Jose Manuel Fragoso

Summary

Affiliation: Genetica Intervencionista
Location: Mexico, City, Mexico
URL: Genetica Intervencionista Instituto Nacional de Cardiologia Ignacio Chavez
Summary:
NOMBRE: José Manuel Fragoso Lona.
NOMBRAMIENTO:Investigador en Ciencias Médicas
INSTITUCION DE ADSCRIPCION:Instituto Nacional de Cardiología Ignacio Chávez
Sistema Nacional de Investigadores nivel I
TEL: 5255-55732911 ext 1460
CORREO ELECTRONICO:mfragoso1275@yahoo.com.mx
LINEA DE INVESTIGACION:
"Estudio de los mecanismos moleculares presentes en inmunidad innata asociados a la aterosclerosis"

Desempeño como Investigador:
Como investigador en el departamento de Biología Molecular del Instituto Nacional de Cardiología Ignacio Chávez, realizo el montaje, el diseño y la estandarización de técnicas moleculares para el estudio de polimorfismos genéticos en la población mexicana y su posible asociación con el desarrollo de la aterosclerosis. En la línea de investigación de la cual soy encargado, se realiza la búsqueda de aquellos mecanismos moleculares relacionados con inmunidad innata, que estén involucrados en esta patología, así como, los marcadores genéticos. Aunado a esto también se demuestra la función de los marcadores genéticos por medio de cultivo celular, expresión de RNAm por tiempo-real y ensayos de lucíferasa que ayudan a demostrar si los genotipos encontrados en realidad están relacionados con dicha patogenia.

Actividades académicas:
Miembro de SIBIC Internacional. Instituto Nacional de Cardiología Ignacio Chavez. 2008-Presente. Miembro THE NEW YORK ACAMEDY OF SCIENCES. 2008-Presente.
Miembro del grupo de trabajo “Genética Intervencionista”. 2010
Miembro del “Grupo de Estudio en Genómica y Proteomica en Enfermedades Cardiovasculares”
Profesor por invitación de asignatura. Maestría en Ciencias Médicas. Facultad de Medicina. UNAM. 2008-presente.
Profesor de asignatura. Licenciatura en Antropología Física. Escuela Nacional de Antropología e Historia. 2005-presente.



Producción científica.
Artículos Internacionales: 23
Artículos Nacionales: 3
Capítulos de libro: 4
Asistencia a Congresos Nacionales: 20
Asistencia a Congresos Internacionales: 11
Publications:
[Genetic and genomic studies in the hypertension: an actualization of the genomic studies].

Ramírez-Bello J, Pérez-Méndez O, Ramírez-Fuentes S, Carrillo-Sánchez S, Vargas-Alarcón G, Fragoso JM.

Arch Cardiol Mex. 2011 Jul-Sep;81(3):240-50. Spanish.

2.

Protective role of interleukin-19 gene polymorphisms in patients with ulcerative colitis.

Yamamoto-Furusho JK, Álvarez-León E, Fragoso JM, Gozalishvilli A, Vallejo M, Vargas-Alarcón G.

Hum Immunol. 2011 Nov;72(11):1029-32. Epub 2011 Sep 1.

3.

[Acute coronary syndrome. Physiopathology and genetics].

Vargas-Alarcón G, Fragoso JM, Delgadillo H.

Rev Invest Clin. 2011 Jan-Feb;63(1):64-74. Review. Spanish.

4.

Alleles and haplotypes of the interleukin 10 gene polymorphisms are associated with risk of developing acute coronary syndrome in Mexican patients.

Fragoso JM, Vallejo M, Alvarez-León E, Delgadillo H, Peña-Duque MA, Cardoso-Saldaña G, Posadas-Romero C, Martínez-Ríos MA, Vargas-Alarcón G.

Cytokine. 2011 Jul;55(1):29-33. Epub 2011 Apr 9.
5.

Interleukin 1 β (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis.

Yamamoto-Furusho JK, Santiago-Hernández JJ, Pérez-Hernández N, Ramírez-Fuentes S, Fragoso JM, Vargas-Alarcón G.

J Clin Gastroenterol. 2011 Jul;45(6):531-5.

6.

The interleukin 6 -572 G>C (rs1800796) polymorphism is associated with the risk of developing acute coronary syndrome.

Fragoso JM, Delgadillo H, Juárez-Cedillo T, Rodríguez-Pérez JM, Vallejo M, Pérez-Méndez O, Alvarez-León E, Peña-Duque MA, Martínez-Ríos MA, Vargas-Alarcón G.

Genet Test Mol Biomarkers. 2010 Dec;14(6):759-63. Epub 2010 Oct 12.

7.

Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans.

Fragoso JM, Delgadillo H, Llorente L, Chuquiure E, Juárez-Cedillo T, Vallejo M, Lima G, Furuzawa-Carballeda J, Peña-Duque MA, Martínez-Ríos MA, Vargas-Alarcón G.

Immunol Lett. 2010 Oct 30;133(2):106-11. Epub 2010 Aug 13.

8.

Depressive symptoms and APOE polymorphisms in an elderly population-based sample.

García-Peña C, Juarez-Cedillo T, Cruz-Robles D, Fragoso JM, Sánchez-García S, Rodríguez-Pérez JM, Gallo JJ, Wagner FA, Vargas-Alarcón G.

Psychiatr Genet. 2010 Oct;20(5):215-20.

9.

Tumor necrosis factor alpha and interleukin 10 promoter polymorphisms in Mexican patients with restenosis after coronary stenting.

Martínez-Ríos MA, Peña-Duque MA, Fragoso JM, Delgadillo-Rodríguez H, Rodríguez-Pérez JM, Miranda-Malpica E, Cruz-Robles D, Cavazos-Quero MM, Rodríguez-Lobato LG, Vargas-Alarcón G.

Biochem Genet. 2009 Oct;47(9-10):707-16. Epub 2009 Jul 8.

10.

Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains.

Vargas-Alarcón G, Fragoso JM, Cruz-Robles D, Vargas A, Martinez A, Lao-Villadóniga JI, García-Fructuoso F, Vallejo M, Martínez-Lavín M.

Arthritis Rheum. 2009 Jul;60(7):2169-73.

11.

No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene in Mexican patients and binary restenosis after coronary stenting.

Martínez-Ríos MA, Peña-Duque MA, Fragoso JM, Delgadillo-Rodríguez H, Pérez-Hernández N, Miranda-Malpica E, Rodríguez-Pérez JM, González-Quesada C, Vargas-Alarcón G.

Clin Chim Acta. 2008 Nov;397(1-2):65-7. Epub 2008 Jul 25.

12.

The interleukin 1B-511 polymorphism is associated with the risk of developing restenosis after coronary stenting in Mexican patients.

Miranda-Malpica E, Martínez-Rios MA, Fragoso JM, Delgadillo-Rodríguez H, Rodríguez-Pérez JM, González-Quesada C, Martínez-Rodríguez N, Saldaña-Mendoza A, Peña-Duque MA, Vargas-Alarcón G.

Hum Immunol. 2008 Feb;69(2):116-21. Epub 2008 Jan 22.

13.

Apolipoprotein E polymorphisms in Mexican patients with coronary artery disease.

Gamboa R, Huesca-Gómez C, Pérez-Méndez O, Cruz-Robles D, Fragoso JM, Juarez-Cedillo T, Vallejo M, Posadas-Romero C, Vargas-Alarcón G.

Clin Chem Lab Med. 2008;46(4):481-5.

14.

A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico.

García-Ortiz L, Vargas-Alarcón G, Fragoso JM, Granados J, Maldonado Noriega L, Navas Pérez A, Huerta Reyes E, Zenteno-Ruiz JC, Martínez-Cordero E.

Genet Mol Res. 2008 Jan 8;7(1):7-15.

15.

Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.

Vargas-Alarcón G, Fragoso JM, Cruz-Robles D, Vargas A, Vargas A, Lao-Villadóniga JI, García-Fructuoso F, Ramos-Kuri M, Hernández F, Springall R, Bojalil R, Vallejo M, Martínez-Lavín M.

Arthritis Res Ther. 2007;9(5):R110.

16.

The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism.

Juárez-Cedillo T, Vallejo M, Fragoso JM, Hernández-Hernández DM, Rodríguez-Pérez JM, Sánchez-García S, del Carmen García-Peña M, García-Carrancá A, Mohar-Betancourt A, Granados J, Vargas-Alarcón G.

Eur J Cancer. 2007 Jul;43(10):1590-5. Epub 2007 May 18.

17.

MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy.

Rodríguez-Pérez JM, Fragoso JM, Alvarez-León E, Martínez-Rodríguez N, Gallardo GJ, Inés-Real S, Granados J, Reyes PA, Vargas-Alarcón G.

Exp Mol Pathol. 2007 Feb;82(1):49-52. Epub 2006 Nov 28.

18.

Beta1-adrenergic receptor gene polymorphisms in Mexican patients with idiopathic dilated cardiomyopathy.

Fragoso JM, Rodríguez-Pérez JM, González J, Cruz D, Pérez-Méndez O, de Jesus García J, de la Peña A, Arce M, Reyes PA, Vargas-Alarcón G.

Exp Mol Pathol. 2006 Jun;80(3):279-82. Epub 2006 Feb 20.

19.

Beta1 adrenergic receptor polymorphisms Arg389Gly and Ser49Gly in the Amerindian and Mestizo populations of Mexico.

Fragoso JM, Rodríguez-Pérez JM, Pérez-Vielma N, Martínez-Rodríguez N, Vargas-Alarcón G.

Hum Biol. 2005 Aug;77(4):515-20.

20.

Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico.

Hernández-Pacheco G, Murguía LE, Rodríguez-Pérez JM, http://www.labome.org/about/get_involved.htmlFragoso JM, Pérez-Vielma N, Martínez-Rodríguez N, Granados J, Vargas-Alarcón G.

Hum Biol. 2005 Jun;77(3):385-91.

Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations. Its role in the lipid profile.

Gamboa R, Zamora J, Rodríguez-Pérez JM, Fragoso JM, Cardoso G, Posadas-Romero C, Vargas-Alarcón G.

Exp Mol Pathol. 2006 Feb;80(1):85-90. Epub 2005 Jul 5.

22.

Association study of LMP gene polymorphisms in Mexican patients with spondyloarthritis.

Vargas-Alarcón G, Gamboa R, Zuñiga J, Fragoso JM, Hernández-Pacheco G, Londoño J, Pacheco-Tena C, Cardiel MH, Granados J, Burgos-Vargas R.

Hum Immunol. 2004 Dec;65(12):1437-42.

23.

Cytochrome P4501A1 polymorphisms in the Amerindian and Mestizo populations of Mexico.

Fragoso JM, Juárez-Cedillo T, Hernández-Pacheco G, Ramírez E, Zuñiga J, Izaguirre R, de la Peña A, Granados J, Vargas-Alarcón G.
Cell Biochem Funct. 2005 May-Jun;23(3):189-93.

24.

Angiotensin-converting enzyme gene (ACE) insertion/deletion polymorphism in Mexican populations.

Vargas-Alarcón G, Hernández-Pacheco G, Rodríguez-Pérez JM, Pérez-Hernández N, Pavón Z, Fragoso JM, Juarez-Cedillo T, Villarreal-Garza C, Granados J.
Hum Biol. 2003 Dec;75(6):889-96.



25.

Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease.
Hernández-Pacheco G, Flores-Domínguez C, Rodríguez-Pérez JM, Pérez-Hernández N, Fragoso JM, Saul A, Alvarez-León E, Granados J, Reyes PA, Vargas-Alarcón G.
J Autoimmun. 2003 Aug;21(1):59-63.

Publications

  1. ncbi Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
    Gilberto Vargas-Alarcon
    National Institute of Cardiology, Juan Badiano 1, Mexico City 14080, Mexico
    Arthritis Res Ther 9:R110. 2007
  2. ncbi A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico
    L García-Ortiz
    Research Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    Genet Mol Res 7:7-15. 2008
  3. ncbi Apolipoprotein E polymorphisms in Mexican patients with coronary artery disease
    Ricardo Gamboa
    Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Clin Chem Lab Med 46:481-5. 2008
  4. ncbi The interleukin 1B-511 polymorphism is associated with the risk of developing restenosis after coronary stenting in Mexican patients
    Emma Miranda-Malpica
    Interventional Cardiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Hum Immunol 69:116-21. 2008
  5. ncbi No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene in Mexican patients and binary restenosis after coronary stenting
    Marco Antonio Martínez-Ríos
    Interventional Cardiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Clin Chim Acta 397:65-7. 2008
  6. ncbi Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains
    Gilberto Vargas-Alarcon
    National Institute of Cardiology Ignacio Chavez, Tlalpan, Mexico City, Mexico
    Arthritis Rheum 60:2169-73. 2009
  7. ncbi Tumor necrosis factor alpha and interleukin 10 promoter polymorphisms in Mexican patients with restenosis after coronary stenting
    Marco Antonio Martínez-Ríos
    Interventional Cardiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Biochem Genet 47:707-16. 2009
  8. ncbi Depressive symptoms and APOE polymorphisms in an elderly population-based sample
    Carmen García-Peña
    Epidemiologic and Health Service Research Unit, Aging Area, Instituto Mexicano del Seguro Social
    Psychiatr Genet 20:215-20. 2010
  9. ncbi Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans
    José Manuel Fragoso
    Department of Molecular Biology and Cardiovascular Disease s Genomic and Proteomic Study Group, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Immunol Lett 133:106-11. 2010
  10. ncbi [Acute coronary syndrome. Physiopathology and genetics]
    Gilberto Vargas-Alarcon
    Departamento de Biologia Molecular, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, DF
    Rev Invest Clin 63:64-74. 2011

Collaborators

  • Gilberto Vargas Alarcon
  • Julio Granados
  • Maite Vallejo
  • Guadalupe Hernández Pacheco
  • Manuel Martinez-Lavin
  • Ruben Burgos-Vargas
  • Carmen García-Peña
  • Joseph J Gallo
  • Cesar Pacheco-Tena
  • Alejandro Mohar-Betancourt
  • Fernando A Wagner
  • Gilberto Vargas-Alarcon
  • Jose Manuel Rodriguez-Perez
  • Marco Antonio Martínez-Ríos
  • Guadalupe Hernández-Pacheco
  • Ricardo Gamboa
  • David Cruz-Robles
  • Emma Miranda-Malpica
  • Teresa Juarez-Cedillo
  • Hilda Delgadillo-Rodríguez
  • Marco Antonio Peña-Duque
  • Nancy Martínez-Rodríguez
  • Nonanzit Pérez-Hernández
  • Julián Ramírez-Bello
  • Oscar Pérez-Méndez
  • José Ignacio Lao-Villadóniga
  • L García-Ortiz
  • Ferrán García-Fructuoso
  • Angelica Vargas
  • Carlos Gonzalez-Quesada
  • Carlos Posadas-Romero
  • Pedro A Reyes
  • Edith Alvarez-Leon
  • Silvestre Ramírez-Fuentes
  • Hilda Delgadillo
  • Silvia Carrillo-Sánchez
  • Aline Martinez
  • María Magdalena Cavazos-Quero
  • Luis Gerardo Rodríguez-Lobato
  • L Maldonado Noriega
  • E Martinez-Cordero
  • E Huerta Reyes
  • G Vargas-Alarcon
  • A Navas Pérez
  • J C Zenteno-Ruiz
  • Claudia Huesca-Gomez
  • Arturo Saldaña-Mendoza
  • Rashidi Springall
  • María del Carmen García-Peña
  • Manuel Ramos-Kuri
  • Alfonso Vargas
  • Guillermo J Gallardo
  • Dulce María Hernández-Hernández
  • Sergio Sánchez-García
  • Alejandro Garcia-Carranca
  • Rafael Bojalil
  • Selene Ines-Real
  • Fernando Hernandez
  • Jose Zamora
  • Guillermo Cardoso
  • Nadia Pérez-Vielma
  • Luis Enrique Murguía
  • Joaquin Zuniga
  • Mario H Cardiel
  • John Londoño
  • Angela Saul
  • Carmina Flores-Dominguez
  • Zinnia Pavón
  • Cynthia Villarreal-Garza

Detail Information

Publications22

  1. ncbi Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
    Gilberto Vargas-Alarcon
    National Institute of Cardiology, Juan Badiano 1, Mexico City 14080, Mexico
    Arthritis Res Ther 9:R110. 2007
    ..This association was not observed in Mexican patients. Studies with a larger sample size are needed in order to verify or amend these preliminary results...
  2. ncbi A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico
    L García-Ortiz
    Research Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    Genet Mol Res 7:7-15. 2008
    ..05) populations, and the G/A genotype was more frequently found in this Mexican population than in Chinese, African and European populations (P < 0.05)...
  3. ncbi Apolipoprotein E polymorphisms in Mexican patients with coronary artery disease
    Ricardo Gamboa
    Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Clin Chem Lab Med 46:481-5. 2008
    ..Thus, the purpose of this study was to investigate the association of apolipoprotein E polymorphisms with coronary artery disease and with plasma lipid levels in a group of Mexican Mestizo patients...
  4. ncbi The interleukin 1B-511 polymorphism is associated with the risk of developing restenosis after coronary stenting in Mexican patients
    Emma Miranda-Malpica
    Interventional Cardiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Hum Immunol 69:116-21. 2008
    ..The results suggest that IL-1B-511 polymorphism could be involved in the risk of developing restenosis after coronary stent placement...
  5. ncbi No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene in Mexican patients and binary restenosis after coronary stenting
    Marco Antonio Martínez-Ríos
    Interventional Cardiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Clin Chim Acta 397:65-7. 2008
    ....
  6. ncbi Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains
    Gilberto Vargas-Alarcon
    National Institute of Cardiology Ignacio Chavez, Tlalpan, Mexico City, Mexico
    Arthritis Rheum 60:2169-73. 2009
    ..We undertook this study to correlate alpha-AR and beta-AR gene polymorphisms with the presence of FM and with different domains of the FM syndrome as measured by the Fibromyalgia Impact Questionnaire (FIQ)...
  7. ncbi Tumor necrosis factor alpha and interleukin 10 promoter polymorphisms in Mexican patients with restenosis after coronary stenting
    Marco Antonio Martínez-Ríos
    Interventional Cardiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Biochem Genet 47:707-16. 2009
    ..001, OR = 0.199) and the -819 TT genotype (P = 0.037, OR = 0.391). These results suggest the IL-10 -819 TT genotype has a protective role against in-stent restenosis...
  8. ncbi Depressive symptoms and APOE polymorphisms in an elderly population-based sample
    Carmen García-Peña
    Epidemiologic and Health Service Research Unit, Aging Area, Instituto Mexicano del Seguro Social
    Psychiatr Genet 20:215-20. 2010
    ..Thus, the purpose was to investigate the association of APOE polymorphisms with depression in elderly adults...
  9. ncbi Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans
    José Manuel Fragoso
    Department of Molecular Biology and Cardiovascular Disease s Genomic and Proteomic Study Group, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Immunol Lett 133:106-11. 2010
    ..Patients with ACS showed increased frequency of "T1C" haplotype when compared to healthy controls. The results suggest that IL-1RN gene polymorphisms could be involved in the risk of developing ACS in Mexican individuals...
  10. ncbi [Acute coronary syndrome. Physiopathology and genetics]
    Gilberto Vargas-Alarcon
    Departamento de Biologia Molecular, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, DF
    Rev Invest Clin 63:64-74. 2011
    ..However, in some cases inconsistent results in different populations have been reported. In this review the physiopathogenesis and the role of several candidate genes involved in the pathogenesis of ACS are discussed...
  11. ncbi Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease
    Guadalupe Hernández-Pacheco
    Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano No 1, Tlalpan 14080, Mexico City, Mexico
    J Autoimmun 21:59-63. 2003
    ..The data demonstrate that RHD is associated with TNF-alpha polymorphisms in the Mexican population; however, these polymorphisms do not have relation with the valve damage...
  12. ncbi The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism
    Teresa Juarez-Cedillo
    Epidemiological Research and Health Services Unit, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Eur J Cancer 43:1590-5. 2007
    ..These results suggest an important role of the CYP1A1 MspI polymorphism in the risk of developing cervical cancer...
  13. ncbi Angiotensin-converting enzyme gene (ACE) insertion/deletion polymorphism in Mexican populations
    Gilberto Vargas-Alarcon
    Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Tlalpan 14080, Mexico DF, Mexico
    Hum Biol 75:889-96. 2003
    ....
  14. ncbi Cytochrome P4501A1 polymorphisms in the Amerindian and Mestizo populations of Mexico
    José Manuel Fragoso
    Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Cell Biochem Funct 23:189-93. 2005
    ..Our data could be helpful in understanding the distribution of these polymorphisms and in clarifying their roles as genetic and evolution markers in Amerindian populations...
  15. ncbi Association study of LMP gene polymorphisms in Mexican patients with spondyloarthritis
    Gilberto Vargas-Alarcon
    Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Hum Immunol 65:1437-42. 2004
    ..05). The data suggest that, besides HLA-B27, LMP2 genotypes are also involved in the genetic susceptibility to develop AS in Mexicans. Furthermore, the age at onset of this disease might also be influenced by genotypes of this gene...
  16. ncbi Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations. Its role in the lipid profile
    Ricardo Gamboa
    Department of Physiology and Grupo de Estudio en Genómica y Proteómica de Enfermedades Cardiovasculares, Instituto Nacional de Cardiología Ignacio Chávez Juan Badiano No 1, Tlalpan 14080, Mexico City, Mexico
    Exp Mol Pathol 80:85-90. 2006
    ..The present data could be helpful to understand the distribution of these polymorphisms and its role as genetic and evolutive markers in the Amerindian populations...
  17. ncbi Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico
    Guadalupe Hernández-Pacheco
    Department of Physiology and Grupo de Estudio en Genómica y Proteómica de Enfermedades Cardiovasculares, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano No 1, Tlalpan 14080, Mexico City, Mexico
    Hum Biol 77:385-91. 2005
    ..For the T-138C genotype, we found differences among the Mexicans. This study could help to define the significance of MGP polymorphisms as genetic markers in Amerindian populations...
  18. ncbi Beta1 adrenergic receptor polymorphisms Arg389Gly and Ser49Gly in the Amerindian and Mestizo populations of Mexico
    José Manuel Fragoso
    Department of Physiology and Grupo de Estudio en Genómica y Proteómica de Enfermedades Cardiovasculares, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano No 1, Tlalpan 14080, Mexico City, Mexico
    Hum Biol 77:515-20. 2005
    ..Mayos present the highest frequency for the *Gly allele. The knowledge of the distribution of these alleles could help define the significance of these polymorphisms as genetic susceptibility markers in Amerindian populations...
  19. ncbi Beta1-adrenergic receptor gene polymorphisms in Mexican patients with idiopathic dilated cardiomyopathy
    José Manuel Fragoso
    Department of Physiology, Cardiovascular Disease s Genomic and Proteomic Study Group, Instituto Nacional de Cardiologia Ignacio Chavez, Tlalpan 14080, Mexico City, Mexico
    Exp Mol Pathol 80:279-82. 2006
    ..16) and *Arg/*Gly genotype (pC = 0.027, OR = 2.70) in the group of IDC patients when compared to healthy controls. The data suggest that Arg389Gly polymorphism could be involved in the genetic susceptibility to develop IDC in Mexicans...
  20. ncbi MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy
    Jose Manuel Rodriguez-Perez
    Department of Physiology, Cardiovascular Disease s Genomic and Proteomic Study Group, Instituto Nacional de Cardiologia Ignacio Chavez, Tlalpan 14080, Mexico City, Mexico
    Exp Mol Pathol 82:49-52. 2007
    ..03, OR=0.26) and HLA-DQB1*0201 (pC=0.04, OR=0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population...
  21. ncbi [Genetic and genomic studies in the hypertension: an actualization of the genomic studies]
    Julián Ramírez-Bello
    Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica México, D F
    Arch Cardiol Mex 81:240-50. 2011
    ....
  22. ncbi Alleles and haplotypes of the interleukin 10 gene polymorphisms are associated with risk of developing acute coronary syndrome in Mexican patients
    José Manuel Fragoso
    Department of Molecular Biology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Cytokine 55:29-33. 2011
    ..The results suggest that IL-10 gene polymorphisms could be involved in the risk of developing ACS in the Mexican population...