L A Levine

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..Due to varying success with verapamil as injectable therapy for Peyronie's disease we performed a double-blind, placebo controlled trial to determine the effectiveness of verapamil delivered through electromotive drug administration...

..At this time, there is no known reliable nonsurgical treatment. This study reviews our experience with external penile traction therapy to correct the deformity associated with this disorder...

..There is interest to develop and validate a specific Peyronie's disease index questionnaire. In the meantime, this article presents specific recommendations to obtaining meaningful objective measures and methods to report them...

..We present our experience with human cadaveric pericardium for tunica albuginea grafting for men undergoing penile reconstruction for Peyronie's disease...

..Further controlled, large-scale studies are necessary to establish the benefits of these nonsurgical approaches. In the meantime, combination therapy appears to make sense in the nonsurgical treatment of men with Peyronie's disease...

..While the best choice of graft material remains controversial, the risk of postoperative erectile dysfunction (ED) is apparent across previous reports...

..We evaluated the efficacy and mechanism of failure in a small case series of VasClip vasectomies...

..EDITS questionnaire results reveal that SC is an agent that allowed successful coitus in 70.8% of males with PD...

..We review the scientific rationale, published literature, clinical experience, and technique of intralesional injection of verapamil...

..We report our experience with buccal mucosa grafts for anterior urethral strictures. We compared outcomes in the pendulous and bulbar urethra as well as the impact of lichen sclerosus on success...

..Erectile dysfunction (ED) frequently accompanies Peyronie's disease (PD) and changes the therapeutic approach...

..Loss of penile length after penile prosthesis implantation is one of the most common complaints. There is no recognized reliable technique to gain length once the device is placed...

..Many men are not candidates for surgery and may fail or have contraindications to medical therapy. This article addresses the oldest available form of noninvasive device therapy for the restoration of erectile function...

..Until a reliable treatment emerges, it does appear that some of the non-surgical treatments discussed can be used to stabilize the scarring process and may result in some reduction of deformity with improved sexual function...

..Limited publications exist regarding long-term outcomes of surgical correction for Peyronie's Disease (PD)...

..0156, Fisher's exact test) of the sildenafil group. Nightly sildenafil administration for 36 weeks after surgery markedly increased the return of normal spontaneous erections...

..The low incidence of complications indicates that this therapy is also clinically safe...

..This article examines the development, mechanism of action, efficacy, and patient satisfaction with regard to vacuum constriction and external erection devices...

..CONCLUSIONS: The Ambicor penile prosthesis is associated with a low complication rate and reliable mechanical function. High satisfaction was reported by patients and partners...

..Loss of length is a common postoperative complaint of the patient who undergoes surgical correction of penile curvature. We investigate the factors influencing complications in patients who have undergone TAP for PD and chordee...

..This article reviews the recent literature on penile length loss after radical prostatectomy and following correction of penile deformity for Peyronie's disease...

..To evaluate the use of percutaneous testicular sperm aspiration in the assessment of azoospermia and its association with seminiferous tubule microliths...

..Clearly further work is necessary to develop safe and effective non-surgical treatments for PD...

..Younger men with PD commonly present with complaints and physical examination findings that differ from the typical patient with PD...

..To our knowledge whether these levels affect change in Peyronie's disease plaque, resulting in improvement in penile deformity, is unknown and requires further placebo controlled trials...

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..The prevalence is significantly higher than the previously reported 1%, and most cases of PD do not spontaneously resolve...

..We assessed the long-term efficacy, complications and patient perceptions of microsurgical denervation of the spermatic cord in the treatment of chronic orchialgia...

..We used ketoconazole and prednisone with dosing titrated according to serum testosterone levels to suppress sleep related erections in an attempt to prevent recurrent episodes...

..Furthermore, basic science research into the pathophysiology of this disorder is likely to yield new insights into potential treatment options and direct future therapies...

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..We characterized matrix metalloproteinases and TIMPs (tissue inhibitors of matrix metalloproteinase) in Peyronie's disease tissue...

..Clearly, further work is necessary to develop safe and effective nonsurgical treatments for PD...

..Peyronie's disease remains a considerable therapeutic dilemma even to today's practicing physicians...

..This device underwent revision of the rear tip extender and reinforcement of the pump tubing connection to decrease fluid leak failure in 1998...

..Findings from published accounts of sildenafil use in the clinical practice setting further demonstrated that sildenafil is an effective treatment for a wide range of patients with ED...

..Erectile dysfunction (ED) may be one manifestation of a generalized vascular disorder characterized by endothelial dysfunction. Statin drugs may improve endothelial function, even before altering the lipid profile...

..After bilateral nerve-sparing radical retropubic prostatectomy (BNSRRP), nocturnal and sexually mediated erections may help to preserve normal erectile function (EF)...