Alkaloidal constituents of Mucuna pruriens seedsLaxminarain Misra
Phytochemistry Division, Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226 015, India
Phytochemistry 65:2565-7. 2004
..DC. after chemical analysis afforded four tetrahydroisoquinoline alkaloids which have been isolated for the first time from M. pruriens. Out of them, two are new whose structures have been elucidated by spectroscopic methods...
- Unusually sulfated and oxygenated steroids from Withania somnifera
Laxminarain Misra
Central Institute of Medicinal and Aromatic Plants, P O CIMAP, Lucknow, UP 226 015, India
Phytochemistry 66:2702-7. 2005
..Compound 8 did not have usual 2,3 unsaturation in A ring while 1 had the rare C-16 double bond. The structures of all the compounds were elucidated by spectroscopic methods and chemical transformation...
- 1,4-Dioxane and ergosterol derivatives from Withania somnifera roots
Laxminarain Misra
Central Institute of Medicinal and Aromatic Plants, P O CIMAP, Lucknow 226015, India
J Asian Nat Prod Res 14:39-45. 2012
..somnifera. The structures of new compounds were elucidated by spectroscopic methods and chemical transformations...
- Extraction of bioactive principles from Mucuna pruriens seeds
Laxminarain Misra
Central Institute of Medicinal and Aromatic Plants, Lucknow, India
Indian J Biochem Biophys 44:56-60. 2007
..5 microg) against DPPH radicals. MWEL-1299 also exhibited encouraging results against 1-methyl-4-phenylpyridinium ion (MPP+) toxicity. The TLC fingerprinting may be used to authenticate the plant material in herbal industry...
- Withanolides from Withania somnifera roots
Laxminarain Misra
Central Institute of Medicinal and Aromatic Plants, P O CIMAP, Lucknow 226015, India
Phytochemistry 69:1000-4. 2008
..The structures were elucidated by spectroscopic methods and chemical transformations...
- Selective reactivity of 2-mercaptoethanol with 5beta,6beta-epoxide in steroids from Withania somnifera
Laxminarain Misra
Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow, India
Steroids 73:245-51. 2008
..The anticancer activity of withaferin A was lost in the reaction product indicating that its activity is also linked to the free 5beta,6beta-epoxide functional group...
- Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection
Narayan Das Chaurasiya
Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226015, India
Phytochem Anal 19:148-54. 2008
..The developed method has been applied to the analysis of leaf and root tissues of Withania somnifera for withanolide content...
- Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera)
Rajender Singh Sangwan
Central Institute of Medicinal and Aromatic Plants CSIR, PO CIMAP, Lucknow 226015, India
Physiol Plant 133:278-87. 2008
..Therefore, withanolides are synthesized in different parts of the plant (through operation of the complete metabolic pathway) rather than imported...
- Withanolide A biogeneration in in vitro shoot cultures of ashwagandha (Withania somnifera DUNAL), a main medicinal plant in Ayurveda
Rajender Singh Sangwan
Central Institute of Medicinal and Aromatic Plants, Lucknow, India
Chem Pharm Bull (Tokyo) 55:1371-5. 2007
..As this compound is a predominant withanolide of native shoots as well and has been already reported to be accumulated in in vitro shoot cultures, its biogeneration observed in these shoot cultures is not discussed in detail...
