Efficacy trial on the purified compounds of the seeds of Carica papaya for male contraception in albino ratNirmal K Lohiya
Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302004, India
Reprod Toxicol 20:135-48. 2005
..It is concluded that both MCP I and ECP I are equally effective in terms of contraceptive efficacy which is likely reversible and without adverse side effects...
- Sperm motility inhibitory effect of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkey, Presbytis entellus entellus
Nirmal K Lohiya
Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India
Asian J Androl 10:298-306. 2008
..To assess the contraceptive efficacy of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkeys...
- Perspectives of contraceptive choices for men
N K Lohiya
Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
Indian J Exp Biol 43:1042-7. 2005
..It is feasible that an ideal male contraceptive, that meets out all the essential criteria will be made available to the community in the near future...
- Sperm characteristics and teratology in rats following vas deferens occlusion with RISUG and its reversal
N K Lohiya
Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India
Int J Androl 33:e198-206. 2010
..The fertility/pregnancy/implantation record and skeletal morphology of the offspring were comparable to control. The results suggest functional success and safety of vas occlusion reversal by DMSO...
- Chloroform extract of Carica papaya seeds induces long-term reversible azoospermia in langur monkey
N K Lohiya
Department of Zoology, University of Rajasthan, Jaipur, India
Asian J Androl 4:17-26. 2002
..To evaluate the antifertility activity of the chloroform extract of Carica papaya seeds by oral administration in langur monkey, Presbytis entellus entellus...
- Vas deferens, a site of male contraception: an overview
N K Lohiya
Department of Zoology, University of Rajasthan, Jaipur, India
Asian J Androl 3:87-95. 2001
..The drug is currently under multicentre Phase III clinical trial...
- Human sperm immobilization effect of Carica papaya seed extracts: an in vitro study
N K Lohiya
Department of Zoology, University of Rajasthan, Jaipur, India
Asian J Androl 2:103-9. 2000
..To examine if the seed extracts of Carica papaya, which showed antispermatogenic/sperm immobilization properties in animal models, could cause human sperm immobilization in vitro...
- Status of spermatogenesis and sperm parameters in langur monkeys following long-term vas occlusion with styrene maleic anhydride
Pradyumna K Mishra
Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur, India
J Androl 24:501-9. 2003
..The sub-cellular features of the normal tubules were similar to those of controls. The results suggest focal degeneration of seminiferous epithelium in the central portion of the testis following long-term vas occlusion with SMA...
- Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeys
Nirmal K Lohiya
Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
Contraception 71:214-26. 2005
..The results suggest that noninvasive reversal is feasible even after long-term vas occlusion with SMA and is safe without adverse side effects...
- Sperm characteristics and ultrastructure of testes of rats after long-term treatment with the methanol subfraction of Carica papaya seeds
Boomi Manivannan
Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur 302004, India
Asian J Androl 11:583-99. 2009
..It is concluded that the MSF is safe for long-term treatment and the mechanism of contraception is shown by its effect on spermatid differentiation in the testis, possibly mediated by the Sertoli cell factors...
- Toxicological investigations on the methanol sub-fraction of the seeds of Carica papaya as a male contraceptive in albino rats
Nirmal K Lohiya
Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur 302004, India
Reprod Toxicol 22:461-8. 2006
..The preliminary results suggest the test substance may be a safe approach to male anti-fertility...
- Safety evaluation of long-term vas occlusion with styrene maleic anhydride and its non-invasive reversal on accessory reproductive organs in langurs
B Manivannan
Department of Zoology, University of Rajasthan, Jaipur-302 004, India
Asian J Androl 7:195-204. 2005
..Conclusion: SMA vas occlusion and its non-invasive reversal do not damage the accessory reproductive organs...
- Safety evaluation of long term oral treatment of methanol sub-fraction of the seeds of Carica papaya as a male contraceptive in albino rats
S Goyal
Centre for Advanced Studies in Zoology, University of Rajasthan, Jaipur 302 004, India
J Ethnopharmacol 127:286-91. 2010
..The manuscript is one of the series of attempts in authenticating scientific documentation of the seeds of Carica papaya being traditionally used for contraception...
- Ultrastructural changes in the testis and epididymis of rats following treatment with the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya
B Manivannan
Reproductive Physiology Section, Department of Zoology University of Rajasthan, Jaipur-302 004, India
Phytother Res 18:285-9. 2004
..It is concluded that the inhibition of sperm motility by the drug could be due to other epididymal factors rather than the subcellular characteristics of testis and epididymis...
- Contraceptive evaluation and toxicological study of aqueous extract of the seeds of Carica papaya in male rabbits
N K Lohiya
Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur, India
J Ethnopharmacol 70:17-27. 2000
....
- Plants for male fertility regulation
Raka Kamal
Laboratory of Medicinal Plants and Biotechnology, Department of Botany, University of Rajasthan, Jaipur 302004, India
Phytother Res 17:579-90. 2003
..The type of extract, dose, animal model and pharmacological activity of these materials have been reviewed in this paper to add impetus to further research and collaboration to resolve the problem of population explosion...
