Research Topics
Genomes and Genes | Eun Yi MoonSummaryAffiliation: Sejong University Country: Korea Publications
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Detail Information
Publications
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathwaysEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea
Life Sci 90:373-80. 2012....- Differential role of peroxiredoxin II (PrxII) on the expression of toll-like receptor 4 (TLR4) and B-cell activating factor (BAFF) in ovalbumin (OVA)-induced mouse asthmaEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Republic of Korea
Int Immunopharmacol 8:935-44. 2008..Collectively, results show that PrxII may have benefits in asthma through reducing ROS. It suggests that BAFF and TLR4 expressions are differentially regulated by PrxII and TLR4 protein level may not be crucial in OVA-induced asthma... - Actin-sequestering protein, thymosin beta-4, is a novel hypoxia responsive regulatorEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
Clin Exp Metastasis 27:601-9. 2010..It suggests that TB4 could be a hypoxia responsive regulator to control tumor cell migration in angiogenesis and tumor metastasis... - Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-kappaB pathway in Raw 264.7 murine macrophagesEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Republic of Korea
Immunol Lett 110:121-5. 2007..It suggests that Epac1-mediated Rap1/NF-kappaB pathway could be helpful for interpretation on various cAMP-mediated physiological responses and it could be used as a target to control their pathological abnormalities... - An increase in mouse tumor growth by an in vivo immunomodulating effect of titanium dioxide nanoparticlesEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea
J Immunotoxicol 8:56-67. 2011..These studies allow us to suggest that TiO? nanoparticles might have the potential to enhance tumor growth through immunomodulation of B- and T-lymphocytes, macrophages, and NK cells... - TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in miceEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Korea
Exp Mol Med 39:343-52. 2007..Collectively, data suggest that asthmatic symptom could be alleviated by scavenging BAFF and then BAFF could be a novel target for the development of anti-asthmatic agents... - ROS/Epac1-mediated Rap1/NF-kappaB activation is required for the expression of BAFF in Raw264.7 murine macrophagesEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Republic of Korea
Cell Signal 23:1479-88. 2011..It suggests for the first time that ROS/Epac1-mediated Rap1/NF-?B pathway could be required for BAFF expression... - An increase in B cell apoptosis by interfering BAFF-BAFF-R interaction with small synthetic moleculesEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Republic of Korea
Int Immunopharmacol 11:1523-33. 2011..It suggests that BAFF-BAFF-R interaction could be a chemical target to develop therapeutics for BAFF-mediated autoimmune diseases... - Actin-sequestering protein, thymosin-beta-4 (TB4), inhibits caspase-3 activation in paclitaxel-induced tumor cell deathEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Korea
Oncol Res 16:507-16. 2007..In conclusion, soluble TB4 peptides produced in cancer cells could be an obstacle to treat tumors with paclitaxel. Therefore, TB4 could be a novel target to control paclitaxel resistance... - Toll-like receptor 4-mediated cAMP production up-regulates B-cell activating factor expression in Raw264.7 macrophagesEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Republic of Korea
Exp Cell Res 317:2447-55. 2011..With these data, it suggests that the activation of PKA and cAMP/Epac1/Rap1 pathways could be required for basal mBAFF expression, as well as being up-regulated in the TLR4-induced mBAFF expression... - B cell activating factor (BAFF) gene promoter activity depends upon co-activator, p300Eun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Republic of Korea
Immunobiology 212:637-45. 2007..Data suggest that mBAFF expression could be regulated by promoter activation through NF-kappaB activation, which might be dependent on the cooperation with co-activator, p300... - Clitocybins, novel isoindolinone free radical scavengers, from mushroom Clitocybe aurantiaca inhibit apoptotic cell death and cellular senescenceEun Yi Moon
Department of Bioscience and Biotechnology, Sejong University, 98 Kunja Dong Kwangjin Gu, Seoul 143 747, Republic of Korea
Biol Pharm Bull 32:1689-94. 2009..It suggests that clitocybins are novel compounds scavenging ROS and protect cells from apoptosis and cellular senescence... - Actin-sequestering protein, thymosin beta-4, induces paclitaxel resistance through ROS/HIF-1alpha stabilization in HeLa human cervical tumor cellsJin Mi Oh
Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea
Life Sci 87:286-93. 2010..We investigated whether actin-sequestering protein, thymosin beta-4 (TB4)-induced reactive oxygen species (ROS) affect the stabilization of hypoxia-inducible transcription factor (HIF)-1alpha and paclitaxel-resistance induction... - Hypoxia-inducible transcription factor (HIF)-1 alpha stabilization by actin-sequestering protein, thymosin beta-4 (TB4) in Hela cervical tumor cellsJin Mi Oh
Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea
Cancer Lett 264:29-35. 2008..It suggests that soluble TB4P could be a novel target to control tumor cell death by regulating tumor cell microenvironment... - Paclitaxel induces vascular endothelial growth factor expression through reactive oxygen species productionHyun Sun Kim
Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
Pharmacology 81:317-24. 2008.... - KR33426, [2-(2,5-dichlorophenyl)-5-methyloxazol-4yl]carbonylguanidine, is a novel compound to be effective on mouse systemic lupus erythematosusGeun Hee Lee
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Republic of Korea
Eur J Pharmacol 668:459-66. 2011..Thus, it suggests that KR33426 is a novel candidate to develop anti-autoimmune therapeutics by the interference of BAFF-BAFF-R interactions, specifically... - Cooperation of actin-sequestering protein, thymosin ?-4 and hypoxia inducible factor-1? in tumor cell migrationYun Kyoung Ryu
Department of Bioscience and Biotechnology, Sejong University, Seoul 143 747, Korea
Oncol Rep 24:1389-94. 2010..The inhibitory effect of T?4-shRNA or HIF-1?-siRNA was also attenuated by treatment with T?4 proteins. Collectively, these findings suggest that T?4 and HIF-1? cooperatively enhance tumor cell migration... - Src activates HIF-1? not through direct phosphorylation of HIF-1? specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathwayHo Youl Lee
Department of Life Science, University of Seoul, Siripdae gil 13, Dongdaemun Gu, Seoul, Korea
Carcinogenesis 32:703-12. 2011..Src-induced ROS reduces cellular vitamin C, which is required for the activity of PHD2, thus Src can block VHL recruitment of HIF-1?, leading to stabilization of HIF-1?... - Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticlesKyeongah Kang
Department of Biological Science and the Research Center for Women s Disease, Sookmyung Women s University, Seoul, Republic of Korea
Toxicol Lett 205:227-34. 2011..Thus, our study suggests that exposure to AgNPs can cause angiogenesis through the production of angiogenic factors... - Red ginseng acidic polysaccharide (RGAP) in combination with IFN-gamma results in enhanced macrophage function through activation of the NF-kappaB pathwayHye Sook Choi
Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi Do, Republic of Korea
Biosci Biotechnol Biochem 72:1817-25. 2008..These data also support the development of clinical studies of this combination... - Adipocyte culture medium stimulates production of macrophage inhibitory cytokine 1 in MDA-MB-231 cellsJae Hyeong Kim
Research Center for Women s Disease, Department of Life Science, Sookmyung Women s University, Seoul 140 742, Republic of Korea
Cancer Lett 261:253-62. 2008..In addition, adipocyte-CM-induced MIC-1 also increased invasiveness of MDA-MB-231 cells... - Prodigiosin isolated from Hahella chejuensis suppresses lipopolysaccharide-induced NO production by inhibiting p38 MAPK, JNK and NF-kappaB activation in murine peritoneal macrophagesJung Eun Huh
Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University, Suwon City, Kyunggi Do, 440 746, Republic of Korea
Int Immunopharmacol 7:1825-33. 2007.... - Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosisSanjay Tiwari
Department of Medicine, Section of Hematology Oncology, Boston Medical Center, MA 02118, USA
Blood 103:2661-7. 2004..002). Our results demonstrate that B-CLL cells uniquely activate Rap1 in response to PDE4 inhibitors and suggest that physiologic stimuli that activate EPAC may transmit an antiapoptotic signal... - Epac1-mediated Rap1 activation is not required for the production of nitric oxide in BV2, murine microglial cellsEun Yi Moon
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology KRIBB, Taejeon, Korea
J Neurosci Res 81:38-44. 2005..This suggests that LPS-stimulated NO production is mainly PKA-dependent and also that Epac1-mediated Rap1 activation is not required for the induction of NO production... - Gender-dependent hepatic alterations in H-ras12V transgenic miceAi-Guo Wang
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, South Korea
J Hepatol 43:836-44. 2005..Our transgenic mice represent a potentially valuable animal model for future investigations... - Inhibitory role of peroxiredoxin II (Prx II) on cellular senescenceYing Hao Han
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology KRIBB, 52 Oun Dong, Yusong, Taejeon 305 806, Korea
FEBS Lett 579:4897-902. 2005..These results suggest that Prx II may function as an enzymatic antioxidant to prevent cellular senescence and skin aging... - Estrogen receptor-independent inhibition of tumor necrosis factor-alpha gene expression by phytoestrogen equol is mediated by blocking nuclear factor-kappaB activation in mouse macrophagesJong Soon Kang
Biovaluation Center, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
Biochem Pharmacol 71:136-43. 2005.... - T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) geneEun Yi Moon
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, Taejeon 305 806, Republic of Korea
Immunol Lett 102:184-90. 2006..Collectively, these data suggest that Prx II inhibits the immune cell responsiveness, which may be regulated by scavenging the low amount of reactive oxygen species (ROS)... - ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistanceSu Young Oh
Department of Human Genomics, Korea Research Institute of Bioscience and Biotechnology KRIBB, Taejeon 305 806, Korea
Exp Cell Res 312:1651-7. 2006..In conclusion, TB4 induced paclitaxel-resistance through the elevation of basal level of ERK phosphorylation. Therefore, TB4 could be a novel target to regulate paclitaxel-resistance... - Reactive oxygen species augment B-cell-activating factor expressionEun Yi Moon
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, KRIBB, Taejeon 305 806, Korea
Free Radic Biol Med 40:2103-11. 2006..Data suggest that TLR4-mediated BAFF expression was increased by ROS and it was inhibited by PrxII controlling ROS production... - B cell-activating factor is a novel diagnosis parameter for asthmaJong-Soon Kang
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB, Yusong-gu, Taejeon, Korea
Int Arch Allergy Immunol 141:181-8. 2006..Thus, BAFF could be a parameter to monitor the severity of asthma symptoms... - Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescenceYing Hao Han
Department of Human Genomics, Korea Research Institute of Bioscience and Biotechnology KRIBB, Taejeon, 305 806, South Korea
Free Radic Res 40:1182-9. 2006..Collectively, results suggest that Prx II deletion activate Ras-ERK-NFkappaB pathways and cellular senescence in Prx II-/- MEF cells was mediated by ERK activation but not by NFkappaB activation... - Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cellsEun-Yi Moon
Department of Medicine, Section of Hematology and Oncology, Boston Medical Center, Massachusetts 02118, USA
Cancer Res 62:5711-9. 2002..Our work demonstrates that addition of a benzylamide moiety to sulindac compounds results in markedly altered pharmacological properties that may be of use in the therapy of lymphoid malignancies... - Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydesEun Yi Moon
Department of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Oun Dong, Yusong gu, Taejeon 305 806, Korea
Eur J Pharmacol 530:270-5. 2006..Data suggest that the delayed hepatic tumor development observed with BCA could be mediated by a long-term immunostimulating effect on T cells... - SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugatesHongyan Wang
Department of Haematology, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Nat Immunol 4:366-74. 2003..Our findings identify a mechanism by which SKAP-55 modulates T cell responses to antigen... - Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinonesSang Hun Jung
College of Pharmacy, Chungnam National University, Taejon 305 764, Korea
Arch Pharm Res 27:478-84. 2004.... - Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymusEun Yi Moon
The Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Eun Dong, Yudong Gu, Taejen 305 606, South Korea
Eur J Immunol 34:2119-28. 2004..Collectively, the results suggest for the first time that thymocyte maturations and proliferations are regulated by ROS levels induced by the deletion of PrxII gene in vivo... - Human placenta promotes IL-8 expression through activation of JNK/SAPK and transcription factors NF-kappaB and AP-1 in PMA-differentiated THP-1 cellsSeok Seong Kang
Department of Oral Microbiology and Immunology, Dental Research Institute, and BK21 Program, School of Dentistry, Seoul National University, Seoul 110 749, Republic of Korea
Int Immunopharmacol 7:1488-95. 2007..Taken together, these results suggest that HPE-induced IL-8 secretion occurs via activation of JNK/SAPK and transcription factors NF-kappaB and AP-1 in PMA-differentiated THP-1 cells... - Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga miceJong Soon Kang
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Chungbuk, Republic of Korea
Int Immunopharmacol 7:1589-97. 2007....