Regulation of lipoprotein metabolism in HepG2 cells by citrus flavonoidsElzbieta M Kurowska
KGK Synergize, Inc, London, ON, Canada
Adv Exp Med Biol 505:173-9. 2002
- Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages
Stewart C Whitman
Laboratory Medicine and Cellular and Molecular Medicine, Department of Pathology, University of Ottawa Heart Institute, 40 Ruskin St, Room H259A, Ottawa, Ont, Canada K1Y 4W7
Atherosclerosis 178:25-32. 2005
..In conclusion, our findings suggest that in addition to reducing plasma cholesterol concentrations, nobiletin may prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation...
- Bioavailability of omega-3 essential fatty acids from perilla seed oil
E M Kurowska
KGK Synergize, Inc, One London Place, 255 Queens Avenue, Suite 1030, London, Ont, Canada N6A 5R8
Prostaglandins Leukot Essent Fatty Acids 68:207-12. 2003
..However, significantly greater increases in plasma ALA levels from baseline to 24h were observed after ingestion of Entrox vs. non-coated product, suggesting a possible benefit of Entrox with long-term treatment...
- Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin
Elzbieta M Kurowska
KGK Synergize Inc, Research and Development Division, London, Ontario, Canada N6A 5R8
Lipids 39:143-51. 2004
..control). The data suggest that tangeretin modulates apoB-containing lipoprotein metabolism through multiple mechanisms...
- Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia
Elzbieta M Kurowska
KGK Synergize Inc, Suite 1030, One London Place, 255 Queens Avenue, London, Ontario, Canada N6A 5R8
J Agric Food Chem 52:2879-86. 2004
..This suggests that PMFs are novel flavonoids with cholesterol- and triacylglycerol-lowering potential and that elevated levels of PMF metabolites in the liver might be directly responsible for their hypolipidemic effects in vivo...
- Hypocholesterolemic properties of nitric oxide. In vivo and in vitro studies using nitric oxide donors
E M Kurowska
Department of Biochemistry, Centre for Human Nutrition, University of Western Ontario, London, Ontario, Canada
Biochim Biophys Acta 1392:41-50. 1998
..We concluded that synthetic NO donors can reduce hypercholesterolemia by affecting apo B metabolism directly in the liver, via the sterol-independent mechanism...
- Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters
Rachel W Li
Division of Medical Technology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA
Life Sci 79:365-73. 2006
..This study suggests that PMF can ameliorate hypertriglyceridemia and its anti-diabetic effects may occur as a consequence of adipocytokine regulation and PPARalpha and PPARgamma activation...
- Relative bioavailability and antioxidant potential of two coenzyme q10 preparations
Elzbieta M Kurowska
KGK Synergize, Inc, London Health Sciences Centre, London, Ont, Canada
Ann Nutr Metab 47:16-21. 2003
..The enhanced bioavailability of the BT product might be due to its predominantly reduced, hydrophilic membrane-complex form...
- In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract
Peter J Ferguson
London Regional Cancer Program, Health Sciences Centre, 790 Commissioners Road East, London, Ontario, Canada
Nutr Cancer 56:86-94. 2006
..05) and also induce cell death within 24 to 48 h of exposure (P < 0.05). These results indicate the presence of a potential anticancer constituent in the flavonoid-containing fractions from cranberry extracts...
