Research Topics
Genomes and Genes | H A KimSummaryAffiliation: Hallym University Country: Korea Publications
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Detail Information
Publications
The association between meniscal and cruciate ligament damage and knee pain in community residentsH A Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Kyunggi Do, Republic of Korea
Osteoarthritis Cartilage 19:1422-8. 2011..To describe the frequency of meniscal and cruciate ligament damage by magnetic resonance imaging (MRI) and to examine its association with knee pain in community residents in Korea...- Tibiofemoral osteoarthritis affects quality of life and function in elderly Koreans, with women more adversely affected than menInje Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
BMC Musculoskelet Disord 11:129. 2010.... - Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in miceHyun Ah Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea
Int Immunopharmacol 7:1286-91. 2007..The development of orally bioavailable, inexpensive inhibitors of tumor necrosis factor (TNF)-alpha is desirable for the treatment of rheumatoid arthritis (RA)... - The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytesHyun Ah Kim
Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 896, Pyongchon dong, Dongan Gu, Anyang, Kyunggi do 431 070, Republic of Korea
Arthritis Rheum 54:2152-63. 2006..To examine the catabolic pathways mediated by Toll-like receptor (TLR) ligands in human osteoarthritic (OA) chondrocytes... - Transduction of Cu, Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into human chondrocytesHyun Ah Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, 896, Pyongchondong, Dongan Gu, Anyang, Kyunggi Do, 431 070, Korea
Arthritis Res Ther 8:R96. 2006..Construction of additional Tat-fusion proteins that can regulate cartilage metabolism favorably and application of this technology in in vivo models of arthritis are the subjects of future studies... - Ultrasonographic findings of the shoulder in patients with rheumatoid arthritis and comparison with physical examinationHyun Ah Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
J Korean Med Sci 22:660-6. 2007..In conclusion, US abnormalities showed frequent tendon tears in our RA patients. Physical examination had low sensitivity and specificity for detecting rotator cuff tear in the rheumatoid shoulder joint... - The epidemiology of total knee replacement in South Korea: national registry dataH A Kim
Hallym University Sacred Heart Hospital, Anyang, South Korea
Rheumatology (Oxford) 47:88-91. 2008..Using data from a national registry, we sought to estimate the incidence of TKR by age and sex, and the trend for TKR utilization from 2002 to 2005 in South Korea... - The mechanism of low-concentration sodium nitroprusside-mediated protection of chondrocyte deathHyun A Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi Do, Korea
Arthritis Res Ther 7:R526-35. 2005..This protective effect was found to be correlated with the upregulation of both HO-1 and NF-kappaB and with the concomitant downregulation of both extracellular signal-regulated protein kinase 1/2 and p38 activation... - Low rate of total hip replacement as reflected by a low prevalence of hip osteoarthritis in South KoreaH A Kim
Hallym University Sacred Heart Hospital, Anyang, Republic of Korea
Osteoarthritis Cartilage 16:1572-5. 2008..We attempted to estimate the rate of total hip replacement (THR) using a national database and the prevalence of hip osteoarthritis (OA) from the reading of intravenous pyelograms (IVPs) in a Korean population... - Phase 2 enzyme inducer sulphoraphane blocks matrix metalloproteinase production in articular chondrocytesHyun Ah Kim
Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Dongan Gu, Anyang, Korea
Rheumatology (Oxford) 48:932-8. 2009..In this study, we examined the influence of sulphoraphane (SPN), one of the most potent inducers of the phase II enzymes on the production of MMPs by pro-inflammatory cytokines in human articular chondrocytes... - Arthritis information on the Web and its influence on patients and physicians: a Korean studyH A Kim
Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea
Clin Exp Rheumatol 22:49-54. 2004..This study was conducted to assess the contents of Web-sourced arthritis information and to determine its influence on arthritis patients and medical practice in Korea... - Use of complementary and alternative medicine by arthritis patients in a university hospital clinic serving rheumatology patients in KoreaHyun Ah Kim
Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, 445 Gil Dong, Kangdong gu, Seoul 134 401, Korea
Rheumatol Int 23:277-81. 2003..Dialogue about CAM use with Korean patients does not seem to have been initiated yet, as the main reason given for not discussing CAM use with physicians was "not being asked.".. - Ultrasonographic findings of painful shoulders and correlation between physical examination and ultrasonographic rotator cuff tearHyun Ah Kim
Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 896, Pyongchondong, Dongan Gu, Anyang, Kyunggi do 431 070, South Korea
Mod Rheumatol 17:213-9. 2007..US examination leads to an anatomical diagnosis of shoulder pain in many patients. Whether the US examination of the painful shoulder improves its treatment should be investigated... - Relationship between chondrocyte apoptosis and matrix depletion in human articular cartilageH A Kim
Department of Internal Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Korea
J Rheumatol 28:2038-45. 2001..Upregulation of Fas ligand in matrix depleted specimens suggested that the Fas pathway may have a role in apoptosis induced by matrix depletion... - Inhibition of NF-kappaB renders human juvenile costal chondrocyte cell lines sensitive to TNF-alpha-mediated cell deathHo Sung Yoon
Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, 445 Gil-dong, Kangdong-gu, Seoul, 134-701, South Korea
Rheumatol Int 26:201-8. 2006..The expression of Bcl-XL, Bcl-2 and XIAP and activation of JNK were affected by ad-IkappaB-SR transduction, implying a role in the NF-kappaB regulated cell survival signaling in human chondrocytes... - Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanateJin Sun Kong
Catholic University of Korea, Seoul, South Korea
Arthritis Rheum 62:159-70. 2010..To investigate whether sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables such as broccoli, regulates synoviocyte hyperplasia and T cell activation in rheumatoid arthritis (RA)... - Calcineurin modulates the catabolic and anabolic activity of chondrocytes and participates in the progression of experimental osteoarthritisSeung Ah Yoo
Catholic University of Korea, Seoul, South Korea
Arthritis Rheum 56:2299-311. 2007..To determine whether intracellular calcineurin (Cn), a calcium-activated phosphatase, regulates the anabolic and catabolic activities of chondrocytes, and is a potential target in the treatment of osteoarthritis (OA)... - Prologation of c-Jun N-terminal kinase is associated with cell death induced by tumor necrosis factor alpha in human chondrocytesHo Sung Yoon
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
J Korean Med Sci 19:567-73. 2004..This effect may be due to downregulation of TNF-alpha induced phosphatase that inactivates JNK and of Bcl-2 family proteins... - Cell death and apoptosis in osteoarthritic cartilageH A Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, Korea
Curr Drug Targets 8:333-45. 2007..Finally, the regulation of the natural inhibitors of apoptosis (c-FLIP, BAR, ARC and HC-gp39) could complement the other strategies to reduce cartilage degradation... - Serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and pentraxin 3 (PTX3) as markers of infection in febrile patients with systemic lupus erythematosusJ Kim
Department of Internal Medicine, Seoul National University Hospital, Korea
Clin Exp Rheumatol 27:773-8. 2009..To investigate the role of sTREM-1 and PTX3 as markers of infection in febrile patients with SLE... - Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clinical trialYeong Wook Song
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
Clin Ther 29:862-73. 2007..Those studies found that SKI306X was associated with an anti-inflammatory and analgesic effect, and that it can delay the destruction of cartilage in rheumatoid arthritis (RA)... - The prevalence and risk factors associated with isolated untreated systolic hypertension in Korea: the Korean National Health and Nutrition Survey 2001J A Kim
Department of Family Medicine, Cheil General Hospital and Women s Health Care Center, Seoul, Korea
J Hum Hypertens 21:107-13. 2007..The findings of the present study demonstrate that the prevalence of untreated ISH in Korea was lower than in Western countries. Age, BMI, TG levels, monthly income and alcohol intake were associated with ISH... - Type III procollagen N-terminal propeptide, soluble interleukin-2 receptor, and von Willebrand factor in systemic sclerosisY J Lee
Department of Internal Medicine, Clinical Research Institute, College of Medicine, Seoul National University, and Chungnam National University, Korea
Clin Exp Rheumatol 19:69-74. 2001..Increased serum levels of sIL-2R in SSc patients support a role for T lymphocyte activation in the pathogenesis of systemic sclerosis... - Glutathione S-transferase M1, T1, and P1 gene polymorphisms and carotid atherosclerosis in Korean patients with rheumatoid arthritisJae Hong Park
Division of Rheumatology, Department of Internal Medicine, Hanyang University College of Medicine and the Hospital for Rheumatic Diseases, Seoul 133 792, Korea
Rheumatol Int 24:157-63. 2004..008). This study suggests that the GSTT1-0 genotype might have an interaction with carotid atherosclerosis related to RA in Korean postmenopausal RA women without histories of smoking... - Role of the oxygen-dependent degradation domain in a hypoxia-inducible gene expression system in vascular endothelial growth factor gene therapyHonglian Jin
Department of Neurosurgery, Spine and Spinal Cord Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
Spine (Phila Pa 1976) 34:E952-8. 2009..CONCLUSION.: These results strongly suggest the potential applicability of this EPO enhancer/ODD domain-based hypoxia-inducible gene expression system in the development of a safer and more effective VEGF gene therapy for SCI... - Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trialEun Young Lee
Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Chongno-gu, Seoul, Republic of Korea
Clin Ther 28:2052-60. 2006..Use of tramadol/APAP may be considered when analgesics are needed in addition to conventional NSAIDs and disease-modifying antirheumatic drugs in subjects with RA... - The prevalence of knee osteoarthritis in elderly community residents in KoreaInje Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
J Korean Med Sci 25:293-8. 2010..Lower level of education was significantly associated with the presence of ROA, and female sex with the presence of SOA. In conclusion, both ROA and SOA are common in the aged adult population of Korea, with preponderance for women... - Dexamethasone-conjugated polyethylenimine as an efficient gene carrier with an anti-apoptotic effect to cardiomyocytesHyunjung Kim
Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea
J Gene Med 11:515-22. 2009..To apply the anti-apoptotic effect of dexamethasone to ischemic disease gene therapy, dexamethasone-conjugated polyethylenimine (PEI-Dexa) was synthesized and evaluated as an anti-apoptotic gene carrier... - Reducible poly(oligo-D-arginine) for enhanced gene expression in mouse lung by intratracheal injectionYoung Wook Won
Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University, Seoul, Republic of Korea
Mol Ther 18:734-42. 2010..Reducible high molecular weight poly(oligo-D-arginine) based on R9 PTD is a very promising nonviral gene carrier for lung diseases by efficiently condensing, stabilizing, and transfecting DNA... - Hemoglobin induces colon cancer cell proliferation by release of reactive oxygen speciesRyung Ah Lee
Department of Surgery, Ewha Womans University Mokdong Hospital, 158 710, 911 1, Mokdong, Yangcheonku, Seoul, Korea
World J Gastroenterol 12:5644-50. 2006..To study whether hemoglobin could amplify colon cancer cell proliferation via reactive oxygen species (ROS) production... - Efficient gene expression system using the RTP801 promoter in the corpus cavernosum of high-cholesterol diet-induced erectile dysfunction rats for gene therapyMinhyung Lee
Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea
J Sex Med 5:1355-64. 2008..The application of gene therapy for a nonlife-threatening disease, such as erectile dysfunction (ED), requires a higher safety level and more efficacious systems for gene transfer... - Augmentation of erythropoietin enhancer-mediated hypoxia-inducible gene expression by co-transfection of a plasmid encoding hypoxia-inducible factor 1alpha for ischemic tissue targeting gene therapySuyeon Lee
Department of Bioengineering, College of Engineering, Hanyang University, 17 Haengdang dong, Seongdong Gu, Seoul, South Korea
J Drug Target 16:43-50. 2008..Therefore, with hypoxia specificity and higher gene expression, co-transfection of pSV-HIF1alpha and pEpo-SV-VEGF may be useful for ischemia targeting gene therapy... - Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissuesHyun Ah Kim
Department of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea
Exp Mol Pathol 80:165-70. 2006.... - A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis painChan Bum Choi
Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, Republic of Korea
Clin Ther 29:1381-9. 2007..Combined tramadol/acetaminophen is used to treat pain related to osteoarthritis. However, adverse events (AEs) leading to discontinuation can occur. Dose titration may decrease the risk for AEs... - Expression, purification and characterization of TAT-high mobility group box-1A peptide as a carrier of nucleic acidsKyunghwa Kim
Department of Bioengineering, College of Engineering, Hanyang University, 17 Haengdang dong, Seongdong Gu, Seoul 133 791, Republic of Korea
Biotechnol Lett 30:1331-7. 2008..Finally, rTAT-HMGB1A had no cytotoxicity to HEK 293 cells suggesting that rTAT-HMGB1A may be useful as a non-toxic gene delivery carrier... - G769A variation of inhibin alpha-gene in korean women with premature ovarian failureHye Jin Jeong
Genome Research Center for Reproductive Medicine and Infertility of Korea Ministry of Health and Welfare, CHA General Hospital, College of Medicine, Pochon CHA University, 606 5 Yeoksam dong, Kangnam Gu, Seoul 135 081, Korea
Yonsei Med J 45:479-82. 2004..We found no variation between the normal subjects and the POF patients. G769A variation of INHalpha is rare in Korea women with POF... - Transcriptional and post-translational regulatory system for hypoxia specific gene expression using the erythropoietin enhancer and the oxygen-dependent degradation domainHyun Ah Kim
Department of Bioengineering, College of Engineering, Hanyang University, 17 Haengdang dong, Seongdong Gu, Seoul 133 791, South Korea
J Control Release 121:218-24. 2007..This highly hypoxia specific gene expression system will be useful for development of targeting gene therapy for ischemic diseases... - Correlation between ultrasonographic findings and the response to corticosteroid injection in pes anserinus tendinobursitis syndrome in knee osteoarthritis patientsHo Sung Yoon
Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea
J Korean Med Sci 20:109-12. 2005..It is of note that the 2 patients who showed the best response were those who showed US evidence of PATB. This finding shows that US can serve as a useful diagnostic tool for guiding treatment in PATB syndrome of OA patients... - Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritisKyung Ho Choi
Department of Biochemistry and Molecular Biology, Biology/Aging and Apoptosis Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea
Exp Mol Med 37:546-52. 2005..These results suggest that anti-filaggrin antibody recognizes the uncitrullinated filaggrin as an antigen and its titer correlates with clinical parameters, explaining the variable sensitivity of anti-filaggrin antibody test...