Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometryDaniel Martin
Centre for Altitude Space and Extreme Environment Medicine, UCL Institute for Human Health and Performance, Archway Campus, Highgate Hill, London, United Kingdom
High Alt Med Biol 8:50-5. 2007
..04). We conclude that exercising while at high altitude can lead to a raised P(CO2) gradient when gastric tonometry is performed, indicating reduced perfusion. This may represent reduced gastric mucosal perfusion under these conditions...
- Concepts in hypoxia reborn
Daniel S Martin
Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Crit Care 14:315. 2010
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- Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude
Daniel S Martin
Centre for Altitude, Space and Extreme Environment Medicine CASE Medicine, University College London Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Crit Care 13:S7. 2009
..We sought to quantify changes in skeletal muscle oxygenation during exercise using near-infrared spectroscopy (NIRS) in healthy volunteers ascending to high altitude...
- Abnormal blood flow in the sublingual microcirculation at high altitude
Daniel S Martin
Centre for Altitude, Space and Extreme Environment Medicine CASE Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, Archway Campus, Highgate Hill, London, N19 5LW, UK
Eur J Appl Physiol 106:473-8. 2009
..Disruption of blood flow within microcirculatory may explain persistent abnormal oxygen flux to tissues following the normalisation of systemic oxygen delivery that accompanies acclimatisation to high altitude...
- From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia
D Martin
Centre for Altitude, Space and Extreme Environment Medicine, Institute of Human Health and Performance, University College London, Archway Campus, Highgate Hill, London, UK
Postgrad Med J 84:622-7; quiz 626. 2008
..Investigating these processes not only helps to unravel the process of acclimatising to altitude, but it may also improve our understanding of the body's response to hypoxia in those with critical illness...
- Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude
Daniel S Martin
UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Exp Physiol 95:880-91. 2010
..Thus, MFI was reduced whilst GX increased in the sublingual mucosa with prolonged exposure to hypoxia and was exaggerated in those exposed to extreme altitude...
- Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia
Denny Z H Levett
Centre for Altitude Space and Extreme Environment Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, London, N19 5LW, UK
BMC Med Res Methodol 10:98. 2010
..The aim of this study was to describe the spectrum of adaptive responses in humans exposed to graded EHH and identify factors (physiological and genetic) associated with inter-individual variation in these responses...
- Variation in human performance in the hypoxic mountain environment
Daniel S Martin
UCL Institute for Human Health and Performance, 2nd Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, Archway, London N19 5LW, UK
Exp Physiol 95:463-70. 2010
..The identification of the relevant genetic elements is in its infancy in humans, but ongoing work is likely to help us gain an increasing understanding of how humans adapt to altitude and to develop mitigating interventions...
- Arterial blood gases and oxygen content in climbers on Mount Everest
Michael P W Grocott
Centre for Altitude, Space, and Extreme Environment Medicine, University College London Institute of Human Health and Performance, London, United Kingdom
N Engl J Med 360:140-9. 2009
..We performed direct field measurements of arterial blood gases in climbers breathing ambient air on Mount Everest...
- Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model
Niall M Corcoran
Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville 3010, Victoria, Australia
J Clin Neurosci 17:1025-33. 2010
..Sodium selenate is a specific activator of PP2A with excellent oral bioavailability, and favourable central nervous system penetrating properties. Clinical studies in patients with AD are envisaged in the near future...
- Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin
Andriana Margariti
Cardiovascular Division, King s College London British Heart Foundation Centre, London, United Kingdom
Circ Res 106:1202-11. 2010
..Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function...
