Research Topics
Species | Julio SoteloSummaryCountry: Mexico Publications
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Publications
Could an aminoacridine interfere with the cellular mechanisms involved in the process of human immunodeficiency virus infection?J Sotelo
National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico
Med Hypotheses 47:43-7. 1996..Theoretically, these actions within the cell and other peculiar pharmacological characteristics of aminoacridines, particularly quinacrine, could pose barriers to human immunodeficiency virus infection and replication...- Ventriculoperitoneal shunt of continuous flow vs valvular shunt for treatment of hydrocephalus in adultsJulio Sotelo
Divisions of Research and Neurosurgery, National Institute of Neurology and Neurosurgery of Mexico, CP 14269 Mexico City, Mexico
Surg Neurol 63:197-203; discussion 203. 2005..Here, we show the long-term performance of the SCF in adult patients with hydrocephalus secondary to a comprehensive variety of neurological disorders... - Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trialJulio Sotelo
National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico
Ann Intern Med 144:337-43. 2006..Preliminary studies suggest that adding chloroquine to conventional therapy may improve treatment outcomes... - Regulation of clinical research sponsored by pharmaceutical companies: a proposalJulio Sotelo
National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico
PLoS Med 3:e306. 2006 - [The general physician, essential actor in the medicine of the future]Julio Sotelo
Gac Med Mex 140:357-61. 2004 - Varicella-zoster virus at relapses of multiple sclerosisJulio Sotelo
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, 14269 Mexico City, Mexico
J Neurol 254:493-500. 2007.... - On the viral hypothesis of multiple sclerosis: participation of varicella-zoster virusJulio Sotelo
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
J Neurol Sci 262:113-6. 2007..If confirmed, complex issues of individual susceptibility and immunopathogenesis would have to be unveiled... - Varicella-zoster virus in cerebrospinal fluid at relapses of multiple sclerosisJulio Sotelo
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery, Center for Research and Advanced Studies, Mexico City, Mexico
Ann Neurol 63:303-11. 2008..Recent studies in peripheral blood mononuclear cells (PBMCs) have indicated that exacerbations of multiple sclerosis (MS) could be associated with the reactivation of latent varicella-zoster virus (VZV)... - The antimalarials quinacrine and chloroquine potentiate the transplacental carcinogenic effect of ethylnitrosourea on ependymal cellsS Reyes
Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico
Brain Tumor Pathol 18:83-7. 2001..Moreover, the antimalarials studied seem to promote the carcinogenic effects of ethylnitrosourea on ependymal cells... - Review of neurocysticercosisJulio Sotelo
National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Neurosurg Focus 12:e1. 2002..Additionally, the rational use of steroid agents facilitates the treatment of inflammation, a conspicuous accompaniment in cases of NCC. A major effort, however, is still required to eradicate this disease... - Pharmacokinetic optimisation of the treatment of neurocysticercosisJ Sotelo
Neuroimmunology, Department, Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico
Clin Pharmacokinet 34:503-15. 1998..Clinical decisions on cysticidal and anti-inflammatory treatments must be made with the information gathered by neuroimaging studies, either computed tomography or magnetic resonance, and by the analysis of cerebrospinal fluid... - Treatment of hydrocephalus in adults by placement of an open ventricular shuntJ Sotelo
Division of Research, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
J Neurosurg 94:873-9. 2001..51 mm as a distinctive element for flow resistance was evaluated for use in the treatment of adult patients with hydrocephalus... - Angiogenesis and expression of estrogen and progesterone receptors as predictive factors for recurrence of meningiomaPatricia Guevara
Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Col La Fama, Tlalpan 14269, Mexico City, Mexico
J Neurooncol 98:379-84. 2010..The most important factor associated with meningioma relapse was vascular density, independently of hormonal status and extent of surgical resection. Patients with a high risk of recurrence could benefit from additional treatment... - Association of a history of varicella virus infection with multiple sclerosisMayela Rodríguez-Violante
Neurodegenerative Diseases Clinical Research Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Clin Neurol Neurosurg 111:54-6. 2009..To analyze the association of a previous history of varicella virus infection with multiple sclerosis (MS) and its subtypes... - Varicella zoster virus in progressive forms of multiple sclerosisGraciela Ordoñez
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico
Clin Neurol Neurosurg 112:653-7. 2010..Both, the molecular and the ultrastructural evidence of VZV became negative in the same patients at the time of remission... - Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiformeEduardo Briceño
Departments of Neuroimmunology and Neurooncology, National Institute of Neurology and Neurosurgery of Mexico, Mexico City 14269, Mexico
Surg Neurol 67:388-91. 2007..In preliminary studies, we have observed a potentiating therapeutic effect when chloroquine was added to the conventional treatment of GBM... - Hepatocyte growth factor in cerebrospinal fluid is associated with mortality and recurrence of glioblastoma, and could be of prognostic valueRoberto Garcia-Navarrete
Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, Distrito Federal CP 14269, Mexico
J Neurooncol 97:347-51. 2010..001). Our findings support the idea that measurement of HGF in CSF could be a useful tool for monitoring the biological activity of malignant glioma. The findings will ultimately need to be confirmed in a much larger study... - Effect of thalidomide in different tumors in rodentsGuadalupe Palencia
Laboratory of Neuroimmunology, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, Mexico 14269, D.F, Mexico
J Exp Ther Oncol 2:158-62. 2002..Further investigations on the use of thalidomide perhaps associated to cytotoxic drugs, for treatment of ectodermic neoplasms seem guaranteed... - Interstitial quinacrine activates a distinctive immune response effective for tumor immunotherapyJulio Sotelo
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico
Surgery 136:700-7. 2004..It constitutes an original approach for regional immunotherapy of neoplasms that is not mediated solely by induction of local, cytotoxic chemical necrosis... - Female gender but not cigarette smoking delays the onset of Parkinson's diseaseAbelardo Martinez-Rumayor
Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugia, Col La Fama, Tlalpan 14269, Mexico City, Mexico
Clin Neurol Neurosurg 111:738-41. 2009..Cigarette smoking has been proposed as a protective factor against Parkinson's disease (PD); however it is not known whether smoking also delays its onset... - Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningiomaOscar Arrieta
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico
Cancer 94:3210-8. 2002..Intratumoral concentration of HGF in human intracranial neoplasms was measured and correlated with prognosis, tumor recurrence, vasogenic edema, cell proliferation index, and vascular density... - Thalidomide inhibits pentylenetetrazole-induced seizuresGuadalupe Palencia
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, 14269 Mexico City, Mexico
J Neurol Sci 258:128-31. 2007..Thalidomide is an effective anticonvulsant, and further studies on this potential antiepileptic substance seem warranted... - Adjuvant immunotherapy of C6 glioma in rats with pertussis toxinMario Orozco-Morales
Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugia INNN, Insurgentes Sur 3877, 14269, Mexico City, Mexico
J Cancer Res Clin Oncol 138:23-33. 2012..The aim of this study was to determine the effect of pertussis toxin (PTx) as immunomodulatory molecule on glial tumors induced by C6 glioma cells... - Thalidomide for treatment of refractory epilepsyGuadalupe Palencia
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico
Epilepsy Res 92:253-7. 2010..The mean number of seizures before thalidomide administration was 26 ± 4 per month; it decreased to 7 ± 1 along thalidomide therapy. Our results indicate that thalidomide has strong therapeutic effects in refractory epilepsy... - Prolonged exposure to lead lowers the threshold of pentylenetetrazole-induced seizures in ratsOscar Arrieta
Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico
Epilepsia 46:1599-602. 2005..The aim of this work was to study the effects of prolonged exposure to lead on the threshold of experimental seizures induced by pentylenetetrazole (PTZ)... - Strong anticonvulsant effect of thalidomide on amygdaloid kindlingGuadalupe Palencia
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City 14269, Mexico
Epilepsy Res 95:263-9. 2011..In amygdaloid kindling, which simulates human epilepsy characterized by focal seizures secondarily generalized, low doses of thalidomide display strong anticonvulsant properties... - Continuous-flow shunt for treatment of hydrocephalus due to lesions of the posterior fossaNicasio Arriada
Research and Neurosurgical Divisions, National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico
J Neurosurg 101:762-6. 2004..The hydrodynamic properties of the CF shunt make it effective, even in severe cases of hydrocephalus caused by lesions of the posterior fossa... - Western and Asian features of multiple sclerosis in Mexican MestizosJacqueline Cordova
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, 14269 Mexico City, Mexico
Clin Neurol Neurosurg 109:146-51. 2007.... - Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosisO Arrieta
Experimental Oncology Laboratory and Medical Oncology Department, Instituto Nacional de Cancerología INCan, Tlalpan 14080, Mexico
Br J Cancer 99:160-6. 2008..These findings suggest that ANGII receptors might be potential therapeutic targets for high-grade astrocytomas... - Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous systemO Arrieta
Neuroimmunology Unit, Instituto Nacional de Neurologia y Neurocirugía and Instituto de Investigaciones Biomédicas, Mexico City, Mexico
J Cancer Res Clin Oncol 127:681-6. 2001.... - Taenia solium disease in humans and pigs: an ancient parasitosis disease rooted in developing countries and emerging as a major health problem of global dimensionsE Sciutto
Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, UNAM, AP70228, D F 04510, Mexico
Microbes Infect 2:1875-90. 2000..Our opinions on the most urgent needs for further research are also presented... - Protective effect of pentoxifylline plus thalidomide against septic shock in miceO Arrieta
Neuroimmunology Unit and Experimental Pathology Laboratory, Instituto Nacional de Neurologia y Neurocirugia and Universidad Nacional Autonoma de Mexico
Int J Exp Pathol 80:11-6. 1999..05). Pentoxifylline seems to potentiate the beneficial effects of thalidomide, reducing mortality and attenuating the pathological changes produced by septic shock... - Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat gliomaO Arrieta
Neuroimmunology Unit of the National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, 14269 Mexico City, Mexico
Br J Cancer 92:1247-52. 2005..Our results suggest that the selective blockage of AT1 diminishes tumoral growth through inhibition of growth factors and promotion of apoptosis... - Post-panning computer-aided analysis of phagotope collections selected with neurocysticercosis patient polyclonal antibodies: separation of disease-relevant and irrelevant peptide sequencesK G Gazarian
Department of Biotechnology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, UNAM
Comb Chem High Throughput Screen 4:221-35. 2001.... - Retinoic acid increases tissue and plasma contents of nerve growth factor and prevents neuropathy in diabetic miceO Arrieta
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, 14269 Mexico City, Mexico
Eur J Clin Invest 35:201-7. 2005..Retinoic acid (RA) promotes the endogenous expression of nerve growth factor and its receptor. We studied the effects of RA on diabetic neuropathy in mice with streptozotocin-induced diabetes... - Clinical manifestations, diagnosis, and treatment of neurocysticercosisJulio Sotelo
The Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City, Mexico
Curr Neurol Neurosci Rep 11:529-35. 2011..Eradication of cysticercosis is an attainable goal by public education and sanitary improvement in endemic areas... - Antiproliferative effect of thalidomide alone and combined with carmustine against C6 rat gliomaOscar Arrieta
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico
Int J Exp Pathol 83:99-104. 2002.... - All-trans retinoic acid induces nerve regeneration and increases serum and nerve contents of neural growth factor in experimental diabetic neuropathyNorma Hernández-Pedro
Neuroimmunology Unit and the Experimental Neuropathology Department, Instituto Nacional de Neurologia y Neurocirugia, Mexico
Transl Res 152:31-7. 2008..RA can revert functional and ultrastructural changes and induce neural regeneration after the establishment of diabetic neuropathy, possibly because of the increased of NGF concentrations in nerve terminals... - Review: treatment of hydrocephalus in adultsNicasio Arriada
National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Surg Neurol 58:377-84; discussion 384. 2002 - Cas IIgly induces apoptosis in glioma C6 cells in vitro and in vivo through caspase-dependent and caspase-independent mechanismsCristina Trejo-Solís
Departamento de Neuroinmunología, Instituto Nacional de Neurologia y Neurocirugia, SSA, Mexico, DF 14269, Mexico
Neoplasia 7:563-74. 2005..Our findings support the use of Cas IIgly for the treatment of malignant gliomas... - Angiotensin II, cell proliferation and angiogenesis regulator: biologic and therapeutic implications in cancerElizabeth Escobar
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, 14269 Mexico City, Mexico
Curr Vasc Pharmacol 2:385-99. 2004..This review discusses the mechanisms by which ANG II participates in neoplastic and non-neoplastic tissue angiogenesis and its possible therapeutic implications... - AT1 receptor is present in glioma cells; its blockage reduces the growth of rat gliomaE Rivera
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico City
Br J Cancer 85:1396-9. 2001..Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor... - Quinacrine enhances carmustine therapy of experimental rat gliomaS Reyes
Neuroimmunology Unit, , Universidad Nacional Autonoma de Mexico, 14269 Mexico City, Mexico
Neurosurgery 49:969-73. 2001..Our results suggest that chemical inhibition of mutagenesis in malignant glial cells during chemotherapy prevents the appearance of resistant clones... - Short communication: preferential concentration of hydroxychloroquine in adenoid tissue of HIV-infected subjectsLucinda Aguirre-Cruz
Departamento de Inmunologia, Instituto Nacional de Neurologia y Neurocirugia, Mexico, D F, Mexico
AIDS Res Hum Retroviruses 26:339-42. 2010..The potential use of HCQ as adjuvant in the therapy of HIV deserves to be explored, as the drug accumulates in relevant tissues for HIV replication and immunopathogenesis... - Chronic malnutrition does not influence the development of ethylnitrosourea-induced brain tumorsG Palencia
Neuroimmunology Laboratory, National Institute of Neurology and Neurosurgery of Mexico, Mexico, DF
Nutr Neurosci 8:323-5. 2005.... - Varicella zoster virus and relapsing remitting multiple sclerosisJulio Sotelo
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City 14269, Mexico
Mult Scler Int 2011:214763. 2011.... - Interaction between grapefruit juice and praziquantel in humansNelly Castro
Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico
Antimicrob Agents Chemother 46:1614-6. 2002..71 +/- 128.5 ng/ml; and Cmax for grapefruit juice treatment, 1,037.65 +/- 305.7 ng/ml, P < 0.05). No statistically significant differences were found in the time to maximum concentration of drug in plasma or elimination half-life... - The National Institute of Neurology and Neurosurgery of Mexico on its 40th anniversaryJulio Sotelo
Surg Neurol 61:204-6. 2004 - [The general physician, essential actor in the medicine of the future]Julio Sotelo
, Insurgentes Sur No. 3877, col. La Fama CP 14269, , DF
Gac Med Mex 140:S3-8. 2004.... - Neurocysticercosis--is the elimination of parasites beneficial?Julio Sotelo
N Engl J Med 350:280-2. 2004 - Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomasMartha Lilia Tena-Suck
Department of Neuropathology, , Mexico
Clin Neurol Neurosurg 108:661-9. 2006..022) were significantly related to recurrence/regrowth. CONCLUSIONS: Residual tumor after surgery, immunoreactivity to p53 and presence of whorl-like arrays are associated to recurrence/regrowth of craniopharyngioma... - Malpractice in Mexico: arbitration not litigationCarlos Tena-Tamayo
National Commission for Medical Arbitration, Mitla #250, Mexico City 03020, Mexico
BMJ 331:448-51. 2005 - Neurocysticercosis: eradication of cysticercosis is an attainable goalJulio Sotelo
BMJ 326:511-2. 2003