James B McAlpine

Summary

Publications

  1. ncbi Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand
    Henriette Gourdeau
    Thallion Pharmaceuticals Inc, 7150 Alexander Fleming, St Laurent, QC, Canada H4S 2C8
    Cancer Chemother Pharmacol 61:911-21. 2008
  2. ncbi Advances in the understanding and use of the genomic base of microbial secondary metabolite biosynthesis for the discovery of new natural products
    James B McAlpine
    Thallion Pharmaceuticals Inc, 7150 Alexander Fleming, Montreal H4S 2C8, Canada
    J Nat Prod 72:566-72. 2009
  3. ncbi Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example
    James B McAlpine
    Ecopia BioSciences, Inc, 7290 Frederick Banting Street, Montreal, Quebec, H4S 2A1, Canada
    J Nat Prod 68:493-6. 2005
  4. ncbi Biosynthesis of diazepinomicin/ECO-4601, a Micromonospora secondary metabolite with a novel ring system
    James B McAlpine
    Thallion Pharmaceuticals Inc, 7150 Alexander Fleming, Montreal, Quebec, H4S 2C8, Canada
    J Nat Prod 71:1585-90. 2008
  5. ncbi Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class
    Arjun H Banskota
    Ecopia BioSciences Inc, 7290 Frederick-Banting, Montreal, Quebec, H4S 2A1, Canada
    J Antibiot (Tokyo) 59:533-42. 2006
  6. ncbi Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach
    Arjun H Banskota
    Ecopia BioSciences Inc, 7290 Frederick Banting, Montreal, Quebec, H4S 2A1, Canada
    J Antibiot (Tokyo) 59:168-76. 2006

Collaborators

Detail Information

Publications6

  1. ncbi Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand
    Henriette Gourdeau
    Thallion Pharmaceuticals Inc, 7150 Alexander Fleming, St Laurent, QC, Canada H4S 2C8
    Cancer Chemother Pharmacol 61:911-21. 2008
    ..In the work presented here, ECO-4601 was further evaluated against brain tumor cell lines. Preliminary mechanistic studies as well as in vivo antitumor evaluation were performed...
  2. ncbi Advances in the understanding and use of the genomic base of microbial secondary metabolite biosynthesis for the discovery of new natural products
    James B McAlpine
    Thallion Pharmaceuticals Inc, 7150 Alexander Fleming, Montreal H4S 2C8, Canada
    J Nat Prod 72:566-72. 2009
    ..Several new biosynthetic pathways have been unearthed, and our general knowledge grows rapidly. This review aims to highlight some of the more striking discoveries and advances of the decade...
  3. ncbi Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example
    James B McAlpine
    Ecopia BioSciences, Inc, 7290 Frederick Banting Street, Montreal, Quebec, H4S 2A1, Canada
    J Nat Prod 68:493-6. 2005
    ..This work exemplifies not only the discovery of novel antibiotics from well-characterized organisms but also the utility of genomics as a further tool, complementary to spectroscopy, to enable rapid determination of complex structures...
  4. ncbi Biosynthesis of diazepinomicin/ECO-4601, a Micromonospora secondary metabolite with a novel ring system
    James B McAlpine
    Thallion Pharmaceuticals Inc, 7150 Alexander Fleming, Montreal, Quebec, H4S 2C8, Canada
    J Nat Prod 71:1585-90. 2008
    ..These studies highlight the enzymatic complexity needed to produce this structural type, which is rare in nature...
  5. ncbi Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class
    Arjun H Banskota
    Ecopia BioSciences Inc, 7290 Frederick-Banting, Montreal, Quebec, H4S 2A1, Canada
    J Antibiot (Tokyo) 59:533-42. 2006
    ..ECO-0501 was chemically modified by esterification (1a-1c), N-acetylation (1d) and hydrogenation (1e) in order to explore structure activity relationships (SAR)...
  6. ncbi Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach
    Arjun H Banskota
    Ecopia BioSciences Inc, 7290 Frederick Banting, Montreal, Quebec, H4S 2A1, Canada
    J Antibiot (Tokyo) 59:168-76. 2006
    ..All three new compounds were tested for their electron transport inhibitory activities. They had IC50 values of 1-4 microg/ml against Ascaris suum NADH-fumarate reductase and 1-12 microg/ml against bovine heart NADH oxidase...