Serge Haan

Summary

Affiliation: University of Luxembourg
Country: Luxembourg

Publications

  1. ncbi Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses
    Caroline Schoenherr
    Department of Biochemistry, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Cell Commun Signal 8:19. 2010
  2. ncbi SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling
    S Haan
    Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg
    Oncogene 28:3069-80. 2009
  3. ncbi An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
    Claude Haan
    Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg
    J Immunol 182:2969-77. 2009
  4. ncbi Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
    Stephanie Kreis
    Laboratoire de Biologie et Physiologie Intégrée, University of Luxembourg, 162A Avenue de la Faïencerie, L 1511 Luxembourg, Luxembourg
    Mol Cancer Res 5:1331-41. 2007
  5. ncbi Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases
    Claude Haan
    Life Sciences Research Unit, University of Luxembourg, 162A, av de la Faïencerie, 1511 Luxembourg, Luxembourg
    J Cell Mol Med 14:504-27. 2010
  6. ncbi Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes
    Herdis Bender
    Department of Biochemistry, University Hospital RWTH Aachen, Aachen, Germany
    Hepatology 50:585-91. 2009
  7. ncbi Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases
    Ulrike Sommer
    Institut fur Biochemie, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Biol Chem 280:31478-88. 2005
  8. ncbi Nucleocytoplasmic shuttling of persistently activated STAT3
    Andreas Herrmann
    Institut fur Biochemie, Universitätsklinikum RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Cell Sci 120:3249-61. 2007
  9. ncbi Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
    Serge Haan
    , , Pauwelsstrasse 30, 52074 Aachen, Germany
    Cell Signal 17:1542-50. 2005
  10. ncbi The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
    Simone Radtke
    Institut fur Biochemie, Uniklinik Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Biol Chem 280:25760-8. 2005

Collaborators

  • M Vogt
  • Peter C Heinrich
  • Claude Haan
  • Nobuyuki Kato
  • S Kreis
  • Andreas Herrmann
  • Ulrike Sommer
  • Caroline Schoenherr
  • Ralf Weiskirchen
  • Herdis Bender
  • Gerhard Muller-Newen
  • Simone Radtke
  • Waraporn Komyod
  • Iris Behrmann
  • Carolin Nordhoff
  • Stephan Ludwig
  • Monique Y Wiesinger
  • Martin Mönnigmann
  • Thomas Clahsen
  • Valeria Poli
  • Uta-Maria Bauer
  • Nigel J Stevenson
  • Angela Jörissen
  • Fred Schaper
  • Heike M Hermanns
  • Christine Schmid
  • James A Johnston
  • Tanya Smyczek
  • Hildegard Schmitz-Vandeleur
  • Sandra Diefenbach
  • Ute Lehmann
  • Radoslaw M Sobota
  • Albert L Pranada
  • Bernd Giese
  • W Becker
  • Andrea Küster

Detail Information

Publications14

  1. ncbi Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses
    Caroline Schoenherr
    Department of Biochemistry, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Cell Commun Signal 8:19. 2010
    ..The aim of this study was to investigate whether IL-27 would also act on hepatic stellate cells (HSC), the second most abundant hepatic cell type, which would demonstrate a more general role of this cytokine in the liver...
  2. ncbi SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling
    S Haan
    Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg
    Oncogene 28:3069-80. 2009
    ....
  3. ncbi An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
    Claude Haan
    Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg
    J Immunol 182:2969-77. 2009
    ..Taken together, the dramatic effects on the phosphorylation status of Jak2 as well as the differential effects on the signaling via different cytokines highlight the importance of this unusual region for the catalytic activity of Jaks...
  4. ncbi Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
    Stephanie Kreis
    Laboratoire de Biologie et Physiologie Intégrée, University of Luxembourg, 162A Avenue de la Faïencerie, L 1511 Luxembourg, Luxembourg
    Mol Cancer Res 5:1331-41. 2007
    ....
  5. ncbi Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases
    Claude Haan
    Life Sciences Research Unit, University of Luxembourg, 162A, av de la Faïencerie, 1511 Luxembourg, Luxembourg
    J Cell Mol Med 14:504-27. 2010
    ..Moreover, we discuss recent chemical genetic approaches which can be applied to Jaks to better understand the role of these kinases in their biological settings and as drug targets...
  6. ncbi Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes
    Herdis Bender
    Department of Biochemistry, University Hospital RWTH Aachen, Aachen, Germany
    Hepatology 50:585-91. 2009
    ..Our results suggest that IL-27 exerts IFN-like functions in liver cells and that it can contribute to the antiviral response in these cells...
  7. ncbi Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases
    Ulrike Sommer
    Institut fur Biochemie, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Biol Chem 280:31478-88. 2005
    ....
  8. ncbi Nucleocytoplasmic shuttling of persistently activated STAT3
    Andreas Herrmann
    Institut fur Biochemie, Universitätsklinikum RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Cell Sci 120:3249-61. 2007
    ..We propose passage of persistently activated STAT3 through the nuclear pore complex as a new target for intervention in cancer...
  9. ncbi Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
    Serge Haan
    , , Pauwelsstrasse 30, 52074 Aachen, Germany
    Cell Signal 17:1542-50. 2005
    ..We also describe that pY-STAT3 is much more efficiently shuttled into the nucleus than pY-STAT1...
  10. ncbi The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
    Simone Radtke
    Institut fur Biochemie, Uniklinik Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Biol Chem 280:25760-8. 2005
    ..Likewise, the signaling capacity of Jak1 was not affected by this point mutation. However, we found that the SH2 domain is structurally important for cytokine receptor binding and surface expression of the OSMR...
  11. ncbi Are STATS arginine-methylated?
    Waraporn Komyod
    , , Pauwelsstrasse 30, 52074 Aachen, Germany
    J Biol Chem 280:21700-5. 2005
    ..Taken together, our data suggest the absence of arginine methylation of STAT1 and STAT3...
  12. ncbi STAT3 is enriched in nuclear bodies
    Andreas Herrmann
    Institut fur Biochemie, Universitätsklinikum RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Cell Sci 117:339-49. 2004
    ..Taken together, our data suggest that STAT3 nuclear bodies are either directly involved in active gene transcription or they serve as reservoirs of activated STAT3...
  13. ncbi Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    Peter C Heinrich
    Institut fur Biochemie, RWTH Aachen, Universitatsklinikum, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 374:1-20. 2003
    ..Also the cross-talk between the JAK/STAT pathway with other signalling cascades is discussed...