Peter S Linsley

Summary

Publications

  1. ncbi Hidden reach of the micromanagers
    Peter S Linsley
    Regulus Therapeutics, 1896 Rutherford Road, Carlsbad, CA 92008, USA
    BMC Biol 8:53. 2010
  2. ncbi Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1
    Timothy A Vickers
    Antisense Core Research, Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    Nucleic Acids Res 37:6927-41. 2009
  3. ncbi Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    Aimee L Jackson
    Regulus Therapeutics, Inc, 1896 Rutherford Road, Carlsbad, CA 92008, USA
    Nat Rev Drug Discov 9:57-67. 2010
  4. ncbi The therapeutic potential of microRNA modulation
    Aimee Jackson
    Regulus Therapeutics, Inc, Carlsbad, California 92008, United States
    Discov Med 9:311-8. 2010

Detail Information

Publications4

  1. ncbi Hidden reach of the micromanagers
    Peter S Linsley
    Regulus Therapeutics, 1896 Rutherford Road, Carlsbad, CA 92008, USA
    BMC Biol 8:53. 2010
    ..A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens...
  2. ncbi Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1
    Timothy A Vickers
    Antisense Core Research, Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    Nucleic Acids Res 37:6927-41. 2009
    ..Finally, we present data suggesting that a significant portion of on-target siRNA activity is also Ago2 cleavage independent, however, this activity does not appear to be P-body associated...
  3. ncbi Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    Aimee L Jackson
    Regulus Therapeutics, Inc, 1896 Rutherford Road, Carlsbad, CA 92008, USA
    Nat Rev Drug Discov 9:57-67. 2010
    ..Here, we describe the types of off-target effects of siRNAs and methods to mitigate them, to help enable effective application of this exciting technology...
  4. ncbi The therapeutic potential of microRNA modulation
    Aimee Jackson
    Regulus Therapeutics, Inc, Carlsbad, California 92008, United States
    Discov Med 9:311-8. 2010
    ..Here we review the evidence for microRNA dysfunction in human disease, as well as recent examples of microRNA modulation that provided therapeutic benefit...