Michael Kuczewski

Summary

Publications

  1. ncbi Development of a polishing step using a hydrophobic interaction membrane adsorber with a PER.C6-derived recombinant antibody
    Michael Kuczewski
    Percivia LLC, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 105:296-305. 2010
  2. ncbi A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line
    Michael Kuczewski
    Percivia LLC, 1 Hampshire St, Cambridge, MA, USA
    Biotechnol J 6:56-65. 2011

Detail Information

Publications2

  1. ncbi Development of a polishing step using a hydrophobic interaction membrane adsorber with a PER.C6-derived recombinant antibody
    Michael Kuczewski
    Percivia LLC, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 105:296-305. 2010
    ..Loading and elution conditions were optimized using statistical design of experiments. Scale-up is further discussed, and the performance of the membrane adsorber is compared to a traditional HIC resin used in column chromatography...
  2. ncbi A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line
    Michael Kuczewski
    Percivia LLC, 1 Hampshire St, Cambridge, MA, USA
    Biotechnol J 6:56-65. 2011
    ..A proof of concept of the entire disposable process was completed for two different scales of the purification train...