Research Topics
Genomes and Genes | Fahd Al-MullaSummaryAffiliation: Faculty of Medicine Country: Kuwait Publications
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Detail Information
Publications
A new model for raf kinase inhibitory protein induced chemotherapeutic resistanceFahd Al-Mulla
Department of Pathology, Health Sciences Center, Kuwait University, Faculty of Medicine, Safat, Kuwait
PLoS ONE 7:e29532. 2012..Our data illuminate, for the first time, the NRF2-KEAP 1 pathway as a possible target for personalized therapeutic intervention in RKIP depleted cancers...- Impaired TGF-? signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetesFahd Al-Mulla
Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
Mol Biosyst 7:3006-20. 2011.... - Microarray-based CGH and copy number analysis of FFPE samplesFahd Al-Mulla
Molecular Pathology Unit, Health Sciences Center, Safat, Kuwait
Methods Mol Biol 724:131-45. 2011..This chapter gives a description of the several CGH-microarray platforms currently available and offers practical steps that guide you through optimal handling and superior aCGH data acquisition of DNA extracted from FFPE tissues... - Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3?Fahd Al-Mulla
Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, Safat, Kuwait, UK
Cancer Res 71:1334-43. 2011..RKIP levels in human colorectal cancer positively correlate with GSK3? expression. These findings reveal the RKIP/GSK3 axis as both a potential therapeutic target and a prognosis-based predictor of cancer progression... - RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motilityFahd Al-Mulla
Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
Mol Biosyst 7:928-41. 2011.... - Age-dependent penetrance of different germline mutations in the BRCA1 geneF Al-Mulla
Department of Pathology, Safat, Kuwait
J Clin Pathol 62:350-6. 2009..This study addresses whether different exon mutations have variable expressivity especially in relation to the age of onset of breast cancer... - Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instabilityF Al-Mulla
Department of Pathology, Molecular Pathology Unit, Faculty of Medicine, Kuwait University, Kuwait
J Clin Pathol 61:524-9. 2008..This study aims at correlating RKIP expression with chromosomal instability in colorectal cancer samples and identifies possible mechanisms of RKIP loss... - Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutationsF Al-Mulla
Kuwait University, Faculty of Medicine, Department of Pathology Molecular Pathology Laboratory, P O Box 24923, Safat, Kuwait 13110
J Pathol 195:549-56. 2001..The precise mechanisms behind these biological differences in vivo and in vitro should now be investigated... - Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14qF Al-Mulla
Department of Pathology, Faculty of Medicine, Molecular Pathology Unit, Kuwait University, Kuwait
J Clin Pathol 59:624-30. 2006..To investigate the prognostic value for loss of heterozygosity (LOH) of chromosomes 4 and 14q in early-stage colorectal cancer (CRC)... - Comparison of two probe preparation methods using long oligonucleotide microarraysFahd Al-Mulla
Kuwait University, Faculty of Medicine, Department of Pathology, Safat, Kuwait
Biotechniques 37:827-33. 2004..Overall, the microarray results generated by the poly(T) priming methodology should be viewed cautiously even when high reproducibility is evident... - BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistryFahd Al-Mulla
Department of Pathology, Molecular Pathology Laboratory, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait
J Histochem Cytochem 53:621-9. 2005..Antibody 8F7 had the highest sensitivity of 100%, but its specificity was 30.4% if mRNA levels were considered as the reference standard... - Genetic profiling of stage I and II colorectal cancer may predict metastatic relapseFahd Al-Mulla
Molecular Pathology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
Mod Pathol 19:648-58. 2006..Accordingly, the molecular genetic features of primary tumours should be considered in the mainstream management of patients with this specific stage of the disease... - Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patientsFahd Al-Mulla
Kuwait University, Faculty of Medicine, Safat, Kuwait
J Clin Oncol 24:5672-9. 2006..We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival... - Utilization of microarray platforms in clinical practice: an insight on the preparation and amplification of nucleic acids from frozen and fixed tissuesFahd Al Mulla
Department of Pathology, Faculty of Medicine, Kuwait University, Safat
Methods Mol Biol 382:115-36. 2007..This chapter decribes the methods used for nucleic acids preparation from frozen and formalin-fixed paraffin-embedded human tissues using macro-and microdissection and show their suitability for use in microarray experiments... - Whole genome amplification of DNA extracted from FFPE tissuesMira Bosso
Faculty of Medicine, Department of Pathology, Kuwait University, Safat, Kuwait
Methods Mol Biol 724:161-80. 2011..GenomePlex(®) is a registered trademark of Rubicon Genomics Incorporation... - Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanismMilad S Bitar
Department of Pharmacology and Toxicology, School of Medicine, Kuwait University, Kuwait
Life Sci 86:844-53. 2010.... - Genotypic and phenotypic differences between nodal and extranodal diffuse large B-Cell lymphomasSalah A Al-Humood
Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
J Histochem Cytochem 59:918-31. 2011..The authors demonstrated for the first time a novel genome and proteome-based signatures that may differentiate the two lymphoma types... - Uses of microarray platforms in cancer: a correlative study between genomic copy number changes and their expression at mRNA and protein levelsFahd Al Mulla
Department of Pathology, Faculty of Medicine, Kuwait University, Safat
Methods Mol Biol 382:77-95. 2007..The protocols described therein can be assimilated for the study of other human tissues including cancerous ones... - Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetesMilad S Bitar
Department of Pharmacology, Kuwait University, School of Medicine, Kuwait
Eur J Pharmacol 511:53-64. 2005..This phenomenon could play a potentially important role in the pathogenesis of diabetic endothelial dysfunction... - A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetesMilad S Bitar
Kuwait University, Faculty of Medicine, Dept of Pharmacology, P O Box 24923, Safat, Kuwait, 13110
Am J Physiol Endocrinol Metab 301:E1119-29. 2011..Moreover, they may also offer a new perspective in the understanding and treatment of nonhealing diabetic wounds... - Expression of estrogen receptor alpha and estrogen receptor beta in fine needle aspirates of breast carcinomaKusum Kapila
Cytology Unit and Cytology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
Acta Cytol 54:25-30. 2010..To evaluate the expression of estrogen receptor beta (ERbeta) in fine needle aspirates (FNAs) and correlate the findings with its expression in tissue sections... - BRCA1 gene expression in breast cancer in Kuwait: correlation with prognostic parametersM Amirrad
Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait
Med Princ Pract 14:67-72. 2005..This study assessed the BRCA1 gene expression in breast cancer in Kuwait, and compared it with other known prognostic factors for the disease... - Oxidative stress--mediated alterations in glucose dynamics in a genetic animal model of type II diabetesMilad S Bitar
Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait, 13110
Life Sci 77:2552-73. 2005.... - Glycolaldehyde induces apoptosis in a human breast cancer cell lineMay A Al-Maghrebi
The Department of Biochemistry, Faculty of Medicine, Kuwait University, P O Box 24923, Safat 13110, Kuwait
Arch Biochem Biophys 417:123-7. 2003..These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity... - Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancerElijah O Kehinde
Division of Urology, Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait
Scand J Urol Nephrol 45:113-21. 2011.... - Expressive genomic hybridisation: gene expression profiling at the cytogenetic levelF Al-Mulla
Department of Pathology, Molecular Pathology Unit, Kuwait University, Faculty of Medicine, PO Box 24923, Safat, Kuwait 13110
Mol Pathol 56:210-7. 2003.... - Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasisSuzanne Hagan
Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory, Glasgow, UK
Clin Cancer Res 11:7392-7. 2005..Therefore, we investigated whether RKIP expression is altered in clinical specimens of human primary breast cancers and their lymph node metastases... - Methods for microarray data analysisVeronique De Bruyne
Applied Maths BVBA, Sint Martens Latem
Methods Mol Biol 382:373-91. 2007.... - Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancerYoshihito Yokoyama
Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki, Amori, Japan
Mol Cancer Ther 6:1379-86. 2007..We conclude that CA could be an effective agent in ovarian cancer and should be tested alone and in combination with other anticancer drugs...