Chris Mathes

Summary

Publications

  1. ncbi QPatch: the past, present and future of automated patch clamp
    Chris Mathes
    Sophion Bioscience, Inc, 675 US Highway One, North Brunswick, NJ 08902, USA
    Expert Opin Ther Targets 10:319-27. 2006
  2. ncbi CRACking ion channel targets: 2nd annual Ion Channel Targets Conference. 12-13 September 2006, Boston, MA, USA
    Chris Mathes
    Sophion Bioscience, Inc, 675 US Highway One, North Brunswick, NJ 08902, USA
    Expert Opin Ther Targets 11:101-4. 2007
  3. ncbi QPatch: the missing link between HTS and ion channel drug discovery
    Chris Mathes
    Sophion Bioscience, Inc, 675 US Highway One, North Brunswick, NJ 08902, USA
    Comb Chem High Throughput Screen 12:78-95. 2009
  4. ncbi Ion channels in drug discovery and development
    Chris Mathes
    High-throughput Electrophysiology Screening, Axon Instruments, 3280 Whipple Road, Union City, CA 94587, USA
    Drug Discov Today 8:1022-4. 2003
  5. ncbi Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp
    Adrienne E Dubin
    Pain and Related Disorders, Johnson and Johnson Pharmaceutical Research and Development, San Diego, CA 92121, USA
    J Biomol Screen 10:168-81. 2005
  6. ncbi Automated patch-clamp technique: increased throughput in functional characterization and in pharmacological screening of small-conductance Ca2+ release-activated Ca2+ channels
    Rikke L Schrøder
    Sophion Bioscience A S, Ballerup, Denmark
    J Biomol Screen 13:638-47. 2008

Collaborators

  • Roger Marrannes
  • Jia Xu
  • Rikke L Schrøder
  • Adrienne E Dubin
  • Morten Sunesen
  • Niels J Willumsen
  • Søren Friis
  • Jutta Rohrbacher
  • Sandra R Chaplan
  • Nadia Nasser
  • An N Hermans
  • Antonio Guia
  • David Gallacher
  • Miroslav Cik
  • Nicholas G Byrne
  • Koen van Rossem
  • Christopher Grantham

Detail Information

Publications6

  1. ncbi QPatch: the past, present and future of automated patch clamp
    Chris Mathes
    Sophion Bioscience, Inc, 675 US Highway One, North Brunswick, NJ 08902, USA
    Expert Opin Ther Targets 10:319-27. 2006
    ..Finally, the modular QPatch 16 was designed with more channels in mind. The upgrade pathway to 48-channels (the QPatch HT) will be discussed...
  2. ncbi CRACking ion channel targets: 2nd annual Ion Channel Targets Conference. 12-13 September 2006, Boston, MA, USA
    Chris Mathes
    Sophion Bioscience, Inc, 675 US Highway One, North Brunswick, NJ 08902, USA
    Expert Opin Ther Targets 11:101-4. 2007
    ..Also described at ICT were voltage-gated sodium, potassium, transmembrane-receptor-potential channels, as well as ligand-gated nicotinic acetylcholine (nAChR) and GABA type A receptors...
  3. ncbi QPatch: the missing link between HTS and ion channel drug discovery
    Chris Mathes
    Sophion Bioscience, Inc, 675 US Highway One, North Brunswick, NJ 08902, USA
    Comb Chem High Throughput Screen 12:78-95. 2009
    ....
  4. ncbi Ion channels in drug discovery and development
    Chris Mathes
    High-throughput Electrophysiology Screening, Axon Instruments, 3280 Whipple Road, Union City, CA 94587, USA
    Drug Discov Today 8:1022-4. 2003
  5. ncbi Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp
    Adrienne E Dubin
    Pain and Related Disorders, Johnson and Johnson Pharmaceutical Research and Development, San Diego, CA 92121, USA
    J Biomol Screen 10:168-81. 2005
    ..Finally, no false hits were observed from a collection of relatively inactive compounds. High-quality data acquisition by PatchXpress should help accelerate secondary screening for ion channel modulators and the drug discovery process...
  6. ncbi Automated patch-clamp technique: increased throughput in functional characterization and in pharmacological screening of small-conductance Ca2+ release-activated Ca2+ channels
    Rikke L Schrøder
    Sophion Bioscience A S, Ballerup, Denmark
    J Biomol Screen 13:638-47. 2008
    ..The study demonstrates that CRAC channels can be rapidly and efficiently targeted with automated patch-clamp techniques for characterization of physiological and pharmacological properties...