Therapeutic dendritic-cell vaccine for chronic HIV-1 infectionWei Lu
Institut de Recherche sur les Vaccins et l Immunothérapie des cancers et du SIDA, Laboratoire d Oncologie et Virologie Moléculaire, Faculté de Médecine René Descartes, Centre Biomédical des Saints Pères, Universite Paris 5, France
Nat Med 10:1359-65. 2004
..The results suggest that inactivated whole virus-pulsed DC vaccines could be a promising strategy for treating people with chronic HIV-1 infection...
- Long-term clinical, immunologic and virologic impact of glucocorticoids on the chronic phase of HIV infection
Jean Marie Andrieu
Institut de Recherche sur les Vaccins et l Immunothérapie des cancers et du SIDA, Laboratoire d Oncologie et Virologie Moléculaire, Centre Biomédical des Saints Pères, Universite Rene Descartes, Paris, France
BMC Med 2:17. 2004
..Here we explore the long-term clinical, immunologic, and virologic impact of prednisolone on the chronic phase of HIV infection...
- Therapeutic dendritic-cell vaccine for simian AIDS
Wei Lu
Institut de Recherche sur les Vaccins et l Immunothérapie des cancers et du SIDA, Paris, France
Nat Med 9:27-32. 2003
..Neutralizing antibody responses were augmented and remained elevated. Inactivated whole virus-pulsed dendritic cell vaccines are promising means to control diseases caused by immuno- deficiency viruses...
- T cell survival/proliferation reconstitution by trifluoperazine in human immunodeficiency virus-1 infection
Ammar Achour
Laboratore d Oncologie et Virologie Moleculaires, Faculte de Medecine Necker, Centre Biomédical des Saint Pères, 75270 Paris, France
Virology 315:245-58. 2003
..Besides antiviral compounds, these data may facilitate immune reconstitution in patients with HIV infection and other immunosuppressive diseases...
- Alopecia areata: pathogenesis and potential for therapy
Wei Lu
Department of Dermatology and Skin Science, University of British Columbia, 835 West 10th Avenue, Vancouver, BC, V5Z 4E8, Canada
Expert Rev Mol Med 8:1-19. 2006
..However, the pathogenetic disease mechanism is particularly robust and the development of a cure for AA will be a significant challenge...
- Morphological alteration of Golgi apparatus and subcellular compartmentalization of TGF-beta1 in Golgi apparatus in gerbils following transient forebrain ischemia
Zhiping Hu
Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Neurochem Res 32:1927-31. 2007
..TGF-beta1 was colocalized with TGN38, a marker molecule for the GA. We conclude that there was morphological alterations of GA and TGF-beta1 was present in GA in the somatosensory cortex after 10 min ischemia...
- Genetic diversity and drug resistance of human immunodeficiency virus type 1 (HIV-1) strains circulating in Shanghai
Ping Zhong
Department of AIDS and STD, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
AIDS Res Hum Retroviruses 23:847-56. 2007
..It is believed that this information may help to guide recommendations for diagnostic assays, vaccine design, and antiretroviral regimen strategies in China...
- [Change and significance of serum pigment epithelium-derived factor in type 2 diabetic nephropathy]
Hai Bing Chen
Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Department of Endocrinology and Metabolism of Shanghai Sixth People s Hospita1 Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 87:1230-3. 2007
..To investigate the change of pigment epithelium-derived factor (PEDF) in type 2 diabetic nephropathy, and to explore the significance of PEDF in the development of diabetic nephropathy...
- Erythropoietin: a potent inducer of peripheral immuno/inflammatory modulation in autoimmune EAE
RuiRong Yuan
Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey, United States of America
PLoS ONE 3:e1924. 2008
..However, no information regarding the effects of EPO therapy on the behavior of the general mononuclear-lymphocyte population, Tregs or Th17 cells in EAE has emerged...
- Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells
Hana Okhrimenko
Gonda (Goldschmied) Medical Diagnosis Research Center, Faculty of Life-Sciences, Bar-Ilan University, Ramat Gan, Israel
Cancer Res 65:7301-9. 2005
..Our results suggest that the cleavage of PKCepsilon and its down-regulation play important roles in the apoptotic effect of TRAIL. Moreover, PKCepsilon regulates AKT expression and is essential for the survival of glioma cells...
- Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis
Hana Okhrimenko
Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel 52900
J Biol Chem 280:23643-52. 2005
..Our results indicate that PKCdelta protects glioma cells from the apoptosis induced by TRAIL and implicate the phosphorylation of PKCdelta on tyrosine 155 and its cleavage as essential factors in the anti-apoptotic effect of PKCdelta...
- Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression
Cheryl A Winkler
Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
J Acquir Immune Defic Syndr 37:1534-8. 2004
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- Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome
Taisheng Li
Department of Infectious Diseases, Peking Union Medical College Hospital, No 1 Shuaifuyuan, Wangfujing, Beijing, China 100730
J Infect Dis 189:648-51. 2004
....
- Rapid loss of both CD4+ and CD8+ T lymphocyte subsets during the acute phase of severe acute respiratory syndrome
Taisheng Li
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
Chin Med J (Engl) 116:985-7. 2003
..To study the alteration of peripheral lymphocyte subsets in severe acute respiratory syndrome (SARS) patients and to help improve the early diagnosis of the disease...
- The biological meaning of anti-HBC positive result in blood donors: relation to HBV-DNA and to other serological markers
Luiz C Arraes
Serviço de Gastrohepatologia de Hospital Universitário Oswaldo Cruz, Recife, PE, Brasil
Rev Inst Med Trop Sao Paulo 45:137-40. 2003
..The addition of other HBV serological markers could represent an alternative in predicting the presence of the virus when compared with PCR. It is recommended that other studies should be carried out to confirm this finding...
- Identification of an epitope of SARS-coronavirus nucleocapsid protein
Ying Lin
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
Cell Res 13:141-5. 2003
..The results indicated that an epitope of the N protein has been identified and N protein specific Abs were produced by peptide immunization, which will be usefull for the study of SARS-CoV...
- Molecular tracing of sexual HIV Type 1 transmission in the southwest border of China
Linlin Bao
Sino French Collaboration Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing, People s Republic of China
AIDS Res Hum Retroviruses 24:733-42. 2008
..The reconstruction of transmission of current HIV-1 outbreaks by molecular epidemiological tracing is instrumental in identifying sources of the epidemic and in defining prevention strategies...
