C I Ezeamuzie

Summary

Affiliation: Kuwait University
Country: Kuwait

Publications

  1. ncbi Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat
    Br J Pharmacol 127:188-94. 1999
  2. ncbi Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase
    Charles I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Biochem Biophys Res Commun 300:712-8. 2003
  3. ncbi Effect of wortmannin on human eosinophil responses in vitro and on bronchial inflammation and airway hyperresponsiveness in Guinea pigs in vivo
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Am J Respir Crit Care Med 164:1633-9. 2001
  4. ncbi Involvement of A(3) receptors in the potentiation by adenosine of the inhibitory effect of theophylline on human eosinophil degranulation: possible novel mechanism of the anti-inflammatory action of theophylline
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
    Biochem Pharmacol 61:1551-9. 2001
  5. ncbi Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, 13110, Kuwait
    Eur J Pharmacol 417:11-8. 2001
  6. ncbi Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait
    Br J Pharmacol 131:482-8. 2000
  7. ncbi IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait
    Int Arch Allergy Immunol 121:300-7. 2000
  8. ncbi Characteristics of asthmatic children in Kuwait
    Z Hijazi
    Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat
    J Asthma 39:603-9. 2002
  9. ncbi The association of skin test reactivity, total serum IgE levels, and peripheral blood eosinophilia with asthma in Kuwait
    M Khadadah
    Department of Medicine, Faculty of Medicine, Kuwait University, Safat
    J Asthma 37:481-8. 2000
  10. ncbi The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages
    C I Ezeamuzie
    Department of Pharmacology, Faculty of Medicine, Kuwait University, Kuwait
    Int Immunopharmacol 7:483-90. 2007

Collaborators

Detail Information

Publications12

  1. ncbi Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat
    Br J Pharmacol 127:188-94. 1999
    ....
  2. ncbi Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase
    Charles I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Biochem Biophys Res Commun 300:712-8. 2003
    ..We conclude that in human eosinophils, an atypical form of A(3) receptors positively coupled to AC may exist. The resulting cAMP generation may underlie the anti-inflammatory actions of A(3) agonists in eosinophils...
  3. ncbi Effect of wortmannin on human eosinophil responses in vitro and on bronchial inflammation and airway hyperresponsiveness in Guinea pigs in vivo
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Am J Respir Crit Care Med 164:1633-9. 2001
    ..This may be relevant to the possible clinical utility of wortmannin in conditions involving eosinophilic inflammation and AHR...
  4. ncbi Involvement of A(3) receptors in the potentiation by adenosine of the inhibitory effect of theophylline on human eosinophil degranulation: possible novel mechanism of the anti-inflammatory action of theophylline
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
    Biochem Pharmacol 61:1551-9. 2001
    ..Together with the potentiation of theophylline action by adenosine, perhaps via the A(3) receptors, these novel actions may, at least in part, contribute to the mechanism of the anti-inflammatory action of this drug in vivo...
  5. ncbi Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, 13110, Kuwait
    Eur J Pharmacol 417:11-8. 2001
    ..This may be relevant to the in vivo effectiveness of PDE IV inhibitors in eosinophilic inflammation...
  6. ncbi Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait
    Br J Pharmacol 131:482-8. 2000
    ..These results suggest that histamine, via stimulation of H(2) receptors and a consequent elevation of intracellular levels of cyclic AMP, inhibits human eosinophil degranulation...
  7. ncbi IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment
    C I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait
    Int Arch Allergy Immunol 121:300-7. 2000
    ..This study evaluated the prevalence of IgE sensitization to moulds among patients with allergic respiratory diseases in Kuwait - a desert country...
  8. ncbi Characteristics of asthmatic children in Kuwait
    Z Hijazi
    Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat
    J Asthma 39:603-9. 2002
    ..Asthmatic children are disadvantaged by delay in diagnosis, undertreatment, exposure to indoor cigarette smoke, and local traditions...
  9. ncbi The association of skin test reactivity, total serum IgE levels, and peripheral blood eosinophilia with asthma in Kuwait
    M Khadadah
    Department of Medicine, Faculty of Medicine, Kuwait University, Safat
    J Asthma 37:481-8. 2000
    ..Skin testing was found to be the most effective measure of atopy in this environment, and correlates well with the other more sensitive newer tests...
  10. ncbi The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages
    C I Ezeamuzie
    Department of Pharmacology, Faculty of Medicine, Kuwait University, Kuwait
    Int Immunopharmacol 7:483-90. 2007
    ..The results also show that while exogenous PGE(2) is a potent inhibitor of TNF-alpha release, the enhanced PGE(2) release induced by adenosine does not appear to contribute to the inhibition of TNF-alpha release...
  11. ncbi Protein kinase C activation inhibits eosinophil degranulation through stimulation of intracellular cAMP production
    Charles I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Br J Pharmacol 143:725-32. 2004
    ..These results show, for the first time, that in human eosinophils, PMA, via activation of PKCdelta isoform, can stimulate cAMP production, and that this may be the basis for its potent anti-degranulatory effect...
  12. ncbi Reactive oxygen species mediate phorbol ester-stimulated cAMP response in human eosinophils
    Charles I Ezeamuzie
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait
    Eur J Pharmacol 543:174-80. 2006
    ..These results reveal a novel involvement of intracellular reactive oxygen species in protein kinase C (PKC)-dependent stimulation of cAMP production in human eosinophils...