A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: a meta-analytic/meta-regression studyAnand Kumar
Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 38:1651-64. 2010
..To assess whether a potential benefit with combination antibiotic therapy is restricted to the most critically ill subset of patients, particularly those with septic shock...
- Clinical review: Myocardial depression in sepsis and septic shock
Olivier Court
Section of Critical Care Medicine, Health Sciences Center, University of Manitoba, Winnipeg, Canada
Crit Care 6:500-8. 2002
..The present paper reviews both the clinical manifestations and the molecular/cellular mechanisms of sepsis-induced myocardial depression...
- Optimizing antimicrobial therapy in sepsis and septic shock
Anand Kumar
Department of Medicine, Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Clin 25:733-51, viii. 2009
..Antimicrobial therapy should be stopped if infection is not considered the etiologic factor for a shock state...
- Critically ill patients with 2009 influenza A(H1N1) infection in Canada
Anand Kumar
Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
JAMA 302:1872-9. 2009
..Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America...
- Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study
Anand Kumar
Division of Cardiovascular Diseases and Critical Care Medicine, Cooper Hospital University Medical Center, Robert Wood Johnson Medical School, Camden, New Jersey, USA
Crit Care 8:R128-36. 2004
..We sought to confirm this to be the mechanism by which high-volume saline administration (comparable to that used in resuscitation of shock) results in improved cardiac output in normal healthy volunteers...
- Nitric oxide-dependent and -independent mechanisms are involved in TNF-alpha -induced depression of cardiac myocyte contractility
Anand Kumar
Section of Critical Care Medicine, Health Sciences Centre, Winnipeg, Manitoba, Canada
Am J Physiol Regul Integr Comp Physiol 292:R1900-6. 2007
..These data suggest that TNF-alpha exposure is associated with a second nitric oxide-independent but calcium-dependent early depressant mechanism that is manifested by reduced contractile and cAMP response to beta-adrenergic stimulation...
- Effect of large volume infusion on left ventricular volumes, performance and contractility parameters in normal volunteers
Anand Kumar
Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612 3833, USA
Intensive Care Med 30:1361-9. 2004
..Characterize the normal human cardiovascular response to large volume infusion of normal saline...
- Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis
Anand Kumar
Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 38:1773-85. 2010
..Current guidelines do not recommend combination therapy except for the express purpose of broadening coverage when resistant pathogens are a concern...
- Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock
Anand Kumar
Section of Critical Care Medicine, Health Sciences Centre St, Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care 12:R35. 2008
..The objective of this study was to assess cardiovascular and metabolic responses to dobutamine as correlates of outcome in patients with severe sepsis or septic shock...
- Early antimicrobial therapy in severe sepsis and septic shock
Anand Kumar
Section of Critical Care Medicine, Section of Infectious Diseases, JJ399d, Health Sciences Centre, 700 William Street, Winnipeg, Manitoba, R3A 1R9, Canada
Curr Infect Dis Rep 12:336-44. 2010
..Recognizing the role of delays in administration of antimicrobial therapy in the poor outcomes of septic shock is central to this effort...
- Optimizing antimicrobial therapy in sepsis and septic shock
Anand Kumar
Section of Critical Care Medicine, Section of Infectious Diseases, Department of Medicine, Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Canada
Crit Care Nurs Clin North Am 23:79-97. 2011
..Antimicrobial therapy should be stopped if infection is not considered the etiologic factor for a shock state...
- Early versus late oseltamivir treatment in severely ill patients with 2009 pandemic influenza A (H1N1): speed is life
Anand Kumar
Section of Critical Care Medicine and Infectious Diseases, Health Sciences Centre and St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
J Antimicrob Chemother 66:959-63. 2011
..Optimal survival and minimal disease severity appear to result when antivirals are started as soon as possible after symptom onset...
- Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock
Anand Kumar
Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
Chest 136:1237-48. 2009
..Our goal was to determine the impact of the initiation of inappropriate antimicrobial therapy on survival to hospital discharge of patients with septic shock...
- Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
Anand Kumar
Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
Crit Care Med 34:1589-96. 2006
..To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock...
- The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels
Anand Kumar
Division of Cardiovascular Diseases and Critical Care Medicine, Cooper Hospital University Medical Center, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey
J Infect Dis 193:251-8. 2006
..This study was designed to examine the relationship between the timing of antibiotic treatment and both survival rates and hemodynamic/inflammatory correlates of survival in a murine model of Escherichia coli septic shock...
- Experimental human endotoxemia is associated with depression of load-independent contractility indices: prevention by the lipid a analogue E5531
Anand Kumar
Section of Critical Care Medicine, Health Sciences Centre, GE706, 820 Sherbrook St, Winnipeg, MB, Canada, R3A 1R9
Chest 126:860-7. 2004
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- Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
Anand Kumar
Division of Cardiovascular Disease and Critical Care Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA
Crit Care Med 32:691-9. 2004
..Neither central venous pressure nor pulmonary artery occlusion pressure appears to be a useful predictor of ventricular preload with respect to optimizing cardiac performance...
- Sepsis and septic shock: a history
Duane J Funk
Anesthesiology and Critical Care, University of Manitoba, Manitoba, Canada
Crit Care Clin 25:83-101, viii. 2009
..The early descriptions and theories about the etiology (microbial pathogens), pathogenesis (toxins and mediators), and treatment of sepsis-associated disease are also discussed...
- Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response
Anand Kumar
Division of Cardiovascular Disease and Critical Care Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA
Crit Care Med 33:331-40. 2005
..Early administration of rhIL-10 can potentially augment elements of the cytokine inflammatory response to lipopolysaccharide. These findings suggest significant limitations of rhIL-10 as a potential immunomodulatory therapy for sepsis...
- Septic shock, multiple organ failure, and acute respiratory distress syndrome
Sat Sharma
Section of Pulmonary Care Medicine, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Curr Opin Pulm Med 9:199-209. 2003
..This review will highlight and discuss recent advances in the pathophysiology and management of sepsis...
- Bacterial DNA and RNA induce rat cardiac myocyte contraction depression in vitro
Bhanu Paladugu
Division of Cardiovascular Disease and Critical Care Medicine, Cooper Hospital, University Medical Center, Robert Wood Johnson Medical School, Camden, New Jersey 08103, USA
Shock 21:364-9. 2004
..These data suggest that bacterial DNA and RNA may contribute to myocardial depression during bacterial sepsis and septic shock...
- Antimicrobial management of sepsis and septic shock
Sat Sharma
Section of Pulmonary Medicine, Department of Internal Medicine, University of Manitoba, 700 William Avenue, Winnipeg, Manitoba, Canada R3E 0Z3
Clin Chest Med 29:677-87, ix. 2008
..Antimicrobial therapy should be stopped if infection is not considered the etiologic factor for a shock state...
- Human endotoxemia and human sepsis: limits to the model
Ramon Anel
Section of Critical Care Medicine, University of North Dakota, Grand Forks, North Dakota, USA
Crit Care 9:151-2. 2005
..The current study demonstrates that human experimental endotoxemia fails to generate evidence of increased vascular permeability within the relatively short time frame of the study...
- Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza
Robert E Ariano
Department of Pharmacy, St Boniface General Hospital, and Department of Internal Medicine, The Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba
CMAJ 182:357-63. 2010
..We documented the pharmacokinetic profile of oseltamivir in patients admitted to intensive care units (ICUs) with suspected or confirmed pandemic (H1N1) influenza...
- Transforming growth factor-beta1 blocks in vitro cardiac myocyte depression induced by tumor necrosis factor-alpha, interleukin-1beta, and human septic shock serum
Anand Kumar
Section of Critical Care Medicine, Division of Cardiovascular Diseases and Critical Care Medicine, Cooper Hospital University Medical Center, Robert Wood Johnson Medical School, UMDNJ, Camden, NJ, USA
Crit Care Med 35:358-64. 2007
..Using an in vitro assay, this study sought to determine the effect of TGF-beta1 on myocyte depression induced by TNF-alpha, IL-1beta, and serum with known depressant activity from patients with septic shock...
- Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada
Darren H Freed
Surgical Heart Failure Program, Cardiac Sciences Program, St Boniface General Hospital, CR3030 Asper Clinical Research Building, 369 Tache Ave, Winnipeg, Manitoba R2H 2A6, Canada
Can J Anaesth 57:240-7. 2010
..In this report, we describe characteristics, treatment, and outcomes of critically ill patients in Canada who had H1N1-2009 infection and were treated with extracorporeal lung support (ECLS)...
- Myocardial dysfunction in the patient with sepsis
Sreenandh Krishnagopalan
Section of Critical Care Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA
Curr Opin Crit Care 8:376-88. 2002
..In addition, septic myocardial depression appears to be mediated in part through combinations of nitric oxide-dependent and -independent alterations of basal and catecholamine-stimulated cardiac myocyte contractility...
- Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza A
Titilayo Oluyomi-Obi
Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada
J Obstet Gynaecol Can 32:443-7, 448-52. 2010
..Information about these cases will be useful to help us understand the potential impact of future outbreaks and review critical illness in pregnancy...
- Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian Province
Manish M Sood
St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Kidney Dis 55:848-55. 2010
..2009 pandemic influenza A(H1N1) has led to a global increase in severe respiratory illness. Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1...
- Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
Ryan Zarychanski
Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
CMAJ 182:257-64. 2010
..The objective of this study was to identify factors correlated with severity of disease in confirmed cases of pandemic H1N1 influenza...
- The history and evolution of circulatory shock
Rizwan A Manji
Cardiac Sciences Program, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Clin 25:1-29, vii. 2009
..The most accepted current definition involves an oxygen supply/demand imbalance that can have various causes-hypovolemia, cardiac dysfunction, vascular failure, or obstructive processes...
- Early intravenous unfractionated heparin and mortality in septic shock
Ryan Zarychanski
Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 36:2973-9. 2008
..Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties. Unfractionated heparin has been shown to increase survival in experimental models of septic shock...
- Cytokine modulation in sepsis and septic shock
Sergio Zanotti
Section of Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Room 214 Jones, 1635 west Congress Parkway, Chicago, Illinois 60612, USA
Expert Opin Investig Drugs 11:1061-75. 2002
..Finally, newer developments related to less known cytokines such as macrophage migration inhibitory factor and high mobility group 1 protein will be evaluated...
- Sedation and analgesia usage in severe pandemic H1N1 (2009) infection: a comparison to respiratory failure secondary to other infectious pneumonias
Kendiss Olafson
Section of Critical Care, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
Ann Pharmacother 46:9-20. 2012
..During the 2009 H1N1 pandemic (pH1N1), patients requiring mechanical ventilation for respiratory failure received high doses of sedation and analgesia...
- Antimicrobial therapy for life-threatening infections: speed is life
Duane J Funk
Department of Anesthesia, Section of Critical Care Medicine, 2nd Floor Harry Medovy House, University of Manitoba, Winnipeg, Manitoba R3E 1X2, Canada
Crit Care Clin 27:53-76. 2011
..If "Time is tissue" when it comes to thrombolytic therapy for acute myocardial infarction and thrombotic stroke, then an appropriate rule for life-threatening infections, particularly septic shock, is "Speed is life."..
- Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression
Thanh Tan Nguyen
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
Psychosom Med 72:535-8. 2010
..To examine retinal vascular caliber, an indicator of early microvascular disease and depression in patients with Type 2 diabetes...
- Ventrally placed craniovertebral junction arachnoid cysts in children: a report of 2 cases and literature review
Sandeep Mohindra
Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
Surg Neurol 68:85-8. 2007
..Arachnoid cysts at the craniovertebral junction are uncommon, and all the reported cases had location posterior to the brain stem. We describe 2 cases of ventral arachnoid cysts among children...
- Biodiesel surrogates: achieving performance demands
Rakesh Sarin
Indian Oil Corporation Ltd, R and D Centre, Faridabad 121 007, India
Bioresour Technol 100:3022-8. 2009
..The cetane number of synthesized esters is 62-69, which is much better than diesel and biodiesel. The blends of the synthesized esters in diesel at 5% and 10% meet Indian standards of diesel...
- Giant dumbbell foramen magnum neurinomas presenting as posterior neck masses: single-stage removal by posterior midline approach
Sunil K Gupta
Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
Neurol India 55:61-3. 2007
..In both patients total surgical removal was achieved by a single-stage posterior midline approach. Both patients had complete neurological recovery...
- Foreign currency-related translation complexities in cross-border healthcare applications
Anand Kumar
Department of Public Health and Medical Informatics, SSPIM CIM 42 Université Jean Monnet, CHU Saint Etienne, 42270 Saint Priest en Jarez, France
Stud Health Technol Inform 150:96-100. 2009
..Such systems would need to come to terms with the complexities involved in such currency-related translations in order to provide the correct data for performance benchmarking...
- Practical lessons from the first outbreaks: clinical presentation, obstacles, and management strategies for severe pandemic (pH1N1) 2009 influenza pneumonitis
Duane J Funk
Department of Anesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 38:e30-7. 2010
..We hope to offer some insight into potential pitfalls and problems that may be experienced by other centers and provide some potential approaches to addressing these issues...
- Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus
Clare D Ramsey
Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 38:e58-65. 2010
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- The utility of tissue Doppler imaging for the noninvasive determination of left ventricular filling pressures in patients with septic shock
Negareh Mousavi
Section of Cardiology, Department of Cardiac Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
J Intensive Care Med 25:163-7. 2010
..Diastolic indices using transthoracic echocardiography (TTE) may provide an accurate estimate of PAWP...
- Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial
R Phillip Dellinger
Cooper University Hospital and University Medicine Dentistry New Jersey PD, Camden, NJ, USA
Crit Care Med 37:2929-38. 2009
..Endotoxin neutralization correlates with the amount of phospholipid in the lipoprotein particles...
- Chemokine receptor 5 ?32 allele in patients with severe pandemic (H1N1) 2009
Yoav Keynan
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
Emerg Infect Dis 16:1621-2. 2010
..We found a large proportion of heterozygosity for the CCR5?32 allele among white patients with severe disease...
- Novel therapies for sepsis: antiendotoxin therapies
Sanjay Manocha
Section of Critical Care Medicine, Health Sciences Center, University of Manitoba, 820 Sherbrook Street, Winnipeg, Manitoba, Canada, R3A 1R
Expert Opin Investig Drugs 11:1795-812. 2002
..This review discusses current knowledge regarding endotoxin signalling, antiendotoxin therapies currently under development, and future areas for research...
- Persistent left superior vena cava: an intensivist's experience and review of the literature
Rajit Pahwa
Section of Critical Care Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL, USA
South Med J 96:528-9. 2003
..This report describes a case of persistent left superior vena cava detected after successful placement of a pulmonary artery catheter...
- H1N1: viral pneumonia as a cause of acute respiratory distress syndrome
Clare Ramsey
Section of Respiratory Medicine, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Curr Opin Crit Care 17:64-71. 2011
..To review the literature on novel swine origin influenza A (H1N1 2009) as a cause of respiratory failure and acute respiratory distress syndrome (ARDS)...
- Antimicrobial therapy of sepsis and septic shock--when are two drugs better than one?
Cybele L Abad
Department of Internal Medicine, Section of Infectious Diseases, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA
Crit Care Clin 27:e1-27. 2011
..In this article, we examine the evidence for, or against, the use of combination drug therapy compared with monotherapy in the management of serious infections, sepsis, and septic shock...
- Nationwide molecular surveillance of pandemic H1N1 influenza A virus genomes: Canada, 2009
Morag Graham
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
PLoS ONE 6:e16087. 2011
..Sequencing has since been conducted at an unprecedented rate globally in order to monitor the diversification of this emergent virus and to track mutations that may affect virus behavior...
- Enrichment of variations in KIR3DL1/S1 and KIR2DL2/L3 among H1N1/09 ICU patients: an exploratory study
David La
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
PLoS ONE 6:e29200. 2011
..To study factors involved in NK cell dysfunction in overactive immune responses to H1N1 infection, KIR3DL1/S1 and KIR2DL2/L3 allotypes and cognate HLA ligands of H1N1/09 intensive-care unit (ICU) patients were determined...
- A systems approach to the early recognition and rapid administration of best practice therapy in sepsis and septic shock
Duane Funk
Department of Medicine, Section of Critical Care Medicine, University of Manitoba, Winnipeg, Canada
Curr Opin Crit Care 15:301-7. 2009
..This review focuses on the early diagnosis of sepsis and the implementation of a systems-based approach to help coordinate the identification and treatment of patients with this disease...
- Leukocyte lysozyme: a novel cause of septic myocardial depression?
Leo Taiberg
Crit Care Med 32:304-5. 2004
- Endotoxemic myocardial depression: a novel inducible nitric oxide synthase suppressant effect of albumin
Anand Kumar
Crit Care Med 31:324-6. 2003
- Comparison of sevoflurane and isoflurane in OPCAB surgery
B G Venkatesh
Department of Anaesthesiology and Critical Care, Escorts Heart Institute and Research Centre, New Delhi
Ann Card Anaesth 10:46-50. 2007
..We conclude that sevoflurane and isoflurane can both be safely used in OPCAB surgery, but the awakening and extubation times are significantly less with sevoflurane...
- Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes
Aseem Kumar
Department of Chemistry and Biochemistry and the Biomolecular Sciences Programme, Laurentian University, Sudbury, Ontario P3E 2C6, Canada
J Biol Chem 280:42619-26. 2005
..These data suggest that transcription factor activation and early myocyte apoptosis play a mechanistic role in septic myocardial depression and sepsis-induced organ dysfunction...
- Nitric oxide and inflammatory cytokines in the heart: the presence of positive feedback loops
Anand Kumar
Crit Care Med 33:2851-2. 2005
- One year of neurosurgery in the eastern region of Nepal
Amit Agrawal
Department of Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
Surg Neurol 69:652-6; discussion 656. 2008
..This article briefly discusses about the present status, future strategies, and perspectives of neurosurgery in the eastern region of Nepal...
- Myocardial depressant substances in meningococcal septic shock
Anand Kumar
Crit Care Med 30:2379-80. 2002
- Circulating substances and energy metabolism in septic shock
Anand Kumar
Crit Care Med 31:632-3. 2003
- Antibiotic management of suspected nosocomial ICU-acquired infection: does prolonged empiric therapy improve outcome?
Mary Anne W Aarts
University of Toronto, Interdepartmental Division of Critical Care Medicine and the Department of Surgery, Toronto, Canada
Intensive Care Med 33:1369-78. 2007
..To characterize empiric antibiotic use in patients with suspected nosocomial ICU-acquired infections (NI), and determine the impact of prolonged therapy in the absence of infection...
- Daily functioning and prefrontal brain morphology in healthy and depressed community-dwelling elderly
Virginia Elderkin-Thompson
Semel Institute for Neuroscience and Human Behavior, Geriatric Division, UCLA, Los Angeles, CA, USA
Am J Geriatr Psychiatry 16:633-42. 2008
..This study examined relationships between self-reported levels of general functioning and the combined volume of three integrated prefrontal structures associated with self-perception and emotion...
- Interleukin-1 gene cluster polymorphisms: all in the family
Aseem Kumar
Crit Care Med 30:1168-9. 2002
- The feasibility of nitric oxide delivery with high frequency jet ventilation
Yaseen Arabi
Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
Respirology 10:673-7. 2005
..In this case we were able to achieve reliable and constant levels of NO. The purpose of this report is to discuss the technical aspects and pitfalls of this method...
- Application of a plain abdominal radiograph transition zone (PARTZ) in Hirschsprung's disease
Akshay Pratap
Division of Pediatric Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
BMC Pediatr 7:5. 2007
..The aim of this study was to determine the utility and diagnostic accuracy of a plain abdominal radiograph transition zone (PARTZ) in predicting the level of aganglionosis...
- Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana
Priyali Pathak
Department of Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110-029, India
Indian J Pediatr 71:1007-14. 2004
..The concurrent prevalence of two, three, four and five micronutrient deficiencies were common...
- Decompressive hemicraniectomy in malignant middle cerebral artery infarction: an analysis of long-term outcome and factors in patient selection
Ashok Pillai
Department of Neurosurgery, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India
J Neurosurg 106:59-65. 2007
..The present study was undertaken to assess the immediate and long-term outcome of this intervention and to help better define the selection criteria for surgery...
- Methylphenidate-enhanced antidepressant response to citalopram in the elderly: a double-blind, placebo-controlled pilot trial
Helen Lavretsky
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
Am J Geriatr Psychiatry 14:181-5. 2006
..The authors evaluated the potential of methylphenidate to accelerate and enhance antidepressant response to citalopram in elderly depressed patients...
- Color Doppler ultrasound as an objective assessment tool for chemotherapeutic response in advanced breast cancer
Seema Singh
Department of General Surgery, Institute of Medical Sciences, B-4 New Medical enclave Banaras Hindu University Varanasi-221005, India
Breast Cancer 12:45-51. 2005
..CONCLUSIONS: Color Doppler was found to be an objective and effective tool or modality compared with clinical evaluation in sequential response assessment, especially for predicting complete histological response...
- The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
Helen Lavretsky
UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
Int J Geriatr Psychiatry 23:55-9. 2008
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