muacevic
European CyberKnife Center Munich, Max Lebsche Platz 31, 81377 Munich, Germany
Technol Cancer Res Treat 7:369-74. 2008
..Longer follow-up and analysis of a larger patient series is required for definitive clinical recommendations...
- Feasibility, safety, and outcome of frameless image-guided robotic radiosurgery for brain metastases
Alexander Muacevic
Cyberknife Center Munich Grosshadern, Max Lebsche Platz 31, 81377, Munich, Germany
J Neurooncol 97:267-74. 2010
..There seems to be no difference in patient selection, adverse effects, treatment outcomes, or system accuracy compared with frame-based SRS...
- Fiducial-free real-time image-guided robotic radiosurgery for tumors of the sacrum/pelvis
Alexander Muacevic
European CyberKnife Center Munich, Munich, Germany
Radiother Oncol 93:37-44. 2009
..We present preliminary clinical results and phantom accuracy measurements of sacral radiosurgery using fiducial-free alignment based on vertebral anatomy distant to tumor location...
- Technical description, phantom accuracy, and clinical feasibility for fiducial-free frameless real-time image-guided spinal radiosurgery
Alexander Muacevic
European CyberKnife Center Munich, Germany
J Neurosurg Spine 5:303-12. 2006
....
- Technical description, phantom accuracy, and clinical feasibility for single-session lung radiosurgery using robotic image-guided real-time respiratory tumor tracking
A Muacevic
European Cyberknife Center, Munich Grosshadern, Munich, Germany
Technol Cancer Res Treat 6:321-8. 2007
..Longer follow-up is needed for definitive clinical results...
- Advances in fiducial-free image-guidance for spinal radiosurgery with CyberKnife--a phantom study
Christoph Fürweger
European CyberKnife Center Munich, Munich, Germany
J Appl Clin Med Phys 12:3446. 2011
..Enhanced Xsight spine tracking measurably improves precision in fiducial-free spinal radiosurgery with the CyberKnife...
- Simultaneous anti-angiogenic therapy and single-fraction radiosurgery in clinically relevant metastases from renal cell carcinoma
Michael Staehler
Department of Urology, University of Munich, Klinikum Grosshadern, Munich, Germany
BJU Int 108:673-8. 2011
..To analyse the safety and efficacy of simultaneous standard anti-angiogenic therapy and stereotactic radiosurgery (SRS) in patients with spinal and cerebral metastases from renal cell carcinoma...
- CyberKnife radiosurgery for malignant spinal tumors: characterization of well-suited patients
Berndt Wowra
European CyberKnife Center Munich, Max Lebsche Platz, Munich, Germany
Spine (Phila Pa 1976) 33:2929-34. 2008
..A prospective interventional case-series study...
- Patient motion and targeting accuracy in robotic spinal radiosurgery: 260 single-fraction fiducial-free cases
Christoph Fürweger
European Cyberknife Center, Munich, Germany
Int J Radiat Oncol Biol Phys 78:937-45. 2010
..To evaluate clinical targeting precision and assess patient movement data during fiducial-free, single-fraction spinal radiosurgery with the Cyberknife (CK)...
- Stereotactic radiosurgery for multiple brain metastases from breast carcinoma
Alexander Muacevic
Department of Neurosurgery, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
Cancer 100:1705-11. 2004
..The current study analyzed the feasibility and outcome of stereotactic radiosurgery (SRS) for treatment of brain metastases from breast carcinoma...
- CyberKnife radiosurgery for brain metastases
Berndt Wowra
European Cyberknife Center Munich Grosshadern, University of Munich, Munich, Germany
Prog Neurol Surg 25:201-9. 2012
..It adds to the oncological armamentarium and confers upon radiosurgery a greater emphasis as an oncological treatment concept...
- Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience
Berndt Wowra
Gamma Knife Center Munik, and Department of Neurosurgery and Ear, Nose, and Throat Surgery, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
J Neurosurg 102:114-8. 2005
..The purpose of the study was to define the therapeutic profile of outpatient gamma knife surgery (GKS) for vestibular schwannoma (VS) by using sequential tumor volumetry to quantify changes following treatment...
- Long term course of WHO grade II astrocytomas of the Insula of Reil after I-125 interstitial irradiation
Jan H Mehrkens
Neurochirurgische Klinik, Klinikum Grosshadern, , , Marchioninistr. 15, 81377, , Germany
J Neurol 251:1455-64. 2004
..Interstitial I-125 irradiation offers a minimal-invasive and low-risk treatment option for circumscribed tumors with a diameter < 3.5 cm. Larger tumors require further evaluation for optimal treatment...
- Radiosurgery of liver tumors: value of robotic radiosurgical device to treat liver tumors
Sebastian Stintzing
Department of Hematology and Oncology, University Hospital Grosshadern, LMU Munich, Munich, Germany
Ann Surg Oncol 17:2877-83. 2010
..Here we present the therapeutic efficacy of a robotic radiosurgery for local control of liver metastases from solid tumors...
- Obliteration dynamics in cerebral arteriovenous malformations after cyberknife radiosurgery: quantification with sequential nidus volumetry and 3-tesla 3-dimensional time-of-flight magnetic resonance angiography
Berndt Wowra
European Cyberknife Center, Munich Grosshadern, Munich, Germany
Neurosurgery 64:A102-9. 2009
..Sunnyvale, CA) by means of sequential 3-T, 3-dimensional (3D), time-of-flight (TOF) magnetic resonance angiography (MRA), and volumetry of the arteriovenous malformation (AVM) nidus...
- Quality of radiosurgery for single brain metastases with respect to treatment technology: a matched-pair analysis
Berndt Wowra
European CyberKnife Center Munich, Max Lebsche Platz 31, Munich 81377, Germany
J Neurooncol 94:69-77. 2009
..A comparison of treatment parameters and quality of clinical outcome in patients with single brain metastases treated with two different technologies for radiosurgery (Gamma Knife and CyberKnife)...
- [Cyberknife radiosurgery: a new treatment method for image-guided and robot-assisted precision radiation]
Alexander Muacevic
,
MMW Fortschr Med 149:42-3. 2007
- Radiosurgery for spinal malignant tumors
Berndt Wowra
Europäisches CyberKnife Zentrum München Grosshadern, Munchen, Germany
Dtsch Arztebl Int 106:106-12. 2009
..A broad base of scientific evidence already exists for the radiosurgical treatment of brain metastases. Recent advances in medical technology now allow radiosurgery to be extended to the spine as well...
- Repeated gamma knife surgery for multiple brain metastases from renal cell carcinoma
Berndt Wowra
Gamma Knife Praxis, Department of Urology, Ludwig Maximilians Universily, Munich, Germany
J Neurosurg 97:785-93. 2002
..The aim of this study was to evaluate the therapeutic profile of repeated gamma knife surgery (GKS) for renal cell carcinoma that has metastasized to the brain on multiple occasions...
- Frameless single-session robotic radiosurgery of liver metastases in colorectal cancer patients
S Stintzing
Department of Hematology and Oncology, University Hospital Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Eur J Cancer 46:1026-32. 2010
..Less invasive techniques have been invented to enhance local disease control. We investigated in a selected patient cohort local control of liver metastasis from CRC using robotic radiosurgery...
- Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI
Indra Yousry
Department of Neuroradiology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
Eur Radiol 14:1169-73. 2004
....
- Combined surgical and radiosurgical treatment of symptomatic aggressive vertebral osteomyelitis
S Zausinger
Department of Neurosurgery, Ludwig Maximilians University, Munich, Germany
Minim Invasive Neurosurg 53:80-2. 2010
..We report a case of combined surgical and radiosurgical treatment of idiopathic vertebral osteomyelitis of L4...
- Special indications in gamma knife surgery
B Wowra
German Gamma Knife Centre Munich, Munich, Germany
Acta Neurochir Suppl 91:89-102. 2004
..The outcome after GKS was much more favourable for typical PA than for atypical. In typical cases a high tumor control with a very low risk of side effects can be achieved...
- Accuracy and clinical applicability of a passive marker based frameless neuronavigation system
A Muacevic
Department of Neurosurgery, Klinikum Grobetahadern, Ludwig Maximilians University Munich, Munich, Germany
J Clin Neurosci 7:414-8. 2000
..The passive marker technology is intuitive and enables the surgeon to use his or her own instruments at any time as a pointing device, thus avoiding further costs for specially designed surgical equipment...
- The risk of haemorrhage after image guided stereotactic biopsy of intra-axial brain tumours--a prospective study
F W Kreth
Department of Neurosurgery, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
Acta Neurochir (Wien) 143:539-45; discussion 545-6. 2001
....
- Stereotactic radiosurgery without radiation therapy providing high local tumor control of multiple brain metastases from renal cell carcinoma
A Muacevic
Department of Neurosurgery, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
Minim Invasive Neurosurg 47:203-8. 2004
..5 %) died because of intratumoral bleedings after SRS. Stereotactic radiosurgery alone achieves excellent local tumor control rates for patients with small brain metastases from renal cell carcinoma...
- Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter
A Muacevic
Department of Neurosurgery, Ludwig Maximilians University, Klinikum Grosshadern, and Gamma Knife Center, Munich, Germany
J Neurosurg 91:35-43. 1999
....
- Functional outcome after gamma knife treatment in vestibular schwannoma
J M Hempel
Department of ENT, Head and Neck Surgery, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Eur Arch Otorhinolaryngol 263:714-8. 2006
..It is associated with a lower rate of facial and trigeminal neuropathy, postoperative complications and hospital stay. The hearing preservation rate is equivalent to MS...
- Clinical quality standards for gamma knife radiosurgery--the Munich protocol
A Muacevic
German Gamma Knife Center Munich, Ludwig Maximilians University Munich, Munich, Germany
Acta Neurochir Suppl 91:25-32. 2004
..The results of the Munich concept in consideration of the described quality standards verifies that gamma knife radiosurgery is a safe and effective treatment option for well selected indications...
- Gamma knife radiosurgery for nonfunctioning pituitary adenomas
A Muacevic
German Gamma Knife Center Munich, Ludwig Maximilians University, Munich, Germany
Acta Neurochir Suppl 91:51-4. 2004
..Postoperative GKS for residual or recurrent small fragments of NPAs is an effective and safe treatment option. The follow-up examination for NPAs should include tumor volumetric analysis...
- Results of outpatient gamma knife radiosurgery for primary therapy of acoustic neuromas
A Muacevic
German Gamma Knife Center Munich, Ludwig Maximilians University, Munich, Germany
Acta Neurochir Suppl 91:75-8. 2004
..Outpatient gamma knife radiosurgery is a safe and effective treatment method for selected patients with sporadic vestibular schwannomas...
- 3T MRI evaluation of the accuracy of atlas-based subthalamic nucleus identification
Joseph Stancanello
Imaging Laboratory, Bracco Imaging, 10010 Colleretto Giacosa, TO, Italy
Med Phys 35:3069-77. 2008
..Automatic atlas-based STN localization provides an accurate and user-friendly tool and can enhance target identification when 1.5 T scanners with limited capability to identify the STN boundaries are used...
- Treatment of brain metastases in renal cell carcinoma: radiotherapy, radiosurgery, or surgery?
Alexander Muacevic
Gamma Knife Praxis, , 80939 Munich, Germany
World J Urol 23:180-4. 2005
..Radiosurgery appears attractive due to its low risk and minimal invasiveness. Multiple lesions can be treated at the same time and retreatments can be performed for local or distant recurrences...
- Safety and efficacy of outpatient gamma knife radiosurgery for multiple cerebral metastases
Berndt Wowra
Gamma Knife Center, Ingolstädter Str 166, D 80939 München, Germany
Expert Rev Neurother 4:673-9. 2004
..Most importantly, the number of brain metastases had no prognostic impact in patients with non-small cell lung cancer, renal cell cancer, malignant melanoma and gastrointestinal cancer...
- Multisession CyberKnife radiosurgery for optic nerve sheath meningiomas
Pantaleo Romanelli
Functional Neurosurgery, IRCCS Neuromed, Pozzilli, Italy
Neurosurg Focus 23:E11. 2007
..In the present report the authors review the clinical presentation and management of ONSMs and describe their preliminary experience using multisession radiosurgery to treat these lesions...
- Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial
Alexander Muacevic
Department of Neurosurgery, Ludwig Maximilians University, Klinikum Grosshadern, Munich 81377, Germany
J Neurooncol 87:299-307. 2008
..Is Gamma Knife surgery alone as effective as surgery plus whole brain irradiation (WBRT) for patients with a single, small-sized brain metastasis?..
- Radiosurgery for hypothalamic hamartomas
Pantaleo Romanelli
Functional Neurosurgery, IRCCS Neuromed, Pozzilli, Italy
Neurosurg Focus 24:E9. 2008
..Radiosurgery is an emerging treatment modality for HHs, which provides excellent seizure outcomes and no lasting complications to date...
- Direct validation of atlas-based red nucleus identification for functional radiosurgery
Joseph Stancanello
Imaging Laboratory, Bracco Imaging, Colleretto Giacosa, Torino, Italy
Med Phys 34:3143-8. 2007
..These results not only confirm the accuracy of the method but also allow fine tuning of the automatic identification method to be performed...
